approach to the patİents wİth chronic arthritis dr. mÜge b iÇakÇigİl kalayci
TRANSCRIPT
APPROACH TO THE PATİENTS WİTH CHRONIC ARTHRITIS
Dr. MÜGE BIÇAKÇIGİL KALAYCI
CHRONIC MONOARTHRITIS
• ESSENTIAL FEATURES• Chronic inflammatory monoarthritis
– infection, crystal-induced arthritis, sarcoidosis, or monoarticular presentation of oligoarthritis or polyarthritis
• Chronic noninflammatory monoarthritis – osteoarthritis, mechanical , Chondromalacia
patellae, and osteonecrosis.
• Arthrocentesis and imaging studies are important dignostic tests
CHRONIC MONOARTHRITIS• INITIAL CLINICAL EVALUATION• Infections, particularly indolent infections, are
a concern with inflammatory monoarthritis that lasts from weeks to months.
• The particular joint involved influences the differential diagnosis.
CHRONIC MONOARTHRITIS
• LABORATORY EVALUATION• A critical step is to determine whether the
monoarthritis is inflammatory, preferably by analyzing synovial fluid.
• Synovial fluid should be sent for culture (bacterial, mycobacterial, and fungal), WBC count, and gram stain and examined for crystals by polarized light microscopy.
CHRONIC MONOARTHRITIS
• Routine laboratory studies (eg, complate blood cell count, creatinine, and urine analysis) and determination of the ESR or CRP and uric acid level can provide helpful information.
• Patients with inflammatory monoarthritis and negative bacterial cultures shoud be tested for reactivity to purified protein derivative (PPD)
CHRONIC MONOARTHRITIS
• IMAGING STUDIES• Unlike in acute monoarthritis , radiographs
can be helpful in evaluating chronic monoarthritis and can point to correct diagnosis in cases of infection, osteoarthritis, and osteonecrosis.
Differential diagnosis of chronic
inflammatory monoarthritisInfection Nongonococcal septic arthritis Gonococcal Mycobacterial Fungal ViralCrystal-induced aarthritisGout Pseudogut
Monoarticular presentation of oligoarthritis or polyarthritis
SpondyloarthropathiesRheumatoid arthritisLupus and other systemic autoimmune diseases.
Sarcoidosis
Uncommon or rareFMFAmyloidosisPigmented villonodular synovitis
Non-inflammatory
OsteoarthritisInternal derangements (eg,torn,meniscus)Chondromalacia patellaOsteonecrosisNeıropathic (charcot) arthropathy
CHRONIC MONOARTHRITIS
• Tuberculous infection of a joint can present after days, weeks or months of symptoms.
• Smears for acid fast bacilli are positive only 20% of cases,
• Cultures for mycobacteria are positive in 80 %, but test results take weeks.
• Synovial biopsy can expedite the diagnosis of tuberculous arthritis , and is also indicated in suspected cases of fungal arthritis.
CHRONIC OLIGOARTHRITIS
• ESSENTIAL FEATURES• Careful description of arthritis and detection
of extraarticular disease facilitate accurate diagnosis.
• Radiographs are often of diagnostic value.
CHRONIC OLIGOARTHRITISCommon inflammatory causesSpondyloartropatiesReactive arthritisAnkylosing spondylitisPsoriatic arthritisInflammatory bowel disease
Uncommon-rare inflammatory arthritis
Subacute bacterial endocarditisSarcoidosisBehçet diseaseCeliac disease
Common non-inflammatory causesOsteoarthritisUncommon-rare non inflammatoryHypotyroidismamyloidosis
CHRONIC OLIGOARTHRITIS
• Spondyloartropathies are the most common cause of chr. Oligoarthritis
• Early onset rheumatoid arthritis must be distinquished.
• Osteoarthritis presents as oligoarthritis of the hips or knees
CHRONIC OLIGOARTHRITIS
• Laboratory evaluation• Synovial fluid analysis- culture- crystals
• RF-dd(x) of RA
• HLA B 27- limited value
CHRONIC OLIGOARTHRITIS
• Radiographs and Imaging studies-considerable value
• Evidence of sacroitis indicates a spondyloarthropaty and narrow dd(x)
• Erosions of RA and Gout
CHRONIC OLIGOARTHRITIS
• Spondyloartropaties- asymmetric oligoarthritis
• RA- symmetric poliarthritis• İn early RA- oligoartitis
• Stiffness and pain in low back- Spa• RA- only cervical spine
CHRONIC OLIGOARTHRITIS
• Dactylitis(sausage digits)- sPA, gout, sarcoidosis• Extraarticular manifestations that point to
correct diagnosis
• Psoriasis –umblicus, external auditory canal, scalp and anal creft
• Diarrea- inflammatory bowel disease.• Anterior uveitis
CHRONIC POLYARTHRITIS
• ESSENTIAL FEATURES• Rheumatoid arthritis and Osteoarthritis are
leading causes.• Careful delineation of the joints involved,
particularly in the hands, can help to the correct d(x)
• The distinction between inflammatory non inflammatory is critical
CHRONIC POLYARTHRITISInflammatory –Common
Rheumatoid arthritisSLEspondyloartropaties (especiaally Psoriatic art)GoutChronic hepatitis C infectionDrug induced lupus syndrome
Inflammatory-Uncommon
Paraneoplastic polyarthritisRemitting seronegative symmetric polyarthritis with pitting edema (RS3PE)Adult onset still disease
Inflammatory- uncommon
VasculitiitisSjögren’s syndromeViral infections other than hepatitis C
Non inflammatory
OsteoarthritisHemachromatosis
CHRONIC POLYARTHRITIS
• Laboratory evaluatıon• If arthrosentesis is feasible- joint aspiration-
cell count and crystals• CBC• RFT• Urine analysis• ESR_CRP• RF-ANA- hepatitis B and C serology
CHRONIC POLYARTHRITIS
• Radiographs are indicated in most cases of chronic polyarthritis
• Erosion-RA-OA-hemachromatosis-gout- SPA
• Non-erosive- SLE-drug induced SLE-chronic hepatitis C.
DD(x) of chronic polyarthritis
• Osteoarthritis and Rheumatoid arthritis have different patterns of joint involvement in the hand.
• OA- involves DIP, PIP and first MCP joints.
• RA- PIP- MCP and wrist
• Osteoarthritis and Rheumatoid arthritis spare certain joints
• OA- does not involve MCP, wrist, elbow, ankles• • RA- spare DIP, thoracic and lumbosacral spine
and sacroiic joints• Psoriatic arthritis- DIP joints
ASSOCIATED HISTORY
• •Predisposing factors• •Medication• •Bowels• •Urinary• •Rashes• •Eyes• •Raynaud’s• •Sicca• •Family History
EXAMINATION
•Multi-system•Disability•Range of movement•Signs of inflammation
INVESTIGATIONS
• •FBE/E/LFT• •ESR/CRP• •Iron studies• •Uric Acid• •Auto antibodies• •HLA-B27• •Viral serology• •Joint fluid• •Imaging
Skin and nail findings and arthritis
Skin rashes
• Diffuse eruption with fever and systemic findings
• Generally viral or due to primary immunological disease
• Must be differentiated from bacterial diseases
• SLE, DM
• Rheumatic fever
• Still disease
• Kawasaki disease
Adult still disease
Papulosquamaus lesions
• Psoriatic arthritis
• Reiter Syndrome
• SLE
SLE
Annular lesions
• Rheumatic fever
• Subcutaneous Lupus
Facial lesions
• Malar and discoid rash
• Lupus pernio: Sarcoidosis
• Dermatomyositis-gottron papules-heliotrope rash
• Lupus vulgaris: cutanous tuberculosis
Nodular lesions
• RA, ARA, crystal artropathies
• Erythema nodosum: Behçet’s disease,Sarcoidosis, spondyloartropathies, tbc
Erysipel like rash (FMF)
Acneiform lesions( behçet’s disease)
Purpura
• purpura:vasculitis
Skin thickening
• Scleroderma
• Eosinophilic fasitis and eosinophilic myalgia
syndrome.
Photosensitive skin eruption
• Connective tissue diseases, SLE, DLE,
DM...
• Phototoxic drug allergies (sulfa,
thiazid..)
Oral ulcers
• Behçet ‘s disase
• Crohn disease
• Spondyloarthropathies
• SLE
Genital ulcers
Behçets disease
Reactive arthritis
Sousage digits/Enthesopathy
• Reactive arthritis
• Psoriatic arthritis
Sousoge digits
Achille tendinitis
Raynaud
• Primary or secondary
• Primary- female- %5-8
• Secondary – connective tissue disorders
• Scleroderma, SLE, SS, RA, DM/PM...
Fever, weight loss, malaise and arthritis
Fever and rheumatological diseases
• ARA
• FMF
• JRA/JİA
• Adult onset Still disease
SLE
Vasculitis
Behcet ‘s disease
Scleroderma
DM/PM
Sarcoidosis
Eye and arthritis
Eye and rheumatological diseases
Uveitis
• Anterior uveitis: BH, Spondyloarthropathies,
Sarkoidosis, JRA..
• Posterior Uveitis: BH, SLE, Sarkoidosis...
Cornea Involvement
• Marginal erosion: RA
• Skleritis/episkleritis: RA
Keratoconjonktivitis sicca
• Primary or secondary Sjögren syndrome
Anterior uveitis an hypopyon
Dry eye and sclera erosions
Abdominal symptoms and arthritis
Abdominal symptoms and arthritis
• Diarrea
• Abdominal pain
• Intestinal bleeding
• Enteropahtic arthritis
• Reactive arthritis
• Behcet disease
• FMF
• Vasculitis
• Connective tissue
diseases
Mono-oligoarthritis
Poliarthritis
Axial involvement