antigenos plaquetarios expo
TRANSCRIPT
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Prof. Boris Valdivia V
UNMSM - 2015
EsSaludMAS SALUD PARA MAS PERUANOS
ANTIGENOS PLAQUETAIOS
!UMANOS " PUEBA #E
$OMPATIBILI#A#
PLAQUETAIA
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A%&'('d'%&'s
) P*as +r'&ra%sf,sio%al's
solo s' r'alia% +ara los
'/a&i's) Uso d' Pla,'&as
so*r'+asa '% +ro/'dio
'l ,so d' (l,las roas.
) 1341-130 ,so d'
+la,'&as a,/'%&o d'
0.61 a 2.7 /illo%'s.
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A%&'('d'%&'s
) 13328 4.9 /illo%'s d'
,%idad's d' +la,'&as
f,'ro% &ra%sf,%didas.
) !NGAI8 12000-15000
+la,'&as:a;o
) 1310< #,='8 'fi(a(ia
&ra%sf,sio% +la,'&as) N,'vos &ra&a/i'%&os >
,so d' (o/+o%'%&'
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ANTIGENOS PLAQUETAIOS
) ABO
) LEWIS
) I
) P
) ANTIGENOS PLAQUETARIOS ESPECIFICOS
o HPA 1 (PLA1
)o HPA 2, etc.
) ANTIGENOS HLA CLASE I
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Antigen! P"#$%et#&i!
Categoria I
A%&?@'%os d' ABO
A%&?@'%os L'< Ii P I%si@%ifi(a%&'sC
A%&?@'%os !LA< $las' I- so% si%&'&iados '%dD@'%a/'%&'> so% +ar&' d' la /'/*ra%a +la,'&aria.
Categoria II
Lla/ados !PA !,/a% Pla&'l'& A%&i@'%sFCA%&?@'%os '(l,sivos d' +la,'&as > /'@a=ario(i&os
So% +rod,(&o d' @'%'s alli(os
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I%/,%olo@?a Pla,'&aria
) Las GP fi@,ra% +ro/i%'%&'/'%&' (o/o aloa%&?@'%os<
a,&oa%&?@'%os > *la%(o d' a%&i(,'r+os d'+'%di'%&'s d'
fHr/a(os
) Los aloa%&?@'%os aso(iados a +la,'&a +,'d'% s'r (lasifi(ados
'% 2 @r,+os 8
) A%&?@'%o +la,'&ario %o 's+'(?fi(o< +r's'%&' '% las +la,'&as
> o&ros &i+os ('l,lar's
) A%&?@'%o 's+'(?fi(o +la,'&ario< ,%i(a/'%&' '+r'sado so*r'
las +la,'&as
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A%&i@'%os Pla,'&arios Es+'(?fi(os
) #' las do('%as d' GP d' /'/*ra%a +la,'&aria r'(o%o(idas< al
/'%os 5 GP Ia< I* alfa > *'&a C< II*< IIIa< > $# 103 C so%
+oli/Drfi(as > 's&H d'/os&rado ,' so% aloi/%,%o@%i(as
) E% la a(&,alidad s' a% d's(ri&o 29 APE< i%(l,>'%do s, lo(alia(iD%
's&r,(&,ral '% la GP d' /'/*ra%a +la,'&aria< (,a%&ifi(a(iD% d'
d'%sidad a%&i@%i(a so*r' la s,+'rfi(i' +la,'&aria > d'&'r/i%a(iD%d' +oli/orfis/o d' A#N '% los @'%'s ,' (odifi(a% los a%&?@'%os.
) P,'d' +r's'%&ars' isoi%/,%ia(iD% a ,%a s'&a @li(o+ro&'?%a la GP
IV $# 97 C ,' 's&H a,s'%&' '% al@,%os i%divid,os.
) A+ro. 9 5 J d' asia&i(os > %'@ros +r's'%&a% a,s'%(ia d' 's&a GP >
+,'d'% s'r s'%si*ilidos a GPIV a &ravs d' &ra%sf,siD% o '/*arao.
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A%&?@'%o +la,'&ario %o 's+'(?fi(o 8
) Es&os aloa%&?@'%os %o 's&H% r's&ri%@idos a li%a' +la,'&a
/'@a(ario(i&o ' i%(l,>'% 'l !LA > los d'&'r/i%a%&'s d' @r,+o
sa%@,?%'o ABO
) Las +la,'&as '+r'sa% a%&?@'%os !LA (las' 1 > %o a>
'vid'%(ia d' '+r'siD% d' ,' 'is&a /ol(,las !LA II
) Los A@ !LA $las' 1 so% al&a/'%&' +oli/Drfi(os > so%
(lasifi(ados (o/o A%&?@'%os A< B< > $
) La '+r'siD% d' 's&os a%&?@'%os so*r' las +la,'&as var?a > 's
i%fl,'%(iado +or 'l dosa' d' @'%'s
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) La (a%&idad d' A%&?@'%os !LA A > !LA B< 's al
/'%os 10 v'('s /a>or ,' la d' !LA $< ,' (,'%&a +ara
la *aa i%/,%o@'%'(idad d' a%&?@'%os !LA $
+la,'&arios
) Es&o a(' i%%'('sario &'s&'ar a%&?@'%os d'l lo(,s !LA $
'% la &ra%sf,siD% d' +la,'&as
) A%&?@'%os d'l @r,+o AB! so% '+r'sados +or ,% %K/'ro
d' GP +la,'&arias &al's (o/o GP I* V- I
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Sis&'/a A%&i@%i(o !LA !PA
) Varios a%&?@'%os +la,'&arios< al@,%os d' los (,al's so%
(o/+ar&idos +or o&ros li%a's ('l,lar's< &al (o/o ABO > !LA.Es&os A@ so% ,%a +ar&' i%&ri%s'(a d' la /'/*ra%a ('l,lar.
) El @r,+o /as @ra%d' d' a%&i(,'r+os r'a(&ivos 's&a diri@ido (o%&ra
a%&?@'%os !LA 1< (o/+ar&ido +or +la,'&as > (l,las *la%(as
) Es&os A(s so% los /as aso(iados (o% r'fra(&ari'dad +la,'&aria< ,''s la falla +ara o*&'%'r ,% ad'(,ado a,/'%&o d' +la,'&as l,'@o
d' ,%a &ra%sf,siD%
) S' d'&'(&a% +or +r,'*as d' li%fo(i&o&oi(idad
) A(s a%&i !LA s' +rod,('% '% +a(i'%&'s +oli&ra%sf,%didos >
/,'r's /,l&?+aras
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Pr'vi'%' aloi%/,%ia(iD% 8
) #'+l'(iD% d' l',(o(i&os) adia(iD% UV
) E+osi(iD% li/i&ada a /Kl&i+l's do%ador's +or ,so d' afr'rsis
A(s a%&i !LA +,'d'% s'r dif'r'%(iados d' A(s a%&i+la,'&arios
r'a(&ivos +or 'l &'s& MAIPA< ,' 's ,% '%sa>o 's+'(?fi(o +ara GP +la,'&aria
ad'/Hs s' d'/os&rD ,' 's /Hs s'%si*l' ,' la L$T '% la d'&'((iD% d'A(s a%&i !LA r'a(&ivo a +la,'&as
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ANTIGENOS
PLAQUETAIOS
ANTIGENOS ESPECIFICOS
INI$IALMENTE UEON EN$ONTA#OS EN PLAQUETAS. TAMBIEN
SE !A #EMOSTA#O EN $ELULAS EN#OTELIALES " MUS$ULO LISO.
SON GP #E LA SUPEAMILIA #E LAS INTEGINAS.
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ANTIGENOS PLAQUETARIOS
Es&r,(&,ras s,+'rfi(ial's d' MP< '+r'sadas +or Polisa(aridos aso(iados a GP
Ma>or +ar&' d'&'r/i%a%&'s a%&i@%i(os s' lo(alia% '% las GP
) So% r's+o%sa*l's d' la a+ari(iD% d' div'rsos (,adro (l?%i(os8
T&'citeni# nen#t#" #" * in'%ne
P+&% t&'citenic# !ttn!-%!in#"
Re#ccine! -e&i"e! n e'"/tic#! !t tn!-%!in#"e!
Re-ct#&ie0#0 # "# tn!-%!in 0e "#$%et#!
P+&% t&'citenic# #%tin'%ne
T&'citeni# in'%n #"&gic# c#%!#0# &
'e0ic#'ent!
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ANTIGENOS PLAQUETARIOS
ISOANTIGENOS
$LASII$A$ION8
ISOANTIGENOS QUE SIMULAN ALOANTIGENOS 8 &odas las
+la,'&as so% i%(o/+a&i*l's
AUTOANTIGENOS 8 r'la(io%ados (o% GP II*-IIIa
$IPTOANTIGENOS 8 A@ T%d'f. N-a('&il@al(-&raC
ENOANTIGENOS 8 d'fi%idos +or s,'ros d' +ro('d'%(ia
a%i/al ISOANTIGENOS ELA$IONA#OS $ON ME#I$AMENTOS 8 i%d,-
(ida +or al@K% /'di(a/'%&oi%/,%o(o/+l'os< adsor(iD% >
+or a((iD% a,&oi%/,%'.
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ANTIGENOS PLAQUETAIOS
!PA-1
!PA-6
!PA-7
!PA-4
!PA-
!PA-10
!PA-9
Aloa%&i@'%o MA
!PA-5
!PA-2
$o/+l'o @li(o+ro&'i(o
II* : IIIa
II* 9
GP Ia : IIa
9 1
GP I*
ALOANTIGENOS
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ANTIGENOS PLAQUETARIOS
CCC
GCC
C
G
(407)
(407)
Prolina
Alanina
IIIaPA!7a
PA!7"
PA!7
CGG
CAG
G
A
(4#$)
(4#$)
Ar%inina
Glu&a'ina
IIIaPA!a
PA!"
PA!
GAGAAG
GA
(0)(0)
Glu&a'inaLisina
IaPA!aPA!"
PA!
CGA
CAA
G
A
(*4+)
(*4+)
Ar%inina
Glu&a'ina
IIIaPA!4a
PA!4"
PA!4
ATC
AGC
T
G
(#4+)
(#4+)
Isol,u-ina
S,rina
II"PA!+a
PA!+"
PA!+
ACG
ATG
C
T
(*4)
(*4)
Tr,onina
.,&ionina
I"PA/a
PA!"
PA!
CTG
CCG
T
C
(++)
(++)
L,u-ina
Prolina
IIIaPA!*a
PA!*"
PA!*
Codon1as,Posi-ionA'inoa-idoGli-o2ro&,inaAn&i%,noSis&,'a
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) Los a%&?@'%os r'+r's'%&ados '% la /'/*ra%a
+la,'&aria s' '%(,'%&ra% dis&ri*,idos '% &r's
sis&'/as8) A,'llos ,' s' '+r'sa% '(l,siva/'%&' '%
+la,'&as los lla/a/os !PA A%&?@'%os Pla,'&arios
!,/a%os C > lo (o%s&i&,>'% 26 aloa%&?@'%os .
) Los +r's'%&'s &a/*i% '% l',(o(i&os '% ,% &o&al d' 5lla/ados !LA d'l &i+o I A< B > $C .
) A%&?@'%os ,' s' alla% dis&ri*,idos '% o&ras (l,las<
(o/o +or ''/+lo '% los 'ri&ro(i&os< lla/ados@'%ri(a/'%&' a%&?@'%os %o +la,'&arios 's+'(?fi(os
ANPEC '% ,% &o&al d' 7 sis&'/as
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) Los aloa%&?@'%os d' +la,'&as s' a@r,+a% '% 2 @ra%d's
(a&'@or?as8
) Los 's+'(?fi(os d' 's&as (l,las< '%&r' los ,' s' '%(,'%&ra% los
A@s !PA-1< !PA-2 !PA-9< !PA-6< !PA-5< !PA-7< !PA-4<
!PA-
) > !PA-10 ,' 's&H% lo(aliados '% las @li(o+ro&'?%as d'
/'/*ra%a II* IIIa > Ia Iia
) Los (o/+ar&idos (o% o&ros &'idos (o/o los a%&?@'%os
'ri&ro(i&arios ABO > las /ol(,las !LA (las' I
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I/+or&a%(ia d' los A%&?@'%os Pla,'&arios
) Ti'%'% i/+or&a%(ia f,%da/'%&al '% 'l (a/+o d' lai%/,%o'/a&olo@?a > &ra%s+la%&' d' Dr@a%os.
) Ad'/Hs so% r's+o%sa*l's d' ,%a @ra% div'rsidad d'
&ras&or%os ,' va% d'sd' las aloi%/,%isa(io%'s f'&o/a&'r%as
> &ra%sf,sio%al's as&a las (i&o+'%ias a,&oi%/,%'.) So% a%&i(,'r+os ,' s' ,%'% a las +la,'&as< lo ,' +,'d'
o(asio%ar ,% a,/'%&o '% la d's&r,((iD% d' las /is/as. Es&o
+rovo(a ,% *ao (o%&'o d' +la,'&as &ro/*o(i&o+'%iaC >
+,'d' 's&ar aso(iado (o% sa%@rado.
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I/+or&a%(ia d' los A%&?@'%os Pla,'&arios
) E% 'l (aso d' las dro@as 's&as s' ,%'% a las +ro&'?%as d' la
/'/*ra%a +la,'&aria /odifi(a%do s, 's&r,(&,ra lo ,' a('
,' 'l sis&'/a i%/,%' %o las r'(o%o(a.
) Es&os a%&i(,'r+os +,'d'% s'r i%d,(idos +or 'l ,so d' al@,%os
/'di(a/'%&os'+ari%aC o la s'%si*ilia(iD%.
) Es&os a(&Ka% (o/o (rio@l,&i%i%as >a ,' la /a>or?a d' las v'('s
solo s' a(&iva% a &'/+'ra&,ra a/*i'%&' > %o a 94R$
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Aloi%/,%ia(iD% Pla,'&ariafa(&or's a &'%'r '% (,'%&a 8
) r'(,'%(ia > (a%&idad d' '/o(o/+o%'%&'s &ra%sf,%didos
) $o/*i%a(iD% d' '/o(o/+o%'%&'s &ra%sf,%didos
) #ia@%Ds&i(o d'l +a(i'%&'
) M'di(a/'%&os i%/,%os,+r'sor's ,sados
) a(&or's @'%&i(os ,sados
) #?fi(,l&ad '% dia@%os&i(ar fa(&or's ,' af'(&a% la r's+,'s&a a&ra%sf,(io%'s d' +la,'&as
) N'('sidad d' dif'r'%(iar '%&r' +a(i'%&'s ,' so% r'fra(&orios
d'*ido a /'(a%is/os I%/,%'s o No-I%/,%'s
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EA$TAIE#A#.- $a,sas
) NO INMUNES
Es+l'%o/'@alia
i'*r'< I%f'((io% $I#
!'/orra@ia
$alidad d' +la,'&as
&ra%sf,%didas S'+sis
#ro@as
) INMUNE
AloI%/,%ia(iD% a8
) !LA) Pla,'&arios
) ABO
A,&oa%&i(,'r+os
M'di(a/'%&os) $o/+l'os i%/,%'s
(ir(,la%&'s
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#ia@%Ds&i(o d' aloi%/,%ia(iD%
) Es *asado '% la d'&'((iD% d' a%&i(,'r+os (o%&ra
+la,'&as > l',(o(i&os o/Dlo@os
) Pr's'%(ia d' a%&i(,'r+os li%fo(i&o&Di(os'vid'%(ia aloi%/,%ia(iD% (o%&ra a%&?@'%os d'l
sis&'/a !LA.
) A%&i(,'r+os a%&i+la,'&arios so% d' %a&,ral'a
Aloi%/,%' o A,&oi%/,%'
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Id'%&ifi(a(iD% d' A%&i(,'r+os A%&i+la,'&arios
) I%/ovilia(iD% d' a%&i(,'r+os /o%o(lo%ar's
MAIPAC
) Ad'r'%(ia a 'ri&ro(i&os '% fas' sDlida) E%i/o i%/,%o'%sa>os ELISAC
) #'%si&o/'&r?a d' fl,o
) $orr'la(iD% (o% la (l?%i(a
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Pri%(i+al's r'a((io%'s +os&-&ra%sf,(io%al's
d'*idas a a%&i(,'r+os o a%&?@'%os
+la,'&arios
) 'a((iD% '*ril No !'/ol?&i(a
) P,r+,ra Tro/*o(i&o+%i(a Pos&Tra%sf,sio%al
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Pa&olo@?as Prod,(idas +or A%&i(,'r+os
A%&i+la,'&arios
) La &ro/*o(i&o+'%ia a,&oi%/,%' TAIC
) La &ro/*o(i&o+'%ia %'o%a&al aloi/,%' TNAIC
) PKr+,ra &ro/*o(i&o+'%ia +os&ra%sf,sio%al PTPC
) 'fra(&ari'dad a las &ra%sf,sio%'s d' +la,'&as
) La &ro/*o(i&o+'%ia i%d,(ida +or fHr/a(os
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M&odos d' La*ora&orio +ara I%v's&i@ar
'l Sis&'/a !LA
Mediante anticuerpos :
SEROLOGIA (Microlinfocitotoxicidad, ELISA,
Citometría de lu!o,etc"
#IOLOGIA MOLEC$LAR:
%CR&SS%, %CR&SSO
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Mi(roli%fo(i&o &oi(idad
) TIPII$A$ION !LA $LASE I
) TIPII$A$ION !LA $LASE II
) PUEBA $UA#A TISULA $OSS MAT$!C
) PANEL #E ANTI$UEPOS EA$TIVOS PAC
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T'(%olo@?a d' as' SDlida
) T'(%olo@?a 's&a *asada '% las +ro+i'dad's ,' +os''% los
+lHs&i(os +ara irr'v'rsi*l'/'%&' a*sor*'r > '%laar
+ro&'?%as > o&ros (o/+,'s&os ,?/i(os.
) A*sor(iD% 's %o 's+'(?fi(a
) Pro&'?%as o (o/+,'s&os ,?/i(os a s'r ,sados d'*'% s'r +,rifi(ados a%&'s d' s'r a;adidos al so+or&' sDlido
+lHs&i(oC.
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Sis&'/as d' as' SDlida
M'/*ra%as ('l,lar's o +ar&?(,las i%f'((iosas so% ad'ridas a
,% so+or&' sDlido a%&'s d' i%i(iars' la +r,'*a. El (o/+o%'%&' i%/o*iliado +,'d' s'r ,% a%&?@'%o o ,%
a%&i(,'r+o d'+'%di'%do d'l +ro+Dsi&o d' la +r,'*a.
El r'a(&a%&' ad'rido al +lHs&i(o sirv' +ara (a+&,rar 'l
(o/+o%'%&' 's+'(?fi(o ,' 's *,s(ado '% la /,'s&ra 'val,ada.
Es&' (o/+o%'%&' 's (a+&,rado o a&ra+ado '% 'l so+or&' sDlido. U% sis&'/a i%di(ador 's ,sado +ara d'/os&rar ,' la r'a((iD%
d's'ada a o((,rido.
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Pruebas de Compatibilidad en
Fase Sólida) #'&'(&a a%&i(,'r+os !LA as? (o/o
a%&i(,'r+os (o%&ra a%&?@'%os +la,'&arios
's+'(?fi(os > a%&i(,'r+os I@G (o%&raa%&?@'%os A > B
) U&ilia +la,'&as fr's(as o (o%s'rvadas +ara
las +r,'*as d' (o/+a&i*ilidad
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Pruebas de Compatibilidad Pruebas de Compatibilidad
Plaquetaria Plaquetaria
) Pro+or(io%a% a>,da '% la s'l'((iD% d'
do%a%&'s +ara 'l +a(i'%&' r'fra(&ario) Ar&?(,los s';ala% la i%'fi(a(ia d' las
&ra%sf,sio%'s d' +la,'&as s'l'((io%adas
'(l,siva/'%&' '% *as' a +r,'*as d' !LA
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Pr,'*as d' $o/+a&i*ilidad '% as'
SDlida
I%(,*ar
Lavar
'
' ' ' ' ' ' ' ' ' ' '
' ' '
' ' ' '
'
'
' ' '
' '
' '
'
' ' '
' '
' ' ' ' ' ' ' ' ' ' '
' ' '
' '
' '
' '
' '
LISS S,'ro+
Pr,'*as d' $o/+a&i*ilidad '% as'
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+
!'/a&?'s
i%di(ador's
$'%&rif,@ar
Posi&ivo
f,'r&'
Posi&ivo
d*il
N'@a&ivo
Pr,'*as d' $o/+a&i*ilidad '% as'
SDlida
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I%/ovilia(iD% d' A@ +la,'&arios 's+'(?fi(os (o%
A( /o%o(lo%al's
Pri%(i+l' of &' Mo%o(lo%al
A%&i*od> I//o*ili'd Pla&'l'&
A%&i@'% MAIPAC &'s&
a%&i@'%s o% +la&'l'& /'/*ra%' ar'
r'(o@%i'd *> a ,/a% !C a%d a/o,s' MC a%&i*od> 9C a%&i@'%
a%&i*od> (o/+l' is sol,*ili'd a%d
disi%&'@ra&'d +la&'l'&s r'/ov'd 6C
Goa& a%&i*odi's (oa&i%@ &'
/i(ro+la&' i//o*ili' +la&'l'&
a%&i@'%s a%d 5C a s'(o%d @oa&a%&i*od>< (o,+l'd &o a% '%>/'<
*i%ds &o &' ,/a% a%&i*od>. U+o%
addi&io% of s,*s&ra&'< (olor is
@'%'ra&'d
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MASPAT
T(%i(a d' ad'r'%(ia 'ri&ro(i&aria '% fas' sDlida
) Mo%o(a+a d' +la,'&as d' do%a%&'
i%/oviliada +or ('%&rif,@a(iD% a la s,+'rfi(i'
d' +o(illos r'(,*i'r&os d' A( /o%o(lo%al's d'
ra&D% +la,'&a 's+'(?fi(os .
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T(%i(a MASPAT C
P"#$%et# 0e" 3n#nte
GR humanos sensibilizados con Ig G
Anti – Ig G monoclonal de ratón
Ac. Plaquetario del suero del paciente
Ac monoclonal plaqueta específico
F#!e S"i0#
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4ASPAT
) M,'s&ra8 s,'ro< ST (o% E#TA
) PP8 do%a%&'s d' @r,+o ABO
) PBS8 sol,(iD% d' lavado
) $'%&r?f,@a +ara /i(ro+la(as
) I%(,*ador s'(o a 94$
) $loro,i%a
Tra&a/i'%&o (o% (loro,i%a
) Es&a &(%i(a s' ,&ilia +aradif'r'%(iar A( !LA d' A( !PA
S%e& P"#$. tt#0#! P"#$. N tt#0#!
$ar'%&' d' A$ 5
A%&i !LA 5 5
A%&i !PA 5
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.
EPOTES #E INTEES
) S'l'((iD% d' Pla,'&as +or !LA %o 's 'i&osa '%
20 a 90J d' (asos Tra%sf,sio% 135C
) La*ora&orios (o/*i%a% +r,'*as d' (o/+a&i*ilidad +la,'&aria (o% +r,'*as d' !LA '% la s'l'((iD% d'
+la,'&as a s'r &ra%sf,%didas.
) ri'd*'r@ > (ol'@as d'/os&raro% ,'8134 !LA $o/+a&i*l'< +rod,o $$I '% 90J
!PA $o/+a&i*l'< +rod,o $$I '% 70J
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$o%(l,sio%'s
) $o%&ri*,>'% al dia@%Ds&i(o d' aloi%/,%ia(iD% +la,'&aria
) P'r/i&' la *,s,'da d' (o%('%&rados +la,'&arios
(o/+la&i*l's
) P'r/i&' la i%divid,aliaviD% d' '/*araadas (o% +o&'%(ial
d' TAIN
) P,'d'% (o/+l'/'%&ar 'i&osa/'%&' las +r,'*as d' +ar'o
!LA
) Pr'di('% /'or 'l i&o d' &ra%sf,sio%'s d' +la,'&as
) Ofr'('% ,% /&odo si/+l' > (o%fia*l' +ara la id%&ifi(a(iD%
d' do%a%&'s (o/+a&i*l's