art of making an antibody

8/6/2019 Art of Making an Antibody

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Art of

By Katy Negus

Making an Antibody



Introduction

For this project we were required to create a 2-3 minute

animation, this included the pre-production, production

and post-production. From the four choices; HIV virus,

making an antibody, fighting an infection and the flu

virus. I picked, making an antibody.



Target Audience

This project is aimed at adults, due to its complexity

when it comes to creating these antibodies. It aims to be

as detailed as possible, but creative and imaginative while

doing so. There are some mild scenes of violence, which

involves an invasion of bacteria. A much younger

audience may find some scenes to be a little bitfrightening for them, as well as hard to understand.



Diagram on How to Make an Antibody



3 Act Structure

1st Act

Starts of with an external view of an artery, then enters the artery to see blood

cells rushing through it. Bacteria enter the scene and continue to flow with the

blood

cells. They are rushing through the artery like some roller coaster ride and

eventually

enter a lymph node.

2nd Act

The bacteria lurk about inside the lymph node looking for unsuspecting cells to

damage. They are seen passing many B cells, which ignore them. Only the antigen

matching B cells can catch them. The bacteria continue to swim pass them until they

start to get captured by the matching B cells one by one. The B cells absorb the

bacteria and expose the bacteria's antigen on their membrane surface and wait for

further instruction.

3rd Act

T cells come along and begin activating the B cells by communicating physically

and chemically to them. After the T cell has finished the B cell starts to divide

into

memory B cells and Plasma cells. The Plasma cells start releasing their

antibodies, which

seek out the bacteria in the lymph node and the rest of the body.



Influence Maps

Bacteria Influence

• Salmonella bacteria

• Bacterium anatomy

• Electric blue scale worm

• Alien chestburster

• Spirillum

• Bacteria



Influence Maps

Cells Influence

• Translucent sea creatures

• T cell

• B cell

• Plasma cell diagrm

• Discus

• Gar scales• Tesselata eel



Influence Maps

Lymph Node Influence

• Vaclav Pajkrt's work

• Lymph node diagram

• Red blood cells

• Gar scales



B Cell Designs



T Cell Designs



Plasma Cell Designs



Bacteria Designs



Antibody Designs



Environment Sketches



Storyboard

Scene 1

Scene 2

Starts off showing the

external view of an artery.

Then zooms in slowly.

Still zooming into the artery,

showing the blood flow and

following its direction.



Storyboard

Scene 5

Scene 6

While following the flow of

the bacteria we zoom out of

the artery.

Still going with the flow, wepan towards the artery’s

end, a lymph node.



Storyboard

Scene 7

Scene 8

Inside the lymph node the

bacteria enter.

The bacteria lurk about

inside the lymph nodeabove many B cells.



Storyboard

Scene 9

Scene 10

The bacteria begin pushing

the B cells out of their way,

as the B cells ignore them.

We follow one of the

bacterium as it continues

knocking the B cells about.

While in the background a

bacterium is captured by a

B cell.



Storyboard

Scene 11

Scene 12

Our bacterium is joined by

another, and they swim

together side by side.

Our bacterium’s mate gets

captured, but our bacterium

manages to escape capture.



Storyboard

Scene 15

Scene 16

The bacterium is dissolved,

but the antigens on its body

are left floating about. The

B cell pushes these to its

membrane wall, exposing

them on its surface.

With the antigens exposed,the B cell waits and calls for

a T cell.



Storyboard

Scene 17

Scene 18

From another part of the

lymph node, T cells are seen

coming to aid the B cells.

A T cell is seen coming to

help out our B cell.



Storyboard

Scene 19

Scene 20

Viewed from above, the

B cell and T cell move

closer to one another.

We spin slowly around them,as the T cell gently wraps its

tentacles around the B cell.



Storyboard

Scene 21

Scene 22

The T cell connects its receptor

to the antigen on the B cell’s

body.

After the T cell has activated

the B cell it leaves.



Storyboard

Scene 23

Scene 24

The B cell begins to clone

itself, creating more B cells

and plasma cells.

We see a plasma cell start to

release it’s receptors, which

are now antibodies.



Storyboard

Scene 25

Scene 26

The released antibodies

start sticking to the

Bacteria, rendering

them harmless.

We follow a swarm of

antibodies as it leaves the

lymph node, which exits

into a vein.



Storyboard

Scene 27

Scene 28

We follow the antibodies

and start zooming out

from the vein.

We continue to zoom

out to view the vein.



Concept Art

Inside The Lymph Node



Concept Art

B Cells



Concept Art

Bacteria



Concept Art

Antibodies



Making the B Cell

Model

Wire Frame

Colour



Making the B Cell

Render



Making the T Cell

Model

Wire Frame

Colour



Making the T Cell

Render



Making the Plasma Cell

Model

Wire Frame

Colour



Making the Plasma Cell

Render



Making the Bacteria

Model

Wire Frame

Colour



Making the Bacteria

Render



Making the Antibody

Model

Wire Frame

Colour



Making the Antibody

Render



Making the Lymph Node



Making the Artery

Model

Wire Frame

Colour



Making the Artery

art of making an antibody

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