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From Technologies to Market

20172017

September 2017

Artificial Artificial Organ

Technology & Market Technology & Market Analysis 2017

Sample

2

OBJECTIVES OF THE REPORT

• Explain the challenges linked to organ transplantation and the limits of the current process.

• Introduce the technologies behind the different types of artificial organs (kidney, liver, lung, heart, pancreas…).

• Give an overview of history of artificial organs from first developments to nowadays, along with a presentation ofmain players and their respective technologies.Who’s providing what, who’s working with whom?

• Provide market data and forecasts.

• Detail the limits of current technology and how it might evolve in the future. Discuss the main challenges, andhow artificial organs companies can overcome them. What do end-users expect? How will the healthcare industrybe impacted? How will the regulatory landscape evolve?

• Provide a focus on technical aspects of artificial organs : batteries, biocompatibility, sensors, pumping systems…

©2017 | www.yole.fr | Artificial organ | Sample

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o OEMs & System Integrators:

• To evaluate benefits of artificial organs

• To identify the artificial organs players, types oforgans and specificities of the differenttechnologies used

• To understand behavioral evolution

o MEMS companies:

• To have a broad overview of all artificial organs applications & markets

• To identify new markets

• To monitor and benchmark potential competitors

• To understand behavior evolution

o R&D players:• To understand new challenges in artificial organs

• To address the right market with the right technology

o Equipment & Material suppliers:

• To understand the technical evolution of artificial organs devices.

• To identify business opportunities and prospects

o Financial & Strategic investors:

• To understand the potential for artificial organs

• To know the latest developments within the industry

• To get a list of artificial organs players and their activities

• To understand which are the sweet spots and what the end-users are pushing for

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• Executive Summary 9

• Introduction 35

• The problems of organ transplantation

• Our definition of artificial organs

• Permanent vs. temporary implants

• Wearable vs. implantable

• Market Segmentation 49

• Technological and economic criteria

• Segmentation of the market

• Market Data and Forecasts 2016-2022 56

• Significant moves

• Fund raising and grants

• Market quantification

• Market data and forecasts

• Roadmap

• Segments Description 73

• Total artificial heart

• Ventricular assist devices

• Artificial pancreas

• Bioartificial pancreas

• Artificial lungs

• Artificial kidney

• Artificial liver

• Technical Aspects 154

• Biocompatibility

• Batteries

• Sensors

• Pumps

• Connectivity

• Software

• Embedded Software for Artificial organs 167

• Definitions and context

• Ventricular assist devices and total artificial heart

• Artificial pancreas

• Supply Chain 183

• Perspectives – Bionics, 3D Bioprinting and 192

Transhumanism

• Regulations: an Overview 215

• Market access of connected medical devices

• Conclusions 236

TABLE OF CONTENTS

• For each segment:• Players

• Market size

• Technological requirements

• Company profiles

• Roadmaps

©2017 | www.yole.fr | Artificial organ | Sample

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Biography & contact

ABOUT THE AUTHORS

Asma Siari

Marjorie Villien, PhD

As a Technology & Market Analyst, Dr. Marjorie Villien works in the Microfluidic & Medical Technologies (MedTech) business unit at Yole Développement, the "Morethan Moore" market research and strategy consulting company. She is a daily contributor to the development of MedTech activities, with a dedicated collection ofmarket & technology reports as well as custom consulting projects. After spending two years at Harvard, Dr. Villien served as a research scientist at INSERM in the fieldof MRI & PET imaging. She has spoken at numerous international conferences and has authored or co-authored 11 papers and one patent. Dr. Villien graduated fromGrenoble INP and holds a PhD in physics & medical imaging.

Email: [email protected]

As a Technology & Market Analyst in the Medical Technologies (MedTech) business unit at Yole Développement (Yole), Asma Siari is involved in the development oftechnology & market reports as well as the production of custom consulting projects. After a Master’s degree in Biotechnologies, Diagnostic Therapeutics &Management, Asma serves as Research Assistant at the Moores Cancer Center (San Diego, CA). She is a coauthor in two scientific publications published in theMolecular Cancer Research Journal. In addition to her mission at Yole, Asma is currently working on her Advanced Master’s degree in International Strategy &Marketing BtoB (EM Lyon Business School, France).

Email: [email protected]

Yohann Tschudi, PhD

As a Software & Market Analyst, Dr. Yohann Tschudi is a member of the MEMS & Sensors business unit at Yole Développement (Yole). Yohann is daily working withYole’s analysts to identify, understand and analyze the role of the software parts within any semiconductor products, from the machine code to the highest level ofalgorithms. Market segments especially analyzed by Yohann include big data analysis algorithms, deep/machine learning, genetic algorithms, all coming from ArtificialIntelligence (IA) technologies.After his thesis at CERN (Geneva, Switzerland) in particle physics, Yohann developed a dedicated software for fluid mechanics and thermodynamics applications.Afterwards, he served during 2 years at the University of Miami (FL, United-States) as a research scientist in the radiation oncology department. He was involved incancer auto-detection and characterization projects using AI methods based on images from Magnetic Resonance Imaging (MRI). During his research career, Yohann hasauthored and co-authored more than 10 relevant papers. Yohann has a PhD in High Energy Physics and a master degree in Physical Sciences from Claude BernardUniversity (Lyon, France).

Email: [email protected]

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Abbott, Accellta, Alcon, Alliqua, Amesys, Amplifon, Animas, Aryballe Technologies, Asante, AWAK, Baxter, Becton

Dickinson, Berlin Heart, Betabionics, Bigfoot Biomedical, Bimba, Biofab, Bionic vision technologies, Bivacor, Breethe

inc., Carmat, Cellnovo, Cochlear Ltd, Debiotech, Dedienne, Defymed, Device Solutions, Dexcom, Diabeloop, Dose

Safety, Draper, Dreamed, Dualis, Edwards Lifesciences, Flex, Fresenius, GN ReSound, Google, Grey Innovation,

HeartWare, HEF R&D, IBM Watson, Imasonic, Inreda Diabetic, InSmart, Insulet Corporation, Intarcia, Invensense,

Jarvik Heart, Johnson and Johnson, Knowles, Kollmorgen, Lilly, MC3, Medtronic, Memscap, Minifab, Mode AGC,

Nanodialysi, Nano-dimension, Nemaura, Neokidney, Novartis, Novo Nordisk, Numerex, Omron, Organovo,

Paxitech, PixiumVision, Reliant Heart, Roche, Second Sigh, Senseonics, Siemens, Sintef, Sivantos, SmartProducts,

Sonion, Sonova, St Jude Medical, ST Microelectronics, Starkey, Syncardia, Tandem, Tandem Life, TDK-Epcos, Techshot,

Terumo, Thoratec, Transonic, TypeZero, ViaCyte, Vignal Artru, Vital Therapies, WAK, Widex, William Demant,

WiTricity, Xenios…

And many more !!

LIST OF COMPANIES MENTIONED IN THIS REPORT

©2017 | www.yole.fr | Artificial organ | Sample

230+ slides of market and technology analysis

Information gathered through direct discussions with technology developers, end-users and key opinion leaders

7

ORGAN TRANSPLANTATION

A problem to solve: shortage of human organ donors

Artificial organs solve one of the medical world’s

thorniest problems

• The disparity between patients awaiting organtransplantation and organ availability increases eachyear.

• Average Median Wait Time to Transplant in the US:

• Kidney – 5 years

• Pancreas – 2 years

• Kidney / Pancreas – 1.5 years

• Liver – 11 months

• Heart – 4 months

• Lung – 4 months

• Many factors are considered while on the waiting listincluding:

• Blood type

• Body size

• Distance from donor

• Severity of illness

• Time on list

** One donor can give more than one organ

Source: https://www.organdonor.gov/

In the USA

Executive Summary

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ORGAN TRANSPLANTATION

Transplants and waiting list by organ type in the US

Kidney transplantation

is by far the most

frequently carried out

transplantation globally

• Kidney transplantation is generally accepted as the best treatment both for quality of life and costeffectiveness.

• Organ transplantation is often the only treatment for end state organ failure, such as liver and heart failure.

Kidney

58%Liver

23%

Heart

9%

lung

7%

Kidney/Pancreas

2%

Pancreas

1%

Transplants performed in 2015 by

organ in the US

Kidney

82%

Liver

11%

Heart

3%

Lung

1%Other

3%

Organs people were waiting for as of

September 2016 in the US

30 814 122 071

Source of the data:

https://www.organdonor.gov/

Executive Summary

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ARTIFICIAL ORGANS

Scope of our report

• We decided to focus on “vital” artificial organsfor our market analysis.

• We broadened the perspectives to the bionicsand transhumanism segments but didn’t quantifythis market specifically.

• We didn’t focus on bionic limbs (hands, feet, legs,exoskeleton…) since the solutions for theseorgans are more linked to robotics and this isanswered in another report “Sensors formedical robotics”.

Artificial

organs

Total

Partial

Bionics /

transhumanism

Prosthetics /

Exoskeleton

Executive Summary

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CONTENT OF THE REPORT

Introduction

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CONTENT OF THE REPORT

Market analysis and segmentation

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CONTENT OF THE REPORT

Market data and forecasts

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13

CONTENT OF THE REPORT

Technical aspects

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CONTENT OF THE REPORT

Focus on the embedded software

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CONTENT OF THE REPORT

Company profiles & technology overview

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CONTENT OF THE REPORT

Perspectives: Bionic man, 3D Bioprinting and Transhumanism

©2017 | www.yole.fr | Artificial organ | Sample

Organ transplantation is often the only treatment for end-state organ failure, such as liver, kidney and heart failure. Tragically, most people on the waiting list die before they ever get an organ. Hence the dream of developing artificial organs made of electronic and mechanical parts has been around for decades. The first total artificial heart transplant was in the 1980s, yet since then few improvements have made these devices more efficient. Newcomers such as Carmat and Bivacor are aiming to change the paradigm from a single mechanical heart towards a smarter solution, with embedded sensors and intelligence. The next wave of development came from the diabetes epidemic that affects every country, hitting more than 8% of the global population today. The artificial pancreas market will therefore experience a huge 49% compound annual growth rate (CAGR) over the next five years, to reach

$1.3B in 2022. The next breakthrough to happen will come in 5-10 years, bringing artificial lungs and kidneys. The first commercially approved devices will be wearable systems such as the Wearable Artificial Kidney Foundation, Inc. (WAKFI) system. Soon after the first wearable kidney we should be able see a leap to an implantable device like that developed by the kidney project at University of California, San Francisco and Vanderbilt University. Artificial organs combine many advantages besides availability, including fewer compatibility issues, eliminating ethical concerns around organ trafficking, and decreasing cost. The artificial organ market will be worth $1.3B in 2017 and its 20% CAGR over the next five years will see it grow to $3.5B in 2022.

This report describes artificial organ market dynamics, players and technological challenges.

ARTIFICIAL ORGAN TECHNOLOGY AND MARKET ANALYSIS 2017Market & Technology report - September 2017

FIVE OUT OF THE TEN LEADING CAUSES OF DEATH IN THE WORLD WILL BENEFIT FROM ARTIFICIAL ORGANS

How will artificial organs revolutionize organ transplants and overcome shortages in the next 20 years?

KEY FEATURES OF THE REPORT Get the sample of the report on www.i-Micronews.com• Introduction to the technological

differences between artificial organs

• Comprehensive market analysis for each segment, covering total artificial hearts, ventricular assist devices, artificial pancreas, bioartificial pancreas, artificial livers, artificial kidneys and artificial lungs

• Funding, investments and acquisitions

• Supply chain• Market data and forecasts for

2016-2040 and market shares in 2017

• Roadmaps: How will the industry evolve?

• Technical aspects of artificial organs such as sensors and emitters, biocompatibility issues, weight and volume, batteries and pumps

• Specifications and requirements for embedded software in the field of artificial organs

• Types of algorithms used and business models in the field of software development

• Over 20 company profiles with pictures and descriptions of their technologies

• Some perspectives in the field of bionics: bionic ears, bionic eyes, bionic noses, 3D bioprinting and transhumanism

Artificial organ market and roadmap - 2016-2040 forecasts

bioprinted heart

1st implantation of a left ventricular assist device

1st implantation of a total artificial heart

Hybrid closed loopartificial pancreas

Implantable artificial heartas a destination therapy

Wearable artificial lung & artificial kidney

Implantableartificial kidney

Implanted

2030

2040

2025

2020

Today

1982

1966

2

6

10

14

18

Others1

Artificialpancreas

Ventricularassist device

Total artificialheart

First bioartificial pancreas

First artificial lung and artificial kidney

First artificial liver

Forecasts includes systems + consumables1Others include artificial liver, artificial kidney, artificial lung and bioartificial pancreas

Rev

enue

s (U

S$B)

(Yole Développement, September 2017)

Bringing a new artificial organ to market is a very long and costly project. The average time of development for such a complex technology is about 15-25 years in addition to the five to ten years of testing and regulatory approval. These gigantic delays explain why few companies have

ever invested in artificial organs, even if the total available market is humungous. Investors have to be patient and developers determined to bring such a technology to market. Ventricular assist devices form an established market, with big players such as Abbott and Medtronic, who

ARTIFICIAL HEART AND ARTIFICIAL PANCREAS: READY TO BLOW UP THE ARTIFICIAL ORGAN MARKET!

ARTIFICIAL ORGAN TECHNOLOGY AND MARKET ANALYSIS 2017

YESTERDAY ARTIFICIAL ORGANS WERE MADE OF MECHANICAL PARTS: TODAY THEY ARE BASED ON ELECTRONICS: TOMORROW THEY WILL BE SMART

Maybe you have watched a ‘transhumanist’ movie. Perhaps you’ve had a conversation about whether or not you would opt for bionic upgrades like superhuman lung capacity, or an immortal self-contained heart. You and your friends probably had different opinions, but concluded that it’s irrelevant because we are far

away from making these choices. Well, it turns out that the option is only a few years away. Artificial organs today only have a few sensors. But in the near future, the next generation of artificial organs will have a myriad of embedded sensors to monitor the status of the patient, and more intelligence to take changes in physiology into account. The software that pilots these artificial organs must parallel engineering developments. For now, particularly in artificial pancreas, a multitude of different algorithms exist, each of those with advantages and disadvantages, but all with an internal control law. These span very simple binary answers and much more complicated combinations of multiple data from sensors, physical laws, and precise output calculations all embedded in a complex, fast algorithm. Next generation algorithms are in development today and we are expecting large improvements. New fashionable methods like machine learning, and deep learning when the data is available, are entering research through fuzzy logic algorithms. These methods seem promising and will allow full automated control of the artificial organ.

This report unravels the different algorithms used in artificial pancreas and total artificial heart. It also describes the technical aspects boosting artificial organ development progress, such as biocompatibility, batteries and sensors.

respectively bought the two leaders of the field Thoratec and HeartWare. However the total artificial heart is still an emerging market, since the only player has been Syncardia for years. With the arrival of newcomers, the total artificial heart market will experience substantial growth with a 15% CAGR2017-2022. We expect penetration of the artificial pancreas to be also very high and fast in the type 1 diabetic population, since the community has wanted this solution for years. Only Medtronic had an artificial pancreas system approved by the US Food

and Drug Administration (FDA) in 2017 and none has a European CE mark. However, many companies are ready for approval and commercialization, especially two collaborations: one between Diabeloop, Dexcom and Cellnovo; and one involving TypeZero, Dexcom and Tandem.

After decades of development, artificial organ products are now ready to enter the medical device market. Yole Développement is uniquely positioned to provide your company with an understanding of the revolution that will happen in the next few years.

Embedded software for artificial organs: Types & context

(Yole Développement, September 2017)

System software Device drivers

Programming software

(CAD, CAE)

Operating System

Malware re

Utility software

Application software Database

Spread sheet

Multimedia

Presentation

Web /Com’

Text Text Text T

Embedded software

Multimedia

Enterprise

Artificial organs: Developmental cycle and funding sources

(Yole Développement, September 2017)

Who pays?

• Public research funding

• Grants • Associations • …

• Fund raising campaign

• Collaborations • Public grants • Investors • Venture capitals • …

REPORT OBJECTIVES• Explain the challenges linked

to organ transplantation and the limits of the current processes.

• Introduce the technologies behind the different types of artificial organs, including kidneys, livers, lungs, hearts and pancreas.

• Give an overview of artificial organ history from first developments to today, along with a presentation of the main players and their respective technologies. Who’s providing what? Who’s working with who?

• Provide market data and forecasts

• Detail the current technology’s limits and how it might evolve in the future.

• Discuss the main challenges and how artificial organ companies can overcome them.

• Focus on artificial organs’ technical aspects: including batteries, biocompatibility, sensors, and pumping systems

Find more details about

this report here:

MARKET & TECHNOLOGY REPORT

Executive summary 9

Introduction 36

> The problems of organ transplantation> Our definition of artificial organs> Permanent vs. temporary implants> Wearable vs. implantable

Market segmentation 50

> Technological and economic criteria > Segmentation of the market

Market data and forecasts 2016-2022 57

> Significant moves > Fundraising and grants> Market quantification> Market data and forecasts> Roadmap

Segment descriptions 72

> Total artificial heart> Ventricular assist devices> Artificial pancreas> Bioartificial pancreas

> Artificial lungs> Artificial kidney> Artificial liver

Technical aspects 153

> Biocompatibility > Batteries> Sensors> Pumps> Connectivity> Software

Embedded software for artificial organs 166

> Definitions and context> Ventricular assist devices and total artificial heart> Artificial pancreas

Supply chain 182

Perspectives – Bionics, 3D bioprinting and transhumanism 191

Regulations: an overview 214

> Market access for connected medical devices

Conclusions

TABLE OF CONTENTS (complete content on i-Micronews.com)

COMPANIES CITED IN THE REPORT (non exhaustive list)Abbott, Accellta, Alcon, Alliqua, Amesys, Amplifon, Animas, Aryballe Technologies, Asante, AWAK, Baxter, Becton Dickinson, Berlin Heart, Betabionics, Bigfoot Biomedical, Bimba, Biofab, Bionic vision technologies, Bivacor, Breethe inc., Carmat, Cellnovo, Cochlear Ltd, Debiotech, Dedienne, Defymed, Device Solutions, Dexcom, Diabeloop, Dose safety, Draper, Dreamed, Dualis, Edwards Lifesciences, Flex, Fresenius, GN ReSound, Google, Grey Innovation, HeartWare, HEF r&d, IBM Watson, Imasonic, Inreda Diabetic, InSmart, Insulet corporation, Intarcia, Invensense, Jarvik Heart, Johnson and Johnson, Knowles, Kollmorgen, Lilly, MC3, Medtronic, Memscap, Minifab, Mode AGC, Nanodialysi, Nano-dimension, Nemaura, Neokidney, Novartis, Novo Nordisk, Numerex, Omron, Organovo, Paxitech, Pixium Vision, Reliant Heart, Roche, Second Sigh, Senseonics, Siemens, Sintef, Sivantos, SmartProducts, Sonion, Sonova, St Jude Medical, ST Microelectronics, Starkey, Syncardia, Tandem, Tandem Life, TDK-Epcos, Techshot, Terumo, Thoratec, Transonic, TypeZero, ViaCyte, Vignal Artru, Vital Therapies, WAK, Widex, William Demant, WiTricity, Xenios and many more !

AUTHORSAs a Software & Market Analyst, Dr. Yohann Tschudi is a member of the MEMS & Sensors business unit at Yole Développement (Yole). Yohann is daily working with Yole’s analysts to identify, understand and analyze the role of the software parts within any semiconductor products, from the machine code to the highest level of algorithms. Market segments especially analyzed by Yohann include big data analysis algorithms, deep/machine learning, genetic algorithms, all coming from Artificial Intelligence (IA) technologies. After his thesis at CERN (Geneva, Switzerland) in particle physics, Yohann developed a dedicated software for fluid mechanics and thermodynamics applications. Afterwards, he served during 2 years at the University of Miami (FL, United-States) as a research scientist in the radiation oncology department. He was involved in cancer auto-detection and characterization projects using AI methods based on images from Magnetic Resonance Imaging (MRI). During his research career, Yohann has authored and co-authored more than 10 relevant papers. Yohann has a PhD in High Energy Physics and a master degree in Physical Sciences from Claude Bernard University (Lyon, France).

As a Technology & Market Analyst in the Medical Technologies (MedTech) business unit at Yole Développement (Yole), Asma Siari is involved in the development of technology & market reports as well as the production of custom consulting projects. After a Master’s degree in Biotechnologies, Diagnostic Therapeutics & Management, Asma serves as Research Assistant at the Moores Cancer Center (San Diego, CA). She is a coauthor in two scientific publications published in the Molecular Cancer Research Journal. In addition to her mission at Yole, Asma prepares today her Advanced Master’s degree in International Strategy & Marketing BtoB (EM Lyon Business School, France).

As a Technology & Market Analyst, Dr. Marjorie Villien works in the Microf luidic & Medical Technologies (MedTech) business unit at Yole Développement, the “More than Moore” market research and strategy consulting company. She is a daily contributor to the development of MedTech activities, with a dedicated collection of market & technology reports as well as custom consulting projects. After spending two years at Harvard, Dr. Villien served as a research scientist at INSERM in the field of MRI & PET imaging. She has spoken at numerous international conferences and has authored or co-authored 11 papers and one patent. Dr. Villien graduated from Grenoble INP and holds a PhD in physics & medical imaging.

• Connected Medical Devices Market and Business Models 2017

• Sensors for drones and robots: market opportunities and technology revolution

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the impact of More-than-

Moore technologies from deviceto system

From A to Z…

Transportation

makers

Mobile phone

and consumer

electronics

Automotive

Medical

systemsIndustrial and

defense

Energy

26©2017 | www.yole.fr | About Yole Développement

o Yole Développement publishes a comprehensive collection of market & technology reports and patent analysis in:

• MEMS & Sensors

• RF devices & technologies

• Imaging

• Medical technologies (MedTech)

• Photonics

• Advanced packaging

• Manufacturing

• Advanced substrates

• Power electronics

• Batteries and energy management

• Compound semiconductors

• Solid state lighting

• Displays

o You are looking for:

• An analysis of your product market

• A review of your competitors evolution

• An understanding of your manufacturing and production costs

• An understanding of your industry technology roadmap and related IPs

• A clear view on the evolution of the supply chain

The combined team of 60+ experts (PhDs, MBAs, industry veterans…) from Yole Développement, System Plus Consulting and KnowMade, collect information, identifythe trends, the challenges, the emerging markets, the competitive environments and turn it into results to give you a complete picture of your industry landscape.

In the past 19 years, we worked on more than 2 000 projects, interacting with technology professional and high level opinion makers from the main players of theindustry.

o Every year, Yole Développement, System Plus Consulting and Knowmade publish +120 reports. Gain full benefit from our Bundle and Annual Subscription offers.

REPORTS COLLECTION

www.i-Micronews.com

27©2017 | www.yole.fr | About Yole Développement

OUR 2017 REPORTS PLANNING (1/2)

MARKET AND TECHNOLOGY REPORTS by Yole Développement

o MEMS & SENSORS

− Acoustic MEMS and Audio Solutions 2017

− 3D Imaging & Sensing 2017

− Microspectrometers Markets and Applications 2017

− Status of the MEMS Industry 2017*

− MEMS & Sensors for Automotive 2017

− High End Inertial Sensors for Defense and Industrial Applications 2017*

− Magnetic Sensors Market and Technologies 2017

− Sensors and Sensing Modules for Smart Homes and Buildings 2017

− Sensing and Display for AR/VR/MR 2017

− MEMS Packaging 2017

− Fingerprint Sensor Applications and Technologies - Consumer Market Focus 2017

o RF DEVICES AND TECHNOLOGIES

− RF Front End Modules and Components for Cellphones 2017

− Advanced RF SiP for Cellphones 2017

− 5G and Beyond (Vol 1): Impact on RF Industry, from Infrastructure to Terminals

2017

− 5G and Beyond (Vol 2): RF Materials Platform, from Infrastructure to Terminals

2017

− RF Technologies for Automotive Applications 2017

− GaN and Si LDMOS Market and Technology Trends for RF Power 2017

o MANUFACTURING

− Glass Substrate Manufacturing 2017

− Equipment & Materials for Fan Out Technology 2017

− Equipment and Materials for 3D TSV Applications 2017

− Emerging Non Volatile Memories 2017*

o MEDTECH

− Status of the Microfluidics Industry 2017

− Solid State Medical Imaging 2017

− Connected Medical Devices: the Internet of Medical Things 2017

− Sensors for Medical Robotics 2017

− Artificial Organs: Market & Technology Analysis 2017

− Organs-on-a Chip 2017

o ADVANCED PACKAGING

− Advanced Substrates Overview 2017

− Status of the Advanced Packaging Industry 2017

− Fan Out Packaging: Market & Technology Trends 2017*

− 3D Business Update: Market & Technology Trends 2017*

− Advanced QFN: Market & Technology Trends 2017**

− Inspection and Metrology for Advanced Packaging Platform 2017**

− MEMS Packaging 2017

− Advanced Packaging for Memories 2017

− Advanced RF SiP for Cellphones 2017

− Power Packaging Market and Technology Trends 2017

− Embedded Die Packaging: Technologies and Markets Trends 2017

o IMAGING & OPTOELECTRONICS

− 3D Imaging & Sensing 2017

− Status of the CMOS Image Sensor Industry 2017*

− Camera Module for Consumer and Automotive Applications 2017*

− Uncooled Infrared Imaging Technology & Market Trends 2017*

− Solid State Medical Imaging 2017

o BATTERY AND ENERGY MANAGEMENT

− Status of Battery Industry for Stationary, Automotive and Consumer Applications

*2016 version still available / **To be confirmed

28©2017 | www.yole.fr | About Yole Développement

OUR 2017 REPORTS PLANNING (2/2)o POWER ELECTRONICS

− Status of Power Electronics Industry 2017*

− Silicon Power Mosfet: Market and Technology Trends 2017

− IGBT Market and Technology Trends 2017

− Power Packaging Market and Technology Trends 2017

− Power SiC 2017: Materials, Devices, and Applications*

− Power GaN 2017: Materials, Devices, and Applications*

− Materials Market Opportunities for Cellphone Thermal Management (Battery

Cooling, Fast Charging, Data Processing, Battery Cooling, etc.) 2017

− Gate Driver Market and Technology Trends 2017

− Power Management ICs Market Quarterly Update 2017

− Power Electronics for Electrical Aircraft, Rail and Buses 2017**

− Thermal Management for LED and Power 2017

o COMPOUND SEMICONDUCTORS

− Power SiC 2017: Materials, Devices, and Applications*

− Power GaN 2017: Materials, Devices, and Applications*

− GaN and Si LDMOS Market and Technology Trends for RF Power 2017

− 5G and Beyond (Vol 2): RF Materials Platform, from Infrastructure to Terminals

2017

− Bulk GaN Substrate Market 2017

o DISPLAYS

− MicroLED Displays 2017

− Display for Augmented Reality, Virtual Reality and Mixed Reality 2017

− Quantum Dots for Display Applications 2017

− Phosphors & Quantum Dots 2017 - LED Downconverters for Lighting & Displays

− Organic Thin Film Transistor 2016: Flexible Displays and Other Applications

− Automotive Lighting 2017 - Technology, Industry and Market Trends

o SOLID STATE LIGHTING

− UV LEDs 2017 - Technology, Manufacturing and Application Trends*

− Horticultural Lighting 2017 - Technology, Industry and Market Trends

− Automotive Lighting 2017 - Technology, Industry and Market Trends*

− Active Imaging and Lidar 2017 (Vol 2) - IR Lighting**

− LED Lighting Module 2017 - Technology, Industry and Market Trends

− IR LEDs and Lasers - Technology Applications and Industry Trends 2017

− Phosphors & Quantum Dots 2017 - LED Downconverters for Lighting & Displays

− MicroLED Displays 2017

− CSP LED Lighting Module 2017

− LED Packaging 2017

− Thermal Management for LED and Power 2017

PATENT ANALYSIS by Knowmade

− Consumer Physics SCiO Molecular Sensor Patent-to-Product Mapping 2017

− Patent Licensing Companies in the Semiconductor Market - Patent Litigation

− Risk and Potential Targets 2017

− MEMS Microphone: Patent Landscape Analysis 2017

− MEMS Microphone: Knowles’ Patent Portfolio Analysis 2017

− Microbolometer: Patents Used in Products 2017

− Microfluidic Technologies for Diagnostic Applications Patent Landscape 2017

− Micropumps: Patent Landscape Analysis 2017

− GaN Technology: Top-100 IP Profiles 2017

− MicroLEDs: Patent Landscape Analysis 2017

− Consumer Physics SCiO Molecular Sensor Patent-to-Product Mapping 2017

− Uncooled Infrared Imaging: Patent Landscape Analysis 2017

− 3D Monolithic Memory: Patent Landscape Analysis 2017

TEARDOWN & REVERSE COSTING by System Plus Consulting More than 60 teardowns and reverse costing analysis and cost simulation tools to be

published in 2017.*2016 version still available / **To be confirmed

29©2017 | www.yole.fr | About Yole Développement

OUR 2016 PUBLISHED REPORTS LIST (1/2)

MARKET AND TECHNOLOGY REPORTS by Yole Développement

o MEMS & SENSORS

− Gas Sensors Technology and Market 2016

− Status of the MEMs Industry 2016

− Sensors for Cellphones and Tablets 2016

− Market and Technology Trends of Inkjet Printheads 2016

− Sensors for Biometry and Recognition 2016

− Silicon Photonics 2016

o IMAGING & OPTOELECTRONICS

− Status of the CMOS Image Sensor Industry 2016

− Uncooled Infrared Imaging Technology & Market Trends 2016

− Imaging Technologies for Automotive 2016

− Sensors for Drones & Robots: Market Opportunities and Technology Evolution 2016

o MEDTECH

− BioMEMS 2016

− Point of Care Testing 2016: Application of Microfluidic Technologies

o ADVANCED PACKAGING

− Embedded Die Packaging: Technology and Market Trends 2017

− 2.5D & 3D IC TSV Interconnect for Advanced Packaging: Business Update 2016

− Fan-Out: Technologies and Market Trends 2016

− Fan-In Packaging: Business update 2016

− Status and Prospects for the Advanced Packaging Industry in China 2016

o MANUFACTURING

− Thin Wafer Processing and Dicing Equipment Market 2016

− Emerging Non Volatile Memories 2016

o COMPOUND SEMICONDUCTORS

− Power GaN 2016: Epitaxy and Devices, Applications and Technology Trends

− GaN RF Devices Market: Applications, Players, Technology and substrates 2016

− Sapphire Applications & Market 2016: from LED to Consumer Electronics

− Power SiC 2016: Materials, Devices, Modules, and Applications

o LED

− UV LED Technology, Manufacturing and Applications Trends 2016

− OLED for Lighting 2016 – Technology, Industry and Market Trends

− Automotive Lighting: Technology, Industry and Market Trends 2016

− Thermal Management Technology and Market Perspectives in Power Electronics and

LEDs 2017

− Organic Thin Film Transistor 2016: Flexible Displays and Other Applications

− Sapphire Applications & Market 2016: from LED to Consumer Electronics

− LED Packaging 2017: Market, Technology and Industry Landscape

o POWER ELECTRONICS

− Power Electronics for EV/HEV 2016: Market, Innovations and Trends

− Status of Power Electronics Industry 2016

− Passive Components Technologies and Market Trends for Power Electronics 2016

− Power SiC 2016: Materials, Devices, Modules, and Applications

− Power GaN 2016: Epitaxy and Devices, Applications, and Technology Trends

− Inverter Technologies Trends & Market Expectations 2016

− Opportunities for Power Electronics in Renewable Electricity Generation 2016

− Thermal Management Technology and Market Perspectives in Power Electronics and

LEDs 2017

− GaN RF Devices Market: Applications, Players, Technology and substrates 2016

o BATTERY AND ENERGY MANAGEMENT

− Beyond Li-ion Batteries: Present and Future Li-ion Technology Challengers 2016

− Stationary Storage and Automotive Li-ion Battery Packs 2016

− Opportunities for Power Electronics in Renewable Electricity Generation 2016

30©2017 | www.yole.fr | About Yole Développement

OUR 2016 PUBLISHED REPORTS LIST (2/2)

PATENT ANALYSIS by Knowmade

− Microbattery Patent Landscape Analysis

− Miniaturized Gas Sensors Patent Landscape Analysis

− 3D Cell Culture Technologies Patent Landscape

− Phosphors and QDs for LED Applications Patent Landscape

− TSV Stacked Memory Patent Landscape

− Fan-Out Wafer Level Packaging Patent Landscape Analysis

TEARDOWN & REVERSE COSTING by System Plus Consulting More than 45 teardowns and reverse costing analysis and cost simulation tools published

in 2016.

MORE INFORMATION

o All the published reports from the Yole Group of Companies are available on our website

www.i-Micronews.com.

o Ask for our Bundle and Annual Subscription offers: With our bundle offer, you choose the

number of reports you are interested in and select the related offer. You then have up to 12

months to select the required reports from the Yole Développement, System Plus Consulting

and KnowMade offering. Pay once and receive the reports automatically (multi-user format).

Contact your sales team according to your location (see the last slide).

31©2017 | www.yole.fr | About Yole Développement

MICRONEWS MEDIA

o About Micronews Media

To meet the growing demand for market,

technological and business information,

Micronews Media integrates several tools able

to reach each individual contact within its

network.We will ensure you benefit from this.

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32©2017 | www.yole.fr | About Yole Développement

CONTACT INFORMATION

o CONSULTING AND SPECIFIC ANALYSIS

• North America: Steve LaFerriere, Director of Northern America Business DevelopmentEmail: [email protected] – +1 31 06 008 267

• Japan & Rest of Asia: Takashi Onozawa, General Manager, Asia Business DevelopmentEmail: [email protected] - +81 3 4405 9204

• Greater China: Mavis Wang, Director of Greater China Business DevelopmentEmail: [email protected] - +886 979 336 809

• RoW: Jean-Christophe Eloy, CEO & President, Yole DéveloppementEmail [email protected] - +33 4 72 83 01 80

o REPORT BUSINESS

• North America: Steve LaFerriere, Director of Northern America Business DevelopmentEmail: [email protected] – +1 31 06 008 267

• Europe: Lizzie Levenez, EMEA Business Development ManagerEmail: [email protected] - +49 15 123 544 182

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• Greater China: Mavis Wang, Director of Greater China Business DevelopmentEmail: [email protected] - +886 979 336 809

o FINANCIAL SERVICES

• Jean-Christophe Eloy, CEO & PresidentEmail: [email protected] - +33 4 72 83 01 80

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