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A personal perspective and a glimpse of the future

School of Biological Sciences, 11 March 2011

Professor R. B. Elliott on behalf of Living Cell Technologies

The Story begins - 1961

George Maxwell

Paul Lacey

1961

Transplant new cells from rats into anterior eye chamber of the eye of diabetic rabbits---failed.

Transplant rat islets inserted into a semi permeable chamber inserted under the skin of diabetic rabbits----- failed

1976

Transplant human foetal islets

intramuscularly into Type 1 diabetic

humans------ failed

1995

Transplant newborn pig islets into peritoneal cavity of humans with T1D failed

David Collinson

1996

Transplant newborn pig islets

encapsulated into semi-permeable

microcapsules

Michael Helyer - 1996

Michael Helyer - 2005

1996 – 2007

Virtual moratorium PERV

Auckland Islands

Auckland Islands, New Zealand.

• Unique source . NO xeno-relevant viruses, bacteria and parasites.

NULL PIGS (PERV).• Herd now bred in documented bio-isolation.

• Three year health records and regular monitoring. Three generations without mammalian content in feed.

• Health Monitoring. Regular testing by IANZ accredited laboratory for all of herd and all donors.

Facilities

Encapsulated Islet

Russian Patient Video

Dr. Paul Tan

NZ Study - Patient # 1 Result

-8 -6 -4 -2 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48 50 520

1

2

3

4

5

6

7

Patient #1: Asymptomatic Hypos

Week Number

Num

ber o

f Asy

mpt

omati

c Hyp

os

Choroid Plexus

Choroid Plexus

Dopamine containing cells

Monkey Study Results

Other Projects

• Restoring auditory nerves

• Liver cells for haemophilia

Other studies under way

• Regeneration of auditory spiral ganglion cells

• Human cells for replacement of the clotting factor V111, haemophilia

For future other possibilities

Providing biologics in excess to treat non-deficiencydiseases

Cells over expressing therapeutics

E.g. localised delivery of TNF for cancer treatmentIntestinal L cells for obesity

Living cell treatment is an exciting new frontier, which

skilled biologists need to explore.

The rewards are likely to be high.

There is nothing more difficult to take in hand, more perilous to conduct, or more uncertain in its success, than to take the lead in the introduction of a

new order of things.

Niccolo Machiavelli