association of serum uric acid

8/20/2019 Association of Serum Uric Acid

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Journal English

Woro Hapsari WahyuningrumSylvia Rachmayati / Nina

Tristina15th A ril 2014



Various actors !

Ag"# poor glyc"miccontrol# hyp"rt"nsion

an$ smo%ing

&asic rol" !

• 'n(ammation• )n$oth"lial

$ysunction



The objective of the study wasto nd an association betweenserum uric acid level andproteinuria level in Type 2Diabetic patients



A cross sectional study (2!!" n # $ %oth gender

Age range & '!)! yo *ith type 2 diabetic +atients, %* was stable - . months /istory of gout (" Treated with allopurinol ("



%ody 0ass 1nde +atient,s history 3urrent medication

1nsulin doses Tobacco use 4amily medical history



5erum creatinine6ric acid/emoglobin A!c (/bA!c"

2' 7h proteinuria

4astingstate



8esults were epressed as mean 9: 5D

3onsidered as statistically signicant when two;sided P < 0.05

Independent‑samples t-test

comparison variables between male <female

5pearman,s rho coe=cient correlation test

correlation of %01 with serum uric acid

+artial correlation coe=cient test

correlation of protenuria with serum uric aci



n # $ T2D patients

5e &

age range& '!)! years>

*"mal"

+al"

?$@ B '2@. B

+"an S,

Age ? years )@. years

5erumcreatinin

@C) mg:d @2) mg:d

5erum uricacid

'@? mg:d @!? mg:d

+roteinuria .)) mg:day 2)@ mg:day

(median # ..@?m da



female maleVS

5erum uric

acid/bA!c

3reatinine

- . 005



%01 5erum6ric acid

5ignicant

positiveassociation

r 042 -

0001



proteinuria5erum

6ric acid

5ignicantpositiveassociation

r 04

- 3 0001

At"r a$usm"nt or

"ight



%01 5erum6ric acid

5ignicantpositive

association

r 042 - 0001



The etiology of D is comple <remains to be claried

+resently> diabetes is the leading cause

of end;stage renal disease in the mostparts of the world

Although the progression of Fidney

disease can be halted partially>D is still regarded as an irreversible <progressive disease



1t has to be essential to nd thepathophysiological mechanisms thatleads to the development and

progression of D 1n this study> was found thesignicant positive association of

serum uric acid with level ofproteinuria> when adjusted for weight



+revious study◦ /yperuricemia and its association with obesity

and various components of metabolicsyndrome have been documented

◦ /yperuricemia is also prevalent in patientswith chronic renal failure

◦ hyperuricemia may have a pathogenic role in

the development and progression of chronicrenal failure> rather than simply reGectingdecreased renal uric acid ecretion



+revious study◦ 1n diabetic patients> serum uric acid early in

the course of diabetes is signicantlyassociated with later development of

persistent macroalbuminuria◦ 1t was shown that Fidney damage in

hyperuricemic rats is not dependent onblood pressure and instead involves therenin7angiotensin system (8A5"



+revious study◦ An association between serum uric acid <

early loss of renal function has been shown inpatients with type ! diabetes

◦ 1n the study (4uFui et al) positive

correlation of serum uric acid and urinaryalbumin ecretion in .'. men with type 2diabetes mellitus was shown

concluded that serum uric acid concentration

is associated with microalbuminuria andsubclinical atherosclerosis in men with type 2diabetes mellitus



+revious study◦ in a study on Chinese diabetic patients>

found that hyperuricemia was signicantlyassociated with abnormal albuminuria inpatients without diuretics or use of

uricosuric agents or alcohol concluded that hyperuricemia were

signicantly related to the presence of

albuminuria in patients with diabetes◦ Elevated level of serum uric acid can lead to

low;grade Fidney injury without depositionof uric acid crystals in animal models



+revious study◦

hyperuricemia in rats induced arteriolopathy ofpreglomerular vessels> resulting in &

impaired autoregulation

glomerular hypertension

endothelial dysfunction 1t was found that microvascular disease in hyperuricemic rats occursindependent of blood pressure and isdependent on activation of thesystemic < local 8A5 < inhibition ofendothelial nitric oide



+revious study

◦(Hbermayr et al) serum uric

acid was found to be &

a predictor of new onset Fidneydisease

independent of other risF factors



This study &

5erum uric acid had a signicantpositive association with D

hypothesiIed that serum uric acid

plays a pathological role in thedevelopment of D in T2D

5uggestion studying of the eect of

lowering uric acid with allopurinol onrenal function in D patients in future@



/ighest Kuality Lreatest Kuantity argest Mariety

3onsistent +rofessionalism Misually Appealing



/ighest Kuality Lreatest Kuantity argest Mariety 3onsistent +rofessionalism Misually Appealing

association of serum uric acid

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