appendix - mhlw...appendix l 4 histological findings: non-neoplastic lesions: summary, rat: female:...
TRANSCRIPT
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テトラクロロエチレンのラット及びマウスを用いた
吸 入 に よ る が ん 原 性 試 験 報 告 書
APPENDIX(L1~T2)
がん原性試験 NO. 0104;0105
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(Study No. 0104.0105)
APPENDIXES (CONTINUED)
APPENDIX L 1 HISTOLOGICAL FINDINGS: NON-NEOPLASTIC LESIONS:SUMMARY, RAT: MALE: DEAD AND MORIBUND ANIMALS( 2-YEAR STUDY )
APPENDIX L 2 HISTOLOGICAL FINDINGS: NON-NEOPLASTIC LESIONS:SUMMARY, RAT: FEMALE: DEAD AND MORIBUND ANIMALS( 2-YEAR STUDY )
APPENDIX L 3 HISTOLOGICAL FINDINGS: NON-NEOPLASTIC LESIONS:SUMMARY, RAT: MALE: SACRIFICED ANIMALS ( 2-YEARSTUDY )
APPENDIX L 4 HISTOLOGICAL FINDINGS: NON-NEOPLASTIC LESIONS:SUMMARY, RAT: FEMALE: SACRIFICED ANIMALS ( 2-YEARSTUDY )
APPENDIX L 5 HISTOLOGICAL FINDINGS: NON-NEOPLASTIC LESIONS:SUMMARY, MOUSE: MALE: DEAD AND MORIBUND ANIMALS( 2-YEAR STUDY )
APPENDIX L 6 HISTOLOGICAL FINDINGS: NON-NEOPLASTIC LESIONS:SUMMARY, MOUSE: FEMALE: DEAD AND MORIBUND ANIMALS( 2-YEAR STUDY )
APPENDIX L 7 HISTOLOGICAL FINDINGS: NON-NEOPLASTIC LESIONS:SUMMARY, MOUSE: MALE: SACRIFICED ANIMALS ( 2-YEARSTUDY )
APPENDIX L 8 HISTOLOGICAL FINDINGS: NON-NEOPLASTIC LESIONS:SUMMARY, MOUSE: FEMALE: SACRIFICED ANIMALS ( 2-YEARSTUDY )
APPENDIX M1 HISTOLOGICAL FINDINGS: NEOPLASTIC LESIONS: SUMMARY,RAT: MALE: DEAD AND MORIBUND ANIMALS ( 2-YEAR STUDY )
APPENDIX M2 HISTOLOGICAL FINDINGS: NEOPLASTIC LESIONS: SUMMARY,RAT: FEMALE: DEAD AND MORIBUND ANIMALS ( 2-YEAR STUDY )
APPENDIX M3 HISTOLOGICAL FINDINGS: NEOPLASTIC LESIONS: SUMMARY,RAT: MALE: SACRIFICED ANIMALS ( 2-YEAR STUDY )
APPENDIX M4 HISTOLOGICAL FINDINGS: NEOPLASTIC LESIONS: SUMMARY,RAT: FEMALE: SACRIFICED ANIMALS ( 2-YEAR STUDY )
APPENDIX M5 HISTOLOGICAL FINDINGS: NEOPLASTIC LESIONS: SUMMARY,MOUSE: MALE: DEAD AND MORIBUND ANIMALS
( 2-YEAR STUDY )
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(Study No. 0104.0105)
APPENDIXES (CONTINUED)
APPENDIX M6 HISTOLOGICAL FINDINGS: NEOPLASTIC LESIONS: SUMMARY,MOUSE: FEMALE: DEAD AND MORIBUND ANIMALS
( 2-YEAR STUDY )
APPENDIX M7 HISTOLOGICAL FINDINGS: NEOPLASTIC LESIONS: SUMMARY,MOUSE: MALE: SACRIFICED ANIMALS ( 2-YEAR STUDY )
APPENDIX M8 HISTOLOGICAL FINDINGS: NEOPLASTIC LESIONS: SUMMARY,MOUSE: FEMALE: SACRIFICED ANIMALS ( 2-YEAR STUDY )
APPENDIX N1 NUMBER OF ANIMALS WITH TUMORS AND NUMBER OFTUMORS-TIME RELATED: RAT: MALE ( 2-YEAR STUDY )
APPENDIX N2 NUMBER OF ANIMALS WITH TUMORS AND NUMBER OFTUMORS-TIME RELATED: RAT: FEMALE ( 2-YEAR STUDY )
APPENDIX N3 NUMBER OF ANIMALS WITH TUMORS AND NUMBER OFTUMORS-TIME RELATED: MOUSE: MALE ( 2-YEAR STUDY )
APPENDIX N4 NUMBER OF ANIMALS WITH TUMORS AND NUMBER OFTUMORS-TIME RELATED: MOUSE: FEMALE ( 2-YEAR STUDY )
APPENDIX O1 NEOPLASTIC LESIONS-INCIDENCE AND TIMU OF TUMOR OCCURRENCE RAT: MALE
APPENDIX O2 NEOPLASTIC LESIONS-INCIDENCE AND TIMU OF TUMOR OCCURRENCE RAT: FEMALE
APPENDIX O3 NEOPLASTIC LESIONS-INCIDENCE AND TIMU OF TUMOR OCCURRENCE MOUSE RAT: MALE
APPENDIX O4 NEOPLASTIC LESIONS-INCIDENCE AND TIMU OF TUMOR OCCURRENCE MOUSE RAT: FEMALE
APPENDIX P1 NEOPLASTIC LESIONS-INCIDENCE AND STATISTICALANALYSIS: RAT: MALE ( 2-YEAR STUDY )
APPENDIX P2 NEOPLASTIC LESIONS-INCIDENCE AND STATISTICALANALYSIS: RAT: FEMALE ( 2-YEAR STUDY )
APPENDIX P3 NEOPLASTIC LESIONS-INCIDENCE AND STATISTICALANALYSIS: MOUSE: MALE ( 2-YEAR STUDY )
APPENDIX P4 NEOPLASTIC LESIONS-INCIDENCE AND STATISTICALANALYSIS: MOUSE: FEMALE ( 2-YEAR STUDY )
APPENDIX Q1 IDENTITY AND PURITY OF TETRACHLOROETHYENE PERFORMED AT THE JAPANBIOASSAY LABORATORY ( 2‐YEAR STUDY )
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(Study No. 0104.0105)
APPENDIXES (CONTINUED)
APPENDIX Q 2 STABILITY OF TETRACHLOROETHYENE AT THE JAPAN BIOASSAY LABORATORY ( 2‐YEAR STUDY )
APPENDIX R1 CONCENTRATION OF TETRACHLOROETHYENE IN INHALATION CHAMBER ( 2‐YEAR STUDY )
APPENDIX R2 ENVIRONMENT OF INHALATION CHAMBER ( 2‐YEAR STUDY )
APPENDIX S1 NUTRIENTS IN RAT AND MOUSE FEED
APPENDIX S2 CONTAMINANTS IN RAT AND MOUSE FEED
APPENDIX T1 METHODS FOR HEMATOLOGY, BIOCHEMISTRY AND URINALYSIS
APPENDIX T2 UNITS AND DECIMAL PLACE FOR HEMATOLOGY AND BIOCHEMISTRY
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APPENDIX L 1
HISTOLOGICAL FINDINGS : NON-NEOPLASTIC LESIONS : SUMMARY
RAT : MALE : DEAD AND MORIBUND ANIMALS
(2-YEAR STUDY)
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APPENDIX L 2
HISTOLOGICAL FINDINGS : NON-NEOPLASTIC LESIONS : SUMMARY
RAT : FEMALE : DEAD AND MORIBUND ANIMALS
(2-YEAR STUDY)
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APPENDIX L 3
HISTOLOGICAL FINDINGS : NON-NEOPLASTIC LESIONS : SUMMARY
RAT : MALE : SACRIFICED ANIMALS
(2-YEAR STUDY)
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APPENDIX L 4
HISTOLOGICAL FINDINGS : NON-NEOPLASTIC LESIONS : SUMMARY
RAT : FEMALE : SACRIFICED ANIMALS
(2-YEAR STUDY)
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APPENDIX L 5
HISTOLOGICAL FINDINGS : NON-NEOPLASTIC LESIONS : SUMMARY
MOSUE : MALE : DEAD AND MORIBUND ANIMALS
MOSUE (2-YEAR STUDY)
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APPENDIX L 6
HISTOLOGICAL FINDINGS : NON-NEOPLASTIC LESIONS : SUMMARY
MOSUE : FEMALE : DEAD AND MORIBUND ANIMALS
(2-YEAR STUDY)
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APPENDIX L 7
HISTOLOGICAL FINDINGS : NON-NEOPLASTIC LESIONS : SUMMARY
MOSUE : MALE : SACRIFICED ANIMALS
(2-YEAR STUDY)
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APPENDIX L 8
HISTOLOGICAL FINDINGS : NON-NEOPLASTIC LESIONS : SUMMARY
MOSUE : FEMALE : SACRIFICED ANIMALS
(2-YEAR STUDY)
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APPENDIX M 1
HISTOLOGICAL FINDINGS : NEOPLASTIC LESIONS : SUMMARY
RAT : MALE : DEAD AND MORIBUND ANIMALS
(2-YEAR STUDY)
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APPENDIX M 2
HISTOLOGICAL FINDINGS : NEOPLASTIC LESIONS : SUMMARY
RAT : FEMALE : DEAD AND MORIBUND ANIMALS
(2-YEAR STUDY)
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APPENDIX M 3
HISTOLOGICAL FINDINGS : NEOPLASTIC LESIONS : SUMMARY
RAT : MALE : SACRIFICED ANIMALS
(2-YEAR STUDY)
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APPENDIX M 4
HISTOLOGICAL FINDINGS : NEOPLASTIC LESIONS : SUMMARY
RAT : FEMALE : SACRIFICED ANIMALS
(2-YEAR STUDY)
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APPENDIX M 5
HISTOLOGICAL FINDINGS : NEOPLASTIC LESIONS : SUMMARY
MOSUE : MALE : DEAD AND MORIBUND ANIMALS
MOSUE (2-YEAR STUDY)
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APPENDIX M 6
HISTOLOGICAL FINDINGS : NEOPLASTIC LESIONS : SUMMARY
MOSUE : FEMALE : DEAD AND MORIBUND ANIMALS
(2-YEAR STUDY)
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APPENDIX M 7
HISTOLOGICAL FINDINGS : NEOPLASTIC LESIONS : SUMMARY
MOSUE : MALE : SACRIFICED ANIMALS
(2-YEAR STUDY)
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APPENDIX M 8
HISTOLOGICAL FINDINGS : NEOPLASTIC LESIONS : SUMMARY
MOSUE : FEMALE : SACRIFICED ANIMALS
(2-YEAR STUDY)
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APPENDIX N1
NUMBER OF ANIMALS WITH TUMORS AND NUMBER OF TUMORS-TIME RELATED
RAT : MALE
(2-YEAR STUDY)
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APPENDIX N2
NUMBER OF ANIMALS WITH TUMORS AND NUMBER OF TUMORS-TIME RELATED
RAT : FEMALE
(2-YEAR STUDY)
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APPENDIX N3
NUMBER OF ANIMALS WITH TUMORS AND NUMBER OF TUMORS-TIME RELATED
MOSUE : MALE
(2-YEAR STUDY)
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APPENDIX N4
NUMBER OF ANIMALS WITH TUMORS AND NUMBER OF TUMORS-TIME RELATED
MOSUE : FEMALE
(2-YEAR STUDY)
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APPENDIX O 1
NEOPLASTIC LESIONS-INCIDENCE AND TIME OF TUMOR OCCURRENCE
RAT : MALE
(2-YEAR STUDY)
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APPENDIX O 2
NEOPLASTIC LESIONS-INCIDENCE AND TIME OF TUMOR OCCURRENCE
RAT : FEMALE
(2-YEAR STUDY)
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APPENDIX O 3
NEOPLASTIC LESIONS-INCIDENCE AND TIME OF TUMOR OCCURRENCE
MOSUE: MALE
(2-YEAR STUDY)
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APPENDIX O 4
NEOPLASTIC LESIONS-INCIDENCE AND TIME OF TUMOR OCCURRENCE
MOSUE : FEMALE
(2-YEAR STUDY)
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APPENDIX P 1
NEOPLASTIC LESIONS-INCIDENCE AND STATISTICAL ANALYSIS
RAT : MALE
(2-YEAR STUDY)
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APPENDIX P 2
NEOPLASTIC LESIONS-INCIDENCE AND STATISTICAL ANALYSIS
RAT : FEMALE
(2-YEAR STUDY)
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APPENDIX P 3
NEOPLASTIC LESIONS-INCIDENCE AND STATISTICAL ANALYSIS
MOSUE: MALE
(2-YEAR STUDY)
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APPENDIX P 4
NEOPLASTIC LESIONS-INCIDENCE AND STATISTICAL ANALYSIS
MOSUE : FEMALE
(2-YEAR STUDY)
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APPENDIX Q 1
IDENTITY AND PURITY OF TETRACHLOROETHYLENE
PERFORMED AT THE JAPAN BIOASSAY LABORATORY
(2-YEAR STUDY)
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APPENDIX Q 2
STABILITY OF TETRACHLOROETHYLENE AT THE JAPAN BIOASSAY LABORATORY
(2-YEAR STUDY)
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APPENDIX R 1
CONCENTRATION OF TETRACHLOROETHYLENE IN INHALATION CHAMBER
(2-YEAR STUDY)
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APPENDIX R 2
ENVIRONMENT OF INHALATION CHAMBER
(2-YEAR STUDY)
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APPENDIX S 1
NUTRIENTS IN RAT AND MOUSE FEED
(2-YEAR STUDY)
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APPENDIX S 2
CONTAMINANTS IN RAT AND MOUSE FEED
(2-YEAR STUDY)
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APPENDIX T 1
METHODS FOR HEMATOLOGY, BIOCHEMISTRY AND URINALYSIS
(2-YEAR STUDY )
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APPENDIX T 2
UNITS AND DECIMAL PLACE FOR HEMATOLOGY AND BIOCHEMISTRY
(2-YEAR STUDY )
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