Anthropometry and Breast Cancer Publication

van den Brandt, P.A., et al. Pooled analysis of prospective cohort studies on height, weight and breast cancer risk. American Journal of Epidemiology. 2000; 152: 514-527.

Sweden Mammography

CohortNurses’ Health Study

Netherlands Cohort Study

New York State Cohort

Iowa Women’s Health Study

Canadian National Breast Screening Study

Cohort Studies in the Pooled Analysis of Anthropometry and Breast Cancer

Total = 337,819 # cases = 4,385 Premeno. = 723 Postmeno. = 3,208

Adventist Health Study

Number of Cases in the Pooled Analysis of Anthropometry and Breast Cancer

Study No. of cases Premeno. Postmeno.

Adventist Health 20 87

Canadian National

122 242 Iowa Women’s

0 643 Netherlands Cohort 0

420 New York State 0

358 Nurses’ Health (a) 383

571 Nurses’ Health

(b) 130 613

Sweden Mammography 68 274 van den Brandt et al, 2000

Pooled Multivariate Relative Risks for Breast Cancer and Body Mass Index

BMI (kg/m2) RR (95% CI) Premenopausal Postmenopausal

<21 1.00 (ref) 1.00 (ref)

21-<23 1.24 (0.97-1.57) 1.14 (0.99-1.33)

23-<25 1.03 (0.78-1.35) 1.15 (1.00-1.34)

25-<27 1.08 (0.79-1.48) 1.26 (1.09-1.47)

27-<29 0.97 (0.66-1.44) 1.43 (1.21-1.67)

29-<31 0.96 (0.60-1.52) 1.21 (1.01-1.46)

31-<33 0.55 (0.26-1.15) 1.29 (1.03-1.60)

>33 0.58 (0.34-1.00) 1.27 (1.03-1.55)

p for trend 0.007 0.001 p-for-interaction = 0.004

van den Brandt et al, 2000

Study-Specific Relative Risks for Premenopausal Breast Cancer and BMI

van den Brandt, et al. 2000Relative Risk.51 5

Combined

Sweden

Nurses' (b)

Nurses' (a)

Canada

Study-Specific Relative Risks for Postmenopausal Breast Cancer and BMI

Relative Risk.8 1 2

Combined

Sweden

Nurses' (b)

Nurses' (a)

NY State

Netherlands

Iowa

Canada

Adventist

van den Brandt, et al. 2000

Body Mass Index and Breast Cancer: Pooled Analysis

van den Brandt et al, 2000

Pooled Multivariate Relative Risks for Breast Cancer and Height by Menopausal Status

Height (m) Premenopausal Postmenopausal

<1.60 1.00 (ref) 1.00 (ref)

1.60-<1.65 1.21 (0.94-1.55) 1.09 (0.98-1.21)

1.65-<1.70 1.06 (0.82-1.36) 1.23 (1.11-1.37)

1.70-<1.75 1.14 (0.86-1.52) 1.24 (1.09-1.41)

>1.75 1.42 (0.95-2.12) 1.28 (0.94-1.76)

p for trend 0.41 <0.001

p-for-interaction = 0.13 van den Brandt et al, 2000

Study-Specific Relative Risks for Premenopausal Breast Cancer and Height

Relative Risk.6 1 2

Combined

Sweden

Nurses' (b)

Nurses' (a)

Canada

van den Brandt et al, 2000

Study-Specific Relative Risks for Postmenopausal Breast Cancer and Height

Relative Risk.8 1 2

Combined

Sweden

Nurses’ (b)

Nurses’ (a)

NY State

Netherlands

Iowa

Canada

Adventist

van den Brandt, et al. 2000

Pooled Multivariate Relative Risks for Breast Cancer and Height

van den Brandt et al, 2000

0.8

1.0

1.2

1.4

1.6

1.8

<1.60

1.60

-<1.

65

1.65

-<1.

70

1.70

-<1.

75

>1.75

Rel

ativ

e R

isk

Height (m)

Van den Brandt et al, 2000

van den Brandt et al, 2000

Height and Breast Cancer: Pooled Analysis