antiasthmatics do not increase risk of perinatal complications

Reactions 1010 - 17 Jul 2004 Antiasthmatics do not increase risk of perinatal complications Maternal use of antiasthmatics is not associated with adverse perinatal outcomes, although oral corticosteroids may increase the risk of preterm birth and low birth weight, according to researchers from the US. To evaluate the relationship between antiasthmatics and perinatal complications, the researchers assessed 2123 pregnant women with asthma aged 13–44 years; 1739 were from an observational cohort study, * and 384 were from a randomised controlled trial of beclometasone vs theophylline. ** No significant relationships were observed between the use of inhaled β-adrenoceptor agonists, inhaled corticosteroids, theophylline or sodium cromoglicate/ nedocromil, and adverse perinatal outcomes, including gestational hypertension, preterm birth, low birth weight, small for gestational age and major malformations. However, maternal use of oral corticosteroids was significantly associated with both preterm birth at < 37 weeks’ gestation, and low birth weight, with adjusted odds ratios of 1.54 (95% CI 1.02, 2.33) and 1.80 (1.13, 2.88), respectively. * National Institute of Child Health and Human Development (NICHD) Maternal Fetal Medicine Units (MFMU) Network asthma observational cohort study ** NICHD MFMU Network randomised controlled trial of beclometasone versus theophylline for moderate asthma during pregnancy Schatz M, et al. The relationship of asthma medication use to perinatal outcomes. Journal of Allergy and Clinical Immunology 113: 1040-1045, No. 6, Jun 2004 800954769 1 Reactions 17 Jul 2004 No. 1010 0114-9954/10/1010-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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Reactions 1010 - 17 Jul 2004

Antiasthmatics do not increase riskof perinatal complications

Maternal use of antiasthmatics is not associated withadverse perinatal outcomes, although oralcorticosteroids may increase the risk of preterm birthand low birth weight, according to researchers from theUS.

To evaluate the relationship between antiasthmaticsand perinatal complications, the researchers assessed2123 pregnant women with asthma aged 13–44 years;1739 were from an observational cohort study,* and 384were from a randomised controlled trial ofbeclometasone vs theophylline.**

No significant relationships were observed betweenthe use of inhaled β-adrenoceptor agonists, inhaledcorticosteroids, theophylline or sodium cromoglicate/nedocromil, and adverse perinatal outcomes, includinggestational hypertension, preterm birth, low birthweight, small for gestational age and majormalformations. However, maternal use of oralcorticosteroids was significantly associated with bothpreterm birth at < 37 weeks’ gestation, and low birthweight, with adjusted odds ratios of 1.54 (95% CI 1.02,2.33) and 1.80 (1.13, 2.88), respectively.* National Institute of Child Health and Human Development(NICHD) Maternal Fetal Medicine Units (MFMU) Network asthmaobservational cohort study** NICHD MFMU Network randomised controlled trial ofbeclometasone versus theophylline for moderate asthma duringpregnancy

Schatz M, et al. The relationship of asthma medication use to perinatal outcomes.Journal of Allergy and Clinical Immunology 113: 1040-1045, No. 6, Jun2004 800954769

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