FRANCE

http://www.google.com/hostednews/afp/article/ALeqM5hhjkSjPnHOFGNnAh7i-tfHBTVHvw

South Asian superbug claims first fatality

(AFP) – 13 August 2010

BRUSSELS — A Belgian man became the first known fatality of a drug-resistant "superbug" originating in South Asia, reinforcing fears the germ could spread worldwide after infecting dozens of people in Britain and Australia.

The unnamed patient became infected while hospitalised in Pakistan and died in June, a doctor from the Brussels hospital where he had been treated told Belgian media on Friday.

"He was involved in a car accident during a trip to Pakistan. He was hospitalised with a major leg injury and then repatriated to Belgium, but he was already infected," the doctor said.

Despite being administered colistin, a powerful antibiotic, the patient died, the doctor said.

A second Belgian picked up the bug after being hospitalised following an accident during a trip to his native Montenegro, but recovered with treatment back in Belgium in July, another expert said Friday.

"The epicentre of the presence of this bacteria seems to be India and Pakistan, but it appears through contact and travel, its spread is becoming wider," Youri Glupczynski, a bacteriologist from the University of Leuven, told AFP.

The superbug comprises a bacterium containing an enzyme gene called New Delhi metallo-lactamase-1 (NDM-1) that makes it impervious to treatment by almost all antibiotics.

These include drugs known as carbapenems, which are often used as a last resort.

A British journal, The Lancet Infectious Diseases, reported this week that bacteria containing the NDM-1 gene had been found in 37 Britons who had received medical treatment in South Asia.

It said health tourists visiting South Asia risked infection and warned the superbug could spread.

Three cases have been identified in Australia among people who had travelled to India for surgery, said Professor Peter Collignon, Canberra Hospital's head of infectious diseases department.

"We found this multi-resistant, untreatable bug in their urine, luckily not causing too many problems to that person. But it's a real problem if it spreads to others," he said.

"The germ we had was untreatable -- there were no drugs we had that could treat it," he added.

1

Collignon said one of the patients caught the bug in intensive care in an Indian hospital after plastic surgery went wrong. But he said another picked up the bug in the general community, indicating the extent of the problem.

He described the cases as just the "tip of the iceberg".

"It probably is killing lots of people but it happens in the developing world and there's no way of measuring it."

Patrice Nordmann, who heads a unit specialising in antibiotic resistance at France's National Institute of Health and Medical Research (Inserm), agreed that the number of real cases was bound to be "certainly higher" than the notified tally.

"There is a large potential reservoir," given the huge population of southern Asia, he said.

The NDM-1 gene is a special worry because it is found in plasmids -- DNA structures that can easily be copied and then transferred promiscuously among different types of bacteria.

These include Escherichia coli, the commonest cause of urinary tract infections, and Klebsiella pneumoniae, which causes lung and wound infections and is generated mainly in hospitals.

The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) said no new antibiotics to treat NDM-1 infections were likely to be available for at least 10 years.

National health watchdogs had to step up monitoring efforts and pool data to track where the infections were occurring and respond to the threat, it said.

The Lancet study sparked a furious response from India.

"To link this with the safety of surgery in hospitals in India and citing isolated examples to show that... India is not a safe place to visit, is wrong," the health ministry said in a statement Friday.

But it also emerged that a team of Indian researchers had warned of the superbug in March.

Researchers from the private Hinduja hospital in Mumbai studied 24 infection cases between August and November last year and said they found 22 incidents of NDM-1 bacteria.

2

http://www.france24.com/en/20100814-fears-grow-spread-deadly-south-asian-superbug-ndm1-bacteria-medical-tourism-india

LATEST UPDATE: 14/08/2010

Fears grow over spread of deadly South Asian 'superbug'

(video)

AFP - A Belgian man became the first known fatality of a drug-resistant "superbug" originating in South Asia, reinforcing fears the germ could spread worldwide after infecting dozens of people in Britain and Australia. The unnamed patient became infected while hospitalised in Pakistan and died in June, a doctor from the Brussels hospital where he had been treated told Belgian media on Friday.

"He was involved in a car accident during a trip to Pakistan. He was hospitalised with a major leg injury and then repatriated to Belgium, but he was already infected," the doctor said. Despite being administered colistin, a powerful antibiotic, the patient died, the doctor said.

A second Belgian picked up the bug after being hospitalised following an accident during a trip to his native Montenegro, but recovered with treatment back in Belgium in July, another expert said Friday. "The epicentre of the presence of this bacteria seems to be India and Pakistan, but it appears through contact and travel, its spread is becoming wider," Youri Glupczynski, a bacteriologist from the University of Leuven, told AFP.

The superbug comprises a bacterium containing an enzyme gene called New Delhi metallo-lactamase-1 (NDM-1) that makes it impervious to treatment by almost all antibiotics.

These include drugs known as carbapenems, which are often used as a last resort.

A British journal, The Lancet Infectious Diseases, reported this week that bacteria containing the NDM-1 gene had been found in 37 Britons who had received medical treatment in South Asia.

It said health tourists visiting South Asia risked infection and warned the superbug could spread.

Three cases have been identified in Australia among people who had travelled to India for surgery, said Professor Peter Collignon, Canberra Hospital's head of infectious diseases department.

"We found this multi-resistant, untreatable bug in their urine, luckily not causing too many problems to that person. But it's a real problem if it spreads to others," he said.

3

"The germ we had was untreatable -- there were no drugs we had that could treat it," he added.

Collignon said one of the patients caught the bug in intensive care in an Indian hospital after plastic surgery went wrong. But he said another picked up the bug in the general community, indicating the extent of the problem.

He described the cases as just the "tip of the iceberg".

"It probably is killing lots of people but it happens in the developing world and there's no way of measuring it."

Patrice Nordmann, who heads a unit specialising in antibiotic resistance at France's National Institute of Health and Medical Research (Inserm), agreed that the number of real cases was bound to be "certainly higher" than the notified tally.

"There is a large potential reservoir," given the huge population of southern Asia, he said.

The NDM-1 gene is a special worry because it is found in plasmids -- DNA structures that can easily be copied and then transferred promiscuously among different types of bacteria.

These include Escherichia coli, the commonest cause of urinary tract infections, and Klebsiella pneumoniae, which causes lung and wound infections and is generated mainly in hospitals.

The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) said no new antibiotics to treat NDM-1 infections were likely to be available for at least 10 years.

National health watchdogs had to step up monitoring efforts and pool data to track where the infections were occurring and respond to the threat, it said.

The Lancet study sparked a furious response from India.

"To link this with the safety of surgery in hospitals in India and citing isolated examples to show that... India is not a safe place to visit, is wrong," the health ministry said in a statement Friday.

But it also emerged that a team of Indian researchers had warned of the superbug in March.

Researchers from the private Hinduja hospital in Mumbai studied 24 infection cases between August and November last year and said they found 22 incidents of NDM-1 bacteria.

4

SPAIN

Spanish News Agency

Experts doubt Europe is ready for the "super bacteria"According to this European Society of Clinical Microbiology, it is likely that new antibiotics are available over the next ten years at least.

Europe is ill-prepared to deal with public health challenge posed by antibiotic-resistant

bacteria such as recently identified in an article published in the journal The Lancet.

"The latest information on the rapid spread of drug-resistant bacteria warn about the

nature and extent of the problem that we are," said in a statement Prof. Giuseppe

Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases

"Across Europe we have been following and informed about the emergency in the last ten

years of similar bacteria resistant to all antibiotics, including carbapenems group, since it

first made its appearance in Verona (Italy)," the expert. "Experiences of countries like Italy,

Greece and Israel indicate that if the professional preparation and lack of resources,

infections caused by bacteria resistant to these antibiotics (last resort) present a major

threat to both patients and health system as a whole, "says Cornaglia.

According to this European Society of Clinical Microbiology, it is likely that new antibiotics

are available over the next ten years minimum, so that health authorities should intensify

their vigilance and monitoring of these infections, both national and multinational. A study

conducted by a team led by Professor Timoothy Walsh, Cardiff University, and published in

The Lancet warned of the spread of antibiotic-resistant bacteria that so far only been

detected in patients from India and Pakistan. The resistance of this bacterium, the genus of

the Enterobacteriaceae, is due to a gene named NDM-1 (New Delhi metallo-b-lactamase 1),

which was discovered recently in some British patients, which is attributed to his travels in

any of these Asian countries. According to the authors of the study, dissemination of this

5

gene can represent a serious global health problem because of the growing ineffectiveness

of the last generation antibiotics to combat infection.

6

http://www.noticias.com/advierten-de-que-europa-esta-mal-preparada-para-combatir-bacteria-resistente.559405

They warn that Europe is ill-prepared to combat resistant bacteria

Aug 12, 2010 |

Europe is ill-prepared to deal with public health challenge posed by antibiotic-resistant

bacteria such as recently identified in an article published in the journal The Lancet.

"The latest information on the rapid spread of drug-resistant bacteria warn about the

nature and extent of the problem that we are," said in a statement Prof. Giuseppe

Cornaglia, president of the European Society of Clinical Microbiology and Infectious

Diseases.

"Across Europe we have been following and informed about the emergency in the last ten

years of similar bacteria resistant to all antibiotics, including carbapenems group, since it

first made its appearance in Verona (Italy)," the expert.

"Experiences of countries like Italy, Greece and Israel indicate that if the professional

preparation and lack of resources, infections caused by bacteria resistant to these

antibiotics (last resort) present a major threat to both patients and health system as a

whole, "says Cornaglia.

According to this European Society of Clinical Microbiology, it is likely that new antibiotics

are available over the next ten years at least, by what authorities [...]

7

SPAINISH NEWSPAPER

http://www.larazon.es/noticia/8601-los-expertos-advierten-de-que-europa-no-esta-preparada-para-hacer-frente-a-la-super-bacteria

The experts cast doubtIs ready for Europe in the "super bacteria"

August 12, 2010 - London - Efe

According to this European Society of Clinical Microbiology, it is likely that new antibiotics are available over the next ten years at least.

Europe is ill-prepared to deal with public health challenge posed by antibiotic-resistant

bacteria such as recently identified in an article published in the journal The Lancet.

"The latest information on the rapid spread of drug-resistant bacteria warn about the

nature and extent of the problem that we are," said in a statement Prof. Giuseppe

Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases

"Across Europe we have been following and informed about the emergency in the last ten

years of similar bacteria resistant to all antibiotics, including carbapenems group, since it

first made its appearance in Verona (Italy)," the expert. "Experiences of countries like Italy,

Greece and Israel indicate that if the professional preparation and lack of resources,

infections caused by bacteria resistant to these antibiotics (last resort) present a major

threat to both patients and health system as a whole, "says Cornaglia.

According to this European Society of Clinical Microbiology, it is likely that new antibiotics

are available over the next ten years minimum, so that health authorities should intensify

their vigilance and monitoring of these infections, both national and multinational. A study

conducted by a team led by Professor Timoothy Walsh, Cardiff University, and published in

The Lancet warned of the spread of antibiotic-resistant bacteria that so far only been

detected in patients from India and Pakistan. The resistance of this bacterium, the genus of

8

the Enterobacteriaceae, is due to a gene named NDM-1 (New Delhi metallo-b-lactamase 1),

which was discovered recently in some British patients, which is attributed to his travels in

any of these Asian countries.According to the authors of the study, dissemination of this

gene can represent a serious global health problem because of the growing ineffectiveness

of the last generation antibiotics to combat infection.

9

SPAINISH NEWS

http://www.hoymujer.com/reportajes/advierten,europa,esta,preparada,123045,8,2010.html

They warn that Europe is ill-prepared to combat resistant bacteria

Agencia EFE

London, Aug 12 (EFE) - Europe is ill-prepared to deal with public health challenge posed by

antibiotic-resistant bacteria such as recently identified in an article published in the journal

The Lancet. "The latest information on the rapid spread of drug-resistant bacteria warn

about the nature and extent of the problem that we are," said in a statement Prof. Giuseppe

Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases

"Across Europe we have been following and informed about the emergency in the last ten

years of similar bacteria resistant to all antibiotics, including carbapenems group, since it

first made its appearance in Verona (Italy)," the expert.

"Experiences of countries like Italy, Greece and Israel indicate that if the professional

preparation and lack of resources, infections caused by bacteria resistant to these

antibiotics (last resort) present a major threat to both patients and health system as a

whole, "says Cornaglia.

According to this European Society of Clinical Microbiology, it is likely that new antibiotics

are available over the next ten years minimum, so that health authorities should intensify

their vigilance and monitoring of these infections, both national and multinational.

A study conducted by a team led by Professor Timoothy Walsh, Cardiff University, and

published in The Lancet warned of the spread of antibiotic-resistant bacteria that so far only

been detected in patients from India and Pakistan.

10

The resistance of this bacterium, the genus of the Enterobacteriaceae, is due to a gene

named NDM-1 (New Delhi metallo-b-lactamase 1), which was discovered recently in some

British patients, which is attributed to his travels in any of these Asian countries.

According to the authors of the study, dissemination of this gene can represent a serious

global health problem because of the growing ineffectiveness of the last generation

antibiotics to combat infection.

11

http://espanol.news.yahoo.com/s/12082010/103/tecnologia-alertan-propagacion-superbacteria.html

Alert propagation of "superbug"

August 12, 2010

MEXICO CITY, Aug 12 (EL UNIVERSAL) .- The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) released a statement warning of the danger of rapid spread of a "superbug" resistant to many antibiotics.

The NDM-1 gene (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics, which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system.The publication in the journal "The Lancet Infectious Diseases warned of several cases of patients in the United Kingdom that had these resistant bacteria in their bodies after a trip to India and Pakistan.

According to "Elmundo.es" U.S. genetic alteration has been detected in people in the country.

In Europe, there has been "monitoring and reporting of the occurrence of similar bacteria during the last decade.

European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

12

http://www.lavanguardia.es/ciudadanos/noticias/20100812/53981298684/europa-esta-poco-preparada-para-hacer-frente-a-la-bacteria-resistente-a-los-antibioticos.html

Europe is ill-prepared to cope with antibiotic-resistant bacteria

The European Society for Infectious Diseases does not believe that the development of new antibiotics to within a decade

8/12/2010 |

London. (EFE) .- Europe is ill-prepared to cope with the challenge to public health posed by bacteria resistant to antibiotics such as recently identified in an article published in the journal The Lancet.

"The latest information on the rapid spread of drug-resistant bacteria warn about the nature and extent of the problem that we are," said in a statement Prof. Giuseppe Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases. "Across Europe we have been following and informed about the emergency in the last ten years of similar bacteria resistant to all antibiotics, including carbapenems group, since it first made its appearance in Verona (Italy)," the expert.

"Experiences of countries like Italy, Greece and Israel indicate that if the professional preparation and lack of resources, infections caused by bacteria resistant to these antibiotics (last resort) present a major threat to both patients and health system as a whole, "says Cornaglia.

According to this European Society of Clinical Microbiology, it is likely that new antibiotics are available over the next ten years minimum, so that health authorities should intensify their vigilance and monitoring of these infections, both national and multinational.

A study conducted by a team led by Professor Timoothy Walsh, Cardiff University, and published in The Lancet warned of the spread of antibiotic-resistant bacteria that so far only been detected in patients from India and Pakistan. The resistance of this bacterium, the genus of the Enterobacteriaceae, is due to a gene named NDM-1 (New Delhi metallo-b-lactamase 1), which was discovered recently in some British patients, which is attributed to his travels in any of these Asian countries. According to the authors of the study, dissemination of this gene can represent a serious problem of global health because of the growing ineffectiveness of the last generation antibiotics to combat infection.

13

http://www.eldia.es/2010-08-12/SOCIEDAD/23-Advierten-Europa-esta-mal-preparada-combatir-bacterias-resistentes.htm

They warn that Europe is ill-prepared to combat resistant bacteria12/08

London, EFE Europe is ill-prepared to deal with public health challenge posed by antibiotic-resistant bacteria such as recently identified in an article published in the journal The Lancet. "The latest information on the rapid spread of drug-resistant bacteria warn about the nature and extent of the problem that we are," said in a statement Prof. Giuseppe Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases ."Across Europe we have been following and informed about the emergency in the last ten years of similar bacteria resistant to all antibiotics, including carbapenems group, since it first made its appearance in Verona (Italy)," the expert."Experiences of countries like Italy, Greece and Israel indicate that if the professional preparation and lack of resources, infections caused by bacteria resistant to these antibiotics (last resort) present a major threat to both patients and health system as a whole, "says Cornaglia.According to this European Society of Clinical Microbiology, it is likely that new antibiotics are available over the next ten years minimum, so that health authorities should intensify their vigilance and monitoring of these infections, both national and multinational.A study conducted by a team led by Professor Timoothy Walsh, Cardiff University, and published in The Lancet warned of the spread of antibiotic-resistant bacteria that so far only been detected in patients from India and Pakistan. The resistance of this bacterium, the genus of the Enterobacteriaceae, is due to a gene named NDM-1 (New Delhi metallo-b-lactamase 1), which was discovered recently in some British patients, which is attributed to his travels in any of these Asian countries. According to the authors of the study, dissemination of this gene can represent a serious global health problem because of the growing ineffectiveness of the last generation antibiotics to combat infection.

14

http://www.diariodenavarra.es/20100812/culturaysociedad/europa-mal-preparada-combatir-bacterias-resistentes-antibioticos.html?not=2010081220341547&idnot=2010081220341547&dia=20100812&seccion=culturaysociedad&seccion2=culturaysociedad&chnl=40&ph=7

Europe ill-prepared to combat antibiotic-resistant bacteriaA study published in The Lancet warning of the spread of antibiotic-resistant bacteria that so far only been detected in patients from India and Pakistan

The spread of the bacteria can represent a serious global health problem because of the increasing ineffectiveness of antibiotics

Thursday, August 12, 2010

Europe is ill-prepared to deal with public health challenge posed by antibiotic-resistant bacteria such as recently identified in an article published in the journal The Lancet. "The latest information on the rapid spread of drug-resistant bacteria warn about the nature and extent of the problem that we are," said in a statement Prof. Giuseppe Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases .

"Across Europe we have been following and informed about the emergency in the last ten years of similar bacteria resistant to all antibiotics, including carbapenems group, since it first made its appearance in Verona (Italy)," the expert.

"Experiences of countries like Italy, Greece and Israel indicate that if the professional preparation and lack of resources, infections caused by bacteria resistant to these antibiotics (last resort) present a major threat to both patients and health system as a whole, "says Cornaglia.

According to this European Society of Clinical Microbiology, it is likely that new antibiotics are available over the next ten years minimum, so that health authorities should intensify their vigilance and monitoring of these infections, both national and multinational.A study conducted by a team led by Professor Timoothy Walsh, Cardiff University, and published in The Lancet warned of the spread of antibiotic-resistant bacteria that so far only been detected in patients from India and Pakistan.

The resistance of this bacterium, the genus of the Enterobacteriaceae, is due to a gene named NDM-1 (New Delhi metallo-b-lactamase 1), which was discovered recently in some British patients, which is attributed to his travels in any of these Asian countries.

15

According to the authors of the study, dissemination of this gene can represent a serious global health problem because of the growing ineffectiveness of the last generation antibiotics to combat infection.

After influenza A, comes the "superbug"

Detected in the UK, a bacteria resistant to nearly all antibiotics In Britain there are 37 hospitals affected by the bacteria, which caused one death in

Belgium So far only been detected in Asia the bacterium, which is capable of withstanding the

most effective antibioticshttp://www.diariodenavarra.es/20100813/culturaysociedad/tras-gripe-llega-superbacteria.html?not=2010081301355986&idnot=2010081301355986&dia=20100813&seccion=culturaysociedad&seccion2=ciencia&chnl=40&ph=9

AGENCIES. LONDON / BRUSSELS Friday, August 13, 2010

Mitigated warning by influenza A, a new threat. A bacterium resistant to almost all antibiotics have been discovered in British hospitals after being transported from southern Asia, a study has raised fears of a global spread.

The first case of infection with an enterobacteria NDM type gene-1 (New Delhi metallo-beta-lactamase), was identified in 2009 by Timothy Walsh (University of Cardiff, UK) in a Swedish patient had been hospitalized in India. But, according to a study published in the British journal The Lancet Infectious Diseases,now have been discovered in 37 patients in Britain, some of whom had traveled to India or Pakistan to undergo cosmetic surgery. Yesterday it was learned that in June also died from a Pakistani resident bacteria in Brussels who suffered a crash in their country of origin. The patient was repatriated to Belgium but was suffering from infection and could not do anything for him.

"The NDM-1 has a strong potential to become a global public health problem and requires a coordinated surveillance," the study authors warned, stressing that "India offers cosmetic surgery to other Europeans and Americans and is likely to the NDM-1 will expand in the world. " The NDM-1 resistant to most types of antibiotics, including carbapenems, reserved for emergencies and the treatment of multidrug-resistant infections."With this type of bacteria, antibiotics have almost exhausted. Only two can fight it and one of them is not very effective. There are no new antibiotics available in ten years. If we let these infections continue without appropriate treatment, mortality will undoubtedly , "said Walsh.

For his part, Professor Giuseppe Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases, noted that "we in Europe have been informed about the emergency in the last ten years like bacteria resistant to all antibiotics, since they made by first appeared in Verona (Italy). Experiences of countries like Italy, Greece and Israel

16

indicate that if the professional preparation and lack of resources, infections caused by bacteria resistant to these antibiotics have a major threat. "

17

Spanish Newspaper

http://www.abc.es/agencias/noticia.asp?noticia=483783

London , Aug 12 ( EFE ) - Europe is ill-prepared to deal with public health challenge posed by

antibiotic-resistant bacteria such as recently identified in an article published in the journal The

Lancet.

"The latest information on the rapid spread of drug-resistant bacteria warn about the nature and

extent of the problem that we are, " said in a statement Prof. Giuseppe Cornaglia , president of the

European Society of Clinical Microbiology and Infectious Diseases .

"Across Europe we have been following and informed about the emergency in the last ten years of

similar bacteria resistant to all antibiotics, including carbapenems group , since it first made its

appearance in Verona ( Italy) , "adds expert.

"Experiences of countries like Italy , Greece and Israel indicate that if the professional preparation

and lack of resources , infections caused by bacteria resistant to these antibiotics ( last resort )

present a major threat to both patients and health system as a whole , "says Cornaglia .

According to this European Society of Clinical Microbiology , it is likely that new antibiotics are

available over the next ten years minimum , so that health authorities should intensify their vigilance

and monitoring of these infections, both national and multinational.

A study conducted by a team led by Professor Timoothy Walsh, Cardiff University , and published in

The Lancet warned of the spread of antibiotic-resistant bacteria that so far only been detected in

patients from India and Pakistan.

The resistance of this bacterium, the genus of the Enterobacteriaceae , is due to a gene named NDM

-1 (New Delhi metallo -b- lactamase 1), which was discovered recently in some British patients ,

which is attributed to his travels in any of these Asian countries.

18

According to the authors of the study, dissemination of this gene can represent a serious global

health problem because of the growing ineffectiveness of the last generation antibiotics to combat

infection. EFE

19

http://www.diariosur.es/v/20100813/sociedad/europa-esta-preparada-ante-20100813.html

Europe is ill-prepared to resistant bacteria

Specialists warn of the threat to the health system, given the increasing ineffectiveness of antibiotics last generation 08/13/1910 AP | LONDON.

Europe is ill-prepared to deal with public health challenge posed by antibiotic-resistant bacteria, such as recently identified in an article published in the journal The Lancet. "The latest information on the rapid spread of drug-resistant bacteria warn about the nature and extent of the problem that we are," he says in a statement Prof. Giuseppe Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases ."Across Europe we have been following and reporting on the emergence in the last ten years of similar bacteria resistant to all antibiotics, including carbapenems group, from which first made its appearance in Verona (Italy)," he adds. "Experiences of countries like Italy, Greece and Israel indicate that if the professional preparation and lack of resources, infections caused by bacteria resistant to these antibiotics (last resort) present a major threat to both patients and health system as a whole, "warns Cornaglia.

According to the European Society of Clinical Microbiology, it is likely that new antibiotics are available over the next ten years, so that health authorities should intensify their vigilance and monitoring of these infections, both national and multinational. A study conducted by a team led by Professor Timothy Walsh of the University of Cardiff, and published in The Lancet warned of the spread of antibiotic-resistant bacteria that so far only been detected in patients India and Pakistan.

Travel AsiaThe resistance of this bacterium is due to a gene named NDM-1 (New Delhi metallo-b-lactamase 1), which was discovered recently in some British patients, which is attributed to his travels through some of these Asian countries. According to the authors of the study, dissemination of this gene can represent a serious global health problem because of the growing ineffectiveness of the last generation antibiotics to combat infection.At present, the bacteria NDM-1 has already caused one death. It was in June in Belgium, was announced yesterday. This is a Pakistani living in Brussels who suffered a traffic accident during a visit to their country of origin and had a major wound, explained Denis Pierard, Hospital of the Free University of Brussels, a Belgian agency. The patient was repatriated, but suffered from the infection.

20

http://www.noticiasdegipuzkoa.com/2010/08/13/mundo/europa-no-esta-preparada-ante-la-bacteria-resistente

Europe is not ready to resistant bacteria

It is a public health challenge germs immune to antibiotics

EFE - Friday, August 13, 2010 -

LONDON. Europe is ill-prepared to deal with public health challenge posed by antibiotic-

resistant bacteria such as recently identified in an article published in the journal Science

and Medicine inThe Lancet.

"The latest information on the rapid spread of drug-resistant bacteria warn about the

nature and extent of the problem that we are," said in a statement Prof. Giuseppe

Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases

"Experiences of countries like Italy, Greece and Israel indicate that if the professional

preparation and lack of resources, infections caused by bacteria resistant to these

antibiotics (last resort) present a major threat to both patients and health system as a

whole, "says Cornaglia.

21

http://www.lavozdegalicia.es/sociedad/2010/08/13/0003_8665865.htm

The following threat: a super-tough bacteria

| New global health alert 08/12/2010In the same week that he officially shelved media pandemic influenza A, the European health authorities are already preparing for the next alert. This comes on the heels of another major health fears this century: the great super-tough bacteria to all antibiotics.The crisis is not new and this superbug, until now known by the acronym in English MRSA (Methicillin-resistant Staphylococcus Aureus) - have already been talked about a decade ago. However, these last days is having a lot of echo in the British media, not just in the daily newspapers, also, but in some as prestigious as The Lancet Infectious deseases, the emergence of a new element. This is the enzyme-producing enterobacteria type NDM-1 (New Delhi Metallo-beta-lactamase), which the medical journal was found in 37 patients in Britain, some of whom had traveled to India or Pakistan undergo cosmetic surgery.The first of this new bacterium was identified Timothy Walsh of the University of Cardiff, and he did in 2009. And Walsh himself spoke this week for the BBC to say that "with this type of bacteria we have almost exhausted the antibiotics. Only two can fight it and one of them is not very effective. No new antibiotics available in ten years. If we allow these infections continue without proper treatment, there will undoubtedly mortality. " And launched the entire global system: "We absolutely need a monitoring mechanism on a global scale and original new antibiotics to fight specifically against this type of bacteria." The answer has been expected since Professor Giuseppe Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases, said that Europe is not ready to deal with something.Some critics believe that behind this health concern may have some interest for the British not to travel to Pakistan or India for their aesthetic operations

http://www.jurnalul.ro/stire-viata-sanatoasa/europa-nu-este-pregatita-sa-combata-bacteria-rezistenta-la-antibiotice-551917.html

Europe is not ready to combat bacteria resistant to antibiotics

22

Europe is not adequately prepared to deal with public health threat posed by antibiotic-resistant bacteria such as bacteria found in an article recently published in the journal Lancet, inform EFE quoted by Agerpres. 13/08/2010

"Latest information on the rapid spread of drug-resistant bacteria cause a reaction alert related to the nature and magnitude of the problem facing us," said in a statement, Professor Giuseppe Cornaglia, President of the European Society of Clinical Microbiology and Diseases infectious.

"I followed across Europe and the stakeholders informed about the emergency that occurred in recent years and is represented by similar bacteria resistant to all kinds of antibiotics, including those for carbapenem ever since and have done first appearance in Verona (Italy) "added the expert.

"Experiences in countries like Italy, Greece and Israel show that if doctors are not well trained and have sufficient resources available, infections caused by bacteria resistant to these antibiotics is a significant threat to patients and health system as a whole his "warned Cornaglia.

According to the European Society of Clinical Microbiology and Infectious Diseases, is unlikely to have antibiotics in November over the next ten years, minimum, so that health authorities should intensify their supervision efforts and monitoring of these infections, both at national and international.

http://www.hoysalud.es/articulo.php?id=1491

Friday 13 August 2010

Europe is ill-prepared to combat resistant bacteria

EFE | Europe is ill prepared to face the challenge to public health posed by antibiotic-

23

resistant bacteria such as recently identified in an article published in the journal The Lancet.

"The latest information on the rapid spread of drug-resistant bacteria warn about the nature and extent of the problem that we are," said in a statement Prof. Giuseppe Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases ."Across Europe we have been following and informed about the emergency in the last ten years of similar bacteria resistant to all antibiotics, including carbapenems group, since it first made its appearance in Verona (Italy)," the expert."Experiences of countries like Italy, Greece and Israel indicate that if the professional preparation and lack of resources, infections caused by bacteria resistant to these antibiotics (last resort) present a major threat to both patients and health system as a whole, "says Cornaglia.According to this European Society of Clinical Microbiology, it is likely that new antibiotics are available over the next ten years minimum, so that health authorities should intensify their vigilance and monitoring of these infections, both national and multinational.A study conducted by a team led by Professor Timoothy Walsh, Cardiff University, and published in The Lancet warned of the spread of antibiotic-resistant bacteria that so far only been detected in patients from India and Pakistan.The resistance of this bacterium, the genus of the Enterobacteriaceae, is due to a gene named NDM-1 (New Delhi metallo-b-lactamase 1), which was discovered recently in some British patients, which is attributed to his travels in any of these Asian countries.According to the authors of the study, dissemination of this gene can represent a serious global health problem because of the growing ineffectiveness of the last generation antibiotics to combat infection.

http://www.elmundo.es/elmundosalud/2010/08/12/noticias/1281621255.html

In warning about the 'superbug'

ELMUNDO.ES | Madrid Thursday 12/08/2010 

24

The finding of NDM-1 gene, a mutation that makes it carry bacteria resistant to many

antibiotics, has alerted health authorities. Following the publication in the journal 'The Lancet Infectious Diseases' of several cases of patients in the United Kingdom that, after

returning from India and Pakistan, were these resistant bacteria in their bodies, the

European Society of Clinical Microbiology and Infectious Diseases (ESCMID ) has released a

statement warning of the danger of "that spread rapidly through Europe.

"The study by Professor Timothy Walsh of the arrival of these super-resistant bacteria gives

an idea of the size of the problem we face, "said Giuseppe Cornaglia, president of ESCMID.

"In Europe we have been monitoring and reporting of the occurrence of similar bacteria

resistant to antibiotics most powerful during the last decade since the first dectetara Verona

(Italy). The experiences of this country, along with those of Greece and Israel, have also

reported cases show that we are facing a public health threat and that if we have no plans

to make the front can undermine the entire health system, "he adds.

The European Society acknowledges that "it is quite possible that we have no new

antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is

essential that medical and health community to make every possible effort to control the

spread of those pathogens. " "We must improve the monitoring system of these bacteria

and found that the control strategies, since we can not continue to rely only on antibiotics,

"says Professor Cornaglia. The ESCMID has over 33,000 European microbiologists and

specialists in infectious diseases. Meanwhile, the U.S. media also echoes of this new genetic

alteration, as it has been detected in citizens. And in the United Kingdom, where they

discovered the gene, reactions were not long in coming.

An article in 'The Guardian' criticism that the pharmaceutical companies invest little in research and development of new antibiotics, because unlike other drugs, they are not

used for life but for specific moments and also because the development of resistance, over

time cease to be useful. However, they warn of the danger this entailed. Without effective

antibiotics may not perform transplants, because the weakened immune system of these

patients could not cope with infections, "appendicitis operation will become a risky surgery

and pneumonia and tuberculosis are serious diseases.

25

http://www.santiagodigital.net/index.php?option=com_content&task=view&id=14737&Itemid=1

In warning about the 'superbugThursday, August 12, 2010

ELMUNDO.ES | Madrid Updated Thursday 12/08/2010 16:01 hours

The finding of NDM-1 gene, a mutation that makes it carry bacteria resistant to many antibiotics, has alerted health authorities. Following the publication in the journal 'The Lancet Infectious Diseases' of several cases of patients in the United Kingdom that, after returning from India and Pakistan, had these resistant bacteria in their bodies, the European Society of Clinical Microbiology and Infectious Diseases (ESCMID ) has released a statement warning of the danger of "that spread rapidly through Europe. "The study by Professor Timothy Walsh of the arrival of these super-resistant bacteria gives an idea of the size of the problem we face, "said Giuseppe Cornaglia, president of ESCMID.

"In Europe we have been monitoring and reporting of the occurrence of similar bacteria resistant to antibiotics most powerful during the last decade since the first dectetara Verona (Italy). The experiences of this country, along with those of Greece and Israel, have also reported cases show that we are facing a public health threat and that if we have no plans to make the front can undermine the entire health system, "he adds.

The European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. " "We must improve the monitoring system of these bacteria and found that the control strategies, since we can not continue to rely only on antibiotics, "says Professor Cornaglia. The ESCMID has more than 33,000 European microbiologists and specialists in infectious diseases.

Meanwhile, the U.S. media also echoes of this new genetic alteration, as it has been detected in citizens. And in the United Kingdom, where they discovered the gene, reactions were not long in coming. An article in 'The Guardian'criticism that the pharmaceutical companies invest little in research and development of new antibiotics, because unlike other drugs, they are not used for life but for specific moments and also because the development of resistance, over time cease to be useful.

However, they warn of the danger this entailed. Without effective antibiotics may not perform transplants, because the weakened immune system of these patients could not cope with infections, "appendicitis operation will become a risky surgery and pneumonia and tuberculosis are serious diseases.

26

Crónicas BárbarasManuel Molares do Val.http://cronicasbarbaras.blogs.com/crnicas_brbaras/2010/08/bacterias-asesinas.html

15/08/1910

Bacteria KillerWe get another epidemic that threatens to kill us en masse, just as they were destroying in Spain 42 million euros invested in A. Influenza vaccine appears NDM-1 gene mutation that becomes resistant to many antibiotics to bacteria carry it.As always, the threat is backed by the authority of a serious scientific journal, The Lancet Infectious Diseases ", an article indicating that some travelers arriving from India and Pakistan bring those bacteria which spread rapidly.

As a result, Giuseppe Cornaglia, president of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) warns that this is a very serious problem that can destroy even more aanzados health systems.

Perhaps this time the wolf is coming. But he does it at the time of diminished credibility on the threat of global epidemics of bacteria, viruses and mutations killer.

Although given the opportunity to show his good heart and locals to the Minister Trinidad Jimenez buying more material and propaganda that Esperanza Aguirre, as he did with that flu that was invented by scientists at the World Health Organization (WHO) who collected laboratory fees.

These are perhaps superbacerias killer, or maybe not. But it will reverse. As with so many evils from which science has replaced the magic.

Remember the last major threats that they would leave this world empty of humans, environmentalists spoke of his deserved demise - ranging from AIDS or mad cow disease, until dozens of other threats that come to Ebola Influenza A , who so feared just a year ago, the NDM-1 now, and everything that Round and round.

Is that there were those who committed suicide after killing his entire family for fear of the flu and probably global warming: to be dramatic rather than tragicomic.

27

http://www.diario.com.mx/nota.php?notaid=629c157c64c47c0dddf72500781059c3

Alert in Europe spread of 'superbug' El Universal | 12.08.2010 | International

London- The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) released a statement warning of the danger of rapid spread of a 'superbug', resistant to many antibiotics.

The NDM-1 gene (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics, which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system.

The publication in the journal The Lancet Infectious Diseases warned of several cases of patients in the United Kingdom that had these resistant bacteria in their bodies after a trip to India and Pakistan.

According to Elmundo.es, U.S. genetic alteration has been detected in people in the country.

In Europe, there has been "to monitor and report the occurrence of similar bacteria during the last decade.

European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

28

GERMANY

http://www.greenpeace-magazin.de/index.php?id=55&tx_ttnews[tt_news]=85714&tx_ttnews[backPid]=54&cHash=eeb92591eb

15th August 2010, 11:00

"Super-bacteria" in GermanyBy Peter and Simone Astashenko Humml, dpa Washington / London / Berlin (dpa) –

There is a point of victory against the bacteria Medicine: In Southeast Asia, Britain, the USA and in Germany, researchers with a new bacterial resistance gene discovered. In Belgium, even one man died. Almost any antibiotic can harm the mutated bacteria that contain a gene for the enzyme NDM-1.

"In Germany we have" first, yet some evidence for an NDM-forming bacteria, reports the Robert Koch Institute (RKI). However, it noted that in the limited scope or drugs such as antibiotics and colistin are Tigezyklin.

At least in the UK, the mutated pathogens were probably introduced by medical tourists, which could operate in India and Pakistan for medical or purely cosmetic reasons. In Asia, they seem to be more widespread.

NDM-1 stands for New Delhi-Metallo-beta-lactamase. You can crack even antibiotics, which were previously often as a last resort. The gene it has been been located at two different bacterial strains. The bacteria with the new gene are resistant to carbapenems, which are reserve antibiotics that are used only in severe, otherwise untreatable infections.

An international team led by Karthikeyan Kumarasamy of the University of Madras in India has done research in patients of several hospitals after the birth. The scientists report of 37 patients in the UK and a total of 140 patients in Bangladesh, India and Pakistan. They present the study in the current journal "The Lancet Infectious Diseases."

29

The germs can pass on their new NDM-1 gene quickly: It is partly due to small gene-rings of the bacteria, the plasmids, which are particularly easy to change between different bacterial strains.

Johann Pitout from the University of Calgary in Canada, called for all people returning from an operation in India have to investigate before any further treatment for multidrug-resistant pathogens. If this emerging threat is ignored, the cost for health care rise dramatically, "he writes in a" Lancet "comment.

The Indian Ministry of Health, however, defends himself against the charge that treatment is in the country would be safe. A mutation of bacteria is not uncommon. «In every moment it is probably" billions of such events, cited the U.S. news network CNN a statement of the ministry. Such organisms would spread around the world through travel. So to say that India was not a safe place for travel and medical treatment would be wrong, said the ministry. Also, the name was "New Delhi" chosen in connection with the gene unhappy.

The RKI certainly sees armed Germany: It refers to its early warning system ARS, the novel covers antimicrobial resistance. The further dissemination of such agents could then "effectively control and prevent targeted hygiene in hospitals and a coordinated antibiotic therapy."

Such a provision was necessary because the development of new antibiotics against bacteria occurring now will take at least ten years, writes the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).

30

http://www.morgenpost.de/web-wissen/article1374930/Superkeim-NDM-1-in-Deutschland-angekommen.html

TÖDLICHER ERREGER

Superkeim NDM-1 in Deutschland angekommenMontag, 16. August 2010 13:04  - Von Peter Astashenko und Simone Humml

Der Kampf zwischen Bakterien und Menschen geht in eine neue Runde: Mutierte Keime mit Resistenz-

Gen verbreiten sich über die ganze Welt.

Es ist ein Punktsieg der Bakterien gegen die Medizin: In Südostasien, Großbritannien, den USA und auch in

Deutschland haben Forscher Bakterien mit einem neuen Resistenz-Gen entdeckt. In Belgien ist sogar schon ein

Mensch daran gestorben. Fast kein Antibiotikum kann den mutierten Bakterien etwas anhaben, die ein Gen für

das Enzym NDM-1 enthalten.

„Auch in Deutschland haben wir erste, bisher einzelne Nachweise für NDM-1 bildende Bakterien“, berichtet das

Robert Koch-Institut (RKI). Es verweist jedoch darauf, dass es im begrenzten Umfang noch Therapeutika wie die

Antibiotika Tigezyklin und Colistin gibt.

Zumindest in Großbritannien wurden die mutierten Erreger vermutlich von Medizintouristen eingeschleppt, die

sich in Indien und Pakistan aus medizinischen oder rein kosmetischen Gründen operieren ließen. In Asien

scheinen sie weiter verbreitet zu sein.

NDM-1 steht für Neu-Delhi-Metallo-Beta-Laktamase. Sie kann sogar Antibiotika knacken, die bisher oft als letzte

Rettung galten. Das Gen dafür wurde bisher bei zwei verschiedenen Bakterienstämmen ausfindig gemacht. Die

Bakterien mit dem neuen Gen sind resistent gegen Carbapeneme, das sind Reserveantibiotika, die nur bei

schweren, sonst unbehandelbaren Infektionen eingesetzt werden.

Ein internationales Team um Karthikeyan Kumarasamy von der Universität von Madras in Indien hat bei

Patienten mehrerer Kliniken nach dem Keim geforscht. Die Wissenschaftler berichten von 37 betroffenen

Patienten in Großbritannien und insgesamt rund 140 Patienten in Bangladesch, Indien und Pakistan. Sie

präsentieren die Studie im aktuellen Journal „The Lancet Infectious Diseases“.

31

Die Keime können ihr neues NDM-1-Gen schnell weitergeben: Es liegt unter anderem auf kleinen Gen-Ringen

der Bakterien, den Plasmiden, die besonders leicht zwischen verschiedenen Bakterienstämmen ausgetauscht

werden.

Johann Pitout von der University of Calgary in Kanada forderte, alle Menschen, die von einer Operation aus

Indien zurückkehren, vor einer weiteren Behandlung auf multiresistente Erreger untersuchen zu lassen. Wenn

diese aufkommende Gefahr ignoriert werde, könnten die Kosten für die Gesundheitssysteme drastisch steigen,

schreibt er in einem „Lancet“-Kommentar.

Das indische Gesundheitsministerium hingegen wehrt sich gegen den Vorwurf, dass eine Behandlung in dem

Land nicht sicher wäre. Eine Mutation von Bakterien sei nichts Ungewöhnliches. „In jedem Moment gibt es

vermutlich Milliarden solcher Ereignisse“, zitiert der US- Nachrichtensender CNN eine Stellungnahme des

Ministeriums. Solche Organismen würden sich durch Reisen weltweit verbreiten. Deshalb zu sagen, Indien sei

kein sicherer Ort für Reisen und medizinische Behandlung, wäre falsch, erklärt das Ministerium. Zudem sei der

Name „Neu Delhi“ im Zusammenhang mit dem Gen unglücklich gewählt.

Das RKI jedenfalls sieht Deutschland gewappnet: Es verweist auf sein Frühwarnsystem ARS, das neuartige

Antibiotikaresistenzen erfasse. Die weitere Verbreitung solcher Erreger könne dann durch gezielte Hygiene in

den Kliniken und eine abgestimmte Antibiotikatherapie „wirksam begrenzt und verhindert werden“.

Eine solche Vorsorge sei auch nötig, denn die Entwicklung neuer Antibiotika gegen die nun aufgetretenen

Bakterien werde mindestens zehn Jahre dauern, schreibt die Europäische Gesellschaft für klinische

Mikrobiologie und Infektionskrankheiten (ESCMID)

32

http://www.krankenkassen.de/dpa/175253.html

"Super-bacteria" in Germany by Peter and Simone Astashenko Humml, dpa

15/08/2010 11:00

The global struggle between bacteria and humans is in a

new round. New seeds are even against certain emergency antibiotics

become resistant - and they spread all over the world.

Washington / London / Berlin (dpa) - There is a point of victory

Bacteria to the medicine: In Southeast Asia, the UK, USA

and also in Germany, researchers have bacteria with a new

Resistance gene discovered. In Belgium, even a human mind

died. Almost any antibiotic can the mutated bacteria something

Who are wearing contained a gene for the enzyme NDM-1.

"In Germany we have first been some evidence

"For an NDM-forming bacteria, reports the Robert Koch Institute

(RKI). However, it noted that there is still a limited extent

Therapeutics such as antibiotics and colistin are Tigezyklin.

At least in Britain, the mutated pathogen

probably introduced by medical tourists in India and

Pakistan for medical or purely cosmetic reasons, to operate

left. In Asia, they seem to be more widespread.

NDM-1 stands for New Delhi-Metallo-beta-lactamase. You can even

Crack antibiotics that were previously often as a last resort. The

Gene for this has been at two different bacterial strains

be traced. The bacteria with the new gene are resistant

against carbapenems, which are reserve antibiotics only in severe,

otherwise untreatable infections are used.

An international team led by Karthikeyan Kumarasamy of the

University of Madras in India in patients of several hospitals

33

researched by the germ. The scientists report of 37

patients in the UK and a total of about 140

Patients in Bangladesh, India and Pakistan. They present the

Study in the current journal "The Lancet Infectious Diseases."

The germs can pass on their new NDM-1 gene quickly: it is

including on small rings of bacterial gene, the plasmids,

the most easily between different bacterial strains

be replaced.

Johann Pitout invited by the University of Calgary in Canada,

all the people returning from an operation in India, before

further treatment to investigate multi-drug resistant pathogens to

. Let If this emerging threat is ignored, could

rising costs of health care dramatically, "he writes in

a "Lancet" comment.

The Indian Ministry of Health, however, defends himself against the

Allegation that a treatment is in the country would be safe. A

Mutation of bacteria is not uncommon. "In every moment

there are probably "billions of such events, as quoted by the U.S.

CNN a statement of the ministry. Such

Organisms were spread around the world through travel. Therefore, to

say that India was not a safe place for travel and medical

Treatment would be wrong, said the ministry. Moreover, it is the name

"New Delhi" in connection with the gene infelicitous.

The RKI certainly sees armed Germany: It refers to

be an early warning system ARS, the novel antimicrobial resistance

covers. The further dissemination of such agents could then by

Targeted hygiene in hospitals and a coordinated

Antibiotic therapy "effectively control and prevent.

Such a provision was necessary because the development of new

Antibiotics against the bacteria will now occurred at least

take ten years, writes the European Society of

Clinical Microbiology and Infectious Diseases (ESCMID).

34

http://www.heute.de/ZDFheute/inhalt/7/0,3672,8100775,00.html

Europe: First dead by "super-bacteria"

Patient dies in Brussels - NDM-1 in Germany

The "super-bacteria 'NDM-1 in Europe has called for a first fatalities. A man from Pakistan who lives in Brussels, after a home visit to seriously ill and died.Now, the resistant germ has been discovered in Germany. NDM-1 was probably introduced by plastic surgery from India and so far occurred mainly in India and Pakistan - but also at least 37 patients in the UK. It is resistant to almost all antibiotics. Already in June As the microbiologist Denis Pierard from the Brussels University Hospital of the Belgian newspaper Le Soir said the resident in Brussels man from Pakistan was following a visit to his homeland in June of seriously ill and then died of infection with the NDM-1 seed. It were probably the first NDM-1-dead on the European mainland. The man was in Pakistan on the leg hurt and there were also treated. In Brussels, the bacteria have proven to be a "terrible resistance" against virtually all antibiotics.Also, treatment with the antibiotic colistin, which has in some other cases, NDM-1 was found to be effective, a failure.

Low infection risk Pierard told the "Le Soir", the risk of infection in Belgium was very low. Virtually all known patients have been infected in treatments in Pakistani or Indian hospitals. Even in Germany there are, according to the Robert Koch Institute, "first, yet some evidence for an NDM-forming bacteria.However, it noted, which usually help some medicines such as antibiotics and colistin Tigezyklin. Johann Pitout from the University of Calgary in Canada, called for all people returning from an operation in India have to investigate before any further treatment for multidrug-resistant pathogens.If this emerging threat is ignored, the cost for health care rise dramatically, "he wrote in a Lancet commentary.

India struggles The Indian Ministry of Health, however, defends himself against the charge that treatment is in the country would be safe. A mutation of bacteria is not uncommon. "In every moment it is probably billions of such events", cited the U.S. news network CNN a statement of the ministry. Such organisms would spread around the world through travel. So to say that India was not a safe place for travel and medical treatment would be wrong, said the ministry. Adds that the name "New Delhi" is selected in connection with the gene unhappy.

35

"Effective limit" The Robert Koch Institute, Germany certainly looks prepared: It refers to its early warning system ARS, the novel covers antimicrobial resistance. The further dissemination of such agents could be targeted by hygiene in hospitals and a coordinated antibiotic therapy "effectively control and prevent." Such a provision was necessary because the development of new antibiotics against bacteria occurring now will take at least ten years, writes the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).

36

Barvarian Broadcasting Company

http://www.br-online.de/ratgeber/gesundheit/ndm-1-bakterien-antibiotika-resistenz-ID128195312395.xml

Bacteria New multi - resistant germs found

In India , a new multi - resistant germ has emerged : This strain has a mutated gene that makes him resistant to almost all antibiotics. The so-called NDM- 1- bacterium has now spread to Europe and called for a first fatalities in Belgium.

08.16.2010

A mutation of bacteria is not uncommon and even multi -resistant germs come again and again , experts explain . The special feature of the new bacterium is his special mechanism , " says Alexander Kallen by the U.S. CDC . The new Superkeim can form by a mutated gene , an enzyme that makes antibiotics ineffective, the so-called enzyme NDM -1 ( New Delhi - Metallo - beta- lactamase ).

This may be the seed of new gene quickly on to other bacteria and make them resistant: The gene is in part to small gene -rings, the plasmids that can be exchanged very easily between different bacterial strains.

NDM -1 makes bacteria resistant to the most effective class of broad spectrum antibiotics , known as carbapenems . These are emergency antibiotics that are used only in severe , otherwise untreatable infections and otherwise restrained . The Robert Koch Institute ( RKI ) has , however, that are effective against the new Superkeim two antibiotics in begenztem scope: Tigezyklin and colistin , which however has some toxic side effects.

The development of new antibiotics against bacteria occurring now will take at least a decade, the European Society of Clinical Microbiology and Infectious Diseases ( ESCMID ). One reason for this is that the antibiotic research has been neglected for years because it is difficult for pharmaceutical companies and not very lucrative.

Protection against the Superkeim in Germany to provide the early warning system , according to RKI ARS, captures the novel antibiotic resistance. The further dissemination of such agents could be targeted by hygiene in hospitals and a coordinated antibiotic therapy have limited effect and prevents , the RKI further. So far, this early warning system seems to not quite grasp , for German hospitals have fallen in recent years in the criticism : Compared with other European hospitals , they were significantly more burdened with multi-resistant germs.

Medical Tourism

The new bacteria strain was NDM -1 previously detected in Southeast Asia, the UK, USA , Belgium and Germany. At least in the UK medical tourists to the multi-resistant pathogens have been introduced after an operation in India , Pakistan and Bangladesh were . The Indian Subkontinet is popular with Britons and Americans, because medical treatments are cheaper there - especially cosmetic surgery.

37

http://www.da-imnetz.de/nachrichten/deutschland/super-bakterium-auch-deutschland-878651.html

"Super-bacteria" in Germany15.08.2010

NDM1 for NewDelhiMetallo-Beta-Lactamase. You can crack even antibiotics, which were

previously often as a last resort. The gene it has been been located at two different bacterial

strains. The bacteria with the new gene are resistant to carbapenems, which are reserve

antibiotics that are used only in severe, otherwise untreatable infections.

"In Germany we have first been some evidence of NDM1-forming bacteria, "says the Robert

KochInstitute (RKI). At least in the UK, the mutated pathogens were probably introduced by

medical tourists, which could operate in India and Pakistan for medical or purely cosmetic

reasons. In Asia, they seem to be more widespread. An international team led by

Karthikeyan Kumarasamy of the University of Madras in India has done research in patients

of several hospitals after the birth. The scientists report of 37 patients in the UK and a total

of 140 patients in Bangladesh, India and Pakistan. They present the study in the current

journal "The Lancet Infectious Diseases". The germs can their new NDM1 -Gen pass quickly:

it is among other things, small geneRings of the bacteria, the plasmids, which are

particularly easy to change between different bacterial strains. Johann Pitout from the

University of Calgary in Canada, called for all people returning from an operation in India

have to investigate before any further treatment for multidrug-resistant pathogens. If this

emerging threat is ignored, the cost for health care rise dramatically, "he writes in a" Lancet

"-Comment. The Indian Ministry of Health, however, defends himself against the charge

that treatment is in the country would be safe. A mutation of bacteria is not uncommon. "In

every moment it is probably billions of such events," cited by the U.S.CNN a statement of

the ministry. Such organisms would spread around the world through travel. So to say that

India was not a safe place for travel and medical treatment would be wrong, said the

ministry. Adds that the name "New Delhi" is selected in connection with the gene unhappy.

The RKI does Germany, however, prepared: It points out that in the limited scope or drugs

such as antibiotics and colistin are Tigezyklin. The early warning system could also detect

ARS novel antibiotic resistance. The further dissemination of such agents could be targeted

by hygiene in hospitals and a coordinated antibiotic therapy "effectively control and

prevent." Such a provision was necessary because the development of new antibiotics

38

against bacteria occurring now will take at least ten years, writes the European Society of

Clinical Microbiology and Infectious Diseases (ESCMID).

39

http://www.bn-net.de/preexport_startseite/1608-gzw-superkeim.html

„Super-Bakterium“ auch in DeutschlandVon Peter Astashenko und Simone Hummldpa Washington/London/Berlin.

Der weltweite Kampf zwischen Bakterien und Menschen geht in eine neue Runde. Neue Keime sind sogar gegen bestimmte Notfall-Antibiotika resistent geworden – und sie verbreiten sich über die ganze Welt.

Es ist ein Punktsieg der Bakterien gegen die Medizin: In Südostasien, Großbritannien, den USA und auch in Deutschland haben Forscher Bakterien mit einem neuen Resistenz-Gen entdeckt. In Belgien ist sogar schon ein Mensch daran gestorben. Fast kein Antibiotikum kann den mutierten Bakterien etwas anhaben, die ein Gen für das Enzym NDM-1 enthalten.

„Auch in Deutschland haben wir erste, bisher einzelne Nachweise für NDM-1 bildende Bakterien“, berichtet das Robert-Koch-Institut (RKI). Es verweist jedoch darauf, dass es im begrenzten Umfang noch Therapeutika wie die Antibiotika Tigezyklin und Colistin gibt.

Zumindest in Großbritannien wurden die mutierten Erreger vermutlich von Medizintouristen eingeschleppt, die sich in Indien und Pakistan aus medizinischen oder rein kosmetischen Gründen operieren ließen. Inzwischen wurde der Erreger dort bei 36 Patienten nachgewiesen. Australien meldete drei Fälle. In Asien scheinen sie weiter verbreitet zu sein.

NDM-1 steht für NeuDelhi-Metallo-Beta-Laktamase. Sie kann sogar Antibiotika knacken, die bisher oft als letzte Rettung galten. Das Gen dafür wurde bisher bei zwei verschiedenen Bakterienstämmen ausfindig gemacht. Die Bakterien mit dem neuen Gen sind resistent gegen Carbapeneme, das sind Reserveantibiotika, die nur bei schweren, sonst unbehandelbaren Infektionen eingesetzt werden.

Ein internationales Team um Karthikeyan Kumarasamy von der Universität von Madras in Indien hat bei Patienten mehrerer Kliniken nach dem Keim geforscht. Die Wissenschaftler berichten von 37 betroffenen Patienten in Großbritannien und insgesamt rund 140 Patienten in Bangladesch, Indien und Pakistan. Sie präsentieren die Studie im aktuellen Journal „The Lancet Infectious Diseases“. Die Keime können ihr neues NDM-1-Gen schnell weitergeben: Es liegt unter anderem auf kleinen Gen-Ringen der Bakterien, den Plasmiden, die besonders leicht zwischen verschiedenen Bakterienstämmen ausgetauscht werden.

Johann Pitout von der University of Calgary in Kanada forderte, alle Menschen, die von einer Operation aus Indien zurückkehren, vor einer weiteren Behandlung auf multiresistente Erreger untersuchen zu lassen. Wenn diese aufkommende Gefahr ignoriert werde, könnten die Kosten für die Gesundheitssysteme drastisch steigen, schreibt er in einem „Lancet“-Kommentar.

Das indische Gesundheitsministerium hingegen wehrt sich gegen den Vorwurf, dass eine Behandlung in dem Land nicht sicher wäre. Eine Mutation von Bakterien sei nichts Ungewöhnliches. „In jedem Moment gibt es vermutlich Milliarden solcher Ereignisse“, zitiert der US- Nachrichtensender CNN eine Stellungnahme des Ministeriums. Solche Organismen würden sich

40

durch Reisen weltweit verbreiten. Deshalb zu sagen, Indien sei kein sicherer Ort für Reisen und medizinische Behandlung, wäre falsch, erklärt das Ministerium. Zudem sei der Name „Neu Delhi“ im Zusammenhang mit dem Gen unglücklich gewählt.

Das RKI jedenfalls sieht Deutschland gewappnet: Es verweist auf sein Frühwarnsystem ARS, das neuartige Antibiotikaresistenzen erfasse. Die weitere Verbreitung solcher Erreger könne dann durch gezielte Hygiene in den Kliniken und eine abgestimmte Antibiotikatherapie „wirksam begrenzt und verhindert werden“. Eine solche Vorsorge sei auch nötig, denn die Entwicklung neuer Antibiotika gegen die nun aufgetretenen Bakterien werde mindestens zehn Jahre dauern, schreibt die Europäische Gesellschaft für klinische Mikrobiologie und Infektionskrankheiten (ESCMID).

41

GERMAN

http://nachrichten.t-online.de/neue-superbakterie-erreicht-deutschland/id_42542276/index

New Superbakterie reached Germany08.15.2010The new Superbakterie is spreading further: In Southeast Asia, the UK, USA and now in Germany, researchers, the bacteria with a new resistance gene discovered. In Belgium, even one man died. Almost any antibiotic can the mutated bacteria harm, the gene for the NDM-1 contain a germ."In Germany we have first been some evidence of an NDM-causing bacteria," says the Robert Koch Institute (RKI). However, it noted that in the limited extent or effective drugs such as antibiotics and colistin are Tigezyklin.

"Germany is ready"The RKI provides armed Germany: It refers to its early warning system ARS, the novel covers antimicrobial resistance.The further dissemination of such agents could be targeted by hygiene in hospitals and a coordinated antibiotic therapy "effectively control and prevent."Such a provision was necessary because the development of new antibiotics against bacteria will now encountered ten years at least, writes the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).

introduced by medical touristsAt least in Britain, the mutated pathogen presumably introduced by medical tourists who are in India, Pakistan, or purely for cosmetic reasons were medical and operate. In Asia, they seem to be more widespread.NDM-1 stands for New Delhi-Metallo-beta-lactamase. You can crack even antibiotics, which were previously often as a last resort. The gene it has been been located at two different bacterial strains. The bacteria with the new gene are resistant to carbapenems, which are reserve antibiotics that are used only in severe, otherwise untreatable infectionsn international team led by Karthikeyan Kumarasamy of the University of Madras in India has done research in patients of several hospitals after the birth. The scientists report of 37 patients in the UK and a total of 140 patients in Bangladesh, India and Pakistan. They present the study in the current journal "The Lancet Infectious Diseases".

India defends itself against allegationsJohann Pitout from the University of Calgary in Canada, called for all people returning from an operation in India have to investigate before any further treatment for multidrug-resistant pathogens. If this emerging threat is ignored, the cost for health care rise dramatically, "he wrote in a Lancet commentary.The Indian Ministry of Health, however, defends himself against the charge that treatment is in the country would be safe. A mutation of bacteria is not uncommon. "In every moment it is probably billions of such events", cited the U.S. news network CNN a statement of the ministry. Such organisms would spread around the world through travel. So to say that India was not a safe place for travel and medical treatment would be wrong, said the ministry. Adds that the name "New Delhi" is selected in connection with the gene unhappy. The "ND" in NDM-1 stands for New Delhi

42

http://www.greenpeace-magazin.de/index.php?id=55&tx_ttnews[tt_news]=85714&tx_ttnews[backPid]=54&cHash=eeb92591eb

15th August 2010, 11:00

"Super-bacteria" in GermanyBy Peter and Simone Astashenko Humml, dpa Washington / London / Berlin (dpa) –

There is a point of victory against the bacteria Medicine: In Southeast Asia, Britain, the USA and in Germany, researchers with a new bacterial resistance gene discovered. In Belgium, even one man died. Almost any antibiotic can harm the mutated bacteria that contain a gene for the enzyme NDM-1.

"In Germany we have" first, yet some evidence for an NDM-forming bacteria, reports the Robert Koch Institute (RKI). However, it noted that in the limited scope or drugs such as antibiotics and colistin are Tigezyklin.

At least in the UK, the mutated pathogens were probably introduced by medical tourists, which could operate in India and Pakistan for medical or purely cosmetic reasons. In Asia, they seem to be more widespread.

NDM-1 stands for New Delhi-Metallo-beta-lactamase. You can crack even antibiotics, which were previously often as a last resort. The gene it has been been located at two different bacterial strains. The bacteria with the new gene are resistant to carbapenems, which are reserve antibiotics that are used only in severe, otherwise untreatable infections.

An international team led by Karthikeyan Kumarasamy of the University of Madras in India has done research in patients of several hospitals after the birth. The scientists report of 37 patients in the UK and a total of 140 patients in Bangladesh, India and Pakistan. They present the study in the current journal "The Lancet Infectious Diseases."

The germs can pass on their new NDM-1 gene quickly: It is partly due to small gene-rings of the bacteria, the plasmids, which are particularly easy to change between different bacterial strains.

Johann Pitout from the University of Calgary in Canada, called for all people returning from an operation in India have to investigate before any further treatment for multidrug-

43

resistant pathogens. If this emerging threat is ignored, the cost for health care rise dramatically, "he writes in a" Lancet "comment.

The Indian Ministry of Health, however, defends himself against the charge that treatment is in the country would be safe. A mutation of bacteria is not uncommon. «In every moment it is probably" billions of such events, cited the U.S. news network CNN a statement of the ministry. Such organisms would spread around the world through travel. So to say that India was not a safe place for travel and medical treatment would be wrong, said the ministry. Also, the name was "New Delhi" chosen in connection with the gene unhappy.

The RKI certainly sees armed Germany: It refers to its early warning system ARS, the novel covers antimicrobial resistance. The further dissemination of such agents could then "effectively control and prevent targeted hygiene in hospitals and a coordinated antibiotic therapy."

Such a provision was necessary because the development of new antibiotics against bacteria occurring now will take at least ten years, writes the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).

44

ROMANIAN MEDIA

http://www.ziarullumina.ro/articole;1342;1;43429;0;Medicii-europeni-nu-pot-lupta-impotriva-bacteriilor-

rezistente-la-antibiotice.html

Monday, August 16, 2010European doctors can not fight against antibiotic-resistant bacteria

According to information published by the EFE, Europe is not adequately prepared to deal

with public health threat posed by antibiotic-resistant bacteria. "I followed across Europe

and the stakeholders informed about the emergency that occurred in recent years and is

represented by similar bacteria resistant to all kinds of antibiotics, including those for

carbapenem ever since and have done first appearance in Verona (Italy), "said Professor

Giuseppe Cornaglia, President of the European Society of Clinical Microbiology and

Infectious Diseases.

"Experiences in countries like Italy, Greece and Israel show that if doctors are not well

trained and have sufficient resources available, infections caused by bacteria resistant to

these antibiotics is a significant threat to patients and health system as a whole his "warned

Cornaglia. According to the European Society of Clinical Microbiology and Infectious

Diseases, is unlikely to have antibiotics in November over the next ten years, minimum, so

that health authorities should intensify their supervision efforts and monitoring of these

infections, both at national and international.

45

http://www.ziare.com/viata-sanatoasa/bacterii/europa-nu-este-pregatita-sa-combata-bacteria-rezistenta-la-antibiotice-1035035

Europa nu este pregatita sa combata bacteria rezistenta la antibiotice

Europa nu este pregatita corespunzator pentru a face fata amenintarii la adresa sanatatii publice reprezentate de bacteriile rezistente la antibiotice, cum ar fi bacteria identificata recent si semnalata intr-un articol publicat in revista The Lancet.

"Ultimele informatii cu privire la raspandirea rapida a unei bacterii rezistente la medicamente provoaca o reactie de alerta legata de natura si magnitudinea problemei cu care ne confruntam", afirma, intr-un comunicat, profesorul Giuseppe Cornaglia, presedintele Societatii Europene de Microbiologie Clinica si Boli Infectioase, transmite Efe.

"La nivelul intregii Europe am urmarit si informat factorii responsabili cu privire la urgenta care a aparut in ultimii ani si care este reprezentata de bacteriile similare rezistente la toate felurile de antibiotice, inclusiv la cele de tip carbapenem, inca de cand si-au facut pentru prima data aparitia la Verona (Italia)", adauga expertul.

"Experientele din tari precum Italia, Grecia si Israelul arata ca, daca medicii nu sunt bine pregatiti si nu au suficiente resurse la dispozitie, infectiile provocate de bacteriile rezistente la aceste antibiotice reprezinta o amenintare importanta atat pentru pacienti, cat si pentru sistemul sanitar in ansamblul sau", a avertizat Cornaglia.

Potrivit Societatii Europene de Microbiologie Clinica si Boli Infectioase, este putin probabil sa se dispuna de antibiotice noi in urmatorii zece ani, ca perioada minima, motiv pentru care autoritatile sanitare trebuie sa-si intensifice eforturile de supraveghere si monitorizare a acestor infectii, atat la nivel national, cat si international.

46

SLOVENIA

http://www.delo.si/clanek/117386

Superbakterija v Evropi terjala prvo žrtevVečina pacientov se je okužila med medicinskimi posegi v Indiji in PakistanuNovih antibiotikov za zdravljenje trdožive bakterije ne bo še 10 let

BRUSELJ – Belgijec (po poreklu iz Pakistana) je prvi Evropejec, ki je umrl zaradi nove superbakterije NDM-1. Preminuli diabetik se je junija letos mudil v Pakistanu, kjer je doživel prometno nesrečo, nakar so ga prepeljali v tamkajšnjo bolnišnico. Oskrbeli so mu veliko rano na nogi in ga s sepso vrnili v Belgijo, kjer je umrl v bruseljski bolnišnici.

Mikrobiolog z bruseljske univerzitetne klinike AZ VUB Denis Pierard je izjavil, da je glavni vzrok za smrt Belgijca prav superbakterija NDM-1.

Bakterija izvira iz južne Azije in je odporna proti skoraj vsem antibiotikom. Proizvaja encim, ki so ga poimenovali newdelhijska metalobetalaktamaza. Tega je leta 2009 izoliral Timothy Walsh iz Cardiffa pri švedskem pacientu, ki se je zdravil v Indiji. Doslej so NDM-1 v Veliki Britaniji našli pri okoli 50 pacientih. Večina se je okužila v sklopu 'medicinskega turizma' v Indiji in Pakistanu.

Bakteriolog univerze v Leuvnu Youri Glupczynski pravi, da sta epicentra bakterije prav ti dve državi, vendar se je zaradi popotnikov razširila po svetu. Tako poročajo tudi o treh pacientih iz Avstralije, ki so se okužili s superbakterijo na zdravljenju v Indiji.

Iz Evropske zveze za klinično mikrobiologijo in nalezljive bolezni (ESCMID) so sporočili, da novih antibiotikov, s katerimi bi lahko zdravili okužbe s superbakterijo, ne bo še vsaj 10 let.

47

MEXICO

Alerts spread of ' superbug ' http://www.vanguardia.com.mx/alertanporpropagaciondesuperbacteria-530523.html

London .- The European Society of Clinical Microbiology and Infectious Diseases ( ESCMID ) released a statement warning of the danger of rapid spread of a ' superbug ' , resistant to many antibiotics.

The NDM -1 gene (New Delhi metallo -b- lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics , which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system.

The publication in the journal The Lancet Infectious Diseases warned of several cases of patients in the United Kingdom that had these resistant bacteria in their bodies after a trip to India and Pakistan.

According to Elmundo.es , U.S. genetic alteration has been detected in people in the country .

In Europe, there has been " monitoring and reporting of the occurrence of similar bacteria during the last decade.

European Society acknowledges that " it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

48

49

Entretodos

http://www.entretodos.com.mx/notacompleta.php?id=49391

Propagation of bacteria Alert

12/08/2010

The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) released a statement warning of the danger of rapid spread of a 'superbug', resistant to many antibiotics.

The NDM-1 gene (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics, which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system.

The publication in the journal The Lancet Infectious Diseases warned of several cases of patients in the United Kingdom that had these resistant bacteria in their bodies after a trip to India and Pakistan.

According to Elmundo.es, U.S. genetic alteration has been detected in people in the country.

In Europe, there has been "to monitor and report the occurrence of similar bacteria during the last decade.

European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

50

http://www.provincia.com.mx/12-08-2010/65031

12.08.2010

Alert for "superbugMexico City The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) released a statement warning of the danger of rapid spread of a "superbug", resistant to many antibiotics.The NDM-1 gene (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics, which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system.The publication in the journal The Lancet Infectious Diseases warned of several cases of patients in the United Kingdom that had these resistant bacteria in their bodies after a trip to India and Pakistan.According to Elmundo.esin the United States and the genetic alteration was detected in inhabitants of the country.In Europe, there has been "monitoring and reporting of the occurrence of similar bacteria during the last decade."European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next ten years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

51

http://www.debate.com.mx/eldebate/Articulos/ArticuloGeneral.asp?IdArt=10102656&IdCat=6104

Alerts spread of 'superbug'In Europe warn of the rapid spread of these resistant bacteria

debate.com.mx | El Universal | Updated: 08/12/2010

Europe - The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) released a statement warning of the danger of rapid spread of a 'superbug', resistant to many antibiotics.The NDM-1 gene (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics, which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system.The publication in the journal The Lancet Infectious Diseases warned of several cases of patients in the United Kingdom that had these resistant bacteria in their bodies after a trip to India and Pakistan.According to Elmundo.es, U.S. genetic alteration has been detected in people in the country.In Europe, there has been "to monitor and report the occurrence of similar bacteria during the last decade.European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens "

52

elsemanario.com.mxhttp://www.elsemanario.com.mx/news/news_display.php?story_id=43989

Launch warns of "superbug" in Europe

The "superbug" more strong that carry the bacteria, creating resistance to any antibiotic

MEXICO CITY, August 12, 2010 .- The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) issued a statement warning about the danger of spreading (faster than normal) of a "superbug", which is resistant to a large number of antibiotics.The new NDM-1 (New Delhi Matallo-b-lactamase 1) makes the bacteria carrying this new species are resistant to many antibiotics.According to research, this new defense would be a danger to the medical environment, and that they could not perform several operations because of weak immune system in the absence of antibiotics, says The Lancet Infectious Diseases.In the article, the magazine mentions several cases in the UK, which carried these bacteria in their bodies after a trip to India and Pakistan, likewise, has detected the appearance of similar bacteria in the last decadeFaced with this phenomenon, Europe is aware that there is no strong antibiotics to treat infections that would bring this new mutation, and could not fight these diseases in the next 10 years, which encourages the medical community makes it necessary to control is the spread of pathogens. (The Weekly Agency, ESA)

elpinerodelacuenca.com.mx

53

http://www.elpinerodelacuenca.com.mx/epc/index.php?option=com_content&view=article&id=23926:alertan-por-propagacion-de-superbacteria&catid=45:salud&Itemid=17

Alerts spread of 'superbug'Thursday, August 12, 2010 18:56

In Europe warn of the rapid spread of these resistant bacteriaEl Universal

Europe, August 12, 2010 .- The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) released a statement warning of the danger of rapid spread of a 'superbug', resistant to many antibiotics.The NDM-1 gene (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics, which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system.The publication in the journal The Lancet Infectious Diseases warned of several cases of patients in the United Kingdom that had these resistant bacteria in their bodies after a trip to India and Pakistan.According to Elmundo.es, U.S. genetic alteration has been detected in people in the country.In Europe, there has been "to monitor and report the occurrence of similar bacteria during the last decade.European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

54

http://www.am.com.mx/Nota.aspx?ID=419608

Alert propagation of "superbug"

MEXICO CITY / EL UNIVERSAL12/08/2010

The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) released a statement warning of the danger of rapid spread of a "superbug", resistant to many antibiotics.

NDM-1 gene (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics, which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system.

The publication in the journal "The Lancet Infectious Diseases warned of several cases of patients in the United Kingdom that had these resistant bacteria in their bodies after a trip to India and Pakistan.

According to "Elmundo.es" U.S. genetic alteration has been detected in people in the country.

In Europe, there has been "monitoring and reporting of the occurrence of similar bacteria during the last decade.

European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

55

http://www.elsiglodedurango.com.mx/noticia/279583.miscelanea.html

13 August 2010. Alert propagation of "superbug" The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) released a statement warning of the danger of rapid spread of a 'superbug', resistant to many antibiotics.The NDM-1 gene (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics, which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system. Hominids used tools three million years ago The hominids used tools to cut and separate the meat from the bones for more than three million years, as has concluded an international group of scientists behind the discovery of two fossil bones with marks made by a sharp instrument.The oldest tools dating from appearing until now does 2.6 or 2.5 million years, but scientists believe that more than three million years ago hominids were already using tools, according to a report this week the journal Nature.

56

http://www.horacero.com.mx/noticia/index.asp?id=NHCVL35570

Alert the medical community spread of 'superbug' which comes from India

Mexico, DF / August 1913 .-The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) released a statement warning of the danger of rapid spread of a "superbug", resistant to many antibiotics.

NDM-1 gene (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics, which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system.La publicación en la revista “The Lancet Infectious Diseases” advierte de varios casos de pacientes en el Reino Unido que tenían estas bacterias resistentes en sus organismos tras un viaje a la India y Pakistán.

According to "Elmundo.es" U.S. genetic alteration has been detected in people in the country.

In Europe, there has been "monitoring and reporting of the occurrence of similar bacteria during the last decade.European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

57

http://www.planoinformativo.com/nota.php?id=81159

Spread of superbug alert

In Europe warn of the rapid spread of these resistant bacteria.

EL UNIVERSAL13/08/2010The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) released a statement warning of the danger of rapid spread of a 'superbug', resistant to many antibiotics.

The gene NDM-1 (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics, which can be a danger, because without effective antibiotics may not be different operations to a person with a weakened immune system.

The publication in the journal The Lancet Infectious Diseases warned of several cases of patients in the United Kingdom that had these resistant bacteria in their bodies after a trip to India and Pakistan.

According to Elmundo.es, U.S. genetic alteration has been detected in people in the country.

In Europe, there has been "monitoring and reporting of the occurrence of similar bacteria during the last decade.

European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

58

http://www.lacronica.com/EdicionEnLinea/Notas/Cienciaytecnologia/13082010/463188.aspx

Launch alert 'superbug'

13th August

MEXICO CITY (AP)The European Society of Clinical Microbiology and Infectious Diseases (ESCMID, for its acronym in English) released a statement warning of the danger of rapid spread of a "superbug", resistant to many antibiotics.

The NDM-1 gene (New Delhi metallo-b-lactamase 1) is a mutation that makes it carry bacteria resistant to many antibiotics.

This can be a danger, because without effective antibiotics may not be various operations of a person against the weakened immune system.

The publication in the journal The Lancet Infectious Diseases warned of several cases of patients in the United Kingdom that had these resistant bacteria in their bodies after a trip to India and Pakistan.

According to elmundo.es, U.S. genetic alteration has been detected in people in the country.

In Europe, there has been "monitoring and reporting of the occurrence of similar bacteria during the last decade."

European Society acknowledges that "it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

59

http://www.frontera.info/EdicionEnLinea/Notas/Cienciaytecnologia/13082010/463188.aspx

Lanzan alerta por ‘superbacteria’ Deja Superbacteria un muerto en Bélgica

Alertan por propagación de 'superbacteria'

MÉXICO, D.F.(Agencias)

La Sociedad Europea de Microbiología Clínica y Enfermedades Infecciosas (Escmid, por sus siglas en inglés) lanzó un comunicado que alerta del peligro de propagación rápida de una “superbacteria”, resistente a un gran número de antibióticos.

El gen NDM-1 (Nueva Delhi metallo-b-lactamase 1) es una mutación que hace a las bacterias que lo portan resistentes a un gran número de antibióticos.

Esto, puede ser un peligro, ya que sin antibióticos eficaces no podrán realizarse diversas operaciones a una persona ante el debilitado sistema inmune.

La publicación en la revista The Lancet Infectious Diseases advierte de varios casos de pacientes en el Reino Unido que tenían estas bacterias resistentes en sus organismos tras un viaje a la India y Paquistán.

De acuerdo con elmundo.es, en Estados Unidos la alteración genética ya se ha detectado en habitantes del país.

En Europa se ha estado “monitoreando e informando de la aparición de bacterias similares durante la última década”.

La sociedad europea reconoce que “es muy posible que no tengamos antibióticos para tratar las nuevas infecciones causadas por estas bacterias al menos en los próximos 10 años, por lo que es esencial que la comunidad médica y sanitaria haga todo los esfuerzos posibles por controlar la propagación de estos patógenos”.

60

ARGENTINA

Alert for " superbug "August 12, 2010 |

http://www.contexto.com.ar/vernota.php?id=32419

The finding of NDM -1 gene , a mutation that makes it carry bacteria resistant to many antibiotics, has alerted health authorities. Following the publication in the journal Lancet Infectious Diseases 'of several cases of patients in the UK after returning from India and Pakistan, had these resistant bacteria in their bodies , the European Society of Clinical Microbiology and Infectious Diseases ( ESCMID ) has released a statement warning of the danger " that spread rapidly across Europe . "

"The study by Professor Timothy Walsh of the arrival of these super- resistant bacteria gives an idea of the size of the problem we face , "said Giuseppe Cornaglia , president of ESCMID .

"In Europe we have been monitoring and reporting of the occurrence of similar bacteria resistant to antibiotics most powerful during the last decade since the first dectetara Verona ( Italy). The experiences of this country, along with those of Greece and Israel, have also reported cases show that we are facing a public health threat and that if we have no plans to make the front can undermine the entire health system , "he adds .

The European Society acknowledges that " it is quite possible that we have no new antibiotics to treat infections caused by these bacteria in at least the next 10 years, so it is essential that medical and health community to make every possible effort to control the spread of these pathogens. "

"We must improve the monitoring system of these bacteria and found that the control strategies , since we can not continue to rely only on antibiotics, " says Professor Cornaglia . The ESCMID has more than 33,000 European microbiologists and specialists in infectious diseases.

Meanwhile, the U.S. media also echoes of this new genetic alteration , as it has been detected in citizens. And in the United Kingdom , where they discovered the gene , reactions were not long in coming. An article in 'The Guardian ' criticizes drug companies underinvest in research and development of new antibiotics, because unlike other drugs , they are not used for life but for specific moments and also because the development of resistance, over time cease to be useful.

However, warn of the dangers that this entails. Without effective antibiotics may not do transplants , because the weakened immune system of these patients could not cope with infections , " appendicitis operation will become a risky surgery and pneumonia and tuberculosis are serious disease

61

COLOMBIA

http://www.eltiempo.com/vidadehoy/salud/bacterias-inmunes-a-antibioticos-tienen-en-guardia-a-todo-el-planeta_7862345-1

Bacteria immune to antibiotics are on guard around the globe

It is very common bacteria and is easily transmitted, such as E-coli.An article reported in the latest edition of the prestigious scientific journal The Lancet has warned the world: some bacteria gene confers a multiple resistance to most known antibiotics.

According to The Lancet, the study authors isolated the bacteria in two major centers in India (one in the south and one in the north) and a reference laboratory in London. In the latter site was established that the British affected by them had traveled to India or Pakistan in the last year or had ties with those countries. The researchers concluded that under these conditions the presence of the gene in bacteria is a potential serious public health problem that requires urgent attention and care by local authorities and health worldwide.

The matter is so serious that the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) issued a statement warning of the danger that bacteria with these characteristics quickly spread to that continent. Reports and rumors began to spread further affected. It is speculated that this might be the cause of death by superinfection of a man in Belgium, who had visited Pakistan (her homeland).

Also Australian said three were in India (including one who underwent plastic surgery in Bombay), were infected with a bacteria with these characteristics. According to Giuseppe Cornaglia, president of the ESCMID, "the detection of multidrug-resistant bacteria has been a priority for us since it was detected first in Verona (Italy) for almost ten years."

Cornaglia also referred to some cases in Greece and Israel. "This is a public health threat because the bacteria travel with people from one country to another (...) It is quite possible that within a decade there are no new antibiotics to treat infections, so that the priority at the moment is to control the spread of infection, "adivirtió Cornaglia.

The problem has now spilled over from the medical and jumped into the political arena

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yesterday, after the Ministry of Health of India rejected the Lancet study, which he described as "alarmist." He also criticized the fact that the gene and the enzyme that generates resistance had been baptized with the name NDM-1: New Delhi-lactamase Metallo-betalo 1.

Hospitals are strengthenedSome of the worst bacteria have acquired resistance in hospitals.

Staphylococcus aureus: immune to penicillin and is believed to produce 19 000 deaths annually in the United States.

Pseudomonas aeruginosa: superinfection mainly in blocks of burnt skin.

Streptococcus pneumoniae: it is so tough that only some strains are sensitive to drugs.

Enterococcus fecalis: if a resistant strain superinfection in patients during surgery, the prognosis is dismal.

Learn how to use these drugsOne of the main causes of antibiotic resistance is the misuse of people do them. So keep in mind:

No press: much of the excessive prescription of antibiotics is that they require patients to doctors who prescribed.

Do not treat: not used to treat colds, fevers, swelling or maluqueras.

Specific: For each bacterium is an antibiotic, so we have to take the doctor says, not the one you suggest others.

Exact dose and time: these drugs are amounts to be respected. If the doctor says 500 milligrams every eight hours, is 500 milligrams every eight hours. Use them for the exact time ordered. Do not discontinue use if you feel better.A battle that the bacteria have gainedThe appearance in 1943, streptomycin is a milestone in medicine, since, thanks to her, were drastically reduced deaths from tuberculosis.

This gain, according to warnings from researchers around the world, has been lost in recent decades on account of the emergence of tuberculosis strains that do not respond to any known antibiotic. This problem, which was detected less than five years in Africa, now affects more than 50 countries. The disease is so severe that half the people who get it (almost all in poor countries), die.

The tubercle bacillus was one of the first bacteria associated with serious resistance. He have been added others, such as some types of e-coli (which cause intestinal infections), the klepsiellas that cause pneumonia, and some streptococci.

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The matter is serious, has been warned on previous occasions. In 1992 Newsweek, in an edition devoted to the topic, said that 13 300 patients in U.S. hospitals that year, died affected by infections caused by bacteria resistant to all antibiotics.

The problem is compounded when you consider that the pharmaceutical industry has stopped investigating new antibiotics, because it is not as profitable as develop other drugs.

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http://www.talcualdigital.com/Avances/Viewer.aspx?id=39172&secid=10

Progress |Health|8/13/2010

global superbug fearNDM -1 is called and makes the bacteria carrying the new species are resistant to all antibiotics . The European Society of Clinical Microbiology and Infectious Diseases warned about the danger of global spread

The European Society of Clinical Microbiology and Infectious Diseases warned in a statement Friday about the danger of spreading a "superbug" , which is resistant to many antibiotics.

NDM -1 is called (New Delhi Matallo -b- lactamase 1) and makes the bacteria carrying this new species are resistant to many antibiotics.

According to research , this new defense would be a danger to the medical environment, and that they could not perform several operations because of weak immune system in the absence of antibiotics, the newsmagazine The Lancet Infectious Diseases.

In the article, the magazine mentions several cases in the UK, which carried these bacteria in their bodies after a trip to India and Pakistan , likewise , has detected the appearance of similar bacteria in the last decade

Faced with this phenomenon , Europe is aware that there is no strong antibiotics to treat infections that would bring this new mutation, and could not fight these diseases in the next 10 years, which encourages the medical community makes it necessary to control is the spread of pathogens

NEW VICTIMSThree Australians who traveled to India were infected with the bacteria resistant to nearly all antibiotics, said Friday a medical expert , raising fears of a global spread after the discovery of dozens of similar cases in Britain

The three infected ( one of which underwent a facelift in Bombay ) are but the tip of the iceberg that sticks out , " said Professor Peter Collignon , director of communicable disease department in Canberra Hospital .

The first case of infection by an enzyme -producing enterobacteria type NDM -1 (New Delhi metallo -beta- lactamase ) , was identified in 2009 by Timothy Walsh (University of Cardiff , UK ) in a Swedish patient who had been hospitalized in India.

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Researchers also discovered in the 37 patients in Britain, after being transported from South Asia by people who made medical tourism, according to a study published this week in the British journal The Lancet Infectious Diseases.

BOLIVIA

Crece la alerta por bacteria resistente a los antibióticos  

La Sociedad Europea de Microbiología Clínica y Enfermedades Infecciosas lanzó ayer un comunicado que alerta del peligro de propagación rápida de una “superbacteria”, resistente a un gran número de antibióticos.

El gen es conocido como NDM-1 (Nueva Delhi metallo-b-lactamase 1) y es una mutación que hace a las bacterias que lo portan resistentes a antibióticos, lo cual puede ser un peligro, ya que por dicha condición no podrán realizarse varias operaciones a una persona ante su debilitado sistema inmune.

Se advierte de varios casos de pacientes en el Reino Unido que tenían estas bacterias tras un viaje a la India y Pakistán y se sospecha de un fallecido

Según Eluniversal.com.mx, en Estados Unidos la alteración genética ya se ha detectado en habitantes del país. En Europa se ha estado “monitoreando e informando de la aparición de bacterias similares durante la última década”.

La sociedad europea reconoce que “es muy posible” no tener antibióticos para las nuevas infecciones bacterianas al menos en los próximos diez años.

Growing alert antibiotic-resistant bacteria

The European Society of Clinical Microbiology and Infectious Diseases released a statement yesterday warning of the danger of rapid spread of a " superbug " , resistant to many antibiotics.

The gene is known as NDM -1 (New Delhi metallo -b- lactamase 1) and is a mutation that makes it carry bacteria resistant to antibiotics , which can be a danger, and that this condition can not be made more operations to a person with a weakened immune system.

It is noted several cases of patients in the UK who had the bacteria after a trip to India and Pakistan and is suspected of a deceased

According Eluniversal.com.mx , U.S. genetic alteration has been detected in people in the country . In Europe, there has been " monitoring and reporting of the occurrence of similar bacteria during the last decade. "

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European Society acknowledges that "very likely "no new antibiotics for bacterial infections in at least the next ten years.

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Bolivia.com News

http://www.bolivia.com/noticias/AutoNoticias/DetalleNoticia43470.asp

de una “superbacteria” resistente a los antibióticos

(Bolivia.com) La Sociedad Europea de Microbiología Clínica y Enfermedades Infecciosas, ESCMID, lanzó un comunicado que alerta del peligro de propagación rápida de una 'superbacteria', resistente a un gran número de antibióticos.

El gen NDM-1 (Nueva Delhi metallo-b-lactamase 1) es una mutación que hace a las bacterias que lo portan resistentes a un gran número de antibióticos, el cual puede ser un peligro, ya que sin antibióticos eficaces no podrán realizarse operaciones a una persona ante el debilitado sistema inmune.

La publicación en la revista The Lancet Infectious Diseases advierte de varios casos de pacientes en el Reino Unido que tenían estas bacterias resistentes en sus organismos tras un viaje a la India y Pakistán.

En Europa se ha estado "monitoreando e informando de la aparición de bacterias similares durante la última década.

La sociedad europea reconoce que "es muy posible que no tengamos antibióticos para tratar las nuevas infecciones causadas por estas bacterias al menos en los próximos 10 años, por lo que es esencial que la comunidad médica y sanitaria haga todo los esfuerzos posibles por controlar la propagación de estos patógenos".

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Gen NDM-1

Publicidad

VIETNAM

http://www.nguoi-viet.com/absolutenm/anmviewer.asp?a=117333&z=5

About medical alert against bacterial super strong antibioticsFriday, August 13, 2010

Have appeared in Vietnamese Male

LONDON - Those Indian healing He brought a new type of genetics may have the effect of all the bacteria become super-strong (superbug) against the antibiotics. Scientists report that they can spread very rapidly throughout the world, according to AP news agency.While currently in India has spread, people began to see appear in the UK and elsewhere. Experts warned that medical tourism industry is a strong break out in India and Pakistan, possibly as bait for the victim increased risk of antibiotic resistance, once that such patients after treatment disease return, his second into the bacteria is extremely dangerous.In Vietnam Male, Tropical Central Hospital recorded a couple of super-strong bacteria has appeared in Vietnam Male, The Sai Gon Giai Phong newspaper.

According to AFP, in Belgium is the first case of a man who died of bacterial super strength comes from the South Asian region, prompting fears they will spread throughout the world. The victim was not clearly known when the infection was hospitalized at Pakistan and died in June. A doctor at the hospital in Brussels, Where he was treated for Belgium or the press Friday.

Belgian doctor said: "He was a car accident during the Pakistan, Was taken into hospital and then taken to Belgium. "Although treated with colistin, an extremely strong antibiotics but he still died.

According to AP, genetic superbugs could be changed bacteria, making them resistant to all drugs. Currently we have identified where 37 people recently returned to England, and after about India Pakistan perform the surgery.

It also shows the presence of them in Australia, Canada, USA, Holland and Sweden. The researchers said that since many Americans and Europeans into India and Pakistan to cosmetic surgery, we are able to spread widely around the world.In a paper published in Lancet Infectious Diseases website, doctors report on the newly discovered genetic types can be called new NDM-1, abbreviated from the word metallolactamase New Delhi-1. This type of genetic change can bacteria, making them

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resistant to virtually all antibiotics, including carbapenems antibiotics are finally brought when others are not brought results.Bacterial membrane NDM-1 was found more in the E. coli, bacteria commonly cause secondary urinary tract infections, and also present in the structure of chromosomal DNA, which is easily copied and transferred to other bacteria.

Lancet Infectious Diseases article is the note: "The NDM-1 which could become a global health issues is very high, there should be international collaboration to find out."AFP quoted Professor Peter Collignon, infectious disease chief at the Canberra Hospital, Said three cases have been identified in Australia among those who return to India for surgery. He said: "We see them appear in the urine of patients, and the subject was not destroyed but fortunately has not caused any serious problems. However, this result is a major problem when they spread to other people. "He added:" We do not have drugs that can treat them all. "

Mr. Collignon said one patient was later transferred to the emergency when the complications of cosmetic surgery. But he said that a person infected with super-strong in a normal case, demonstrating that this problem is becoming quite popular. He said: "Maybe this powerful super virus has killed more people since then but this happens in developing countries, we do not have the means to probe for accurately."ESCMID Organization (European Society of Clinical Microbiology and Infectious Diseases), said at least 10 more years to wait until we can find out which remedy is treatable bacterial substances NDM-1.In Vietnam, a research hospital Central Tropical done recently in 16 hospitals in Vietnam has detected bacteria resistant carbapenems similar group of bacteria found in India but brought another type of gene. (TP)

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SINGAPORE

http://www.straitstimes.com/BreakingNews/TechandScience/Story/STIStory_566234.html

'Superbug' claims 1st victim

BRUSSELS - A BELGIAN man became the first known fatality of a drug-resistant 'superbug'

originating in South Asia, reinforcing fears the germ could spread worldwide after infecting

dozens of people in Britain and Australia. The unnamed patient became infected while

hospitalised in Pakistan and died in June, a doctor from the Brussels hospital where he had

been treated told Belgian media on Friday. 'He was involved in a car accident during a trip to

Pakistan. He was hospitalised with a major leg injury and then repatriated to Belgium, but

he was already infected,' the doctor said.

Despite being administered colistin, a powerful antibiotic, the patient died, the doctor said.

A second Belgian picked up the bug after being hospitalised following an accident during a

trip to his native Montenegro, but recovered with treatment back in Belgium in July,

another expert said on Friday. 'The epicentre of the presence of this bacteria seems to be

India and Pakistan, but it appears through contact and travel, its spread is becoming wider,'

Youri Glupczynski, a bacteriologist from the University of Leuven, told AFP.

The superbug comprises a bacterium containing an enzyme gene called New Delhi metallo-lactamase-1 (NDM-1) that makes it impervious to treatment by almost all antibiotics. These include drugs known as carbapenems, which are often used as a last resort. A British journal, The Lancet Infectious Diseases, reported this week that bacteria containing the NDM-1 gene had been found in 37 Britons who had received medical treatment in South Asia. It said health tourists visiting South Asia risked infection and warned the superbug could spread. Three cases have been identified in Australia among people who had travelled to India for surgery, said Professor Peter Collignon, Canberra Hospital's head of infectious diseases department. 'We found this multi-resistant, untreatable bug in their urine, luckily not causing too many problems to that person. But it's a real problem if it spreads to others,' he said. 'The germ we had was untreatable - there were no drugs we had that could treat it,' he added. – AFP

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CHINA China Times

"International community" super bacteria life-threatening , the world first heard

http://money.chinatimes.com/news/news-content.aspx?id=20100815001434&cid=120715/08/2010

Originated in the South Asian subcontinent , drug-resistant super NDM ─ 1 " super bacteria " , came from the world's first confirmed deaths . Belgian media reported on the 13th , a man than the country travel to Pakistan this year, a car accident , leg and hospitalized in nosocomial infection with NDM ─ 1 ( enzyme ) of the bacteria , before returning home to diathesis , in June Died .

Another man than the country had a similar experience , but fortunately escaped . He was born in the visit , located in Southern Europe, the Balkans, Montenegro accident when a patient is also infected with bacteria NDM ─ 1 July to return the treatment to save his life .

University of Leuven , Belgium , said bacteriologist Ge Lupu JI : "NDM ─ 1 bacteria appears to be the birthplace of India and Pakistan, but through personal contact and international travel, has spread more widely . "

Currently Britain has emerged Saqi cases , they have had a history of hospitalization in the South Asian countries . Australia also has three cases are invariably the patients had surgery in India . Canberra Hospital, Professor Kelin Nong , director of infection , the current case there is only tip of the iceberg , NDM ─ 1 bacteria developing countries probably have killed a lot of lives .

British medical journal "The Lancet Infectious Diseases ─ " has reports , NDM ─ 1 has entered the Escherichia coli and Klebsiella pneumoniae , two common bacteria to which the most widely effective carbapenem antibiotics. E. coli is one of the main urinary tract infection , Klebsiella pneumoniae are common in lung and wound infections .

Currently only about prime ring for additional grams of dysentery and two antibiotics neomycin , barely able to deal with NDM ─ 1 bacteria . European Society of Clinical Microbiology and Infectious Diseases (ESCMID) pointed out that to develop effective treatment for bacterial NDM ─ 1 new antibiotics, at least ten years .

Because NDM ─ 1 of the "ND" is named after the Indian capital New Delhi , triggering public protests in India , fear of a blow to the tourism industry . But Indian media reported on the 13th , Mumbai Hinduja hospital doctors from August to November last year , once found Nianer a bacterial super- infection NDM ─ 1 case , in March this year and in the "

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Journal of Indian Society of Internal Medicine , " published papers , but Not attract attention. ( News source: China Times ─ Yanji Yu / roundup)

http://www.zaobao.com/wencui/2010/08/taiwan100815h.shtml

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http://www.allvoices.com/contributed-news/6518414-scientists-worry-about-spread-of-drugresistant-superbug-as-it-claims-its-first-known-fatality

Scientists Worry About Spread of Drug-Resistant SuperBug As It Claims Its First Known Fatality14TH August

New Delhi Metallo-beta-lactamase (NDM-1) is a newly-identified enzyme that makes bacteria resistant to broad range of beta-lactam antibiotics. This includes antibiotics of the carbapenem family that were a mainstay for the treatment of other antibiotic-resistant bacteria. The gene for NDM-1 is one member of a large gene family that encode beta-lactamase enzymes called carbapenemases. Bacteria that carry such genes are often referred to in the news media as "superbugs", since infections with these bacteria are very hard to treat successfully. Indeed, the United Kingdom Health Protection Agency has stated that "most isolates with NDM-1 enzyme are resistant to allstandard intravenous antibiotics for treatment of severe infections.

The first known fatality of the drug-resistant "superbug" originating in South Asia is a Belgian man. This may reinforce fears that the germ could spread worldwide after infecting dozens of people in Britain and Australia.The unnamed patient became infected while hospitalised in Pakistan and died in June, a doctor from the Brussels hospital where he had been treated told Belgian media on Friday."He was involved in a car accident during a trip to Pakistan. He was hospitalised with a major leg injury and then repatriated to Belgium, but he was already infected," the doctor said.

Despite being administered colistin, a powerful antibiotic, the patient died, the doctor said.A second Belgian picked up the bug after being hospitalised following an accident during a trip to his native Montenegro, but recovered with treatment back in Belgium in July, another expert said Friday.

"The epicentre of the presence of this bacteria seems to be India and Pakistan, but it appears through contact and travel, its spread is becoming wider," Youri Glupczynski, a bacteriologist from the University of Leuven, told AFP.

The superbug comprises a bacterium containing an enzyme gene called New Delhi metallo-lactamase-1 (NDM-1) that makes it impervious to treatment by almost all antibiotics.These include drugs known as carbapenems, which are often used as a last resort.A British journal, The Lancet Infectious Diseases, reported this week that bacteria containing the NDM-1 gene had been found in 37 Britons who had received medical treatment in South Asia.Three cases have been identified in Australia among people who had travelled to India for surgery, said Professor Peter Collignon, Canberra Hospital's head of infectious diseases department.

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"We found this multi-resistant, untreatable bug in their urine, luckily not causing too many problems to that person. But it's a real problem if it spreads to others," he said."The germ we had was untreatable -- there were no drugs we had that could treat it,"According to Collignon, one of the patients caught the bug in intensive care in an Indian hospital after plastic surgery went wrong. But he said another picked up the bug in the general community, indicating the extent of the problem.He described the cases as just the "tip of the iceberg".

"It probably is killing lots of people but it happens in the developing world and there's no way of measuring it."

The NDM-1 gene is a special worry because it is found in plasmids -- DNA structures that can easily be copied and then transferred promiscuously among different types of bacteria.These include Escherichia coli, the commonest cause of urinary tract infections, and Klebsiella pneumoniae, which causes lung and wound infections and is generated mainly in hospitals.

The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) said no new antibiotics to treat NDM-1 infections were likely to be available for at least 10 years.

The Indian health ministry has disputed the conclusion of the August 2010 Lancet study that the gene originated in India or Pakistan, describing this conclusion as "unfair" and stating that Indian hospitals are perfectly safe for treatment. Indian politicians have described linking this new drug resistance gene to India as “malicious propaganda” and blamed multinational corporations for what they describe as selective malignancy. A Bharatiya Janata Party politician has instead argued that the journal article is bogus and represented an attempt to scare medical tourists away from India.The Indian Ministry of Health released a statement "strongly refut[ing]" naming the enzyme "New Delhi".

The primary author of the 2010 Lancet study, who is based in the University of Madras, has stated that he does not agree with the part of the article that advises people to avoid elective surgeries in India.In contrast, an editorial in the March 2010 issue of the Journal of Association of Physicians of India blamed the emergence of this gene on the widespread misuse of antibiotics in the Indian healthcare system, stating that Indian doctors have "not yet taken the issue of antibiotic resistance seriously" and noting little control over the prescription of antibiotics by doctors and even pharmacists.The Times of India states that there is general agreement among experts that India needs both an improved policy to control the use of antibiotics and a central registry of antibiotic-resistant infections.

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