association of bmi with clock genetic variants
TRANSCRIPT
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Welcome to my presentation
Name:
Hasan Al Banna
Exam Roll: 1513
Reg. No.: Ha- 2515
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Paper Title:
Habitual sleep duration is associated with BMI and macronutrient intake,
and may be modified by CLOCKgenetic variants
Name of Journal:
The American Journal of Clinical Nutrition
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Publishing Date: First online published November 26, 2014,
Present edition: Am J Clin Nutr January 2015 vol. 101 no. 1 page 135-143
Authors: Hassan S Dashti, Jack L Follis, Caren E Smith, Toshiko Tanaka, Brian E Cade, Daniel J Gottlieb, Adela Hruby, Paul F Jacques, Stefania Lamon-Fava, Kris Richardson, Richa Saxena, Frank AJL Scheer, Leena Kovanen, Traci M Bartz, Mia-Maria Perälä, Anna Jonsson, Alexis C Frazier-Wood, Ioanna PanagiotaKalafati, Vera Mikkilä, Timo Partonen, Rozenn N Lemaitre, Jari Lahti, Dena G Hernandez, Ulla Toft, W Craig Johnson, Stavroula Kanoni, Olli T Raitakari, Markus Perola, Bruce M Psaty, Luigi Ferrucci, Niels Grarup, Heather M Highland, Loukianos Rallidis, Mika Kähönen, Aki S Havulinna, David S Siscovick, KatriRäikkönen, Torben Jørgensen, Jerome I Rotter, Panos Deloukas, Jorma SA Viikari, Dariush Mozaffarian, Allan Linneberg, Ilkka Seppälä, Torben Hansen, Veikko Salomaa, Sina A Gharib, Johan G Eriksson, Stefania Bandinelli, OlufPedersen, Stephen S Rich, George Dedoussis, Terho Lehtimäki, José M Ordovás.
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Importance of the study
Public Health Concern
Obesity
Hypertension
Cardiovascular disease
Mortality
Diabetes
Short Sleep
Duration
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Importance of the study (Continued…)
Increase total energy intake and
risk of obesity….
Influence appetite related
hormone
Sleep Restriction
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Importance of the study (Continued……..)
But…..We didn’t know the answer that•Whether chronic metabolic
abnormalities associated with short sleep duration
•Whether CLOCK variants modify the association between habitual short
sleep duration and relative macronutrient intake
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What was the objective of the study?
Two basic objective the study:
• Examining associations between habitual sleep duration, body mass index (BMI), and macronutrient intake
a
• Assessing whether CLOCKvariants modify these associations.
b
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Methods used in the study
• For habitual dietary intake data collection:
Food Frequency Questionnaires (FFQ)
o interviewer-administered FFQ
o self-administered FFQ
o modified-Block FFQ
• Assessment methods for BMI calculation:
Calculated from measured ratio fromweight (kg) / height (m)2
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Methods used in the study (Continued……..)
• For Sleep duration data collection:
By self-reported responses to questions
• For tSNP selection
The web-based service of the Tagger option within Haploview Software
• For testing heterogeneity across studies
Cochran’s Q statistic and quantified by using the I2 statistic
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Uniform analysis plan…
Associations between sleep duration and BMI were estimated by using linear regression models
Investigated of associations between CLOCK tSNPs and dietary intake were by using linear fixed-effect
regression models or linear mixed-effects models
Investigation of the sleep duration and tSNP effect modification on dietary intake
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Sample Collection• 14,906 participants of European descent from
9 cohort studies of the CHARGE Consortium Nutrition Working Group
•Participants provided written informed consent
•The protocol was approved by local institutional review boards and oversight committees.
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Result Analysis
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Continued……..
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Continued……..
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Summary of Result
Identified a significant association between sleep duration and BMI
Associations between sleep duration and intake tended to be age- and sex-specific
CLOCK variants could modify the associations between sleep duration and dietary intake.
Geographic location could have influenced these associations, particularly between CLOCK and PUFA.
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Prospects for future study
Geographic Difference
Relevant to Chronic Disease
Potential Interaction Elsewhere
Other dimension
of sleep
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Limitation of the Study
Interactions that met pre-specified criteria
Limited to individuals
of European descent
Self-reported habitual sleep duration
The temporal
relation or the causal pathway linking CLOCK,
sleep, and diet.
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Concluding remarks
One of the largest observational
study
Public health implications
personalized sleep recommendations
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Thanks to all……Wish You All The Best
Hasan Al Banna
Exam Roll: 1513
Reg. No.: Ha- 2515
Department of Biochemistry and Molecular Biology
University of Dhaka