anti hemostatic drugs
TRANSCRIPT
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ANTI - HEMOSTATIC DRUGS
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• ANTI THROMBOTIC
• THROMBOLYTIC DRUGS
• ANTI COAGULANTS
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ANTI THROMBOTIC• Anti platelet drug• Aspirin-Low dose (80-160 mg)• • Ticlopidine• Clopidogrel
• Mab –
• Dipyridamole • Pentoxiphylline
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Dipyridamole
(-)
Platelet activation
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Pentoxiphylline
• Xanthine analogue
• Increases deformability of RBCs thus increases microcirculation, reduce fibrinogen levels, inhibit pl. aggregation.
• Uses-CVAs esp.TIA(transient ischemic attacks) , Ischemic ulcers of legs
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Anti fibrinolytic
• Streptokinase• • Staphylokinase
• Alteplase=t-PA
• Reteplase =U-PA
• Tenecteplase
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ANTICOAGULANTS
ENDOGENOUS EXOGENOUS
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ANTICOAGULANTS
ENDOGENOUS
1. HEPARIN2. ANTOTHROMBIN III3. PROTEIN C4. α2 MACROGLOBULIN
EXOGENOUS
1. HEPARIN2. VIT K ANTAGONISTS3. Ca SEQUESTERS4. DEFIBRINATION
SUBSTANCES5. COLD6. HIRUDIN
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ANTICOAGULANTS
• FOR BLOOD COLLECTION
• FOR TREATMENT
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ANTICOAGULANTS
• FOR BLOOD COLLECTION
1. HEPARIN2. Ca SEQUESTERS3. COLD
• FOR TREATMENT
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• HEPARIN
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CALCIUM SEQUESTERS• MOA
• OXALATES• CITRATE • TRISODIUM CITRATE• EDTA• SODIUM FLUORIDE• HEPARIN
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OXALATES• Acts by insoluble salts with calcium in blood to
ppt Ca • Ammonium :Potassium oxalate =2:3
• 2mg/dl
• Uses • PCV• ESR
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CITRATE
• Acts by deionisation of calcium in blood
• Blood banks• ACD• CPD• CPD-A
• 0.4 ml Na citrate in 1.6mlof blood
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TRISODIUM CITRATE
• 3.8%
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EDTA
• Sequester or chelating effect on calcium
• 1mg/dl
• ESR• PT
• Uses- routine blood tests
Three types of EDTA salt – sodium potassium lithiumDipotassium salt more soluble than Disodium salt, hence preferred
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SODIUM FLUORIDE
• deionisation of calcium in blood
FIBRINOGENPTPTTESR(by westergren method)
USES
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COLD
• 5-10 0C
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ANTICOAGULANTS FOR TREATMENT
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ORAL
VIT K ANTAGONISTS
PROTEIN C
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VITAMIN K ANTAGONISTS• COUMARIN DERIVATIVES- DICOUMAROL
• WARFARIN
• PHENINDIONE
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VITAMIN K
• SOURCES:
Causes of deficiency• Obstructive jaundice• New born babies• c/c diarrhoea• Side effect of antibiotic
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VITAMIN K
• II• VII• IX• X• PROTEIN C• PROTEIN S
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HEPARIN
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PARENTERAL- I V OR S/C
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• COLD-5-10 0C
• HIRUDIN –leech-anti thrombin
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• DEFIBRINATION SUBSTANCES
• Malaysian pit viper venom
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Hemostatic drugs
• INHIBIT FIBRINOLYTIC SYSTEM
• COAGULATION SYSTEM
• CAPILLARY INTEGRITY
• VASOCONSTRICTORS
• WOUND SEALING AGENTS
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INHIBIT FIBRINOLYTIC SYSTEM
• Eaca• Transexemic acid• aprotinin
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COAGULATION SYSTEM
• vit k• Botropase
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CAPILLARY INTEGRITY
• Ethamsylate adrenochrome• Vitamin c
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VASOCONSTRICTORS
• Somatostatin• adrenaline
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WOUND SEALING AGENTS
• feracrylum