Donald School Journal of

Editors-in-ChiefAsim Kurjak (Croatia)Frank A Chervenak (USA)

January-March 2015 Volume 9 Number 1 ISSN 0973-614X

www.jaypeebrothers.comwww.jaypeejournals.com

The Official Journal of the Ian Donald Inter-University School of Medical Ultrasound

Ultrasound in Obstetrics and

Gynecology

ii

2. Ethical Considerations

3. Copyright

Ultrasound in Obstetrics and Gynecology

Donald School Journal of

Manuscripts submitted for publication must comply with the following ethical considerations:

Informed consentInformed consent of the patients must be taken before they are considered for participation in the study. Patient identifying information, such as names, initials, hospital numbers or photographs should not be included in the written descriptions. Patient consent should be obtained in written and archived with the authors.

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Following guidelines must be followed before submission of the manuscript: The articles must represent original research material, should not have been published before and should not be under consideration of publi­cation elsewhere. This, however, does not include previous publication in form of an abstract or as part of published literature (review or thesis). It is the duty of the author to obtain the necessary permissions for extensive quotations, tables, illustrations or any other copyrighted material they are using in the paper before a paper can be considered for publication. Copyright of the article gets transferred to Jaypee Brothers, once the article has been accepted for publication. The author would be asked to sign the ‘Copyright Transfer Form’ before his/her article is considered for publication. Once the copyright transfer statement has been signed by the corres ponding author, no change in authorship or in the order of the authors listed on the article would be accepted by Jaypee Brothers. Also by signing the above­mentioned form, the author reassigns the rights of copublishing or translation if considered necessary in future to the publisher. In the advent of occurrence of any dispute, the matter would be resolved within the jurisdiction of New Delhi court. While all care has been taken to provide accurate and correct information in accordance with the date of publication, neither the authors, editors and nor the publisher takes any legal responsibility for any unintentional omission or error. The publisher makes no expressed or implied warranty with respect to the information contained herein. The published material cannot be photocopied for the following purposes: general distribution, promotion, new works or resale. If this is required, specific written permission requires to be obtained from the publisher. Exclusive rights to reproduce and distribute the articles in this journal have been protected by copyright. This also covers the rights to reproduce or distribute the article as well as the translation rights. No material published in this journal can be reproduced in digital format or stored in form of electronic databases, video disks, etc. Both the conflict of interests and financial disclosure need to be handled well while conducting the research study. Disclosure of such relationships is also important in connection with all articles submitted for publication. Both of these have also been included in the copyright transfer form. Authors should give due acknowledgment to the individuals who provide

writing or other assistance while conducting the research study and also disclose the funding source for the research study.

Copyright© Jaypee Brothers Medical Publishers (P) Ltd.

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1. Aims and Scope

The Donald School Journal of Ultrasound in Obstetrics and Gynecology publishes quality review articles of all aspects of ultrasound as it impacts diagnosis and management in the field. As the technology and its applications are constantly improving, there is a need for lifelong learning for all sonologists so that they can optimize their care of gynecologic, maternal and fetal patients on an ongoing basis. The Ian Donald Inter­University School of Medical Ultrasound with its 50 active member nations is proud to suppor t. The Donald School Journal of Ultrasound in Obstetrics and Gynecology and provide continuing medical education to sonologists throughout the world.

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Publishing Center

Publisher Jitendar P Vij

Associate DirectorChetna Vohra

Managing EditorEkta Aggarwal

Editorial Associate Pankaj K Singh

Creative Designer Radhe Shyam Singh

Editors­in­Chief

Asim Kurjak CroatiaFrank A Chervenak USA

Editorial OfficeJournals DepartmentJaypee Brothers Medical Publishers (P) Ltd.4838/24, Ansari Road, Daryaganj New Delhi­110 002, IndiaPhone: +91­11­43574357Fax: +91­11­43574314e-mail: journals@jaypeebrothers.com

January-March 2015 Vol. 9 No. 1

Donald School Journal ofUltrasound in Obstetrics and Gynecology

DSJUOG

Production OfficeJaypee Brothers Medical Publishers (P) Ltd.4838/24, Ansari Road, DaryaganjNew Delhi­110 002, India Phone: +91­11­43574357 Fax: +91­11­43574314e-mail: journals@jaypeebrothers.com

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Executive Editors

Sanja Kupesic Plavsic USARitsuko K Pooh Japan

Ivica Zalud USAWaldo Sepulveda Chile

Panagiotis Antsaklis GreeceTuangsit Wataganara Thailand

Editorial BoardSameer Abdullah Saudi Arabia

Nelson Aguilar Colombia

Vincenzo D’Addario Italy

Tony Duan China

Alaa Ebrashy Egypt

Sebija Izetbegovic Bosnia and Herzegovina

Orion Gliozheni Albania

Alfredo Guzman Peru

Tze Kin Lau Hong Kong

Aleksandar Ljubic Serbia

Abdal-Latif Ashmaig Khalifa Sudan

Berivoj Miskovic Croatia

Oliver Vasilj Croatia

Anton Mikhailov Russia

Azen Salim Indonesia

Cihat Sen Turkey

Yuriy P Vdovychenko Ukraine

Liliana Voto Argentina

Hari Shrestha Nepal

Alexandra Matias Portugal

Syed Amir Gilani Pakistan

Corazon Yabes-Almirante Philippines

Abdallah Adra Lebanon

Mohamed S Elmahaishi Libya

Fawaz Akhazaleh Jordan

Jiri Sonek USA

Yaron Zalel Israel

Official Director of Publishing

Jitendar P Vij India

Secretary of the Journal

Jadranka Cerovec

Website ManagerHarish Upadhayay

Phone: +91­9871855331e-mail: contact@jaypeejournals.com

harish.upadhayay@jaypeebrothers.com

Co­Editors

Kazuo Maeda Japan—HistoryAna Bianchi Uruguay—Obstetrics

Giovanni Monni Italy—Invasive diagnostic proceduresZoltan Papp Hungary—Prenatal diagnosis

Eberhard Merz Germany—3D/4D sonographyVeljko Vlaisavljevic Slovenia—Human reproduction

Miroslaw Wielgos Poland—EducationRadu Vladareanu Romania—GynecologyMilan Stanojevic Croatia—Neonatology

Narendra Malhotra India—Developing countriesCarmina Comas Gabriel Spain—Echocardiography

Aris Antsaklis Greece—TwinsAshok Khurana India—Urogynecology

Waldo Sepulveda Chile—1st trimester screening

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iAn DONALD SCHOOL DIRECTORScountry e-mail address

School DirectorsAsim Kurjak Croatia asim.kurjak@public.carnet.hrFrank A Chervenak USA fac2001@med.cornell.eduVice-DirectorEberhard Merz Germany emerz@mail.uni­mainz.deRegional DirectorsJaideep Malhotra (Indian Subcontinent)Ritsuko K Pooh (Asia and Oceania)Giovanni Monni (Europe)Ana Bianchi (Latin America)Abdallah Adra (Arabic World)Executive BoardSanja Kupesic Plavsic (Chairman) USA sanja.kupesic@ttuhsc.eduRitsuko K Pooh Japan pooh27ritsuko@fetal­medicine­pooh.comIvica Zalud USA ivica.zalud@gmail.comPanagiotis Antsaklis Greece panosant@gmail.comWaldo Sepulveda Chile waldosep@yahoo.co.ukMilan Stanojevic Croatia milan.stanojevic@optinet.hrTuangsit Wataganara Thailand twataganara@yahoo.comAdvisory BoardGiampaolo Mandruzzato (Chairman) Italy mandruzzatogiampaolo@tin.itJose Maria Carrera Spain jmcarrera@matres­mundi.orgGian Carlo Di Renzo Italy direnzo@unipg.itJoachim Dudenhausen Germany joachim.dudenhausen@charite.deToshiyuki Hata Japan toshi28@med.kagawa­u.ac.jpKazuo Maeda Japan maedak@mocha.ocn.ne.jpSonal Panchal India sonalyogesh@yahoo.comDirectors of National BranchesSameer Abdullah Saudi Arabia samirabdullah@hotmail.com, drsabdullah@gmail.comAbbas Aflatoonian Iran abbas_aflatoonian@yahoo.comMuna Al Kuwari Dubai, UAE muna.alkuwari@yahoo.comGhalia Gaber Abd El Mottaleb Abu Dhabi, UAE ghgaber@gmail.comNelson Aguilar Colombia nelsonyesid@gmail.comMandy Abushama Qatar mdabushama@hotmail.comSaadia Amour Sultan (Al Riyami)/Kanchana Rajan Oman drsaadiaalriyami@gmail.com/raajaan@omantel.net.omAris Antsaklis Greece arisants@otenet.grShahana Afroz Bangladesh nmcdhaka@agni.comAna Bianchi Uruguay anabbianchi@gmail.comCarmina Comas/Bernat Serra Barcelona, Spain carcom@dexeus.com/BERSER@dexeus.comPavel Calda Czech Republic calda@gynstart.czVincenzo D’Addario Bari, Italy v.daddario@gynecology4.uniba.itGiovanni Monni Cagliari, Italy prenatalmonni@tiscali.it Tony Duan/Chen Min China tduan@yahoo.com/chenm@cuhk.edu.hkAlaa Ebrashy Egypt ebrashy3@yahoo.comSebija Izetbegovic Bosnia and Herzegovina s.izetbegovic@gmail.comOrion Gliozheni Albania gliorion@icc­al.orgErasmo Huertas Tacchino/Alfredo Guzman Peru erasmohuertas@hotmail.com/alfredoguz@gmail.comTze Kin Lau Hong Kong drtklau@hkparamount.comAleksandar Ljubic Serbia gakljubic@gmail.comRitsuko K Pooh Japan pooh27ritsuko@fetal­medicine­pooh.comAbdal­Latif Ashmaig Khalifa Sudan profashmaig@hotmail.comNarendra Malhotra/Jaideep Malhotra India mnmhagra3@gmail.com/jaideepmalhotraagra@gmail.comSonal Panchal Ahmedabad, India sonalyogesh@yahoo.comAna Tikvica Luetic/Oliver Vasilj Croatia ana_tikvica@yahoo.com/oliver.vasilj@gmail.comAnton Mikhailov St Petersburg, Russia amikhailov@AM2697.spb.eduAlexander Papitashvili Georgia ampsmpge@hotmail.comZoltan Papp Hungary papp.zoltan@maternity.hu

Contd...

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Azen Salim Indonesia azen364@msn.comCihat Sen/Murat Yayla Turkey csen@perinatal.org.tr, csen@iandonald.org/

myayla99@yahoo.comFlorin Stamatian/Radu Vladareanu Romania florin_stamatian@yahoo.com/vladareanu@gmail.com Yuriy P Vdovychenko/Andrew Tkachenko Ukraine vdovichenko@perinatolog.com.ua/avt@perinatolog.com.uaVeljko Vlaisavljevic Slovenia vlai@ukc­mb.siLiliana Voto/Jorge Hamer Argentina lvoto@intramed.net/drjorgehamer@hotmail.comMiroslaw Wielgos Poland miroslaw.wielgos@wum.edu.plIvica Zalud Honolulu, USA ivica.zalud@gmail.comRoberto Cassis Martinez Ecuador robertocassis@hotmail.comHari Kishor Shrestha Nepal harishrestha340@hotmail.com, omhrc@wlink.com.npEberhard Merz Germany emerz@mail.uni­mainz.deYves Ville France ville.yves@gmail.comFarah Sulaiman Youssif Bahrain farahnuaimy@yahoo.comAlexandra Matias Portugal matiasalexand@gmail.comFrancisco Filho Mauad Brazil fmn@ultra-sonografia.com.brSyed Amir Gilani Pakistan profgilani@gmail.comSnezana Crnogorac Montenegro snezanacrnogorac1@gmail.com, snezana_cg@yahoo.comKarl Erwin Schweinfurth Alvarado Honduras karlerwin64@gmail.comMiguel Antonio Ruoti Cosp Paraguay mruoticosp@gmail.comCorazon Yabes­Almirante Philippines cora313@yahoo.comMohammad Hashim Wahaaj Afghanistan wahaajhospital@yahoo.comAbdallah Adra Lebanon adramfm@inco.com.lbMohamed S Elmahaishi Libya elmahaishi@elmahaishi.comFida Mahmoud Ahmad Thekrallah Jordan fidaaymen@hotmail.comHa To Nguyen/Pham Viet Thanh Vietnam hatonguyen@gmail.com/bvtudu@hcm.vnn.vn/

thuky.bgd@tudu.com.vnMonia Ferchiou Cherif/Mounira Nouri Chaabane Tunisia moniaferchiou@yahoo.fr/chaabanem@hotmail.frTuangsit Wataganara Thailand twataganara@yahoo.comRuben Quintero Miami, USA yvrq@aol.comJeanne Hortence Fouedjio Cameroon fouedjiojeanne@yahoo.frYaron Zalel Israel zalel1954@gmail.comKwabena Appiah­Sakyi Ghana kasak@doctors.org.ukAbdulfetah Abdulkadir Ethiopia chechera68@gmail.comGordana Adamova Macedonia gadamova@hotmail.comRodrigo Ayala Yáñez Mexico rayalaabc@gmail.comMarina Degtyareva/Lali Sichinava Moscow, Russia mvdegtyareva@gmail.com/lalisichinava@gmail.comWaldo Sepulveda Chile waldosep@yahoo.co.ukJose De Lancer Despradel/Fauzi Bacha Arbaje Dominican Republic josedelancer@yahoo.com, fauzibacha@hotmail.comLira Kalieva Kazakhstan lira_kali@mail.ruGwang Jun Kim Korea gjkim@cau.ac.krTeuta Daullxhiu Kosovo teutadaullxhiu@hotmail.com, teutadaullxhiu@gmail.comSalim Daya Canada dayas@mcmaster.caRoumen Gueorguiev Dimitrov Bulgaria roumendim@abv.bgMark P Brincat Malta brincatm@maltanet.netFatma Gahramanli Azerbaijan fatigy@yahoo.comRuzanna Abrahamyan Armenia r_abrahamyan@mail.ruTamara Illescas Molina Madrid, Spain tamaraillescas@hotmail.comGendenjamts Battulga Mongolia btulga05@yahoo.comFreddy Gonzalez Arias Venezuela freddygonarias@gmail.com

Aliyu Labaran Dayyabu Nigeria zainalabidinaliyu@yahoo.comMohamed Bayari Morocco mohamed.bayari@gmail.comLarisa Belotserkovtseva/Tatyana Petrova Surgut, Russia info@surgut­kpc.ru, lbelotserkovtseva@gmail.com/

shuvaeva66@mail.ruFiras Jawdat Abdeljawad Palestine dr_firasjawdat@yahoo.comWilliam Ching Hua Hsiao Taiwan hsiaochh2866@gmail.comAdolfo Liao Sao Paulo, Brazil a.liao@proafeto.com.br, liao@usp.brNatalia Bondarenko Irkutsk, Russia bondnatasha@mail.ruRenato Augusto Moreira de Sá Rio de Janeiro, Brazil renatosa.uff@gmail.comHisham Ahmad Arab Jeddah, Saudi Arabia arab123@gmail.comRaul Moreira Neto Porto Alegre, Brazil raul@ecomoinhos.com.br, rmneto@cpovo.netAdministrative Secretary of the SchoolJadranka Cerovec Croatia jadranka.cerovec@yahoo.com

Contd...

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IAN DONALD SCHOOL COURSES IN 2015Date city, country Number of Participants

February 4­6 Bangkok, Thailand 420

February 21 Athens, Greece

April 10­12 Adana, Turkey

April 15­16 Sarajevo, BIH

April 19 Zagreb, Croatia

May 1­2 Saudi Arabia

May 7­9 Mexico City, Mexico

May 14­16 Ljubljana, Slovenia

May 20­22 Guayaquil, Ecuador

June 11 St. Petersburg, Russia

June 19­21 Cagliari, Italy

August 7­8 Honolulu, Hawaii, USA

September Jordan

September 25­26 Skopje, Macedonia

October 2­3 Rio de Janeiro, Brazil

October 3­4 Gifu, Japan

November 19­21 Tbilisi, Georgia

December 11­13 Athens, Greece

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ANNOUNCEMENT

GLOBAL MARKETING PARTNER

Ian Donald Inter­University School of Medical Ultrasound is pleased to announce that

Dialog India Services Pvt LtdUnit No. 5, Gr Floor, Dilkap Chambers

Behind Balaji Telefilms, Veera Desai Rd ExtnAndheri (W), Mumbai­400053, Maharashtra, India

Tel: 66990140/60, Fax: 66990150Cell: 9004656306

www.dialogindia.com

has been appointed as exclusive global educational marketing partner of the School.

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Scientific Program:Thursday 26th March 2015Crowne Plaza Hotel Bucharest08:00-09:00 Registration09:00 Conference Opening—Welcome Speech09:15-11:00 Chair: Asim Kurjak, Aida Salihagic-Kadic09:15-10:00 Introductory Lecture Fetal neurology—evolving challenges Asim Kurjak10:00-10:30 Fetal neurology—the role of fetal stress Aida Salihagic-Kadic10:30-11:00 Fetal EEG, Ultrasound and MRI. A new approach for the study of the development of the central nervous

system in utero Florin Stamatian11:00-11:20 Coffee break11:20-11:45 Thenewparadigmincervicalcancerprevention Radu Vladareanu11:45-13:15 Chair: Ritsuko Pooh, Toshiyuki Hata11:45-12:15 3D Ultrasound Sonoembryology Ritsuko Pooh12:15-12:45 HDlive and 4D ultrasound in the assessment of fetal facial expressions Toshiyuki Hata12:45-13:15 Magneticresonancespectroscopy:apromisefordetectionofmetabolicchangesinthebrainofIUGR

fetuses? Radu Vladareanu13:15-13:30 Short break

PHARMA SYMPOSIUMS + LUNCH BOX, Crown A + B + C Hall13:30-15:30 Chair: Radu Vladareanu, Nicolae Suciu15:30-17:00 Chair: Milan Stanojevic, Simona Vlădăreanu15:30-16:00 HDlive and 4D ultrasound assessment of twin pregnancy Toshiyuki Hata16:00-16:30 Antenatal and postnatal assessment of neurobehavior—which one should be used? Milan Stanojevic16:30-17:00 Fetal isolated mild ventriculomegaly (IMVM)—are there neonatal consequences? Simona Vladareanu17:00-17:15 Coffee break17:15-19:15 Chair: Stefania Tudorache, Panos Antsaklis17:15-17:45 Firsttrimesterdiagnosisinisolatedopenspinabifida Ștefania Tudorache17:45-18:15 Controversies surrounding early diagnosis of fetal brain anomalies Dominic Iliescu18:15-18:45 Assessmentoffetalneurobehaviorindiabeticpregnancy Panos AntsaklisFriday 27th March 2015Crowne Plaza Hotel Bucharest08:30-11:00 Round Table SessionModerator IsKANETreadyforintroductionintoclinicalpractice? Asim Kurjak with: Milan Stanojevic, Simona Vladareanu, Ritsuko Pooh, Stefania Tudorache, Florin Stamatian, Panos

Antsaklis, Dominic Iliescu, Toshiyuki Hata, Radu Vladareanu, Raul Moreira Neto

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KANET test in fetal anomalies of the CNS Ritsuko Pooh KANET in Brasil: First study Raul Moreira Neto11:00 Conference closing

xii

Donald School Journal of

Ultrasound in Obstetrics and Gynecology

January-March 2015 Volume 9 Number 1

Contents

Original Article

KANET in Brazil: First Experience ............................................................................................... 1-5 Raul Moreira Neto

Review Articles

Fetal Neurology: Past, Present and Future .................................................................................. 6-29 Asim Kurjak, Panagiotis Antsaklis, Milan StanojevicFetal Neurology: The Role of Fetal Stress ................................................................................. 30-39 AidaSalihagićKadićMagnetic Resonance Spectroscopy: A Promise for Detection of Metabolic

Changes in the Brain of Intrauterine Growth Restriction Fetuses ......................................... 40-43 VladZamfirescu,RaduVladareanu,SimonaVladareanuHDlive and 4D Ultrasound in the Assessment of Fetal Facial Expressions ............................ 44-50 Toshiyuki Hata, Kenji Kanenishi, Uiko Hanaoka, Genzo MarumoHDlive and 4D Ultrasound in the Assessment of Twin Pregnancy .......................................... 51-60 Toshiyuki Hata, Kenji Kanenishi, Uiko Hanaoka,

Mohamed Ahmed Mostafa AboEllail, Genzo MarumoPrenatal Development of the Human Central Nervous System,

Normal and Abnormal ................................................................................................................. 61-66 Kohei ShiotaAntenatal and Postnatal Assessment of Neurobehavior: Which One

should be used? ............................................................................................................................ 67-74 Milan StanojevicFetal Isolated Ventriculomegaly: Is There any Neonatal Consequences? .............................. 75-79 Simona Vladareanu, Vlad Andrei Traistaru, Radu VladareanuFirst Trimester Anomaly Scan—The Last Redoubt Won: Open Spina Bifida ...................... 80-90 Stefania Tudorache, Iliescu Dominic Gabriel, Adina Turcu, Maria Florea,

RoxanaDrăgușin,LilianaNovac,CerneaNicolae,DanielaCerneaIs in utero Fetal Neurological Assessment Comparable to Postnatal

Neurological Assessment? ........................................................................................................... 91-95 Oliver VasiljFirst Experience in Clinical Application of KANET ................................................................ 96-99 AnaTikvicaLueticUltrasound in Infertility .......................................................................................................... 100-110 SonalPanchal,CBNagori