Volume XIX June 2018

In This Issue

• President’s Message • Annual Business Meeting

and Reception • Membership Dues • 2018 Election Results • Membership News • In Memoriam • 2018 Mildred Christian

Award Winner • 2019 Mildred Christian

Award Nominations • Committee News • Annual ATS Fellow Spotlight • 2018 Annual Business

Meeting and Reception Pictures

The Academy of Toxicological Sciences

PO Box 98954 Raleigh, NC 27624

www.acadtoxsci.org

ATS CONNECTIONLEIGH ANN’S LETTER… (AKA THE PRESIDENT’S MESSAGE) I had such a good time at our open reception at SOT this year and I hope you did, too! I surmised as much by the din of the conversation – that didn’t quite subside during our business meeting portion of the evening (which I found a very positive sign of success, by the way). And at least a couple of the folks who attended submitted applications and are now new Fellows! We thought we’d move back to Wednesday for next year but many folks have said they liked the new night so we decided to let the Fellows decide. Please be on the lookout for the quick, one question survey of the Fellows regarding our reception at SOT next year. We are currently polling to see whether the majority prefer Monday, Tuesday or Wednesday after the President’s Reception (as was the standard event night until 2017). We’ll need that data back soon as Susie will need to reserve the date with SOT in July.

In the corporate world, summer is often a time for mid-year progress reviews. Not necessarily my favorite thing to do in the summer, but a good time to check in and see how things have been going and make adjustments as needed. Summer also happens to transition time for the ATS Board of Directors. So in my last message to you as your President I thought I would review some of the activities from the second half of this ATS year and what will be continuing into next year under Ruth Roberts’ leadership. A few quick highlights include the completion of the Climate Change Survey described later in the newsletter [link to website?], finalization of the LinkedIn group site [link], and completion of the transition to our new management company. We also hosted our first open and cash bar reception. Related to the Climate Change Survey, the Society of Toxicology Council has tasked the Occupational and Public Health Specialty Section to draft an Issue Statement on this topic. If you have a specific interest and would like to be involved with this activity please let me know so I can connect you.

Anyone who has ever worked with our Executive Director, Susie Masten, knows that she is extremely organized and efficient. One of her objectives for this year and the coming year is to be sure the Board has some clear and citable policies and procedures for the many activities we undertake. For all our activities, Susie has asked about where she and new Board members and Committee members could review procedures for these. What we found was that most things were passed down by word of mouth from one chair to another. I think we have been relatively consistent in what we have done over the years but when you expand your involvement beyond the Board itself, it realistically doesn’t scale. And even within the Board there could be drift over time. So having some procedural documents in place is going to help us significantly. In the second half of this year, we focused on the Awards Committee. Thank you to John Lipscomb and Susie for leading the activity. Not only do we have a better defined process for selection of our award winners, we also better defined what we wanted to see in the nominations. We’ll be continuing to do this with other committees in the coming year.

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ATS CONNECTION LEIGH ANN’S LETTER… (AKA THE PRESIDENT’S MESSAGE) CONTINUED

The most recent activity undertaken by the Board this year was to provide a response to the EPA proposed rule on strengthening transparency in regulatory science. This, as you might have guessed, was a difficult undertaking. The Board represents all Fellows and we know that not everyone will have the exact same opinion. We also recognized that there was the added layer – real or perceived – that any response could be considered a political position. Despite this, the Board felt strongly that some specific aspects of the proposed rule directly impacted the use of scientific data for the purposes of regulatory decision making, and as written could also prevent the ability to use critical epidemiological data in these decisions because of the important need to maintain privacy of the individuals in the study. We started with a conceptual draft that ATS Fellow Ron Hines helped to craft, and worked as a group to assure that our letter was focused on the science, with examples where appropriate. Since we initially came to a final response, the deadline was extended by EPA (from May 30 to Aug 16) and a public hearing date (July 17) was added. I encourage all of our Fellows to review the proposed rule and send your personal comments, if desired. I am aware that some of you have done so already.

Finally, I’d like to welcome Michael Aschner (incoming VP), Michael Dourson, Ofelia Olivero, and Jan Hulla to the ATS Board of Directors. You are joining a wonderful group of individuals who work hard and are committed to continuing the broader engagement of all our members and increasing the impact of ATS on our discipline. Thank you to my fellow Board members for your dedication and especially to Susie and Laurie for keeping us organized and on track. And thank you, fellow Fellows, for letting me serve you in this capacity. It has truly been an honor and a privilege, and I remain excited for the future of the Academy. I hope you all enjoy the rest of your summer!

*As an employee of EPA, Board Member Jane Ellen Simmons recused herself from the process. *As a contractor to the Biomedical Advanced Research and Development Authority, Board member Carol Sabourin recused herself from the process.

Sincerely,

Leigh Ann Burns Naas, PhD DABT ATS ERT ATS President, 2017-2018

ATS ANNUAL BUSINESS MEETING AND RECEPTION

A poll was sent out via Survey Monkey to determine what day to have the annual Business Meeting and Reception during SOT in Baltimore next year. The date will be posted on the ATS website when the poll has closed. Please note all responses must be received by July 20, 2018.

MEMBERSHIP DUES INFORMATION Please note that the Annual Membership Dues is due by September 15 of each year. You will receive a notice later in the summer for dues payment, and we ask that you remember to pay your dues promptly. Fellows who have not paid their annual dues as of December 1 will be considered delinquent. For any Fellow who remains delinquent for 30 days (January 1), the Fellow will be encouraged to pay dues in a prompt manner so that their certification and privileges are not suspended pending dues payment. If dues remain unpaid for one year (September 15 of the following year), the Fellow will be informed that their Fellowship status has been revoked. The designation of Fellow can no longer be used, including any professional media and correspondence, from that day forward. This includes, but is not limited to, business cards, letterhead, curriculum vitae, etc.

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ATS CONNECTION ELECTION RESULTS

ATS Fellows cast their ballots for Vice President in February 2018 along with ballots to elect new members to serve on the ATS Board of Directors and Committees. The ballot included an impressive list of candidates who stepped forward to serve the membership. We are pleased to welcome Michael Aschner, Albert Einstein College of Medicine, as ATS Vice President; Michael Dourson, Toxicology Excellence for Risk Assessment Center; Ofelia Olivero,

National Cancer Institute; and Janis Hulla to the ATS Board of Directors. In addition, we are pleased to welcome Daniel Acosta, Jr. to the Nominating Committee and Nancy A. Monteiro-Riviere to the Awards Committee. Be sure to visit the ATS website at https://acadtoxsci.org/board-of-directors/ to read about the incoming Board members. The Board would like to express their gratitude to all candidates that participated in the election process.

ATS Board of Directors Terms

2017-2018 Leigh Ann Burns Naas, President (2013-2019) Ruth Roberts, Vice President (2017-2020) Paul M. D. Foster, Secretary/Treasurer (2014-2018) Mary Ellen Cosenza, Secretary/Treasurer-Elect (2017-2020) Matthew Bogdanffy, Past President (2013-2018) Lorrene Buckley (2015-2018) Jon Cook (2016-2019) Myrtle Davis (2016-2019) Donald A. Fox (2015-2018) Kyle Kolaja (2015-2018) Timothy Pastoor (2017-2020) Carol Sabourin (2017-2020) Jane Ellen Simmons (2015-2018)

2018-2019 Ruth Roberts, President (2017-2020) Michael Aschner, Vice President (2018-2021) Mary Ellen Cosenza, Secretary/Treasurer (2017-2020) Leigh Ann Burns Naas, Past President (2013-2019) Jon Cook (2016-2019) Myrtle Davis (2016-2019) Michael Dourson (2018-2021) Janis Hulla (2018-2021) Ofelia Olivero (2018-2021) Timothy Pastoor (2017-2020) Carol Sabourin (2017-2020) A special thanks to our outgoing Past President, Matthew Bogdanffy, for his service and commitment to ATS.

MEMBERSHIP NEWS We are happy to welcome the following new Fellows who became members since January 2018:

Donna Dambach Ayse Basak Engin Elaina Kenyon Donald Stump Jia-Sheng Wang

Emeritus status was granted to the following Fellows: Jay Means Robert Osterberg Colin Rousseaux Robert Snyder

In addition, the following Fellows successfully com-pleted the recertification process:

Michael Aschner William Boyes James Bruckner Lucio Costa Yvonne Dragan Bengt Fadeel Ali Faqi Jodi Flaws Ronald Hines Roger McClellan James Stevens Sidney Stohs William Stokes Lawrence Thomas Adam Woolley

IN MEMORIAM We are saddened to announce the passing of Frederick Oehme and John Willson.

DID YOU KNOW ATS HAS TWO TYPES OF FEES? • ANNUAL DUES • RECERTIFICATION FEE DUE EVERY FIVE YEARS (IN ADDITION TO DUES)

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ATS CONNECTION ATS 2018 MILDRED CHRISTIAN AWARD WINNER

LINDA S. BIRNBAUM, PHD, DABT, ATS Dr. Linda S. Birnbaum, PhD, DABT, ATS, received the Mildred S. Christian Career Achievement Award from the Academy of Toxicological Sciences on March 12, 2018. In honor of Dr. Christian, this award recognizes individuals who demonstrate extraordinary scientific achievement and a lasting impact on toxicological sciences through publications, professional activities, and leadership that has enhanced the practice of toxicology.

As the first female, and the first toxicologist, to serve as the Director of both the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP), Dr. Birnbaum embodies the spirit of the Mildred S. Christian award. Under Dr. Birnbaum’s leadership, the NIEHS has become the world leader in toxicology research, and NIEHS science underlies regulatory decision making in the U.S. and abroad.

Dr. Birnbaum has demonstrated an unwavering commitment to focusing research on community concerns over environmental hazards and health problems. She has long been recognized nationally and internationally for her distinguished achievements in scholarly research. Her numerous scientific papers, book chapters, and reports have been cited by scientists, government officials, and community environmental activists, her leadership that has inspired toxicologists and women scientists throughout the world.

2019 MILDRED CHRISTIAN AWARD DEADLINE AND NOMINATION CHANGES ATS established the Mildred S. Christian Career Achievement Award to honor the memory of Dr. Christian, known to many as “Millie.” The ATS award is conferred to an ATS Fellow who has clearly demonstrated a lasting impact on toxicological sciences. The criteria for the award include, but are not limited to, the following:

1. The awardee must be an ATS Fellow in good standing as either a full ATS Fellow or ATS Emeritus. A Fellow that is a current member of the Board of Directors of ATS is not eligible to receive the award.

2. The awardee must have demonstrated extraordinary scientific achievement through publications, professional activities, and/or leadership that have enhanced the practice of toxicology as judged by the Board of Directors.

The ATS Board of Directors is requesting nominations from the ATS Fellows for the 2019 Mildred S. Christian Award. Nominations remain active for two years.

2019 Changes

All nominations for the 2019 award must be submitted on the official ATS Mildred Christian Award Nomination form, available on the ATS website. While the candidate’s CV must accompany the nomination form, the nominator must also describe on the form how they believe their candidate meets the criteria for the award. Only one secondary letter per candidate is requested. If more are submitted in addition to the one listed on the nomination form, the Awards Committee will consider these at their discretion. Note that nominations submitted in 2018 do not need to be resubmitted using the new form.

If you believe an ATS Fellow meets the criteria for this award, we request that you submit the nomination form along with the nominee’s biographical information (complete CV if possible) to Susie Masten for the Board’s consideration. The deadline for receipt of nominations and secondary letters for the 2019 award is November 1, 2018. For full information about the award, a list of past winners and the nomination form, please visit the ATS website at: https://acadtoxsci.org/mildred-christian-award

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ATS CONNECTION COMMITTEE CORNER

Reminder: ATS LinkedIn Page

The ATS LinkedIn page is active! It is a public site which provides a forum for showcasing ATS as a premier toxicology credentialing organization. Our ATS LinkedIn site provides a mechanism for the external environment to connect with the expertise of our experienced Fellows. One feature submitted by the Recognition Task Force is developing profiles for “Fellow of the Month” and “ATS Awardees.” The second “Fellow of the Month” featuring Myrtle Davis has just been published. Be sure to follow the ATS LinkedIn page to see it!

ATS LinkedIn Fellows Group

In addition to the public LinkedIn page, a private LinkedIn group called “Fellows of the Academy of Toxicological Sciences” has been created as an interactive site for ATS Fellows only. The group is a hidden group. Send an email to Susie at smasten@acadtoxsci.org for instructions on joining the private ATS LinkedIn group.

Global Change Survey Results

Thank you to those of you who responded to the survey of Fellows regarding climate change as it relates to toxicology. The results have posted on the ATS website at https://acadtoxsci.org/announcements/. It is hoped that future activities will garner a greater response.

ATS 2018-2019 Committee List

Below is a list of ATS Committees and members for the 2018-2019 fiscal year. The Board would also like to thank Committee members who finished their terms: Mary Beth Genter, Awards; Jose Manautou, Nominating; Berna Magnusen, Communications; and Wei Zhang; Recruitment. Fellows interested in serving in future open Committee positions are encouraged to let either the Committee chair or Susie know. Nominating

Leigh Ann Burns Naas, Chair Jon Cook Carol Sabourin Daniel Acosta Yvonne Dragan Awards Ruth Roberts, Chair Michael Aschner Mary Ellen Cosenza Nancy Monteiro-Riviere John Lipscomb Communications Timothy Pastoor, Chair Michael Dourson Dan Petersen Jim Popp Recognition Myrtle Davis, Chair Janis Hulla Sharon Myers Jodi Flaws Recruitment Carol Sabourin, Chair Ofelia Olivero Barbara Beck Ken Hastings

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ATSCONNECTION

ANNUAL ATS FELLOW SPOTLIGHT ATS Fellows Awards, Accomplishments and Appointments Linda S. Birnbaum Arnold J. Lehman Award Society of Toxicology Jim Bus Outstanding Leadership in the field of

Dose-Response Co-Author Awardee: Best Published Paper in the Application of Risk Assessment

International Dose-Response Society Society of Toxicology Risk Assessment Specialty Section

Samuel M. Cohen Member EPA Science Advisory Board Felix de la Iglesia Elected Member Academy of Medical Sciences in Cordoba, Argentina John DeSesso Edward W. Carney Distinguished

Service Award The Teratology Society

Bruce Fowler

Distinguished Annuitant Award Board of Directors Board of Directors

Blue Cross and Blue Shield Federal Employee Program Fulbright Association SOT Endowment Fund

Peter Goering Lifetime Achievement Award – Science and Research

US Food and Drug Administration

Maureen Gwinn Public Communications Award Society of Toxicology Janis Hulla President-elect Society of Toxicology's Women In Toxicology Special Interest

Group Abigail Jacobs FDA Lead ICH S5 (R3) Guideline on developmental and reprotox Ali E. Karakaya Lifetime Achievement Award IUTOX Kannan Krishnan Co-Author Awardee: 2017 Paper of the

Year Award Society of Toxicology Occupational and Public Health Specialty Section

Roger McClellan Distinguished Toxicology Scholar Award

Society of Toxicology

Ruth Roberts Founders Award Society of Toxicology Keith Soloman Global Partners Award for Capacity

Building 2018 Outstanding Contribution to Canadian Ecotoxicology

Society for Society for Environmental Toxicology and Chemistry Canadian Ecotoxicology Workshop

Jia-Shen Wang Translational Impact Award Society of Toxicology David Warheit Invited Keynote Speaker

Invited Debater “Can product stewardship replace regulation?”

Australian Toxicology and Risk Assessment Society Meeting Helsinki Chemicals Forum

Myra Weiner Keynote Speaker iPharma Conference Adam Woolley Carol C,Lemire Unsung Hero Award American College of Toxicology Wei Zheng President

Outstanding Graduate Faculty Mentor Award

International Society for Trace Elements Research in Humans Purdue University

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ATS CONNECTION ATS Fellow Publications These publications have shared by ATS Fellows for inclusion in this newsletter.

Jim Bus Richard A. Becker, David A. Dreier, Mary K. Manibusan, Louis A. (Tony) Cox, Ted W. Simon, and James S. Bus. How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data? Regulatory Toxicology and Pharmacology 90 (2017) 185-196

Michael Derelanko Derelanko, M. (2018). The Toxicologist's Pocket Handbook, Third Edition. Boca Raton: CRC Press.

Bruce A. Fowler FowlerBA. Electronic Waste: Toxicology and Public Health Issues. Elsevier Publishers, Amsterdam (2017) pp.84. NordbergGF, Fowler BA. Risk Assessment for Human Metals Exposures-Mode of Action and Kinetic Approaches. Elsevier Publishers, Amsterdam 2018, (In press)

Joseph Hanig Joseph Hanig and William Slikker. Toxicology Prediction - Regulatory Perspective in Comprehensive Medicinal Chemistry III, , Volume 4, pp. 285 - 303. Edited by: Samuel Chackalamannil, David Rotella and Simon Ward. Elsevier Press. (2017) Joseph Hanig and Geeta Negi. Myelin Structure, Function, Pathology and Targeted Therapeutics in Handbook of Developmental Neurotoxicology (2nd edition) Chapter 4, pp.33 – 52, January 2018, edited by William Slikker, Merle Paule and Cheng Wang Publisher – Elsevier Press Serguei Liachenko , , Jaivijay Ramu, Merle G. Paule, and Joseph Hanig. Comparison of quantitative T2 and ADC mapping in the assessment of 3-nitropropionic acid-induced neurotoxicity in rats. Neurotoxicology 65: 52-59 2018. John F. Bowyer, Karen M. Tranter, Sumit Sarkar and Joseph P. Hanig. Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency. Neurotoxicology, 65:98 - 110, 2018.

Kannan Krishnan Sandrine F. Chebekoue, Kannan Krishnan; Derivation of Occupational Thresholds of Toxicological Concern for Systemically Acting Noncarcinogenic Organic Chemicals, Toxicological Sciences, Volume 160, Issue 1, 1 November 2017, Pages 47–56,

Myra Weiner Weiner, M.L. 2018. Her STEM Career: Adventures of 51 Remarkable Women, Ed. Diane Propsner, Book 1, p. 187-190. Weiner, M.L., 2016 Parameters and pitfalls to consider in the conduct of food additive research, Carrageenan as a case study. Food Chem Toxicol. 87; 31-44. McKim, J.M., Baas, H., Rice, G.P., Willoughby, J.A., Sr., Weiner, M.L., Blakemore, W.R. 2016. Effects of carrageenan on cell permeability, cytotoxicity, and cytokine gene expression in human intestinal and hepatic cell lines. Food Chem Toxicol. 96; 1-10. Weiner, M.L., McKim, J.M., Blakemore, W.R. 2017. Addendum to Weiner, M.L. (2016) Parameters and Pitfalls to Consider in the Conduct of Food Additive Research, Carrageenan as a Case Study. Food Chem Toxicol.107, 208-214. McKim, J.M., Blakemore, W.R., Weiner, M.L. 2018. Clarifying the Confusion Between Poligeenan and Carrageenan: A review of the chemistry, nomenclature, and in vivo toxicology by the oral route. Critical Reviews in Food Science and Nutrition, in press.

Errol Zeiger Dearfield, K.L., Gollapudi, B.B., Bemis, J.C., Benz, R.D., Douglas, G.R., Elespuru, R.K., Johnson, G.E., Kirkland, D.J., LeBaron, M.J., Li, A.P., Marchetti, F., Pottenger, L.H., Rorije, E., Tanir, J.Y., Thybaud, V., van Benthem, J., Yauk, C.L., Zeiger, E., Luijten, M. (2017) Next generation testing strategy for assessment of genomic damage: a conceptual framework and considerations. Environ. Mol. Mutagen. 58: 264-283.

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Zeiger, E. (2017) Reflections on a career and on the history of genetic toxicity testing in the National Toxicology Program. Mutat. Res. 773: 282-292.

Zeiger, E. (2018) Genetic toxicology testing. In Comprehensive Toxicology, Third Edition, vol. 9. Ed. McQueen, C.A. Oxford:Elsevier. pp. 216-232.

Green, S., Levy, D.D., Lorentzen, R.J., Zeiger, E. (2018) William Gary Flamm (1935-2017). Environ. Mol. Mutagen. 59:100-102.

The following article has been shared by ATS Fellow Janis Hulla Career Credentials that Serve the Public Interest Author: Janis E. Hulla, Ph.D., DABT, ERT, Fellow-ATS US Army Corps of Engineers, Sacramento District, ED-E, 1325 J Street, Sacramento, CA, 95814 (Opinions expressed herein do not represent the policies of the USACE, Army or the DOD)

The National Academies’ Committee on Science, Technology, Law Policy and Global Affairs produced the Reference Manual on Scientific Evidence: Third Edition in 2011.1 The authors included members from both the Federal Judicial Center and the National Academies.2,3 Relevant to Fellows of the Academy of Toxicological Sciences is information contained in the chapter titled, “Reference Guide on Toxicology”. Therein, the authors provide advice to members of the judiciary on the qualifications to be considered when identifying who is an expert in the field of toxicology. Cited as expert qualifications are education and research experience relevant to the specific toxicological topics that are at issue in the legal proceeding under consideration. Cited as more general qualifications are professional certifications and affiliations, i.e., “…Has the Proposed Expert Been Certified by the American Board of Toxicology, Inc., or Does He or She Belong to a Professional Organization, Such as the Academy of Toxicological Sciences or the Society of Toxicology?”4 In these contexts, being a Fellow of the Academy of Toxicological Sciences serves the public’s interest by helping to ensure scientific integrity. I encourage you to review the chapter titled, “Reference Guide on Toxicology” and disseminate the information it provides.

References

1. National Research Council. 2011. Reference Manual on Scientific Evidence: Third Edition. Washington, DC: The National Academies Press. https://doi.org/10.17226/13163.

2. From the introductory information of the Reference Manual on Scientific Evidence: “The Federal Judicial Center is the research and education agency of the federal judicial system. It was established by Congress in 1967 (28 U.S.C. §§ 620–629), on the recommendation of the Judicial Conference of the United States, with the mission to “further the development and adoption of improved judicial administration in the courts of the United States.” By statute, the Chief Justice of the United States chairs the Federal Judicial Center’s Board, which also includes the director of the Administrative Office of the U.S. Courts and seven judges elected by the Judicial Conference.”

3. From the introductory information of the Reference Manual on Scientific Evidence: “The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters.”

4. National Research Council. 2011. Reference Manual on Scientific Evidence: Third Edition. Washington, DC: The National Academies Press. https://doi.org/10.17226/13163, page 677

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ATS CONNECTION 2018 ANNUAL BUSINESS MEETING AND RECEPTION

The 2018 Annual Business Meeting and Reception was a great success! Held at the Grand Hyatt in San Antonio, the format was different than in past years. There was no charge to attend and all attendees were provided with a free drink ticket. Feedback received regarding the changes was all positive. A drawing was held for a one-of-its-kind ATS bag which was won by new Fellow Nancy Claude. The highlight of the evening was the presentation of the 2018 ATS Mildred Christian Achievement Award to Linda Birnbaum. ATS President Leigh Ann Burns Naas welcomed new Fellows and gave an update on ATS activities over the past year. Plaques were presented to Lorrene Buckley, Paul Foster, Don Fox and Jane Ellen Simmons thanking them for their service on the Board. Kyle Kolaja was thanked for his service in absentia. Incoming President Ruth Roberts presented Leigh Ann with the traditional gavel plaque.

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