aula aline dna traducao bioinfo
TRANSCRIPT
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Código Genético e Síntese de Proteínas
Profa. Dra. Aline Maria da Silva
Instituto de Química- USP
Bibliografia:
Genes VII - Benjamin Lewin
Biologia Molecular Básica-Arnaldo Zaha
Lenhinger Principles of Biochemistry (3a. Ed.)
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Replicação
Transcrição
Tradução
Proteína
- Processo para síntese das proteínas da célula
- Processo que ocorre nos ribossomos
- Processo para síntese das proteínas da célula
- Processo que ocorre nos ribossomos
Transcrição Reversa
Replicação de RNA
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Síntese e Processamento de Proteínas
Transcrito primário
Processamento pós-transcricional
Modificações covalentes nos aminoácidos
Processamentopós-tradução
Proteína ativa
Transcrição
mRNA maduro
Tradução Dobramento
Proteína (inativa)
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tRNA
-Estrutura secundária com grampos e alças formando um trevo
-Alto número de bases modificadas depois da sua transcrição
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tRNA
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2a. Letra do códon1
a. L
etra
do
códo
n
Degeneração do código genético
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Pareamento oscilante da terceira base do códon
(wobble base-pairing)
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Pareamento oscilante da terceira base do códon(wobble base-pairing)
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Código genético alternativo em mitocondrias
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Etapas da síntese de proteínas
1. Ativação do aminoácido
2. Iniciação
3. Elongação
4. Terminação
5. Dobramento/processamento pós-tradução
Etapas da síntese de proteínas
1. Ativação do aminoácido
2. Iniciação
3. Elongação
4. Terminação
5. Dobramento/processamento pós-tradução
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Ribossomo bacteriano70S (2,7 x 106)
Ribossomo Eucariótico80S (4,6 x 106)
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O ribossomo acomoda dois tRNAs carregados
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1. Ativação do aminoácido1. Ativação do aminoácido
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Aminoacil- tRNA
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Seqüência de Shine-Dalgarno ou Ribossomal Binding Site (RBS)
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2. Iniciação (bactéria)2. Iniciação (bactéria)
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2. Iniciação (eucariotos)2. Iniciação (eucariotos)
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2. Iniciação (eucariotos)2. Iniciação (eucariotos)
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3. Elongação3. Elongação
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Translocação
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4. Terminação4. Terminação
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Peptídeo sinal direciona proteínas secretadas e/ou glicosiladas para o retículo endoplasmático (ER)
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Síntese de proteínas acoplada ao ER
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Nuclear localization sequence (NLS) direciona proteínas para o núcleo