anti-asthmatic drugs ยารักษาโรคหอบหืด...lp(a) levels siqnificantly....
TRANSCRIPT
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Drugs used in dyslipidemia
ยารักษาภาวะไขมันในเลือดผิดปกติ
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• Sarayut Lahnwong, M.D., Ph.D.
• Department of Pharmacology, Faculty of Medicine
• Khon Kaen University
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Objectives
• Site of actions
• Mechanism of actions
• Clinical uses
• Important side effects
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References
• Goodman and Gilmans The Pharmacological Basis of Therapeutics 13e (2018)
• Katzung & Trevor's Pharmacology: Examination & Board Review, 12e (2019)
• เภสชัวทิยา ส าหรับนักศกึษาวทิยาศาสตรส์ขุภาพ เลม่ 1, ภาควชิาเภสชัวทิยา คณะแพทยศาสตร ์มหาวทิยาลยัขอนแกน่ (2562)
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Plasma lipoproteins
• Chylomicrons
• Very low-density lipoproteins (VLDL)
• Intermediate density lipoproteins (IDL)
• Low-density lipoproteins (LDL)
• High-density lipoproteins (HDL)
• Lp(a) lipoprotein
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Plasma lipoproteins
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Plasma lipoproteins
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Management
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Drugs used in dyslipidemia
• HMG-CoA reductase inhibitors: Statins
• Fibric acid derivatives: Fibrates
• Nicotinic acid: Niacin
• Bile acid binding resins
• Inhibitors of intestinal sterol absorption
• Omega-3 fatty acids (fish oil derivatives)
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1. HMG-CoA reductase inhibitors
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Mechanism of action
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2. Fibric acid derivatives
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3. Nicotinic acid: Niacin
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4. Bile acid binding resins
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5. Inhibitors of intestinal sterol absorption
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6. Omega-3 fatty acids (fish oil derivatives)
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Q & A