Anti aging cream Review

Wadher et al, 2009 formulated and evaluated cream of Azadirachta indica

leaves on skin renewal rate. Three creams containing 0.5 %, 1.0 % and 2.0 %

w/w of hydroalcoholic macerate extracts of leaves of neem were prepared.

Creams were prepared in model FAPG base. Students t test shows that 1.0 %

and 2.0 % hydroalcoholic macerate creams shows increase in skin renewal

rate , which is significant at p<0.005 level of significance. While 0.5 %

hydroalcoholic macerate extracts cream is significant at p<0.05 level of

significance.

Bernantoniene et al, 2010 formulated and evaluated hydrophilic cream of

Callendula officinalis (L.) with antioxidant activity. Different formulation

with 0.3 %, 0.6% and 0.9% concentration of the extract were prepared. In case

of the cream with 0.3% of Calendula extract was content of the active

constituents low and weak antioxidant activity, the values did not differ from

these of the cream base. Measured values of the active compounds in the

cream with 0.9% of Calendula extract differed statistically significant (p <

0.05), therefore this cream was chosen for further microscopic evaluation and

stability testing. This cream was then examined microscopically, and stability

studies including evaluation of organoleptic properties, microbiologic quality

and antioxidant activity.

Kamakaen et al, 2010 developed peacock flower extract as anti- wrinkle

formulation. This study supports the traditional. The use of Caeselpinia

pulcherrima (0.7% w/w) as an ingredient in cosmetic products with

antioxidant and with antiwrinkle activity. The best effect was achieved by the

ethanolic extract which corresponds to the traditional extraction practice. The

results of DPPH radical scavenging assay showed the strongest activity

(IC50= 34.74 μg/ml) of the crude extract from the red petals of C.

pulcherrima, followed by the extract of the orange petals (IC50=35.63 μg/ml)

and the yellow petals (IC50=102.27 μg/ml), respectively. The ABTS cation

radical scavenging assay demonstrated the strongest activity (IC50=227.66

μg/ml) for the orange petals followed by the red petals (IC50=243.01 μg/ml)

and the yellow petals (IC50=338.72 μg/ml). The amount of phenolic

compounds in term of gallic acid suggests that the flowers of C. pulcherrima

may be a good source of natural antioxidants which may be incorporated into

a range of cosmetics and health products.

Rasul et al, 2011 formulated and evaluated anti- aging effects of an emulsion

containing basil extract using non-invasive biophysical techniques. A single

blinded study was conducted using non-invasive methods. Formulation

containing 3% of the concentrated extract of Basil was developed by

entrapping in the inner aqueous phase of w/o emulsion and base contained no

extract. Both creams were stored at different storage conditions of 8°C, 25°C,

40°C and 40°C+ 75% relative humidity to predict their stabilities. The

formulation and base were evaluated for their effects on various skin

parameters i.e., moisture and trans epidermal water loss (TEWL), volume,

energy and surface evaluation of the living skin (SELS). Significant effects

(p≤0.05) were observed for both creams in the case of TEWL. The base

showed insignificant (p≤0.05) while formulation showed significant effects on

skin moisture. Volume, SELS SEr (skin roughness), SEsc (skin scaliness),

SEsm (skin smoothness), SEw (skin wrinkles) parameter showed significant

decline while texture parameter of ‘Energy’ showed significant increase.

Sabale et al, 2011 formulated and evaluated topical antiaging preparation of

fruit of Benincasa hispida. Two formulas were prepared for cream base. The

effect of the Benincasa hispida fruit extract (5%) cream on skin renewal was

evaluated. The results show that Formula no. 2 had good spreadability

(average spreadability 18.4 ± 1.38) as compared with Formula no. 1 (average

spreadibility 8.8 ± 1.22). Formula no. 1 showed a decrease in water number as

compared with Formula no. 2, which represents its less-water-absorbing

capacity (3.0 ml vs. 2.0 ml). Formula no. 2 showed good diffusibility (average

diffusibility 2.05 ± 0.07) than Formula no. 1 (average diffusibility 1.35 ±

0.05). Thus, Formula no. 2 was found to satisfy all the desirable properties of

oil-in-water cream base and was decided to be the final cream base.

Akhtar et al, 2011 evaluated various functional parameters using a topical

cream of Calendula officinalis extract. Base without active and formulation

having 3% extarct of calendula in the aqueous phase were prepared. Samples

were stored at different storage conditions that is, 8, 25, 40, 40°C+75% RH

for four weeks to predict their stability. The newly formulated base and

formulation were applied to the cheeks of 21 healthy human volunteers for a

period of 8 weeks. The base showed insignificant (p>0.05) effects while the

formulation decreased TEWL however this decrease was statistically

insignificant (p> 0.05). Skin moisture content was significantly (p_0.05)

increased by the formulation. The base showed insignificant (p>0.05) effects

while the formulation showed statistically significant (p_0.05) decrease in

skın melanın content. Skın erythema was significantly reduced by the

formulation. Skin sebum was significantly (p_0.05) incresaed by both creams

(base and formulation). Both creams were aesthetic with respect to sensory

evaluation. The topical non-invasive application of Calendula officinalis

cream showed a positive rejuvenating effect on human skin.

Sahu et al, 2011 formulated and evaluated curcuminoid (2% w/w) based

herbal face cream. Evaluation of formulated cream with parameters - type of

emulsion, ashing at 600 oC, pH, homogeneity and sensory parameters has

been conducted. Accelerated stability testing of 16 prepared formulations has

been conducted at elevated temperature of 40 oC ± 1oC for 20 days. 4 out of

16 products have shown stability with no signs of bleeding and no change in

the color of the product. The Draize test for sensitivity testing has shown that

the stable formulations are safe in respect to skin irritation and allergic. The

formulated turmeric based herbal face cream is a cosmeceutical that contains

quantified amount of curcuminoids. It is safe and stable too.

Bambal et al, 2011 studied the sunscreen activity of herbal cream containing

flower extracts of Nycanthes arbortristis L.(1% w/w) and Tagetes erecta L.

(1% w/w). The in vitro SPF of the formulations was determined according to

the UV Spectrophotometric method of Mansur et al. The sunscreen cream

containing ethanolic extract of N. arbortristis under study produced high

absorbance at 290-320 nm wavelength range and SPF obtained was

10.21±2.18. The sunscreen cream containing ethanolic extract T. erecta

obtained the SPF 8.67±1.35. From the result obtained in the study, we can

positively conclude that N. arbortristis sunscreens will enhance and

significantly contribute to the UV absorbing properties of conventional

sunscreen formulation. It will also help in broadening the UV protection

ability of the sunscreen along with the greatest advantage of avoiding the

adverse and undesired effects of synthetic sunscreen compounds.

Rasul et al, 2012 formulated and evaluated anti- aging potential of a cream

containing milk thistle (Silybum marianum) extract. The study was designed

to formulate and evaluate antı-agıng effects of a topical cream (water in oil

(w/o) emulsion) containig extract of milk thistle (Silybum marianum) against

its vehicle (Base) as control. Base containing no extract and a formulation

containing 4% concentrated extract of Silybum marianum was developed by

entrapping in the inner aqueous phase of w/o emulsion. Both the base and

formulation were stored at 8°C0.1°C (in refrigerator), 25°C0.1°C, 40°C0.1°C

and 40°C0.1°C with 75% RH (in incubator) for a period of 8 weeks to predict

their stability. The evaluation parameters consisted of colour, smell, type of

emulsion, electrical conductivity, liquefaction and pH.