ans-receptors overview - mis e jurusan pendidikan dokter umum fakultas kedokteran universitas...

7/25/2019 ANS-Receptors Overview - MIS E jurusan pendidikan dokter umum fakultas kedokteran universitas sriwijaya

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ANS-Receptors Overview - MIS

Cholinergic Receptors

Nicotinic Muscarinic

GanglionicSkeletalMuscle

NeuronalCNS

Receptors and signal transduction in theANS


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Receptors and signal transduction in the

ANS:Nicotinic Receptors

ACH ACHNa+


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ANS:Nicotinic Receptors

ACH ACHNa+

NH3

COOH


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ANS

Cholinergic Receptors

Nicotinic Muscarinic

M1 M5M3 M4M2


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Receptors and signal transduction in theANS:

Muscarinic receptors are 7 transmembrane domain!-protein coupled receptors


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Receptors and signal transduction in the ANS:Muscarinic receptors

"M# M$ M%&

NH3

COOH

Gq

Phospho-

lipase C

(+)

PIP2

IP3

Diacylglycerol

Increase Ca2+ Actiate Protein!inase C

"esponse


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Receptors and signal transduction in theANS:

Muscarinic Receptors(#2 an$ #%)

NH3

COOH

GI

(-)

A&P cA#P

"e$'ce cA#P-Depen$entProtein !inase Actiity

"esponse

A$enylate Cyclase

(+)!+


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Receptors and signal transduction in theANS

Adrenergic Receptors

A

2

*

D

2A

2*

2C

2

3


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Receptors and signal transduction in the ANS:

#-Adrenergic

Receptors

NH3

COOH

Gq

Phospho-

lipase C

(+)

PIP2

IP3 Diacylglycerol

Increase Ca2+ Actiate Protein!inase C

"esponse


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Receptors and signal transduction in the ANS:

'-Adrenergic

Receptors

GI

(-)

A&P cA#P

"e$'ce cA#P-Depen$entProtein !inase Actiity

"esponse

A$enylate Cyclase

(+)!+

NH3

COOH


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Receptors and signal transduction in the ANS:-Adrenergic

Receptors

G

(+)

A&P cA#P

Increase cA#P-Depen$entProtein !inase Actiity

"esponse

A$enylate Cyclase

NH3

COOH


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,ector OrganA$renergic"esponse "eceptor

Cholinergic"esponse "eceptor

Heart"ate o Contraction Increase Decrease #2

.orce o Contraction Increase Decrease #2

.'nctional "esponses #e$iate$ /y the AN

0


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(unctional Responses Mediated b)the ANS



Arteries (1ost) asoconstriction ---------- --

eins asoconstriction 2 ---------- --

eletal #'scle aso$ilation 2 ---------- --

,n$otheli'1 ---------- -- "elease ,D". #3


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4'ng

*ronchiolar

s1ooth 1'scle

*roncho$ilation *ronchoconstriction #3

2


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*la$$er 5all "ela6ation 2 Contraction #37reter Contraction "ela6ation #3phincter Contraction "ela6ation #37ter's (pregnant) "ela6ation 2 aria/le

Penis8as $eerens ,9ac'lation

Genito'rinary0 s1ooth 1'scle

Contraction #3

#3,rection


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(unctional Responses Mediated b)the ANS,ector Organ

A$renergic"esponse "eceptor


aliary Glan$s Increase secretion

Increase secretion1ooth #'scle:

"ela6ation 2 02 #3

phincters Contraction "ela6ation #3

ecretion ---------- -- Increase secretion #3

Gastrointestinal &ract

#3

;alls Contraction


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Hair ollicles0

1ooth 1'scle

Contraction0

Piloerection

-------------- --

5eat glan$s&her1oreg'lation Increase secretion

in

----------------#3

Increase secretion Apocrine (stress) ----------------


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Iris

"a$ial 1'scle Contraction

,ye

----------------

-------------Circ'lar 1'scle #3Contraction--

Ciliary 1'scle


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*h)siolog) o+ the e)e

4ens

Iris

"a$ial1'scle ()

Circ'lar1'scle (#3)

Canal ochle11

&ra/ec'lar

1esh5or

Ciliary

1'scle (#3) Ciliaryepitheli'1 (2)


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P'pil

Circ'lar 1'scle

(#3 "eceptors)


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P'pil

Contraction o circ'lar1'scle lea$s to

1iosis


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P'pil

Contraction o circ'lar1'scle lea$s to

1iosis


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P'pil

"a$ial #'scle( "eceptors)


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P'pil

Contraction o ra$ial1'scle lea$s to

1y$riasis


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4ier Glycogenolysis -------------- --

.at cells 4ipolysis -------------- --

!i$ney Increase renin

secretion

-------------- --

Pancreas Decrease ins'linrelease

#eta/olic 'nctions

----------------

03

2

Gl'coneogenesis

02

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