approach to gastrointestinal bleeding
TRANSCRIPT
![Page 1: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/1.jpg)
Approach to gastrointestinal bleeding
Samir Haffar M.D.
Associated Professor of Gastroenterology
![Page 2: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/2.jpg)
Clinical Presentation of GI bleeding
• Hematemesis Vomiting of fresh or old blood
Proximal to Treitz ligament
Bright red blood = significant bleeding
Coffee ground emesis = no active bleeding
• Melena Passage of black & foul-smelling stools
Usually upper source – may be right colon
• Hematochezia Passage of bright red blood from rectum
If brisk & significant → UGI source
• Occult bleeeding Bleeding not apparent to patient
May lead to dyspnea, AP & even MI
![Page 3: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/3.jpg)
Assessing the severity of bleedingFirst step
Bleeding severity Vital Signs Blood loss (%)
Minor Normal < 10 %
Moderate Postural (Orthostatic hypotension)
10 – 20 %
Massive Shock (Resting hypotension)
20 – 25 %
![Page 4: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/4.jpg)
ResuscitationProportional to bleeding severity
• 2 large-bore IV catheters: Normal saline – Ringer lactate
• Oxygen by nasal cannula or facemask
• Monitoring of vital signs & urine output
• Blood Transfusion: Ht raised to Elderly: 30 % Young: 20 – 25 % PHT: 27 – 28 %
• Fresh frozen plasma & platelet transfusion If transfusion of > 10 units of packed red blood cells
![Page 5: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/5.jpg)
History
• Elderly Diverticula - Angiodysplasia - Cancer
• Young Peptic ulcer – Varices – Esophagitis • < 30 years Meckel diverticula • Previous bleeding Bleeding from similar causes• Aortic surgery Aortoenteric fistula• Known liver disease Esophageal or gastric varices• NSAIDs • Retching Mallory-Weiss tear• Non GI sources Especially from nasopharynx
![Page 6: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/6.jpg)
Physical examination
• PHT Spider naevi – caput medusa …
• Acanthosis nigricans Underlying cancer
• Pigemnted lip lesions Peutz-Jeghers syndrome
• Cutaneous lesionsNeurofibromatosis
• Purpura Henoch-Schonlein purpura
• Splenomegaly PHT - portal vein thrombosis
• Telangiectasia Osler-Weber-Rendu disease
![Page 7: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/7.jpg)
Spider Naevi
Central arteriole
Blanch if occluded with pinhead
SVC Chest above nipple
Face
Arms
Hands
DD Childhood
Pregnancy
Chronic liver disease
![Page 8: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/8.jpg)
Direction of blood flow in anterior abdominal wall
PV obstruction
S Sherlock & J Dooley. Diseases of the Liver & Biliary System – 2002.
IVC obstruction
![Page 9: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/9.jpg)
Collateral circulation
Vein dilatation & tortuosity in abdominal wall
of a cirrhotic patient suffering from ascites & jaundice
![Page 10: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/10.jpg)
Caput Medusa
Portal hypertension
Seen much less frequently
![Page 11: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/11.jpg)
Occlusion of the IVC
![Page 12: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/12.jpg)
Gynecomastia in cirrhosis
Seen in cirrhotic males
Spironolactone is frequent cause
Absent hair body
Associated diminished libido
Associated testicular atrophy
![Page 13: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/13.jpg)
Palmar erythema
Exagereted red flushing of palms
Fades on pressure
Specially Thenar eminence
Hypothenar eminence
Bases of fingers
DD Pregnancy
Thyrotoxicosis
Bronchial carcinoma
Genetically determined
![Page 14: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/14.jpg)
White nails
• Congenital
• Cirrhosis:
Present in most patients
Due to hypoalbuminemia
![Page 15: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/15.jpg)
BruisingClotting disorder
Around venepuncture site
From intramuscular injection
![Page 16: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/16.jpg)
Acanthosis nigricans
Pigmentation of Axilla
Groins
Angles of mouth
Hands
Malignant disease Gastric carcinoma
Pancreatic carcinoma
Bronchial carcinoma
![Page 17: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/17.jpg)
Hereditary telangiectasiaRendu-Osler-Weber disease
StomachTongue
![Page 18: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/18.jpg)
Peutz-Jeghers Syndrome
![Page 19: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/19.jpg)
Neurofirmatosis“von Recklinghausen’s Disease”
“Café au lait” spotsNeurofibromas
![Page 20: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/20.jpg)
Henoch-Scholein purpura
Age Prepubertal boys (6 m – 6 years)
Can occurs in adults
Tetrad Purpuric rash: feet – buttocks – legs
Colicky abdominal pain - bloody diarrhea
Arthralgia
Glomerulonephritis
Prognosis Self-limited
Complications Rapidly progressive renal failure
GI hemorrhage
![Page 21: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/21.jpg)
Henoch-Scholein Purpura
Extenseor surfaces of legs
Buttocks
![Page 22: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/22.jpg)
Thyphoid feverRose spots
Frequency: 10 – 90 %
During second week
Erythematous macules (2 – 4 mm)
Upper abdomen & anterior thorax
Occur in small numbers
Blanch on pressure
Lasts 2 – 3 days
![Page 23: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/23.jpg)
Laboratory evaluation
• Hematocrit May not reflect blood loss accurately
• Elevated BUN Not correlated to creatinine level
Breakdown of blood proteins to urea
Mild reduction of GFR
• Iron deficiency anemia
• Low MCV
• Low ferritin level
![Page 24: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/24.jpg)
Hematocrit values before & after bleeding
![Page 25: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/25.jpg)
Diagnostic test in GI bleeding
• Upper GI endoscopy• Colonoscopy• Small bowel endoscopy• Capsule endoscopy & double balloon enteroscopy• Barium radiograph• Radionuclide imaging• Angiography• Miscellaneous tests: abdominal US or CT
![Page 26: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/26.jpg)
Causes of UGI bleeding
Common
Peptic ulcer
Varices
Mallory-Weiss
Less Frequent
Dieulafoy’s lesion
Vascular ectasia
Watermelon stomach
Gastric varices
Neoplasia
Esophagitis
Rare
Esophageal ulcer
Erosive duodenitis
Hemobilia
Crohn’s disease
Aorto-enteric fistula
![Page 27: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/27.jpg)
Causes & associations of PU
Sleisenger & Fordtran’s Gastrointestinal & Liver Disease -1998
Common forms of PU (95%)
HP-associated
NSAID-associated
Stress ulcer
Uncommon forms of P U(5%)
Acid hypersecretion :ZES – mastocytosis
Other infections: HSV type 1 – CMV
Duod obstruction: bands-annular pancreas
Radiation-induced lesions
Chemotherapy-induced lesions
Idiopathic
![Page 28: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/28.jpg)
![Page 29: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/29.jpg)
Predisposing factors to bleeding PU
• Acid Most prominent factor
• Helicobacter pylori
• NSAIDs
• Biphosphnate alendronate
• Chronic pulmonary disease
• Cirrhosis
• Anticoagulants
• Ethanol
![Page 30: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/30.jpg)
Bleeding peptic ulcer
• Most frequent cause of UGI bleeding (50%)
• Especially high on gastric lesser curvature
or postero-inferior wall of duodenal bulb
• Most ulcer bleeding is self-limited (80%)
![Page 31: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/31.jpg)
Forrest’s classification for PU bleeding
Stage Characteristics Rebleeding
I a Jet arterial bleeding 90 %
Ib Oozing 50 %
IIa Visible Vessel 25 - 30 %
IIb Adherent clot 10 - 20%
IIc Black spot in ulcer crater 7 - 10%
III Clean base ulcer 3 - 5 %
![Page 32: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/32.jpg)
Forrest’s classification for PU bleeding
III (clean base)II-b (adherent clot)
II-a (visible vessel)I-b (oozing)
II-c (black spot)
I-a (arterial jet )
![Page 33: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/33.jpg)
GI side effects of NSAIDs
Organ Side Effects
Esophagus Esophagitis – Ulcer – Stricture
Stomach & duodenum Subepithelial hemorrhage – Erosion – Ulcer
Small Intestine Ulcers – Strictures – NSAID enteropathy
Colon No pre-existing colonic disease:Ulcerations – Stricture – Diaphragm – Colitis Pre-existing colonic disease: ↑ Complications of diverticular disease Activate IBD
Ano-rectum Inflammation – Ulcer – Stricture
![Page 34: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/34.jpg)
Highest risk Azapropazone Tolmetin Ketoprofen Piroxicam
GI safety of non-selective NSAIDsRR of different NSAIDs could differ 10-fold
Lowest risk Ibuprofen * Diclofenac
* Risk at higher doses (> 1.5 –2.4 g/d) comparable to others NSAIDsBr Med J 1996 ; 312 : 1563 – 1566.
Longer half-time
Moderate risk Indomethacin Naproxen SulindacAspirin
![Page 35: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/35.jpg)
Prevention of GI toxicity
due to NSAIDs
![Page 36: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/36.jpg)
Patients at increased risk for NSAIDs CV toxicity
High risk Patients with risk factors for CV disease often receive prophylactic aspirin
Arbitrarily defined as requirement for low-dose aspirin for prevention of serious CV events
Low risk No risk factors
![Page 37: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/37.jpg)
Patients at increased risk for NSAIDs GI toxicity
High risk 1. History of complicated ulcer especially recent 2. Multiple (> 2 risk factors)
HP is independent & additive risk factor & addressed separately
ACG guidelines for prevention of NSAID-related ulcer complications . Am J Gastroenterol 2009 ; 104: 728 – 738.
Moderate risk (1 – 2 risk factors)
1. Age > 65 years 2. High dose NSAID therapy 3. Previous history of uncomplicated ulcer 4. Concurrent use of aspirin 5. Concurrent use of corticosteroids 6. Concurrent use of anticoagulants
Low risk No risk factors
![Page 38: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/38.jpg)
Prevention of NSAID-related ulcer complications
Naproxen may have some cardioprotective properties
Patients with ulcer history: search for HP & if present eradicated
ACG guidelines for prevention of NSAID-related ulcer complications. Am J Gastroenterol 2009 ; 104: 728 – 738.
NSAID alone (least ulcerogenicat lowest dose)
NSAID+
PPI/misoprostol
Alternative therapyor
Coxibs + PPI/misoprostol
Naproxen +
PPI/misoprostol
Naproxen +
PPI/misoprostol
Avoid NSAIDs & coxibs
Use alternative therapy
High GI riskModerate GI risk Low GI risk
Low CV risk
High CV risk
![Page 39: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/39.jpg)
Treatment of bleeding PU
• Pharmacological PPI 80 mg IV bolus
8mg / hr / 72 hours IV infusion
• Endoscopic Injection (epinephrine 1/10.000)Monopolar coagulation
Bipolar coagulation
Heater probe
Hemoclips
Argon plasma coagulation
• Surgical When endoscopic treatment fails
![Page 40: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/40.jpg)
Summary of therapy of bleeding PU
• Patients must be adequately resuscitated
• UGI endoscopy is the primary diagnostic modality
• Intubation if severe bleeding or altered mental status
• Endoscopic therapy indicated in high risk lesions
Combine 2 methods of endoscopic treatment
• IV PPI should be used in high risk patients
![Page 41: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/41.jpg)
Classification of esophageal varices
Grade 1Small
Minimally elevated
veins above surface
AASLD practice guidelines: prevention & management of gastroesophageal varices.Hepatology 2007 ; 46 : 922 – 938.
Grade 2Medium
Tortuous veins occupying
< 1/3 of esophageal lumen
Grade 3Large
Occupying > 1/3 of
esophageal lumen
![Page 42: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/42.jpg)
New classification of esophageal varices
• Small Varices: < 5 mm
• Large Varices: > 5 mm
![Page 43: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/43.jpg)
Classification of gastric varices
Yamada T et all. Yamada’s textbook of gastroenterology.Blackwell Publishing, West Sussex, UK, 5th edition, 2009.
Gastro-Oesophageal Varices
Type I Along lesser curve
Type II To gastric fundus
Isolated Gastric Varices
Type I Fundal
Type II Ectopic
![Page 44: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/44.jpg)
Predictive factors for risk of bleedingNorth Italian Endoscopic Club Index
• Variceal size Best predictor of bleeding
• Severity of liver disease Expressed by Child-Pugh
• Red signs On the varices
NIEC. N Engl J Med 1988 ; 319 : 983 – 989.
![Page 45: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/45.jpg)
Child-Pugh score
Category 1 2 3
Bilirubin (mg/dl) < 2 2 - 3 > 3
Albumin (g/l) > 35 28 – 35 < 28
Ascites Absent Mild- Moderate Severe
Encephalopathy 0 I – II III – IV
INR < 1.7(70%)
1.7 – 2.3(40 – 70%)
> 2.3(< 40%)
Class A: 5 – 6 Class B: 7 – 9 Class C: 10 – 15
![Page 46: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/46.jpg)
MELD Score
0.957 x Loge (creatinine mg/dL)
+
0.378 x Loge (bilirubin mg/dL)
+
1.120 x Loge (INR)
+
0.643∗Multiply score by 10 & round to nearest whole number
Laboratory values < 1.0 are set to 1.0Maximum creatinine within MELD score: 4.0 mg/dl
Dialysis twice/week prior to creatinine test: creatinine 4.0 mg/dl* 0.643 for etiology to make score comparable to previous published data
![Page 47: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/47.jpg)
Score 3 month mortality
≥ 40 100%
30 – 39 83%
20 – 29 76%
10 – 19 27%
< 10 4%
Interpretation of MELD score
The maximum score given for MELD is 40
All values > 40 are given a score of 40
www.unos.org/resources/MeldPeldCalculator
![Page 48: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/48.jpg)
Treatment of acute variceal bleeding Recommendations - 1
• Best approach is combined use of: - Pharmacological agent started from admission &
- Endoscopic procedure
• Terlipressin & somatostatin preferable if availableOctreotide, vasopressin + nitroglycerin may be used
• Drug therapy maintained for at least 48 h 5 day therapy recommended to prevent early rebleeding
![Page 49: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/49.jpg)
Treatment of acute variceal bleeding Recommendations - 2
• Bleeding EV
Band ligation is the endoscopic treatment of choice
Sclerotherapy may be used
• Bleeding GV
Obturation with cyanoacrylate
• TIPS
Rescue procedure if medical & endoscopic tt fails
Bleeding from GV may require earlier decision for TIPS
![Page 50: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/50.jpg)
• Shunt surgery
Mesocaval graft shunts or traditional portacaval shunts
may be an alternative to TIPS in Child A patients
• Blood transfusion
Done cautiously using packed red cells (Ht: 25 – 28 %)
Plasma expanders to maintain hemodynamic stability
• Prophylaxis of infection
Given to all patients (norfloxacin 400 mg /12 hours)
Treatment of acute variceal bleeding Recommendations - 3
![Page 51: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/51.jpg)
Esophageal varices
Endoscopic view of
esophageal varices
Varix endoscopically
ligated with a band
![Page 52: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/52.jpg)
TIPS
![Page 53: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/53.jpg)
Transjugular Intrahepatic Portosystemic Shunt
Technique Metallic stent between branch of PV & HV
Under sedation with local anesthesia
US guidance essential during the procedure
Time of procedure: 1 – 2 hours
Difficult (skilled interventional radiologist)
Indications Control of bleeding from EV or GV
Medical & endoscopic tt given before TIPS
Results Bleeding control 90 %
Mortality < 1 %
![Page 54: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/54.jpg)
General results of surgical shunts
Bleeding Prevented or at least decreasedVarices disappear in 6 – 12
months
Complications Post-operative jaundiceIncrease cardiac output & failure
Hepatic encephalopathy May be transientChronic changes in 30 – 40 %Increase with the size of shuntMore common in older patients
Mortality 5 % in good-risk patients50 % in poor-risk patients
![Page 55: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/55.jpg)
Side-to side porto-caval shunt
![Page 56: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/56.jpg)
Distal spleno-renal shunt
Veins feeding varices ligated: coronary-rt gastric-rt gastroepiploic
Spleen is preserved
![Page 57: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/57.jpg)
Distal spleno-renal shunt
Mortality similar to non-selective shunts
Hepatic encephalopathy similar to non-selective shunts
Better results in non-alcoholic patients & in gastric varices
Does not interfere with subsequent liver transplant
Technically difficult (fewer surgeons willing to perform it)
![Page 58: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/58.jpg)
Causes of bleeding in PHT
• Esophageal varices
• Gastric varices
• Ectopic varices
• Portal hypertensive gastropathy
![Page 59: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/59.jpg)
Portal gastropathy
Mosaic-like mucosal pattern
Snake-skin appearance
![Page 60: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/60.jpg)
Endoscopic images of PHT gastropathy New Italian Endoscopic Club
• Mosaic-like mucosal pattern (snake-skin appearance)
• Red point lesions
Small (<1 mm), red, flat, point-like marks
• Cherry-red spots
Large (>2 mm), round, red-colored, protruding lesions
• Black–brown spots
Irregular black & brown flat spots not fading upon washing
Might represent intramucosal hemorrhage
Primignani M et al. Gastroenterology 2000 ; 119 : 181 – 187.
![Page 61: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/61.jpg)
PHT gastropathy – Four main findingsMild (pink) Moderate (red)
Mosaic-like patternSnake-skin appearance
Black-brown Brown spot Black–brown spots
Red point lesions
Small (<1 mm)
Cherry-red spotsLarge (>2 mm)
Gastroenterology 2000;119:181-187.
![Page 62: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/62.jpg)
Mallory-Weiss syndrome
Retroflexed view
5- 10 % of UGI bleeding
Typically in gastric mucosa
Stop spontaneously in 80-90%
Not bleeding: discharge promptly
Active bleeding: injection – banding
![Page 63: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/63.jpg)
LA classification system of esophagitis Grade A
One (or more) mucosal break, no longer than 5 mm,
that does not extend between tops of 2 mucosal folds
![Page 64: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/64.jpg)
One (or more) mucosal break, more than 5 mm long, that
does not extend between tops of two mucosal folds
LA classification system of esophagitis Grade B
![Page 65: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/65.jpg)
One (or more) mucosal break continuous between tops of >
2 mucosal folds, but which involves < 75% of circumference
LA classification system of esophagitis Grade C
![Page 66: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/66.jpg)
One (or more) mucosal break that involves at least
75% of the esophageal circumference
LA classification system of esophagitis Grade D
![Page 67: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/67.jpg)
Barrett’s esophagus
Endoscopic view of distal esophagus from a patient with GERD
Tongue of Barrett’s mucosa (b) & Schatzki’s ring(s) (arrow)
![Page 68: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/68.jpg)
Esophageal candidiasis
Multiple small white plaques of Candida seen on background
of abnormally reddened esophageal mucosa
![Page 69: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/69.jpg)
Herpes Simplex in the esophagus
Appearance not diagnostic of HSV infection
It could be due to drug-induced lesion (K supplement)
Presence of vesicles in mucosa virtually diagnostic of HSV
Small volcano-like ulcers due to HSV
![Page 70: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/70.jpg)
CMV esophagitis
Solitary deep well-circumscribed ulcer
at gastroesophageal junction
![Page 71: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/71.jpg)
Cancer of gastroesophageal junction
Large malignant mass at GE junction
![Page 72: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/72.jpg)
Watermelon stomach
Gastrointest Endosc 2005; 61 : 631 - 633.
![Page 73: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/73.jpg)
AmpullomaEndoscopic view
![Page 74: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/74.jpg)
Hemobilia
Blood clot protruding from the ampulla
Corresponding ERCP
![Page 75: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/75.jpg)
Causes of lower GI bleeding
Common
Diverticula
Vascular ectasia
Less Frequent
Neoplasia
IBD
Colitis: ischemia – radiation
Hemorrhoids
Small bowel source
UGI source
Rare
Dieulafoy’s lesion
Colonic ulceration
Rectal varices
![Page 76: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/76.jpg)
Diverticular disease of the colon
Wide-mouthed openings to diverticula are present
They were seen throughout the sigmoid colon in this patient
![Page 77: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/77.jpg)
Mucosal telangiectasia of the colon
The patient presented with hematochezia
The lesion was subsequently cauterized endoscopically
![Page 78: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/78.jpg)
Telangiectasia
Telangiectasia in duodenum in
patient with microcytic anemia
Treatment with APC
(Argon Plasma Coagulation)
![Page 79: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/79.jpg)
Endoscopic polypectomy
Snare passed through endoscope
& positioned around polyp (P)
Cautery applied & polyp resected
leaving clean mucosal defect
![Page 80: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/80.jpg)
Ulcerative colitis
Colonic mucosa in a patient with idiopathic ulcerative colitis,
showing a friable mucosa, extensive ulceration, and exudates.
![Page 81: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/81.jpg)
Ulcerative colitis
Air contrast barium enema demonstrating luminal narrowing
& loss of haustra in sigmoid & descending colon in UC
![Page 82: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/82.jpg)
Crohn’s disease
Aphthous ulcers in the rectum in a patient with Crohn’s disease
Lee YJ et al. Endoscopy 2006; 38 : 592 – 597.
![Page 83: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/83.jpg)
Crohn’s disease
Longitudinal ulcers & cobblestone appearance
in a patient with Crohn’s disease
Lee YJ et al. Endoscopy 2006; 38 : 592 – 597.
![Page 84: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/84.jpg)
Crohn’s disease of the ileum
Luminal narrowing
Mucosal ulceration
Separation of barium-filled loops (thickening of bowel wall)
Small bowel follow-through in ileal Crohn’s disease
![Page 85: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/85.jpg)
NSAIDs-induced colitis
Endoscopically nonspecific findings
Histologically nonspecific
DD: infections, IBD, ischemia, vasculitis
![Page 86: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/86.jpg)
Radiation proctitis
Radiation proctitis in a patient with hematochezia
Extensive neovascularization of the mucosa
![Page 87: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/87.jpg)
Rectal Dieulafoy’s lesion
Gastrointest Endosc 2004 ; 60 : 796.
Endoscopic appearance During ligation After ligation
![Page 88: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/88.jpg)
Classification of hemorrhoids
Degree Description
First degree Project a short way into anal canal Only symptom is bleeding
Second degree Prolapse during defecation Reduce spontaneously
Third degree Must be reduced manually
Fourth degree Irreducible
![Page 89: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/89.jpg)
Internal hemorroids Seen with the proctoscope
![Page 90: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/90.jpg)
Prolapse of 3 mains hemorrhoidal piles
![Page 91: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/91.jpg)
Preferences for treatment of hemorrhoids
Degree or Grade Treatment
1 Sclerosing injectionsInfrared coagulation
2 Infrared coagulation Rubber band ligation
3 Rubber band ligation
4 Hemorrhoidectomy
![Page 92: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/92.jpg)
Sclerosing injection
![Page 93: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/93.jpg)
Infrared photocoagulation
![Page 94: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/94.jpg)
Rubber band ligation
![Page 95: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/95.jpg)
Rubber band ligation
![Page 96: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/96.jpg)
Anal fissure
![Page 97: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/97.jpg)
Meckel’s divertculum
Isotope scan with Tc99m
![Page 98: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/98.jpg)
Approach to lower GI bleeding
• Less common than UGI bleeding
• Usually less hemodynamicaly significant
• Most common cause of severe bleeding: diverticula
• Most common cause of minor bleeding: hemorrhoids
• Controversial best diagnostic approach if severe:
Urgent colonoscopy – RBC scintigraphy – angiography
![Page 99: Approach to gastrointestinal bleeding](https://reader036.vdocuments.site/reader036/viewer/2022062303/554b00dbb4c905fc0e8b4fc0/html5/thumbnails/99.jpg)
Thank You