ap biology. cell specialization during development an organisms cells differentiate from stem cells...
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AP Biology
Cell Specialization
• During development an organisms cells differentiate from Stem cells
• Stem cell – any unspecialized cell that can produce, during a single division one identical daughter cell and one more specialized daughter cell
• This occurs via structural and functional divergence of cells
Cellular organization
1. Molecular level (chemicals)
2. Cell
3. Tissue
4. Organ
5. Organ system
6. Organism
Form and Function
Homeostasis
Feedback
Environment
Disruption
Abiotic Biotic
Response
Behavioral • Timing and
coordination of events
Physiological • Defense • Development
Positive and Negative feedback
• Negative – Reduces frequency, regulates physiological processes back to a target set point (long term)
• Positive – Increase frequency or amplify processes (short term)
Target set point
Negative feedback
Stabilization
Temperature regulation
Plant responses to water
Positive feedback
Amplification
Fruit ripening Lactation in mammals
Child birth
Temp. regulation
Regulator
Vs
Conformer
To become attractive plants produce fruit, this makes them desirable so animals will take and carry off their seeds.
Plants communicate via ethylene – a gas
Other Positives
• Lactation in mammals – When baby drinks milk, hormones prolactin and oxytocin are released, this causes milk to be released and produced.
• Child birth – pressure on cervix causes contractions. Contractions cause more pressure
• Blood clotting – vascular spasms
Decrease blood flow, plug
formation, coagulation
Alteration of feedback
• Some changes to homeostasis are regulated and many are controlled by hormones.• Examples:• Women’s menstrual cycle• Circadian rhythm (changes that occur every 24 hours) • Acclimation- gradual process in which animal adjusts to
external environment
Normal alterations
Maintaining homeostasis physiological
• Thermoregulation – process by which animals maintain an internal temperature
• Endothermic – warmed by heat they generate via metabolism
• Ectothermic – gain heat via external sources
Maintaining homeostasis
• Balancing Heat Loss and gain
• Integumentary system• Insulation • Circulatory adaptations • Cooling via evaporative heat loss
Maintaining homeostasis
• Increases blood flow to help keep warm
• Decreases blood flow to help keep cool
Maintaining homeostasis
• Countercurrent exchange- exchange of heat via fluids or between fluids that are moving in the opposite direction
Maintaining homeostasis behavioral
• Maximize sunlight absorption • Postures• Huddling together• Torpor • Hibernation
Form and Function
Homeostasis
Feedback
Disruptions In Homeostasis
• Homeostatic disruptions are anything that affects the individual or the environment in which the individual lives in
• Can be: • Molecular level• Ecosystem level
Diabetes
• Problem in feedback loops
• Can be • Type I (juvenile or child onset)• Type II
• Both cases cells are not communicating in the feedback loop dealing with blood sugar
Alteration of feedback
Insulin
Blood glucose
glucagon
Diabetes
Molecular disruption
Dehydration:
Molecular disruption
1-2% loss increase in body temperature, thirst, discomfort, loss of appetite, dry skin, constipation
5% loss All above and: headaches, increased heart rate, nausea, tingling limbs
6% loss All of the above and: muscle spasms, cramping
10% loss All above and: susceptibility to heat stroke, circulatory collapse, vision dims, urination stops
50% loss death
Ecosystem disruptions
• Invasive species: A species, often introduced by humans, that takes hold outside its native range
Form and Function
Homeostasis
Feedback
Form and Function
• Response: Anything an organism does as a result of its surroundings
• Can be: • Behavioral • Physiological
Behavioral Responses
• Occurs as a population or a group of organisms• Examples:
1. Hibernation
2. Migration
Can be learned or inherited
Physiological responses
• Changes within the organism• Examples:
1. Shivering
2. Sweating- evaporative cooling
Form and Function
Homeostasis
Feedback
Physiological-Defense
• Plants and animals defend themselves from pathogens• Pathogens- invaders • 2 major forms of defense:
1. Nonspecific
2. Specific
Nonspecific
• Kills anything that invades (skin, saliva, normal bacteria, swelling, inflammation etc.)
• Plants sense pathogens using Hypersensitive Responses
Nonspecific - hypersensitive
• R gene in chromosomes – senses invading proteins
• R gene will initiate a hypersensitive response
• Oxidative burst – apoptosis • Proteins sent to adjacent cells
will change cell wall
• Memory does not occur
Specific
• Specific responses identify pathogens and attack them• Occurs in 2 forms:
1. Humoral – occurs in humor/liquid/blood/lymphatic
2. Cell mediated – target infected cells
Humoral
• Humoral responses are governed by B cells• B cells produce memory Antibodies• Antibodies target invaders• Invaders are called antigens -
Humoral
• Antibodies have antigen-binding sites
• Antigen- is an antibody generating organism
• fungus, bacteria, virus etc.
Humoral
1. Antigen present – invader
2. Antigen is engulfed (eaten) by a WBC or macrophage
3. WBC will take some of the antigen and put it on the surface of its cell (Antigen Presenting Cell)
4. Helper T cells- recognize the shape of the antigen
5. Helper T cells- activate B cells to make antibodies
a. plasma B – makes antibodies
b. memory B
6. B cells invade antigens
Cell-mediated
• This response targets infected cells• Called cytotoxic T cells – kills own cells that are infected
Form and Function
Homeostasis
Feedback
Physiological- Development
How does this happen?
Physiological
• Seed Germination – • When planting seeds it needs 2 things to survive (water and
temperature) must be in correct combination• Germinating cells will appear different
Physiological
• First step in development is cellular differentiation
• DNA will express specific proteins that determine each tissue – called tissue specific proteins
• Cells will eventually specialize
Physiological - differentiation
• Zygote makes a copies of itself• Forms a sphere (blastula) • Blastula folds in on itself (gastrula) forms ectoderm,
mesoderm and endoderm• Transcription factors give off proteins that help to
determine what should happen
Physiological - induction
• Step 2 is embryonic induction:• Cells induce other cells to become like them, give off
proteins • Cells induce adjacent cells next to it
Physiological – cell death
• Just as important as cell growth• Hid, Grim, Reaper Genes• These genes are needed between fingers and toes etc. • microRNA genes – control hid, grim, reaper genes
Physiological- Homeotic genes
• How do cells “know” the body plan of organisms?• Homeotic genes – are a series of genes that “tell”
drosophila where to put the organs/appendages etc.• Famous ones are HOX genes
We learned from the mutants
Ultrabithroax will duplicate the thorax
Antp- one leg will grow of the head
Series of genes that codes for body plan
Form and Function
Homeostasis
Feedback
Timing and control
When traveling – especially across time zones jet-lag occurs
Timing and control - plants
1. Phototrophism – how plants grow toward or away from light
Toward light +
Away from light –
Hormone: Auxin
Timing and control - plants
2. Photoperiodism – how plants respond to changing amounts of light during the season
Phytochrome – light receptor- when absorb light, will change shape to let plant know what time of day and season it is (regulates cellular activities)
Timing and control - animals
• Circadian rhythms – • Animals sense light- • Sent to pineal gland • Releases melatonin which sets internal clock
Timing and control – bacteria
• Bacteria use Quorum Sensing• How bacteria talk or communicate with each other• Can be among species or between species• Bacteria give off autoinducers
Form and Function
Homeostasis
Feedback
Where does evolution fit?
How does change support homeostasis???
Homeostatic evolution
• Homeostasis reflects BOTH common ancestry and divergence!!!
• Continuity • Change
Continuity - Example
• Excretory system – All serve same purpose (get rid of waste)• Flatworms• Earthworms• Vertebrates
flatworms
• Excretory system called Protonephridia• Protonephridia forms networks of tubes connected to
external openings• Flame bulbs (cells) is how waste moves out of the
platyhelminthes
• Rotifers, some annelids, mollusc larvae, and lancelets
Annelids
• Earthworms contain segments have Metanephridia• Metanephridia are excretory organs that collect fluid
directly from the coelom• Each segment has one• Cilia funnel surrounds the opening which excretes waste
out of earthworm
Vertebrates
• Kidneys are present, function in osmoregulation and excretion
• Kidney tubules – nephron
Continuity –
Each phylum of organisms has a way to get rid of waste.
Each are similar but with modification “descent with modification”
Common ancestry
Change
• Homeostatic mechanisms also support change in response to changing environments
• Vertebrates must have oxygen in their environment, must have water in their environments
change
• Example – Respiratory systems
• Aquatic • Terrestrial
Form and Function
Homeostasis
Feedback
Where does evolution fit?
How does change support homeostasis???
Homeostasis contd.
• Organisms exhibit complex properties between organs and systems
• Example: Respiratory and Circulatory systems
Homeostasis
Homeostasis
Homeostasis
Homeostasis
Nervous System works with all systems
How does nervous system function??
Relay system
1. Stimulus2. Receptor3. Afferent pathway 4. Integration center5. Efferent pathway6. Effector organ7. Response
Divisions of nervous System
N.S
Peripheral
Somatic Autonomic
Parasympathetic Sympathetic
Central
Nerve impulses
Nerve impulses
Nerve impulses
Steps:
1. Resting (polarized)
K+
K+K+
Na+
Na+
Na+ Na+
Na+
Na+
Na+
Na+
Na+
Nerve impulses
• Step 2 Depolarization (polarity is reversed)
Nerve impulses
• Step 3 Repolarization • initiation of sodium potassium pumps • Restores initial electrical configuration
Form and Function
Homeostasis
Feedback
Environment
Disruption
Abiotic Biotic
Responses
General
Behavioral • Timing and
coordination of events
Physiological • Defense • Development
Behaviors
• Fixed action pattern
Ex: sticklebacks
Behaviors
• Migration – using environmental cues to guide regular, long-distance change in location
Behaviors
• Courtship – fixed behaviors
1. Visual communication2. Chemical communication 3. Tactile communication
Behaviors
• Cortship
Behaviors
• Honey bee Dances
Behaviors
Behaviors
Behaviors
• Innate behavior – developmentally fixed within an organism
• Learning- the modification of behavior based on specific experiences
Behaviors
• Imprinting – formation at a specific stage in life a long-lasting behavioral response to a particular individual or object
Behaviors
• Associative learning – associate environmental features with another
Classical Conditioning – Pavlov’s dogOperant conditioning – trial and error
Behaviors
• Social Learning:
Behaviors
• Foraging – food-obtaining behaviors
Behaviors
Behaviors
• Mating Systems and Mate Choice• Promiscuous mating
– no strong pair bond
• Monogamous – mates remain together for a longer period
• Polygamous – one male and several females or visa versa
Behaviors
• Altruism – selflessness, reduces an animal’s individual fitness, but increases the fitness of the others in the population