annual reporting for faculty supported research centres ... · including any advances in knowledge,...

June2,2017

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AnnualReportingforFacultySupportedResearchCentresandNetworks

AllCentres(provisionalCentres;McGillCentres),ResearchgroupsandNetworksthatreceivefundingfromtheFacultyofMedicinearerequiredtoprovidetwocomponentsofreporting:• AnnualReportofActivities,Outcomes• End-of-YearFinancialReport/ProposedBudget

TheAnnualandEndofYearReportscoveringtheperiodfromthe1stMayuntilthe30thAprilaredueby4pmonMay26th2017.FuturefundingwillbedependentonthepromptreceiptofalldocumentsaswellastheevaluationsmadebythecommitteeandtheFacultyfundsavailable.

ThecompletedAnnualReportandtheFinancialStatementshouldbeforwardedbyemailto:

JenniferClarke([email protected])FacultyofMedicineResearchOfficePhone:514-398-5815

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AnnualReportforFacultyofMedicineFundedCentresandNetworksTheAnnualReportshouldbesetinthecontextoftheCentre’s,Corefacility’sandNetwork’s

overallgoalsandobjectives,programsandresearchpriorities,performanceindicatorsoutlinedintheapplication(orsubsequentlydeveloped),activitiesandstrategies.Pleaseprovidethefollowing:

1. NameofCentre,UnitorInstitute:

McGillUniversityResearchCentreonComplexTraits(MRCCT)

2. NameandcontactinformationoftheDirectorand/orAdministrativeAssistant:Director:Dr.SilviaVidal/[email protected]

SeniorAdminCoordinator:MarianneProvost/[email protected]

3. IsthecentrerecognizedasanofficialSenateapprovedMcGillResearchCentre?

YesXNo_____

4. ThedatethecentrereceivedSenateapprovalasanofficialMcGillResearchCentreFebruary16,2016

5. PleaseprovidetheURLoftheResearchCentre’sorNetwork’swebsite.

Note:TheResearchCentre’sorNetwork’swebsiteshouldcontainthefollowinginformation:• allsourcesoffundingsupport,• theListofMembersandtheirinstitutionalaffiliation,• theactivitiessupportedbytheResearchCentre,CoreFacilityorNetwork,and• AnnualReports.

URL:http://mcgill.ca/mrcct/

6. Asummaryofthepastyear’sgoalsandobjectives,programsandresearchprioritiesandanychangestothesethatmayhaveoccurredduringthepastyear.Pleaseindicatetheextenttowhichtheobjectiveshavebeenmet.(limit200words)InfectiousandchronicinflammatorydiseaseshavegrowntoepidemicproportionsoverthelastdecadesandconsumealargepartofCanada'shealthcareresources.Understandingtheunderlyinggenetic,molecularandimmunologicalprocessesthatleadtodiseasearekeyrequirementsforthesuccessfuldesignofmedicalinterventions.Toaddressunmetclinicalneeds,facilitateinnovativeresearch,knowledgemobilizationandtechnologytransfer,theMRCCTnetworksinternationallyrecognizedbasicscientistsandclinicalinvestigatorsfromacademiaandtheprivatesector.Membershipincludes12primarymembersfromthedepartmentsofMedicine,HumanGenetics,MicrobiologyandImmunology,BiochemistryandPhysiologyaswellas21associatemembersfromleadinguniversities(UniversityofToronto,

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UniversitédeLiège,CambridgeUniversityandInstitutPasteur),hospitalresearchcenters(MUHC,Maisonneuve-Rosemont,StJustine,SikKids,TorontoGeneralHospital)andpharmaceuticalincubators(InceptionIBD,LallemandInc,JanssenResearch&Development,LLC).MRCCTheadquartersareatthe3rdflooroftheLifeSciencesComplex,Bellinibuilding.

Withthegoalofcreatingathrivingenvironmentforresearch,trainingandentrepreneurship,theMRCCTaimsto:

1.provideinnovativeplatformstoinvestigatehowhostgeneticfactors,theimmunesystem,themicrobiotaandpathwaysthatcontrolinflammationinfluencethedevelopmentandprogressionofinfectiousandchronicinflammatorydiseases;

2.trainanewgenerationofscientistswithmultidisciplinaryexpertiseintheanalysisofbigdata,genetics,genomics,microbiology,immunology,cellbiology,biochemistryandbioinformatics;

3.translatebasicscienceresultsfromthebenchtothebedsidebysystematicallyexploringandexploitingthe“druggability”ofnewdiseasetargetsthroughcollaborationswithcliniciansandclinicianscientistsandthepharmaceuticalsector;

ThisreportprovidessupportiveevidencethatMRCCThasbeenhighlysuccessfulinmeetingtheseobjectives.OurCenterhasfacilitatedthetrainingofhighlyqualifiedpersonal,drugtargetidentification,knowledgedisseminationandcommercializationtoultimatelyimprovethehealthofCanadianswhilefurtheringMcGill’sinternationalpositioninthefieldofcompleximmune-mediateddisorders.

PleasedocumentthemajorachievementsresultingfromtheuseoftheFundsfromtheFaculty,includinganyadvancesinknowledge,relevantpublications,orinternationalcollaboration.Youmayselectfromthemenuofreportingitems/performanceindicatorsinAppendix1thatmayberelevant,butmustinclude,atminimum,informationonpublications/presentations,outreachactivities,qualityofthetrainingenvironment.(Pleaselimityourtextresponsetoamaximumof1pageofprose.Pleaseincludelistsofpublications,grants,activitiesasappendices.)

Centeredonitstrainees,theMRCCThashadanimpressiverecordofexcellenceingraduateandpost-graduateeducation.Primarymembersinstructed70trainees(Appendix1,TablesI-IV)whoparticipatedinallstagesofthediscoveryprocessandcontributedtoanimpressiverecordofpublications.ResearchoutputsfromMRCCTresultedin318articles(87fromprimarymembersand231papersfromassociatemembers(Appendix8)).Majorreportsincluded:1)astudyledbyDrFritz(incollaborationwithMalo,VidalandQureshi)demonstratingthattypeIinterferonscansuppresspulmonaryinflammationthroughtheirregulatoryactionon2innatelymphoidcells(NatImmunol,2016);2)acollaborativestudyleadbyDrNijnik(withPelletierandGros)showingthattheHistoneH2AdeubiquitinaseMYSM1isessentialforthesurvivalofhematopoieticstemcellsviatherepressionofp53-targetgenes(CellDeathandDiff,2016);3)acollaborativestudybyDrsDanskaandVinhshowingtheprotectiveroleoftheNKandTcellreceptorSLAMF7inthephagocytosisofhematopoieticcells(Nature,2017);4)astudyledbyDrGros(incollaborationwithAntel,Krawczyk,Lathrop,Vidal)revealingthatdeficiencyintheUbiquitinSpecificPeptidase15(USP15)canprotectagainstmicrobialandautoimmuneneuro-inflammation(NatImmunol,2016).WorkonUSP15(USpatent61/652,271;licensedbyAmorchem/NewChem)ledtothefoundationofaspin-offcompany,CorbinTherapeutics,topursueUSP15-baseddrugdiscoveryformultiplesclerosisandotherformsofneuroinflammation.Thisproductivityinresearchwasenabledby(i)ahighleveloffundingfromCIHR,FRSQ,GenomeCanada,theUSdepartmentofDefenseandseveralotherfederalagenciesandcharitiestotaling$5,8Mforprimarymembers(Appendix9).Amongthehighlights,DrsGrosandFritzhaveeachreceivedCIHRFoundationGrantsinthefall2016competitionwhereasDrsNijnik,MandlandSalehwererecipientsofCIHRprojectgrantsinthe2016and2017competitions;(ii)manynationalandinternationalcollaborationswithacademicandindustrial

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partnerssuchascollaborationswithDrJean-LaurentCasanova(RockefellerUniversity)fortheanalysisofrarevariantsinpatientswithprimaryimmunodeficiencies;withDrColinMcPhee(GlaxoSmithKlein)toexaminetheroleofaphospholipaseinthecontrolofinfluenzavirusinfection;withDrAlainBitton(MUHC)tostudytheroleofprogrammednecrosisinCronh’sDisease;withDrThomasTompkins(LallemandHealthSolutions)toinvestigatetheroleofprobioticsinhostdefenseagainstbacterialandviralinfectionsandwithDrPrinz(UniversityofFreiburg)tounderstandtheroleofUSP18inthecontrolofCNSinflammation(Appendix10).

Both,thetrainees’researchexperienceandresearchcollaborationshavebeenenhancedbyourtargetactivities(Appendix2andAppendix3).Wehavedevelopedtwotoolsofstructuredcommunicationsincluding(i)weeklywork-in-progressmeetingsattheBelliniwherePIandtraineespresenttheirlatestresultstothegroup,honetheirpresentationskillsandgetfeed-backontheirresearch;(ii)aseminarseriesnamedExcellenceinGeneticsandImmunology,whichlastyearhasfeatured13talksfromleadersinfundamentalandclinicalresearchworkingintheareasofinfectiousdiseases,inflammationandimmunology.Duringthisactivity,traineescanmeetinformallyduringlunchhourwiththespeakersandtheyareencouragedtodiscussabouttheirresearchprojectsorotherscientifictopicofinterest.TheseeventsarewellattendedbylocalMRCCTmembers(seelistinpoint7,below)andarehighlyvaluefortheopportunitiesofcollaborationandvisibilitythattheygenerateforourstudents.

ThenationalandinternationalvisibilityofMRCCTinvestigatorsisdemonstratedbynumerousinvitationstopresentinnationalandinternationalvenues(Appendix4),thenumberofhonoursandawards(RoyalSocietyofCanada,CanadaResearchChairs,FRSQchercheurboursier,CIHRinvestigators)(Appendix5),outreach(Appendix6)andconsultingactivities(Appendix7).

Wecontinueourcommitmenttoinnovationthroughtheestablishmentofnewplatforms.DrMandldirectstheplatformofintravitalimaging,theonlyofitskindatMcGill.TheplatformhasbecomefullyfunctionalinadedicatedBSL-2roomtomonitorimmunecelldynamicsinmodelsofinfectionorinflammation.Thedual2-photon/confocalmicroscopeisfullyequippedtomeasurecellularmovementandinteractionswithothercellsinreal-timeandinlivemice,aswellasbeingabletoperformmultiparameterconfocalmicroscopyoflargetissuesectionsorofwholeorgans.

DrFritzdirectstheCellVisionCorefacility(http://www.mcgillgcrc.com/facilities/flow),aflowcytometryplatformjointlyrunwiththeGoodmanCancerResearchCenter(GCRC).Theplatformismanagedbyalabmanager(JulienLecompte,M.Sc.).Inthepastterm,thefacilityhasserved55labsincluding175users.

Asco-leaderofTheCenterforPhenogenomics(TCP),DrVidalsecuredfundsfromGenomeCanada($200,000;2017-2022)toestablishaMcGillcoreinInfectionandInflammation.TCPisoneofthe10GenomicsTechnologyPlatformsthemandateofwhichistoserveCanadianscientistswithunparalleledaccesstoleading-edgegenomicservicesindiseasemodelproductionandevaluation.AsTCPco-applicant,DrPelletierwilldevelopnewsystemsbasedonmodifiedCas9-transgenicmicetoeasegeneeditingofpointmutationsinmousestemcells.

Weorganizedthe1stInternationalSymposiumonGeneticsofInfectiousandInflammatoryDiseases,Montreal,Nov28-29,2016(Appendix11).TheSymposiumbroughttogether31MRCCTinvestigatorsand215attendeesandprovidedanextraordinaryopportunitytoconnect,exchangeandfeaturethebreadthofresearchcarriedatMRCCTthrough21presentationsbyMRCCTPIs.MRCCTtraineespresented47postersanddelivered22talks(1slide3minutes).ThekeynotespeakerwasDrMarcoPrinz,DirectoroftheInstituteofNeuropathologyUniversityMedicalCenter,UniversityofFreiburg,andaspecialistinthestudyofbrain-specificimmunefunctionsinmultiplesclerosis.TheSymposiumwasfollowedbya2hoursroundtablewiththeScientificAdvisoryBoardandtheClinicalAdvisorswhoprovidedguidanceandsuggestedstrategiestomoveforward.

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7. PleaseprovideaListofNewMemberswhojoinedinthepastyear(Full,Associate,Trainee

notingwhethergraduatestudentorpost-doctoralfellow)andinstitutionalaffiliations.PleasealsoindicateanymemberswhohavelefttheCentreorNetwork.Addrowsasnecessary.

Pleaseindicatetotalnumberofmembers:35

PleaseindicatetotalnumberofMcGillFacultyofMedicinemembers:21Localmembers,studentsparticipatingtoweeklywork-in-progressmeetingsName MRCCTMemberStatus InstitutionalAffiliation(s)

JackAntel Associatemember MontrealNeurologicalInstituteLukeHealy PDFLuisBarreiro Associatemember

CHUStJustine,UniversitédeMontréal

GolshidBaharian PDFJoaquínSanzRemón PDFTiagoCarvalho PDFRenataSindeaux PDFYohannNédélec PhDAlainPacis PhDFlorenceMailhot-Léonard PhDGenelleHarrison PhDMohamedHawash PhDHaleyRandolph PhDOlivierTastet MScVaniaYotova RAJean-ChristopheGrenier RAMathieuBlanchette Associatemember

SchoolofComputerScience,McGillUniversity

DouglasHoen PDFGlennHickey PDFChristopherCameron PhDPabloCingolani PhDRolaDali PhDMickaelLeclercq PhDAtefehMahajeri RAMaiaKaplan MScFaizyAhsan MScArinAhia-Tabibi PhDGuillaumeBourque Associatemember

McGillUniversityandGenomeQuebecInnovationCenter(MUGQIC)

TobyDylanHocking PDFMaikoNarahara PDFPatriciaGoerner PhDJeanMonlong PhDJoeSu MScInesColmegna Associatemember

McGillUniversityHealthCentre(MUHC)

MaximilienLora RAAnastasiaCheng MScNataliaShimabukuro PhDJoseNavarro PhDJorgFritz Primarymember

MicrobiologyandImmunology,McGillUniversity

ClaudiaDuerr PDFBarbaraMindt PhDFernandoAlvarez PhDAlexHarrison MScPhilippeGros Primarymember

Biochemistry,McGillUniversity

DavidLanglais PDFNedaMoradin PDFAurélieLaroque PhD

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JamesKennedy PhDVickiLeung PhDJean-FrédéricOlivier PhDThiviyaJeyakumar MScChristianGualtieri MScNassimaFodil RAMariaPolyak RASamanthaGruenheid Primarymember


MitraYousefi PDFNathaliaGiannakopoulou PhDEugeneKang PhDTylerCannon MScAlannaCrouse MSCTravisAckroyd MScSidongHuang Associatemember


YiboXue PhDGenevièveMorin PhDSaraFerwati PhDTimKong MScHongBoChen MScNadaJabado Primarymember


JonathanPratt PDFElvisValera PDFMelissaMcConechy PDFMicheleZeinieh PDFAlexanderWeil PDFAshotHarutyunyan PDFTenzinGayden PDFShriyaDeshmukh PhDAbdulshakourMohammadnia MSCSimaKhazaei MScConnieKrawczyk Associatemember


GiselleBoukhaled PhDHannahGuak PhDSoYoonWon MScBenedetaHasaj RABrendanCordeiro MScLinTzeTung MScMarioCorrado MScSilvieLesage Associatemember

UniversitédeMontréal,Maisonneuve-RosemontHospital

ErinE.Hillhouse RAGenevièveChabot-Roy RAAlexandraParadis RARoxanneCollin PhDCindyAudiger PhDVictorMullins-Dansereau MScDanielleMalo Primarymember

Medicine;HumanGenetics,McGillUniversity

SeanBeatty PhDMeganEva PhDAlannaCrouse MScKyokoYuki PhD

JudithMandl Primarymember

Physiology,McGillUniversity

DakotaRogers PhDCaitlinSchneider PhDPatricioArtusa PhDYvonneDeng BScBenjaminForestell BScAngelicaGopal PDF

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AnaNijnik Primarymember

Physiology,McGillUniversity

MichaelFoerster PDFRupinderBoora MScJessicaPetrov MScAmandaFiore PhDYunHsiaoLin(Minnie) PhDMartinOlivier Primarymember


CarolineMartel RAVanessaDinizAtayde PDFAlonsoLirhaFilo PhDAndrezzaRaposoBorgesDeMelo PDFKristinVandenHam PhDAnupamAdhikari PDFJamilahAbusarah PhDNirminAlsahafi PhDAlejandraVilla MScMelaniePerik MScSaiPriyaAnand MScAndreaVicutic MScArethaChan MScJerryPelletier Associatemember


PatrickSénéchal RAFrancisRobert PhDReginaCencic PhDJuttaSteinberger PhDAlexandraKatigbak MScJenniferChu MScTeresaLee MScRayelleItouaMaiga MScKatiaSleiman MScCiriacoPiccirillo Associatemember

MicrobiologyandImmunology,McGillUniversityHealthCentre(MUHC)

KhalidBinDhuban PhDFernandoAlvarez PhDRomanIstomine PhDStevenShao MScRyadBoukherrouf MScHelenMason MScSabrinaBartolucci MScSalmanQureshi Primarymember HumanGenetics,

McGillUniversityHealthCentre(MUHC)MitraShourian MSc

MayaSaleh Primarymember

Medicine,McGillUniversity

IanGervais-Rodrigue PDFMostafaKhair PDFMarioSongane PDFAlexanderSkeldon PhDMaryseDagenais PhDToddDouglas PhDErwinSchurr Associatemember HumanGenetics,


AlessandraRicciardi PhDConstantinaBoikos PhDSilviaVidal Primarymember

HumanGenetics,McGillUniversity

GabrielLeiva-Torres PhDMathieuMancini PhDJenniferMarton PhDKathiriyaVaibhav MScMuYang MScDonaldVinh Primarymember

McGillUniversityHealthCentre(MUHC)Marijalandekic PhD

RebeccaIliza MSc

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CatherineLe BScRebecaPaulaLesanu MSc

NationalandInternationalmembersName MRCCTMemberType InstitutionalAffiliation(s)

Anderson,Paul AssociateMember InceptionIBD,Montréal

Awadalla,Philip AssociateMember UniversityofToronto

Bar-O,Amit AssociateMember PerelmanSchoolofMedicine-PennUniversity

Danska,Jayne AssociateMember UniversityofToronto

Georges,Michel AssociateMember UniversityofLiège,Belgium

Haston,Christina AssociateMember UniversityofBritishColumbia

Kain,Kevin AssociateMember UHN-TorontoGeneralHospital

Lathrop,Mark AssociateMember MUGQIC

Parkinson,John AssociateMemberDiscoveryImmunology,JanssenResearch&Development,LLC

Sakuntabhai,Anavaj AssociateMember InstitutPasteur,Paris

Sawcer,Stephen AssociateMember UniversityofCambridge

Thérien,Alex AssociateMember InceptionIBD,Montréal

Turvey,Stuart AssociateMember UniversityofBritishColumbia

8. PleasedescribehowyouractivitiesalignwiththeAcademicorResearchmission(Strategic

ResearchPlan)oftheFacultyofMedicineand/orotherFacultiesatMcGillfocusingontheactivitiesforthecurrentyearandstrategicplansforthesubsequentyear(limit200words)TheCreationoftheMRCCTwiththemissionofdecipheringthegeneticandpathogenicmechanismsofhumancomplexinfectiousandinflammatorydiseases,andamandatetoacceleratethetranslationofresearchoutcomesisanchoredonstrongstrategicprioritizationandcommittedinstitutionalsupportforthisresearchareaatMcGill.First,itgreatlyenhancesandbroadenstheComplexTraitsresearchthemeandpromotesandfacilitatesnewresearchopportunitieswithinkeyresearchthemesoftheMcGillLifeSciencesComplexandaffiliatedResearchCentres,withhighimpactonthenationalandinternationalscene.Second,itstimulatesnovelmultidisciplinaryresearchinteractionsthuscontributingtodevelopmentofinnovativeresearchandacademicprograms.Third,itmaximizesinvestmentintheMcGillLifeSciencesComplexaswellasintheGenomeCentre,keyareasofstrategicimportanceenhancingMcGill’sabilitytoattract,retainanddevelopoutstandingfaculty,studentsandresearchstaff.Fourth,itcapitalizesonthemosteffectiveuseofresearchandfundingthroughitspotentialforintellectualpropertyandresearchcommercialization.

Finally,itaddstoMcGillauniqueclaimofhousingthefirstCentreinCanadadedicatedtothestudyofComplexGeneticDiseases.

9. Otherinformation:PleaseindicatehowtheResearchCentre,CoreFacilityorNetworkhas:• Tackledorplanstotackleissuesinamannerthatmaynototherwisehavebeenachievable

withoutthefinancialsupportoftheFacultyofMedicine• Increasedorisplanningtoincreasethescaleandfocusofresearchactivities• Facilitatedmultidisciplinary,multi-institutionalorinternationalcollaborations(Pleaselimitresponseto200words)

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ThefundsprovidedbytheFacultyofMedicinearevitaltotheMRCCToperations.ThesefundsarebeingusedtopayanAdministrativeCoordinator(Ms.M.Provost)whosemainfunctionsarecoordinatetheseminarseries,coordinatework-in-progressmeetings,coordinateequipmentpurchaseandmaintenance,maintainourwebsite,andprovideadministrativesupporttoMRCCTPIsandtotheVice-DeanLifeSciences(MRCCTassociatedirectorDrGros).Mariannealsoplaysakeyroleintheorganizationofthesymposium,whichweexpecttore-editinthecomingyear.

FacultyofMedicinefundsarealsocrucialtoinvitenationalandinternationalleaderstoourseminarseries.Asmentionedbefore,theseseminarseriesareveryhighlyvaluedfortheopportunitiesthattheygenerate,suchasenhancingthevisibilityforourowntrainees.Thiswasthecaseforoneofourpost-doctoralfellowsforwhomaconversationwithaninvitedspeakerledtoherrecruitmenttoU.ofMainz,Germany(Dr.ClaudiaDüerr).

Tocontinueexpandourfundingbase,inthespring2017,MRCCTmembersundertheleadershipofDrVidalsubmittedapre-applicationtotheGenomeCanadaprogramLarge-ScaleAppliedResearchProjectCompetition:GenomicsandPrecisionHealth.TheprojectisentitledFunctionalgenomicspipelinetowardsthediscoveryofnewanti-inflammatorytargetswithintheunexploreddruggablegenome(totalvalueof$8,69M)andregroups25multidisciplinaryresearchersfromMRCCT(12membersfromMcGill,MUGQIC,CambridgeU.),U.ofToronto,U.ofChicoutimi,U.ofManitobaandU.ofVictoria.

Asecondgoalfortheperiod2017-2018,willbetocontinuetoenhancethebreadthoftheCenteraswellasthecohesivenessofourmembershipthroughestablishedandnew-targetedactivities.1)Wearehavestartedplanningaone-dayretreatforwinter2018,2)followingthememorandumofunderstandingbetweenRikenlaboratory(Japan)andMcGill,wehaveestablishedlinkswiththeRIKENCenterforIntegrativeMedicalSciences.ThroughstructuredcollaborationswehopetostrengthenRIKEN-McGilllinksandattractnewfundingfromourrespectivefundingagencies.3)Wewillcontinueseekingopportunitieswiththeindustry(InceptionIBD(Anderson,Therrian),EnGene(GhaniaChikh),GSK(ColinMacPhee),Merk(JoshuaMcElwee)toleverageonMcGillinvestments.

TheYearEndFinancialReportreportson:• ExpenditureoffundingprovidedbytheFacultyofMedicineandothersources,towardsmeeting

theobjectivesoftheResearchCentreorNetwork;and• Detailsofanyin-kindcontributionsprovidedtotheCentreorNetwork.• Pleaseincludeaprojectedbudget(includingrequestfromFacultyofMedicine)forthecoming

year• SeeAppendix2forthe“YearEndFinancialReport”formtocomplete

Appendices• Seeattachments

APPENDICES CTG.

Table of Contents

Appendix 1: Graduate and post‐graduate students

‐Table I: Training Graduate Students Page 1

‐Table II: Post‐Doctoral Fellows Page 1

‐Table III: Contributions to undergraduate & graduate teaching Page 2

‐Table IV: Students Project Titles Pages 3‐5

Appendix 2: Targeted Activities

‐Table V: Work in progress: MRCCT Group meetings Pages 6‐7

Appendix 3: List of Seminars hosted by the MRCCT in 2016‐2017 Page 8

Appendix 4: Invitation of MRCCT Core Center PIs as guest speaker Pages 9‐11

Appendix 5: Honours awards and prizes Page 12

Appendix 6: Outreach Activities Page 13

Appendix 7: Consulting Activities Pages 14‐15

Appendix 8: PUBLICATIONS ‐ Primary members (pp 16‐21) ‐ Associate members (pp 21‐32)

Pages 16‐32

Appendix 9: Funding: Individual and Joint Grants Pages 33‐37

Appendix 10: Collaborations Pages 38‐41

Appendix 11: Program of our first symposium Pages 42‐54

Appendix 12: Year End Financial Report form Pages 55‐58

MRCCT |Annual Report 2016‐2017

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TABLE I: TRAINING GRADUATE STUDENTS / MAY 1, 2016 ‐ APRIL 30, 2017 MRCCT Primary

Members Number of

M.Sc. Students Number of

Ph.D. Students Number of M.Sc. Degrees

Awarded Number of Ph.D. Degrees

Awarded Jörg FRITZ 1 2

Philippe GROS 2 5 1 2

Samantha GRUENHEID 3 2 1

Nada JABADO 2 1

Danielle MALO 1 3 3

Judith MANDL 3

Ana NIJNIK 3 2

Martin OLIVIER 5 3 1 1

Salman Qureshi 1

Maya SALEH 3 1

Silvia VIDAL 1 3 1 1

Don VINH 2 1

TOTAL: 19 27 6 9

TABLE II: POST‐DOCTORAL FELLOWS / MAY 1, 2016 – APRIL 30, 2017

MRCCT Primary members NAME PROJECT TITLE

Jörg FRITZ Claudia U. Duerr 2011‐2018: “Regulation of group 2 innate lymphoid cells and its implications in type 2 immunity”

David Langlais 2011‐Jan. 2017: “Identification of the IRF8, IRF1, and PU.1 Transcriptional programs in Myeloid cells, and in response to Interferon Gamma” Philippe GROS

Neda Moradin 2014‐2016. “Role of the CCDC88B protein in intestinal colitis” Samantha GRUENHEID Mitra Yousefi 2014‐Present: “Genetic control of susceptibility to intestinal infections”

Jonathan Pratt 2017‐present, Department of Human Genetics Elvis Valera 2016‐present, Department of Human Genetics

Melissa McConechy 2015‐present, Department of Human Genetics

Michele Zeinieh 2015‐present, Department of Human Genetics Alexander Weil 2014‐present, Department of Human Genetics

Ashot Harutyunyan 2014‐present, Department of Human Genetics

Nada JABADO

Tenzin Gayden 2012‐present, Department of Human Genetics

Ana NIJNIK Michael Foerster June 2013‐Dec. 2016. Project title: “Roles of Histone H2A Deubiquitinase MYSM1 in B and T Cell Mediated Immunity”

Vanessa Atayde 2012‐Present. Project title: “LRV1 and Macrophage activation” Martin OLIVIER

Anupam Adhikari 2013‐2017. Project title: “Role of hepatocytes in leishmaniasis” Salman Qureshi n/a

Ian Gervais‐Rodrigue

2009‐June 2016 “Characterization of the molecular network required for virus‐induced inflammasomes”

Mostafa Khair Oct 2016‐Present: “Investigation of the role of O‐Glcnacylation in macrophage function, inflammation and cell death signaling”

Maya SALEH

Mario Songane Jan 2017‐Present: “Defining the role of the inflammasome in cancer immunosurveillance and immunotherapy”

Danielle MALO Megan Eva March 2016‐Present: “Characterization of the function and mechanism of action of the gene Ncoa7 (nuclear receptor coactivator 7) during infection with Salmonella Typhimurium and in inflammatory conditions”

Judith MANDL Angelica Gopal January 2017 – present: “Actin dynamics in migrating T cells”

Silvia VIDAL Mu Yang Co‐supervision with Dr Ji Zhang, Dentristry, McGill. “Production of MCMV mutant strains to explore the impact of inflationary memory in model of Guillan Barré syndrome”

Don VINH N/A


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TABLE III: CONTRIBUTIONS TO UNDERGRADUATE & GRADUATE TEACHING ‐ MAY 1, 2016‐APRIL 30, 2017

MRCCT Primary members

TEACHING LOAD (HRS) (not including

research project supervision)

COURSE # UNDERGRADUATE RESEARCH

PROJECT STUDENTS SUPERVISED (# OF STUDENTS)

3 hrs MIMM509B 3 hrs EXMD609 6 hrs MIMM384 3 hrs PHGY313

Jörg FRITZ

3 hrs PHGY531B Philippe GROS n/a n/a

2 hrs MIMM211 50 hrs MIMM212 2 hrs MIMM465 5 hrs MIMM384 3 hrs MIMM386 1

Samantha GRUENHEID

6 hrs PHGY419 1 2 hrs HGEN690 2 hrs EXMD635 Nada JABADO

5 hrs HGEN695 30 hrs EXMD602 12

Danielle MALO 32 hrs PHGY419 1 33 hrs PHGY212 5 hrs MIMM384 32 hrs PHGY419 3 hrs PHGY313

Judith MANDL

2 hrs PHGY513 24 hrs PHGY488 1 10 hrs PHGY351 24 hrs PHGY419

Ana NIJNIK

3 hrs PHGY516 Martin OLIVIER n/a n/a

5 hrs EXMD 516‐508B 10‐20 6 hrs MIMM509 18 5 hrs Block B Leader: Respiration

Salman Qureshi

5 hrs PHYG 531 3 hrs PHGY13 9 hrs MIMM386 15 hrs MMIM502D1/D2

Maya SALEH

6 hrs MIMM618 6 hrs MIMM498/499 (coordinator) 6 hrs MIMM384D Silvia VIDAL

3 hrs PHGY552‐531B 2 hrs per BIM6074 5 1 hr per INDS‐117 (Meningitis) 100 1 hr per INDS‐117 (Bone and joint infections) 100 1 hr per INDS‐117 (Genetic defects of Immunity & Infections) 100 2 hrs per BIM6074 5

Don VINH

12 hrs ID‐MM Primary Immunodeficiencies


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Table IV: Students Project Titles (MRCCT Primary Members) JORG FRITZ LAB: ‐Claudia U. Duerr, PDF, 2011‐2018. Department of Microbiology and Immunology (Project title: Regulation of group 2 innate lymphoid cells and its implications in type 2 immunity).

‐Barbara Mindt, PhD, 2012‐present. Department of Microbiology and Immunology (Project title: Role of c‐Rel in regulating group 2 innate lymphoid cell function). ‐Fernando Alvarez, PhD, 2014‐present (co‐supervision with Dr. Ciriacco Piccirillo), Department of Microbiology & Immunology (Project title: Plasticity of T regulatory cells during infection).

‐ Alex Harrison, M.Sc., 2016‐present (cu‐supervision with Dr. Nathalie Grandvaux), Department of Microbiology & Immunology. (Project Title: Functional analysis of the redox post‐translational modifications of STAT1 Cysteines).

PHILIPPE GROS LAB: ‐David Langlais, PDF, 2011‐Jan 2016. Department of Biochemistry (Project title: Identification of the IRF8, IRF1, and PU.1 Transcriptional programs in Myeloid cells, and in response to Interferon Gamma) ‐Neda Moradin, PDF, 2014‐2016. Department of Biochemistry (Project title: Role of the CCDC88B protein in intestinal colitis) ‐Aurélie Laroque, PhD, 2008‐2017. Department of Biochemistry (Project title: “Creation of a mouse mutant lacking pantetheinase (Vnn3); Characterization of role of Vnn3 in resistance to infections”) ‐ James Kennedy, PhD, 2011‐present. Department of Biochemistry (Project title: Identification of novel genes involved in neuroinflammation by ENU mutagenesis) ‐ Vicki Leung, PhD, 2012‐present. Department of Human Genetics (Project title: Role of Vangl proteins in retinal development) ‐Jean‐Frédéric Olivier, PhD, 2013‐present. Department of Biochemistry (Project title: Functional role of CCDC88B in myeloid cells) ‐ Thiviya Jeyakumar, MSc, 2016‐present. Department of Biochemistry (Project title: Contribution of inflammatory response genes to colorectal cancer) ‐Christian Gualtieri, MSc, 2013‐2016. Dept of Biochemistry (Project title: Role of Human PKLR variants in susceptibility to malaria) ‐Nassima Fodil, Research Associate, 2013‐present. Department of Biochemistry (Project title: Immunological studies of resistance to encephalitis in independent ENU‐generated mouse mutants) ‐Maria Polyak, Research Associate, 2014‐present. Department of Biochemistry (Project title: Role of USP15 in acute neuroinflammation) SAMANTHA GRUENHEID LAB: ‐Mitra, Yousefi, PDF, Sept. 2013‐present. Department of Microbiology and Immunology (Project title: Genetic control of susceptibility to intestinal infections). ‐Nathalia Giannakopoulou, PhD Sept. 2014‐present. Department of Microbiology and Immunology (Project title: Virulence and fitness factors of pathogenic E. coli). ‐Eugene Kang, PhD, Sept. 2013‐present. McGill University, Department of Microbiology and Immunology (Project title: Rspondins link inflammation and intestinal homeostasis). ‐Tyler Cannon, MSc, Sept. 2016‐present. Department of Microbiology and Immunology (Project title: Mitochondrial antigen presentation and infection). ‐Alanna Crouse, MSc, Sept. 2016‐present. Department of Microbiology and Immunology (Project title: Genomic variation and virulence in Salmonella serovars). ‐Travis Ackroyd, MSc, Sept. 2013‐Sept. 2016. Department of Microbiology and Immunology (Project title: CFTR and intestinal infection).


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NADA JABADO LAB: ‐Jonathan Pratt, PDF, 2017‐present, Department of Human Genetics. ‐Elvis Valera, PDF, 2016‐present, Department of Human Genetics ‐Melissa McConechy, PDF, 2015‐present, Department of Human Genetics, awarded the Banting Postdoctoral Fellowship by the Canadian Institutes of Health Research. ‐Michele Zeinieh, 2015‐present, PDF, Department of Human Genetics, funded by the Rosalind & ‐Morris Goodman Cancer Research Center throught the McGill Integrated Cancer Research Training Program (MICRTP). ‐Alexander Weil, PDF, 2015‐present, Dept of Human Genetics, funded by R. Shibata Cedars Cancer Fellowship Award ‐Ashot Harutyunyan, PDF, 2014‐present, Department of Human Genetics, funded by postdoctoral fellowship from Fonds de Recherche de Quebec en Sante. ‐Tenzin Gayden, PDF, 2012‐present, Department of Human Genetics , funded by an Internal Postdoctoral fellowship from the Faculty of Medicine. ‐Shriya Deshmukh, BSc, MD/Ph.D. Program, 2015‐present, Department of Human Genetics. Degree expected PhD. Funded by the Sir Edward W. Beatty Memorial Scholarship. ‐Abdulshakour Mohammadnia, 2016‐present, MSc. Department of Human Genetics; ‐Sima Khazaei, 2014‐present, MSc, Department of Human Genetics; Degree expected PhD. DANIELLE MALO LAB: ‐Sean Beatty, PhD, 2008‐2016. McGill University, Department of Human Genetics (Project title: Identification and characterization of the genetic basis of Salmonella resistance/susceptibility in the recombinant congenic strains AcB60 and AcB61). ‐Megan Eva, PhD, 2009‐2016. McGill University, Department of Human Genetics (Project title: Identification of novel susceptibility genes to Salmonella Typhimurium infection using ENU chemical mutagenesis in mice: positional cloning of Ity14). Studentship from the MUHC. ‐Alanna Crouse, MSc, 2016‐Present. Department of Human Genetics (Project Title: Genomic variation and virulence in Salmonella serovar) ‐Kyoko Yuki, PhD, 2008‐2016, McGill University, Department of Human Genetics (Project title: Identification of novel susceptibility genes to Salmonella Typhimurium infection using ENU chemical mutagenesis in mice: positional cloning of Ity16. Studentship from the Faculty of Medicine). JUDITH MANDL LAB: ‐ Dakota Rogers, PhD, NSERC USRA, May 2016 – present, Department of Physiology (Project title: Characterizing naïve CD4 T cell heterogeneity) ‐Caitlin Schneider, PhD, 2016‐present, Department of Microbiology and Immunology (Project title: DOCK8‐deficiency associated migration defects in T cell homeostasis and effector differentiation) ‐Patricio Artusa, PhD, June 2015‐present, Department of Physiology (Project title: The role of T‐cell repertoire diversity in CD4 T cell responses and T cell competition for homeostatic signals) ‐Yvonne Deng, BSc, April 2017‐present, Department of Microbiology and Immunology (undergraduate student volunteer) ‐ Benjamin Forestell, BSc (hons) Sept 2016 – Aug 2017, Department of Microbiology and Immunology (Project title: Regulatory T cell recirculation dynamics through secondary lymphoid organs) ‐ Angelica Gopal, PDF, Jan 2017 – present. Department of Physiology (Project Title: “Actin dynamics in migrating T cells”) ANA NIJNIK LAB: ‐Michael Foerster, PDF, June 2013‐Dec. 2016. McGill University, Department of Physiology (Project title: Roles of Histone H2A Deubiquitinase MYSM1 in B and T Cell Mediated Immunity) ‐Rupinder Boora, MSc, June 2014‐Sept. 2016, Department of of Physiology (Project title: Molecular Mechanisms of p53 Regulation by MYSM1 in Hematopoiesis). ‐Jessica Petrov, MSc, Jan. 2015‐Sept. 2016, Department of of Physiology (Project title: Role of Apoptotic Regulator PUMA/Bbc3 in Mysm1‐knockout Bone Marrow Failure) ‐ Amanda Fiore – 09/2016‐ on medical leave. McGill University, Department of Physiology (Project: Molecular Mechanisms of MYSM1 Activity in Transcriptional Regulation) ‐Yun Hsiao Lin (Minnie) – PhD, 09/2016‐ present. McGill University, Department of Physiology (Project: Testing the role of MYSM1 Catalytic Activity in Hematopoietic Stem Cell Maintenance)


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MARTIN OLIVIER LAB: ‐Vanessa Atayde, PDF, 2012‐Present, Dept. Microbiology and Immunology (Project title: LRV1 and Macrophage activation). ‐Anupam Adhikari, PDF, 2013‐2017. Dept. Microbiology and Immunology (Project title: Role of hepatocytes in leishmaniasis. ‐Kristin Van den Ham, Ph.D, 2011‐present, Dept. Microbiology and Immunology. ‐Alonso da Silva Lira Filho, Ph.D. 2015‐present (Project title: Science without Border» CNpQ Ph.D. Award). ‐Jamilah Abusarah, Ph.D., 2017‐present, Dept. Microbiology and Immunology. ‐Nirmin Alsahafi, Ph.D. 2014‐present, Dpt. Microbiology and Immunology. ‐Alejandra Villa, M.Sc., 2013‐present, Dept. Microbiology and Immunology. ‐Mèlanie Perik, M.Sc. 2016‐2017, Dept. Microbiology and Immunology. ‐Sai Priya Anand, M.Sc., 2016‐present, Dept. Microbiology and Immunology. ‐Andrea Vicutic, M.Sc., 2017‐present, Dept. Microbiology and Immunology. ‐Aretha Chan, M.Sc., 2017‐present, Dept. Microbiology and Immunology. SALMAN QURESHI LAB: ‐Mitra Shourian MSc, 2010‐present, Division of Experimental Medicine, McGill University (Project title: Genetic regulation of host resistance to Cryptococcus neoformans) MAYA SALEH LAB: ‐Ian Gervais‐Rodrigue, PDF, Nov 2009‐June 2016. Department of Medicine, McGill University (Project title: Characterization of the molecular network required for virus‐induced inflammasomes) ‐Mostafa Khair, PDF, Oct 2016‐present. Department of Medicine, McGill University (Project title: Investigation of the role of O‐Glcnacylation in macrophage function, inflammation and cell death signaling) ‐Mario Songane, PDF, Jan 2017‐present. Department of Medicine, McGill University (Project title: Defining inflammasome regulation in inflammatory and metabolic diseases) ‐Alexander Skeldon, PhD, Sept 2010‐Aug 2016. McGill University, Department of Biochemistry (Project title: Characterization of innate immunity sensors in obesity and type 2 diabetes) ‐Maryse Dagenais, PhD, Sept 2010‐present. McGill University, Department of Biochemistry (Project title: Characterization of innate immunity and cell death effectors in colitis, colorectal cancer and breast cancer) ‐Todd Douglas, PhD, Sept. 2012‐present. Department of Microbiology and Immunology (Project title: Ubiquitination mechanisms in inflammasome regulation) SILVIA VIDAL LAB: ‐Gabriel Leiva‐Torres, PhD, 2012‐present, Department of Human Genetics (Project title: Functional genetics approach in mice to identify susceptibility genes to herpes encephalitis). ‐Mathieu Mancini, PhD, 2015‐present. Department of Human Genetics (Project title: Role of c‐Rel in susceptibility to virus infection and neuroinflammation). ‐Jennifer Marton, PhD, 2012‐2016, Department of Human Genetics (Project title: Identification of genetic determinants of host susceptibility to coxsackieviral myocarditis). ‐Kathiriya Vaibhav, MSc., 2016‐present. Department of Human Genetics (Project title: Expression and function of GNL1 GTPase in human natural killer cells). ‐Mu Yang : Co‐supervision with Dr Ji Zhang, Dentristry, McGill. (Project title: Production of MCMV mutant strains to explore the impact of inflationary memory in model of Guillan Barré syndrome).

DON VINH LAB: ‐Marija Landekic, Ph.D. (Micro & Immuno), Aug 2016‐Aug 2020 (Project title: Characterizing the role of CARD9 in monocyte/macrophage immunity to candidiasis). ‐Rebecca Iliza, M.Sc., Biotechnology Research Project (BTEC 623), May 2016‐Sept 2016 (Project title: Characterizing the impact of p.I513T variant on SLP‐76 protein expression and function). ‐Catherine Le, B.Sc. (Pharmacology); Jan 2016‐Sept 2016 (Project title: Genotypic identification of Primary Immunodeficiency).


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Table V: Work in progress: MRCCT Group meetings 2016‐2017 One series of “work in progress” presentations by MRCCT members located around Montreal, graduate students and post‐docs presentations, which is held every week from Sept.‐Oct. to June. This series gives the opportunity to all trainees to present their work to the rest of the group, and provides them with an opportunity to hone their presentation skills, while getting feedback and input on their research by other members of the group. This is an important knowledge transfer activity where all members are exposed to and benefit from specific activities taking place in other PIs labs. http://mcgill.ca/mrcct/mrcct‐group‐meetings

2 0 1 7

January 9 Fernando Alvarez (Piccirillo Lab)

"Understanding the role of alarmins in the functional adaptation of regulatory T cells"

Mathieu Mancini (Vidal Lab) "Neuroinflammation, cell death and viral control

in a model of herpes simplex encephalitis"

January 16 Alonso Lira Filho (Olivier Lab) “Leishmania‐derived Exosomes: From Virulence Factor to a Potential Vaccine? “

1h‐2h PI Presentation ‐ Mathieu Blanchette

“Computational approaches to study chromatin conformation dynamics”

PI Presentation ‐ Judith Mandl "Visualizing the spatio‐temporal dynamics of T cells in homeostasis and immunodeficiency"

January 30

2h‐4h * Wine and cheese mixer right after the group meeting ‐ Bellini *

February 6 Patricio Artusa (Mandl Lab) "The role of T‐cell repertoire diversity in CD4+ T cell responses"

February 13 Genelle Harrison (Schurr & Barreiro Labs) "The advent of agriculture has shaped innate

immune responses to pathogens"

James Kennedy (Gros Lab) "Loss of Zbtb7b Protects Mice from Pathological Inflammation Induced by Cerebral Malaria"

February 20 Barbara Mindt (Fritz Lab) "Role of c‐Rel in IL‐33 mediated ILC2 activation"

Mitra Shourian (Qureshi Lab) "Essential role of IL‐1RI signaling in protection against Cryptococcus neoformans infection"

February 27 Roman Istomine (Piccirillo Lab)

"The role of translation regulation in CD4+ T cell subset differentiation and function"

Jean‐Frédéric Olivier (Gros Lab) “From Cerebral Malaria Resistance to Cellular Migratory Defects: Deciphering the Role

of CCDC88B in Dendritic Cells“

March 6 Maria Polyak (Gros Lab) “USP15: Deciphering its role in neuropathogenesis”

Marija Landekic (Vihn Lab) "CARD9‐mediated Mechanisms of Macrophage

Immunity to Candida albicans"

March 20 Claudia Duerr (Fritz Lab)

“Isolation and Characterization of mouse and human ILC2”

Steven Shao (Piccirillo Lab) Title to come

April 3 Étienne Flamant (Malo Lab)

"Characterization of Fam49b, a new player in regulating the early response to Salmonella infection"

Todd Douglas (Saleh Lab) “Cross‐regulation between the inflammasome and linear ubiquitin assembly complex machinery”

April 10 Alain Pacis (Barreiro Lab)

“Epigenetic regulation of innate immune responses to infection”

Nassima Fodil (Gros Lab) "CCDC88B, a novel immune regulator

for IBD pathogenesis"

April 24 Dakota Rogers (Mandl Lab)

“Predicting functional characteristics of naïve CD4 T Cells by characterizing cell‐Intrinsic heterogeneity”

Victor Mullins‐Dansereau (Lesage Lab) "An unbiased linkage approach reveals that the p53

pathway is coupled to NK cell maturation"


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Table VI ‐ Continued Work in progress: MRCCT Group meetings 2016‐2017

May 1 Thiviya Jeyakumar (Gros Lab) "Deciphering the role of THEMIS and IRF1

in the pathogenesis of CA‐CRC"

Alanna Crouse (Malo Lab) "A Syst‐OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis"

May 15 Han Chen Wang (Nijnik Lab) “ChIP‐Seq Data Analysis Indicated the Role of MYSM1 in the Transcriptional Regulation of Ribosomal Protein Genes”

June 5 Vickie Leung (Gros Lab) “Characterization of Curlybob a novel Vangl2 mouse mutant”

June 12 Benjamin Foretell (Mandl Lab)

Joaquín Sanz Remón (Barreiro Lab)

June 19 PI Presentation Martin Olivier

PI Presentation Ana Nijnik

June 26 Mostafa Khair (Saleh Lab)

2 0 1 6

October 24 Gabriel André Leiva (Vidal Lab)

"Identification of an ENU mutation in STAT5A crucial for host response to herpesvirus infection"

Maryse Dagenais (Saleh Lab) "A critical role for cIAP2 in intestinal

homeostasis"

October 31 Roxanne Collin (Lesage Lab)

"Genetic interaction between Idd2 and Idd13 loci in determining immunoregulatory CD4‐CD8‐ T cell

proportion"

Megan Eva (Malo Lab) "Ncoa7 regulates inflammation and immunity

to typhoid‐like disease"

November 21 Caitlin Schneider (Mandl Lab)

“The type‐2 CD4 T cell effector bias associated with the migration defect caused by DOCK8 deficiency is T cell extrinsic

and GMCSF‐dependent”

Cindy Audiger (Lesage Lab) "Characterization of mcDC homeostasis”

December 5 Luke Healy (Antel Lab)

"MerTK as a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells"

David Langlais (Gros Lab) From Functional Genomics of Inflammation to

Therapeutics"


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Appendix 3: List of Seminars hosted by the MRCCT in 2016‐2017 http://mcgill.ca/mrcct/2016‐2017‐mrcct‐seminars

DATE SPEAKER TITLE OF TALK Time & Location

2 0 1 7 Monday

January 23

Marc LECUIT, MD, PhD Director of the Biology of Infection Unit Institut Pasteur and Inserm (U1117)

“Listeria invasion of host tissues: mechanisms and

effects”

4:00PM Martin

Room 504

Friday, February 15

Julien Karim MALET, PhD Bacteria‐Cell Interaction Unit (Dr. Pascale Cossart) Institut Pasteur, Paris‐ Candidate for: PDF position

“Alteration of host cell proteome in response to Listeria monocytogenes

infection”

12:15PM Karp

Room 501

Wednesday, March 15

Thomas KUFER, PhD Professor, Head of Department of Immunology University of Hohenheim / Stuttgart, Germany

“The NLR protein NOD1 ‐ cellular function and

regulation”

11:00AM Karp

RM 501

Monday March 27

Jean‐Pierre de VILLARTAY, PhD Directeur de Recherche INSERM Lab Director “Genome Dynamics in the Immune System” (DGSI), Institut Imagine / Paris

“DNA double strand breaks in the Immune System: a

dangerous game“

4:00PM Martin

Room 504

Wednesday April 5

Alexander V. CHERVONSKY, MD, PhD Professor & Chairman, Committee on Immunology, Department of Pathology / University of Chicago

“Host‐commensal symbiosis” 4:00PM Martin

Room 504

Wednesday April 26

Johannes TEXTOR, PhD Tumor Immunology, Radboud University Medical Center, Nijmegen, The Netherlands

“Landscapes of tumor infiltrating Lymphocytes:

Quantification, Modeling and Clinical Relevance”

1:30PM Karp

Room 501

Monday‐Tuesday May 8‐9

RIKEN – McGill Symposium Excellence in Immunology & Genetics

McCord Museum 690 Rue Sherbrooke West Montréal, QC / H3A 1E9

J. Armand Bombardier Amphitheatre

Wednesday May 17

Fumio TAKEI, PhD Distinguished Scientist, Terry Fox Laboratory, Professor, Pathology & Laboratory Medicine, Associate Member, Medical Genetics, Associate Member, Microbiology, UBC

“Group 2 innate lymphoid cell memory: what and how

do they remember?”

12:00PM Meakins Room 521

Monday May 29

Michel NUSSENZWEIG, PhD Investigator, Howard Hughes Medical Institute, Senior Physician Zanvil A. Cohn and Ralph M. Steinman Professor, Laboratory of Molecular Immunology / The Rockefeller University

"The HIV Vaccine Problem" 4:00PM Martin

Room 504

2 0 1 6 Friday

November 11

Ichiro TANIUCHI, MD, PhD / Riken, Japan Group Director, Laboratory for Transcriptional Regulation Center for Integrative Medical Sciences

“Transcriptional Regulation of T Cell Development in The

Thymus”

12:00PM Karp

Room 501

Monday‐Tuesday November 28‐29

Hosted by the MRCCT: 1st Montreal Symposium on Immunogenetics of Infectious and Inflammatory diseases

McGill University Research Centre on Complex Traits M

– MRCCT ‐

9h‐5h New Residence Hall

Ballroom

Monday December 12

Nan YAN, PhD Assistant Professor, Rita C. and William P. Clements, Jr., Scholar in Medical Research, Department of Immunology, UT Southwestern Medical Center

“Innate immune response in infection and autoimmune

disease”



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Appendix 4: Invitation of MRCCT Primary members as guest speaker

FRITZ, Jörg ‐ Invited ‐MUHC: Meakins Christie Laboratories Seminar Series, 26th September 2016 (invited by Dr. Carolyne Baglole): Type I IFN restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. ‐McMaster University – Farncombe Institute, 09th November 2016 (invited by Dr. Elena Verdu): Type I IFN restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. ‐MRCCT 1st International Symposium on Immunogenetics of Infectious and Inflammatory Diseases; “Roles of Group 2 Innate Lymphoid Cells in Health and Disease“ – November, 2016. ‐EMBO Conference – Innate Lymphoid Cells, Berlin Germany, 30th November 2016 (invited by Dr. Chiara Romagnani): Type I IFN restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. ‐CETI – Inauguration Symposium, MUHC, Montreal, 16th December 2016 (invited by Dr. Ciro Piccirillo): Type I IFN restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells.

GROS, Philippe – Invited. ‐Abbvie Canada; Phamaceutical Research and Development “Gene Discovery and Validation in Neuroinflammation” Mtl, May 12, 2016. ‐RIKEN Insitute for Integrative Medical Sciences. cInfectious and Inflammatory Diseases Genomics: A growing intersection of genetic risk”. Wako, Japan, July 21, 2016. ‐Boehringer‐Ingelheim Pharmaceuticals Inc. “Gene discovery and Validiation in inflammatory diseases” July 27, 2016. ‐Blueline Bioscience‐MaRS, Toronto “Novel anti‐inflammatory molecules with activity in neuroinflammation” Sept. 28, 2016. GRUENHEID, Samantha – Invited ‐Pasteur Institute, Paris, France. “Analyzing the stromal cell response to Citrobacter rodentium infection of mice“ (small group presentation, Sansonetti lab). 2017 ‐University of Lyon, Molecular Microbiology and Structural Biochemistry, Lyon, France. “Susceptibility to intestinal infection: Analysis of host genetic and dietary effects in the C. rodentium mouse model“. 2017 ‐12th Annual Bellairs research Workshop: “Cell Biology of Disease, Folkestone, Barbados. R‐spondin 2: tipping the balance from homeostasis to dysfunction during intestinal infection“. 2016 JABADO, Nada – Invited ‐American Association of Cancer Research (AACR) Annual Meeting, Session on Pediatric Cancer: Epigeneitcs and Chromatin. Title: Oncohistones in cancer: Pickpockets and epigenome hijackers. Washignton, DC, USA, April 1‐5, 2017 ‐Advances in Genome Biology and Technology (AGBT) Annual General Meeting, Title: Oncohistones: Professional hijackers of the epigenome? Hollywood Beach, FL, USA, Feb 13‐16, 2017. ‐Systems Biology and Proteomics Conference, Title: Oncohistone‐associated Cancers. Bridgetown, Barbados, Jan 14‐18 2017. ‐Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, Genome Integrity Seminar Series, New York, NY, USA, December 08, 2016. ‐Alex’s Young Investigator Summit 2016 of Alex’s Lemonade Stand Foundation, Chicago, IL, USA October 16‐28, 2016. ‐12th European Association of Neuro‐Oncology Meeting, Plenary Session Pediatric Neuro‐Oncology, Rapid (Pre)Clinical Developments. Title: Genome and Transcriptome Analysis in HGG, Mannheim, Germany, October 12‐16, 2016 ‐National Brain Tumor Society (NBTS). Leveraging the Inflection Point in Cancer Research to Advance Brain Tumor Treatments, NBTS Summit Boston, MA, USA September 29, 2016 ‐Genomics of Common Diseases, Title: Oncohistone‐Associated Cancers: A Tale of Histone Tail. Baltimore, USA Sept 25‐28, 2016 ‐Fifth Global Symposium on Ketogenic Therapies, Treating Epilepsy, Brain Cancer, Autism and Cognitive Disorders. Title: Epigenetic Regulation of Tumorigenesis. Banff, AB, Canada, September 20‐24, 2016 ‐Molecular Pathogenesis of Tumor Development and Treatment Resistance in Pediatric Low Grade Glioma Conference, Padua, Italy, Sept 6‐7, 2016 ‐Seventeenth International Symposium on Pediatric Neuro‐Oncology, High‐Grade Gliomas. Liverpool, UK, June 12‐15, 2016. ‐Cancer and Epigenetics Colloquium, Title: Oncohsitone‐mediated cancers: a tale of histone tail. College de France, Paris, France, May 9‐10, 2016 MALO, Danielle – Invited ‐ Université Laval, Québec, Canada. “A Syst‐OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis“. Oct 7 2016


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MANDL, Judith – Invited ‐Departmental Seminar, Department of Pathology, University of Cambridge, “Know thy self: the architecture of a T cell receptor repertoire.” ‐MRCCT 1st International Symposium on Immunogenetics of Infectious and Inflammatory Diseases; “Visualizing the spatio‐temporal dynamics of T cells in homeostasis and immunodeficiency“ – Nov. 2016. ‐Riken‐McGill Symposium Excellence in Immunology & Genetics, “Visualizing the spatio‐temporal dynamics of T cells in homeostasis and immunodeficiency.” – May 2017. NIJNIK, Ana – Invited ‐MRCCT 1st International Symposium on Immunogenetics of Infectious and Inflammatory Diseases; “Hematopoietic stem cells: transcriptional regulation and genomic stability“ – Nov. 2016 ‐Stem Cell Talks Montreal: Research Talk for high‐school students and general public, “Stem Cells 101”. March, 2016 OLIVIER, Martin – Invited ‐5th Gordon Research Conference on “Tropical Infectious Diseases”, Symposium: “Microbiomes of Tropical Disease Vectors”. Impact of Sandfly Nanobiomes on Cutaneous Leishmaniasis Development. Galveston, Texas, USA. March 2017 ‐Centre de Recherche du CHUS, Université de Sherbrooke. Vésicules Extracellulaires et Nanobiome: Impact sur le Développement de la Leishmaniose. Sherbrooke, Québec, Canada. February 2017 ‐3rd International Conference on “Perspectives of Cell signaling and Molecular Medicine”, Celebration of the “100 years of the Bose Institute”. Leishmanial Exosomes : From Phosphatases, Leishmaniasis and Treatment. Kolkatta, India. January 2017 ‐Centre of Excellence in Translational Immunology (CETI) Symposium. Extracellular Vesicles in Host‐Pathogen Interactions: From Pathology to Vaccine Development. Montréal, Québec, Canada. December 2016 ‐1st Montreal Symposium on the Immunogenetics of Infectious and Inflammatory Diseases. Vector‐Transmitted Pathogen Exosomes: Impact on Innate Immune Response and Infection. Montréal, Canada. November 2016 ‐International Society for Extracellular Vesicles Workshop. Vector Transmitted Leishmania Exosomes. Cross‐Organism Communication by Extracellular Vesicles: Hosts, Microbes, Parasites. Sao Paulo, Brazil. November 2016 ‐International Society for Extracellular Vesicles Workshop. Sand Fly‐Inoculated Leishmania Exosomes: Impact on Cutaneous Leishmaniasis Development. Cross‐Organism Communication by Extracellular Vesicles: Hosts, Microbes, Parasites. Sao Paulo, Brazil. November 2016 ‐International Conference on Global Challenges in Neglected Tropical Diseases, Symposium “Multiomics”. Impact of Leishmanial Sand fly Vector Nanobiome on Cutaneous Leishmaniasis. Leon, Spain. July 2016 ‐Gordon Research Conference, “Biology of Host‐Parasite Interactions”, Nanobiome of Leishmanial Sand fly Vector: Impact on Leishmaniasis development. Newport, Rhode Island, USA. June 2016 ‐Wardle Award Lecture, Canadian Society of Zoologists. Trekking in Host‐Parasite Interaction: An Exciting Journey… London, Ontario, Canada. May 2016 QURESHI, Salman – Invited ‐McGill University Health Centre Critical Care Rounds, “Catastrophic antiphospholipid syndrome: diagnosis and management” 2016 (September 16) ‐International Conference of the American Thoracic Society (Invitation: Dr. Scott Evans), “Subversion of immunity by endemic fungal pathogens”, 2016 ‐Symposium Chair: American Thoracic Society International Conference. “New insights into the predisposition, pathogenesis, and management of fungal pneumonia”, 2016 (May 16) SALEH, Maya – Invited ‐University of Bordeaux, Bordeaux, France. Visiting Professor & invited speaker: “Crosstalk of innate immunity and cell death pathways in inflammatory diseases and cancer“. 07/2016. ‐MRCCT 1st International Symposium on Immunogenetics of Infectious and Inflammatory Diseases; “Inflammasome control of inflammatory diseases and cancer“. Nov. 2016. ‐Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. Visiting Professor & invited speaker: “Crosstalk of innate immunity and cell death pathways in inflammatory diseases and cancer“. 03/2017. ‐Ottawa Heart Institute: symposium on “Inflammation in Cardiometabolic Disease”. Ottawa, Canada. Invited speaker: Regulation of cell death and innate immunity crosstalk in health and disease. 03/2017. ‐ Riken‐McGill Symposium Excellence in Immunology & Genetics, “Crosstalk of innate immunity and cell death pathways in inflammatory diseases and cancer.” May 2017. ‐FOCIS 2017 Member Society Symposium, Chicago, USA. Invited speaker: “Inflammasomes and cell death pathways in inflammatory diseases and Cancer. 06/2017.


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VIDAL, Silvia – Chair: ‐MRCCT 1st International Symposium on Immunogenetics of Infectious and Inflammatory Diseases; “Inauguration of the McGill University Research Center on Complex Traits” – Nov., 2016 VINH, DON – Invited: ‐Association des Médecins Omnipraticiens de Montréal – Zoster vaccination : More than skin deep. May 2016. ‐Oral presentation: Human Genetic defects of Antibody deficiency. Scientific Forum of IRCM [invited by: Dr. H Gu). June 2016. ‐McGill University Research Centre on Complex Traits (MRCCT) – First symposium on Immunogenetics of Infectious and Inflammatory Diseases. McGill University (Montréal). [invited by Dr. S. Vidal]. Nov. 2016. ‐Canadian Immunization Conference: “Waking up the Sleeping Giant: Immunosenescence in the Elderly as a Barrier to Vaccination”. Dec. 2016. MUHC, Division of Hematology Rounds: Inborn Errors of Immunity [invited by: Dr. M. Warner]. Dec. 2016 ‐American Transplant Congress: “Neutropenia in kidney and liver transplant recipients: Risk factors and consequences” (Chicago). April 29, 2017.


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Appendix 5: Honours awards and prizes MRCCT Primary members AWARDS

Jörg FRITZ ‐New Investigator Award (A), Salary Support, Canadian Institutes of Health Research (CIHR), (2012‐2017) ‐Programme de bourses de chercheur‐boursier “Junior 1”, Fonds de recherche du Québec FRQS (2013‐2018)

Philippe GROS

‐James McGill Professorship (2010‐2017) ‐Royal Society of Canada – Fellow (2003‐present) ‐Canadian Institute for Advance Research/CIFAR (2015‐2017), Senior Fellow of the Canadian Institute for Advance Research (CIFAR) program in Humans & the Microbiome ‐Canadian Institute for Advance Research/CIFAR (2016‐present), Trottier Fellow ‐ Canadian Institutes of Health Research, Chair, College of Reviewers (one of fifteen) ‐Ordre du Canada / Officer (2016)

Samantha GRUENHEID

‐Nominee, Small World Initiative Joe Caruso Award for excellence in mentorship (2016) ‐Nominee, Small World Initiative Support Person of the Year (2016) ‐Fonds de recherché du Quebec‐ Sante (FRQS) Chercheur‐boursier, Senior (2016‐2017) ‐Nominee, McGill Faculty of Science Leo Yaffe Award for Excellence in teaching (2016) ‐ Visiting Professor (sabbatical): Sanofi R&D: Infectious Diseases Therapeutic Area /Marcy L’Etoile, France January – July 2017

Danielle MALO n/a Nada JABADO ‐Fellow, Royal Society of Canada, Academy Of Science, Life Sciences Division Judith MANDL ‐Canada Research Chair in Immune Cell Dynamics (Tier‐2): 2015‐2020

‐Canadian Immunology Society, New Investigator Travel Award 2017

Ana NIJNIK ‐Canada Research Chair in Hematopoiesis and Lymphocyte Differentiation, Tier 2 (2013‐2018) ‐Nominee, Maude Abbott Prize (2017)

Martin OLIVIER

‐Bose Institute Centenary Celebration Recognition (Kolkata, India, 2017) ‐Robert Arnold Wardle Award (CSZ 2016)

Salman QURESHI

n/a

Maya SALEH

‐McGill University William Dawson Award renewal 2016‐2021 ‐ Fonds de la Recherche en santé du Québec : Chercheur‐Boursier Senior 2013‐2017 (salary support) ‐ Ebiosciences Research Award (Recognition for Outstanding research contributions). Department of Microbiology and Immunology, 2016

Silvia VIDAL ‐Canada Research Chair in Host Response to Virus Infections: 2011‐2018 (Tier 1) ‐F1000 Faculty member 2016‐present

Don Vinh ‐Association of Medical Microbiologists and Infectious Disease specialists (AMMI) Canada: Young Investigator Award ‐RI‐MUHC Foundation: Lilian Wilkins Fellowship Award


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Appendix 6: Outreach Activities Samantha Gruenheid ‐ Advisory board member: International Young Scientists Mentorship Program (IYSMP): Provide advice to a student‐lead organization with a mandate to encourage youth involvement in STEM related activities, promote interdisciplinary thinking, expose students to new STEM fields and applications, show students the relevance of STEM research and innovations to their lives, with emphasis on targeting populations that are most often underrepresented in various STEM fields (e.g. females, aboriginals, ethnic minorities ‐ Career Day panelist for high school students: Stem cell talks/Lets talk Science Anastasia Nijnik ‐ 03/2017 ‐ presentation at an event for undergraduate students of McGill Physiology Department, “Introduction to Stem Cell Biology and Hematopoiesis” ‐ 11/2016 ‐ Poster Session Judge, Montreal Symposium on Immunogenetics of Infectious and Inflammatory Diseases; ‐ 10/2016 – Organizing Committee Member, McGill Stem Cell and Regenerative Medicine Symposium; ‐ 05/2016 ‐ Poster Judge, Annual Physiology Graduate Research Day, McGill University; ‐ 03/2016 ‐ Stem Cell Talks Montreal, Research Talk for high‐school students and general public, “Stem Cells 101”.


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Appendix 7: Consulting Activities

CONSULTING ACTIVITIES / MAY 1, 2016 – APRIL 30, 2017 PRIMARY Members Organization Role Period

PLOS ONE Academic Editor (handling of ~100 manuscripts) 2010‐present

Canadian Institutes for Health Research

Project Grant Competition Peer Review 2017 Jörg FRITZ

Natural Sciences and Engineering Research Council of Canada

External Reviewer, Discovery Grant Panel 2016

CIHR Panel Member, College Chair, College of Reviewers 2016‐present

Bill and Melinda Gates Foundation Grand Challenges Explorations Program (Evaluation Panel) 2010‐present Philippe GROS

Corbin Therapeutics (Mtl, QC) Consulting activities 2016‐present

International Young Scientists mentorship Program (IYSMP)

Advisory board member 2015‐present

Small World Initiative Intl Teaching Collaborative

Co‐leader, scientific committee and Rep. for Canada 2015‐present

Canadian Society of Microbiologists McGill representative 2013‐2017

Samantha GRUENHEID

Canadian Association for Gastroenterology Member, Research Affairs Committee 2016‐

present

Facility Animal Care Committee Chairperson 2009‐present

Université de Montréal Reviewer: Évaluation du programme de maîtrise et de doctorat en medicine vétérinaire

2016

CIHR Fellowship‐Post‐PhD committee 2015‐2017

Danielle MALO

FRSQ Évaluateur du centre de recherche du centre hospitalier de l’Université de Montréal (CR‐CHUM).

2016

AACR Co‐Chair, AACR Special Conference on Pediatric Cancers 2017

Alex’s Lemonade Stand Foundation Member, Scientific Advisory Board 2016‐present

Research Network Scientific Advisory Committee

Chair, C17 Children’s Cancer and Blood Disorders 2015‐present Nada JABADO

Biology committee for pediatric low‐grade gliomas

Co‐Chair, Pediatric Brain Tumour Consortium (PBTC) 2013‐present

CIHR Project Grant Competition Peer Review 2017 Judith MANDL Natural Sciences and Engineering

Research Council of Canada External Reviewer, Discovery Grant Panel 2016

CIHR Doctoral Research Awards A committee (9 applications) 2016

CIHR Pilot Project Grant Competition Peer Review, (16 grants) 2016 Ana NIJNIK Natural Sciences and Engineering Research Council of Canada

External Reviewer, Discovery Grant Panel “Genes, Cells and Molecules” 2016

Martin OLIVIER Bill and Melinda Gate Foundation Co‐Organizer: IUIS Immunology Training Conferences, University of Gondar 2016‐2017

CIHR (Peer review committee) Clinical Investigation B Scientific Officer 2013‐2017 Salman QURESHI MTPI Program Committee, International Meeting 2014‐2017

American Society for Microbiology Chair, Division E (Immunology) 2011‐present

FRSQ Fellowship Review Panel, Comité FF5‐10P, Panel member 2014‐present

CIHR Grant review panel 2017 Maya SALEH

National Institutes of Health Grant review panel 2016


15

CONSULTING ACTIVITIES / MAY 1, 2016 – APRIL 30, 2017 ‐ CONTINUED

PRIMARY Members Organization Role Period

MRCCT 1st International Symposium Chair of the Committee 2016

American Heart Association Immunology BSc 2, Committee Member Oct 2016

Institute Pasteur Grant review panel (Incentive Research Programs and Partnerships) 2016

FNRS (F.R.S.‐FNRS – Belgium) Grant review panel 2016

Silvia VIDAL

American Heart Association Immunology BSc 2, Committee Member April 2017

Héma‐Québec: Medical Consultant Scientific and Medical Selection / Immunoglobulin category 2016

United Kingdom Wellcome Trust Peer Review

External reviewer ad hoc grant (201378/Z/16/Z) 2016 Don VINH

Institut national d’excellence en santé et en services sociaux

Medical Advisor, Committee for use of PET scans in Infectious Diseases (INESS) 2016‐2017


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Appendix 8: PUBLICATIONS ‐ MRCCT Primary members & Associate members Publications: MRCCT Primary members JORG FRITZ

1. Xue D., Kaufman G.N., Dembele M., Beland M., Massoud A.H., Mindt B.C., Fiter R., Fixman E.D., Martin J.G., Friedel R.H., Divangahi M., Fritz J.H., Mazer B.D. Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells. Journal of Immunology 198(1):71‐81 (2017). (IF:4.985; citations: 0)

2. Daugan M., Murira A., Mindt B.C., Germain A., Tarrab E., Lapierre P., Fritz J.H., Lamarre A. Type I Interferon Impais Specific Antibody Responses Early during Establishment of LCMV infection. Frontiers in Immunology 7:564 (2016) (IF:5.695; citations: 1).

3. Förster M., Farrington K., Petrov J.C., Belle J.I., Mindt B.C., Witalis M., Duerr C.U., Fritz J.H., Nijnik A. MYSM1‐dependent checkpoints in B cell lineage differentiation. Journal of Leukocyte Biology Nov 28. pii: jlb.1AB0415‐177RR. [Epub ahead of print] (2016). (IF: 4.165; citations: 0).

4. Liu Y., Goulet M.L., Sze A., Hadj S.B., Belgnaoui S.M., Lababidi R.R., Zheng C., Fritz J.H., Olagnier D., Lin R.RIG‐I‐Mediated STING Upregulation Restricts Herpes Simplex Virus 1 Infection. Journal of Virology 90(20):9406‐19. (IF:4.606; citations: 0).

5. Sila‐Barrios S., Smans M., Duerr C.U., Qureshi S.T., Fritz J.H., Descoteaux A., Stager S.Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia. Cell Reports 15(11):2427‐37 (2016). (IF:7.870; citations: 4)

6. Duerr C.U., Fritz J.H.**. Cytokine‐mediated regulation of group 2 innate lymphoid cells. Cytokine, 87:1‐8 (2016). (IF: 2.940; citations: 3)

7. Yun T.J., Lee J.S., Machmach K., Shim D., Choi J., Wi Y.J., Jang H.S., Jung I.H., Kim K., Yoon W.K., Miah M.A., Li B., Chang J., Ebgo M.G., Pham T.N., Loschko J., Fritz J.H., Krug A.B., Lee S.P., Keler T., Guimond J.V., Haddad E., Cohen E.A., Sirois M.G., El‐Hamamsy I., Colonna M., Oh G.T., Choi J.H., Cheong C.Indoleamine 2,3‐Dioygenase‐expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. Cell Metabolism, 23(5):852‐66 (2016). (IF: 17.303; citations: 1).

8. Duerr C.U., McCarthy C.D.A., Mindt B.C., Rubio M., Meli A.P., Pothlichet J., Eva M.M., Gauchat J.F., Qureshi S.T., Mazer B.D., Mossman K.L., Malo D., Gamero A.M., Vidal S.M., King I.L., Sarfati M., Fritz J.H.**. Type I interferon restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. Nature Immunology, 17(1):65‐75 (2016). (IF: 19.381; citations: 29)

PHILIPPE GROS

1. Belle, JI., Petrov, JC., Langlais, D., Robert, F., Cencic, R., Shen, S., Pelletier, J., Gros, P. and Nijnik, A. “ Repression of p53‐target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance” Cell Death Differentiation 23(5):759‐75, 2016. PMID:26768662

2. Langlais, D., Bareiro, L.B. and Gros, P. “The macrophage IRF1/IRF8 regulome is required for protection against infections and is associated with chronic inflammation ” J. Exp. Med 213(4):585‐603, 2016. PMID: 27001747. PMCID: PMC4821649

3. Moradin, N., Torre, S., Gauthier, S., Tam, S., Hawari, J., Vandercruyssen, K., De Spiegeleer, B., Fortin, A., Stevenson, M.M., and Gros, P. “Cysteamine broadly improves the activity of artemisinins against blood stage and cerebral malaria” Malaria J. 15:260‐271, 2016. PMC4858922

4. Torre, S., Polyak, MJ, Langlais, D., Fodil, N., Kennedy, HM, Radovanovic, I., Berghout, J., Leiva‐Torres, G., Krawczyk, C., Ilangumaran, S., Mossman, K., Liang, C., , Knobeloch, K.P., Healy, LM., Antel, J., Arbour, N., Prat, A., Majewski, J., Lathrop, M., Vidal, SM and Gros, P. “USP15 regulates type I interferon response in vivo and is required for pathogenesis of microbial and autoimmune neuroinflammation” Nature Immunol. 18(1): 54‐63, 2017. PMID:27721430

5. Van der Kraak, L., Langlais, D., Jothy, S., Beauchemin, N., and Gros. P. “Mapping hypersusceptibility to colitis associated colorectal cancer in FVB/NJ mice” Mammalian Genome 27:213‐24, 2016. PMID:26979842

6. Langlais, D., Fodil, N. and Gros, P. “New Insights into Genetics of Infectious and Inflammatory Disease: Overlap Between Discoveries from GWAS and Exome Sequencing” Annual Reviews Immunology, 35:1‐30, 2017. PMID: 27912315. PMID: 27912315

7. Laroque, A., Min‐Oo, G., Tam, M., Ponka, P., Stevenson, MM. and Gros, P. “The Mouse Char10 locus regulates the severity of pyruvate kinase deficiency and susceptibility to malaria” PLOS One, 2017 (in press). Fodil, N., Moradin, N., Leung, V., Olivier, JF., Radovanovic, I., McFarquhar, A., Cayrol, R., Bozec, D., Kubo, M., Dimitrieva J., Louis, E., Theatre, E., Dahan, S., Momozawa, Y., Georges, M., Yeretssian, G. and Gros, P. “CCDC88B is required for pathogenesis of inflammatory bowel disease”. Nature Communications 2017 (submitted).

8. Valanparambil, RM., Tam. M., Gros, PP., Auger, JP., Mariela Segura, M., Gottschalk, M., Gros, P., Jardim, A., Geary, TG., Ozato, K. and Stevenson, MM. “IRF‐8 regulates expansion of myeloid‐derived suppressor cells and Foxp3+ regulatory T cells and contributes to deficient Th2 responses during gastrointestinal nematode infection”. 2017 (submitted).

9. Kong X‐F, Martinez‐Barricarte, R., Mele, F., Kennedy, J., Lazarov, T., Deenick, EK., Breton, G., Bousfiha, Aytekin, AC., Ma, CS., Trouillet, C., Jabot‐Hanin, F., Picard, C., Langlais, D., Lasseau, T., Latorre, D., Hambleton, S., Deswarte, C., Abarca, K., Moraes‐Vasconceles, D., Ailal, F., Abel, L., Boisson‐Dupuis, S., Nussenzweig, MC., Bernd Schröder, B., Geissmann, F., Tangye, ST., Sallusto, F., Gros, P., Bustamante, J. and Casanova, JL. “Impaired development of IL‐12/IL‐23‐producing mDC1 and mycobacteria‐specific IFN‐γ‐producing Th cells in patients with inherited SPPL2a deficiency” Nature, 2017 (submitted).

10. Forster, M., Boora, RK., Petrov, JC., Fodil, N., Albanese, I., Kim, J., Gros, P. and Nijnik, A. “A role for the H2A histone deuibiquitinase in maintenance of CD8+ T cells”. Immunology. 151(1):110‐121, 2017 (ePub ahead of print). PMID: 28066899

11. Petrov, JC., Belle, JI., Langlais, D., Lin, YH., Nguyen, H., Gros, P. and Nijnik, A. “p53 mediated mechanisms lead to anemia and thrombocytosis in Mysm1‐deficiency” Hematologica, 2017 (submitted).


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SAMANTHA GRUENHEID 1. Thomassin JL, Leclerc JM, Giannakopoulou N, Zhu L, Salmon K, Portt A, Daigle F, Le Moual H*, Gruenheid S*. Systematic analysis of

two‐component systems in Citrobacter rodentium reveals positive and negative roles in virulence. Infect Immun. 2016 Nov 21. pii: IAI.00654‐16. [Epub ahead of print] PMID:27872242

2. Kang E, Yousefi M, Gruenheid S. R‐spondins are expressed by the intestinal stroma and are differentially regulated during Citrobacter rodentium‐ and DSS‐induced colitis in mice. PLoS One. 2016 Apr 5;11(4):e0152859. doi: 10.1371/journal.pone.0152859. eCollection 2016. PMID: 27046199

3. JG Emond‐Rheault, J Jeukens, L Freschi, Irena Kukavica‐Ibrulj, Brian Boyle, Marie‐Josée Dupont,Anna Colavecchio, Virginie Barrere, Brigitte Cadieux, Maud Kerhoas, Alanna Crouse, Lei Zhu, Line Larivière, Ana Victoria Pilar, Camille Cavestri, Travis K. Chapin, Denise Tremblay, Caroline Vincent, Eric Fournier,Khadidja Yousfi, Ida Ngueng Feze, Lingqiao Song, Valentine Usongo, Florence Doualla‐Bell, Chrystal Berry,Aleisha R. Reimer, Nguyet Kong, Carol B. Huang, Karen Fong, Emily D. Wilson, Kakali Mukhopadhyay,Walid Mottawea, Dele Ogunremi, Hongsheng Huang, Gitanjali Arya, Ann Perets, Catherine Yoshida, James Andrew Robertson, Joel Weadge, Michelle D. Danyluk, John Rohde, Rafael Garduno, Siyun Wang, Céline Nadon,Paul Thomassin, Yann Joly, Ismail Fliss, Gisele LaPointe, Linda Harris, Roger Stephan, Elton Burnett, Sylvain Moineau,Sandeep Tamber, Sadjia Bekal, France Daigle, S Gruenheid, D Malo, Thomas Wittum, Pascal Delaquis, A Gill, Kenneth E. Sanderson, M Wiedmann, E Franz, L Wijnands, B C. Weimer, L Goodridge and Roger C. Levesque. A Syst‐OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis. Front. Microbio.‐Food Microbiology

NADA JABADO

1. Kernohan K, Grynspan D, Ramphal R, Bareke E, Wang YC, Nizalik E, Ragoussis J, Care4Rare Canada Consortium, Jabado N, Boycott KM, Majewski J, Sawyer SL. H3.1 K36M mutation in a congenital‐onset soft tissue neoplasm. , April 2017 in press DOI:10.1002/pbc.26633 ISI 2.634

2. Cohen KJ, Jabado N, Grill J (2017). Diffuse intrinsic pontine gliomas ‐current management and new biologic insights. Is there a glimmer of hope? Neuro Oncol doi: 10.1093/neuonc/nox021. ISI 7.371

3. Fossey M, Li H, Afzal S, Carret AS, Eisentat DD, Fleming A, Hukin J, Hawkins C, Jabado N, Johnston D, Brown T, Larouche V, Scheinemann K, Strother D, Wilson B, Zelcer S, Huang A, Bouffet E, Lafay‐Cousin L. (2017). Atypical teratoid rhabdoid tumor in the first year of life: the Canadian ATRT registry experience and review of the literature. J Neurooncol doi: 10.1007/s11060‐016‐2353‐0. ISI 3.070

4. Papillon‐Cavanagh S, Lu C, Gayden T, Mikael LG, Bechet D, Karamboulas C, Ailles L, Karamchandani J, Marchione DM, Garcia BA, Weinreb I, Goldstein D, Lewis PW, Dancu OM, Dhaliwal S, Stecho W, Howlett CJ, Mymryk JS, Barrett JW, Nichols AC, Allis CD, Majewski J*, Jabado N*. (2017) Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas. Nat Genet 49(2):18‐185. ISI 31.616

5. Fiset PO, Fontebasso AM, De Jay N, Gayden T, Nikbakht H, Majewski J, Jabado N, Albrecht S. (2017). Longitudinal mutational analysis of a cerebellar pilocytic astrocytoma recurring as a ganglioglioma. Pediatr Blood Cancer 64(2):275‐278. ISI 2.634

6. Torchia J#, Golbourn B#, Feng S#, Ho KC#, Sin‐Chan P, Vasiljevic A, Norman JD, Guilhamon P, Garzia L, Agamez NR, Lu M, Chan TS, Picard D, de Antonellis P, Khuong Quang DA, Planello AC, Zeller C, Barsyte‐Lovejoy D, Lafay‐Cousin L, Letourneau L, Bourgey M, Yu M, Gendoo DMA, Dzamba M, Barszczyk M, Medina T, Riemenschneider AN, Morrissy AS, Ra Y‐S,22, Ramaswamy V, Remke M, Dunham CP, Yip S, Ng H‐K, Lu J‐Q, Mehta V, Albrecht S, Pimentel J, Chan JA, Somers GR, Faria CC, Roque L, Fouladi M, Hoffman LM, Moore AS, Wang Y, Choi SA, Hansford JR, Catchpoole D, Birks DK, Foreman N, Strother D, Klekner A, Bognar L, Garami M, Hauser P, Hortobagyi T, Wilson B, Hukin J, Carret A‐S, Van Meter TE, Hwang EI, Gajjar A, Chiou S‐H, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat DE, Scheineman K, Fleming AJ, Johnston D, Michaud J, Zelcer S, Hammond R, Afzal S, Ramsay DA, Sirachainan N, Hongeng S, Larbcharoensub N, Grundy RG, Lulla RR, Fangusaro JR, Druker H, Bartels U, Grant R, Malkin D, McGlade JC, Nicolaides T, Tihan T, Phillips J, Majewski J, Montpetit A, Bourque G, Bader GD, Reddy AT, Gillespie YG, Warmuth‐Metz M, Rutkowski S, Tabori U, Lupien M, Brudno M, Schuller U, Pietsch T, Judkins AR, Hawkins CE, Bouffet E, Kim S‐K, Dirks P, Taylor MD, Erdreich‐Epstein A, Arrowsmith CH, De Carvalho DD*, Rutka JT*, Jabado N*, Huang A* (2016). Integrated (epi)‐Genomic Analyses Identify Subgroup‐Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer Cell 30(6): 891‐908 ISI 23.523.

7. Bender S, Gronych J, Warnatz H‐J, Hutter B, Gröbner S, Ryzhova M, Pfaff E, Hovestadt V, Weinberg F, Halbach S, Kool M, Northcott PA, Sturm D, Bjerke L, Zichner T, Stütz AM, Schramm K, Huang B, Buchhalter I, Heinold M, Risch T, Worst BC, van Tilburg CM, Weber UD, Zapatka M, Raeder B, Milford D, Heiland S, von Kalle C, Previti C, Lawerenz C, Kulozik AE, Unterberg A, Witt O, von Deimling A, Capper D, Truffaux N, Grill J, Jabado N, Sehested AM, Sumerauer D, Hmida‐Ben Brahim D, Trabelsi S, Ng H‐K, Zagzag D, Allen JC, Karajannis MA, Gottardo NG, Jones C, Korbel JO, Schmidt S, Wolf S, Reifenberger G, Felsberg J, Brors B, Herold‐Mende C, Lehrach H, Brummer T, Korshunov A, Eils R, Yaspo M‐L, Pfister SM, Lichter P, Jones DTW for International Cancer Genome Consortium PedBrain Tumor Project (2016). Recurrent MET fusion genes represent a drug target in pediatric glioblastoma. Nat Med 22(11):1314‐1320. ISI 30.357

8. Packer RJ, Pfister S, Bouffet E, Avery R, Bandopadhayay P, Bornhorst M, Bowers DC, Ellison D, Fangusaro J, Foreman N, Fouladi M, Gajjar A, Haas‐Kogan D, Hawkins C, Ho CY, Hwang E, Jabado N, Kilburn LB, Lassaletta A, Ligon KL, Massimino M, Meeteren SV, Mueller S, Nicolaides T, Perilongo G, Tabori U, Vezina G, Warren K, Witt O, Zhu Y, Jones DT, Kieran M (2016). Pediatric low‐grade gliomas: implications of the biologic era. Neuro Oncol pii: now209 ISI 7.371

9. Lassaletta A, Scheinemann K, Zelcer SM, Hukin J, Wilson BA, Jabado N, Carret AS, Lafay‐Cousin L, Larouche V, Hawkins CE, Pond GR, Poskitt K, Keene D, Johnston DL, Eisenstat DD, Krishnatry R, Mistry M, Arnoldo A, Ramaswamy V, Huang A, Bartels U, Tabori U, Bouffet E (2016). Phase II Weekly Vinblastine for Chemotherapy‐Naïve Children With Progressive Low‐Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study. J Clin Oncol. pii: JCO681585. ISI 20.982

10. Lee TH, Chennakrishnaiah S, Meehan B, Montermini L, Garnier D, D’Asti E, Hou W, Magnus N, Gayden T, Jabado N, Eppert K, Majewska L, Rak J 2016. Barriers to horizontal cell transformation by extracellular vesicles containing oncogenic H‐ras. Oncotarget 7(32): 51991‐52002. ISI 6.359

11. Jones C, Karajannis MA, Jones DT, Kieran MW, Monje M, Baker SJ, Becher OJ, Cho YJ, Gupta N, Hawkins C, Hargrave D, Haas‐Kogan DA, Jabado N, Li XN, Mueller S, Nicolaides T, Packer RJ, Persson AI, Phillips JJ, Simonds EF, Stafford JM, Tang Y, Pfister SM, Weiss WA (2016). Pediatric high‐grade glioma: biologically and clinically in need of new thinking. Neuro Oncol pii: now101 DOI: 10.1093/neuonc ISI 7.371


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Nada JABADO ‐ CONTINUED 12. Ramaswamy V, Hielscher T, Mack SC, Lassaletta A, Lin T, Pajtler KW, Jones DT, Luu B, Cavalli FM, Aldape K, Remke M, Mynarek M,

Rutkowski S, Gururangan S, McLendon RE, Lipp ES, Dunham C, Hukin J, Eisenstat DD, Fulton D, van Landeghem FK, Santi M, van Veelen MC, Van Meir EG, Osuka S, Fan X, Muraszko KM, Tirapelli DP, Oba‐Shinjo SM, Marie SK, Carlotti CG, Lee JY, Nageswara Rao AA, Giannini C, Faria CC, Nunes S, Mora J, Hamilton RL, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognár L, Klekner A, Hortobágyi T, Leary S, Ermoian RP, Olson JM, Leonard JR, Gardner C, Grajkowska WA, Chambless LB, Cain J, Eberhart CG, Ahsan S, Massimino M, Giangaspero F, Buttarelli FR, Packer RJ, Emery L, Yong WH, Soto H, Liau LM, Everson R, Grossbach A, Shalaby T, Grotzer M, Karajannis MA, Zagzag D, Wheeler H, von Hoff K, Alonso MM, Tuñon T, Schüller U, Zitterbart K, Sterba J, Chan JA, Guzman M, Elbabaa SK, Colman H, Dhall G, Fisher PG, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera‐Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro AM, Pollack IF, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins CE, Rutka JT, Dirks P, Pfister SM, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Ellison DW, Taylor MD (2016). Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis. J Clin Oncol 34(21): 2468‐2477 ISI 18.428

13. Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon‐Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD*, Jabado N*, Lewis PW* (2016). Histone H3K36 mutations impair mesenchymal differentiation and promote sarcomagenesis. Science 352(6276):844‐849. ISI 33.611

14. Nikbakht H, Panditharatna E, Mikael LG, Li R, Gayden T, Osmond M, Ho C‐Y, Kambhampati M, Hwang EI, Faury D, Siu A, Papillon‐Cavanagh S, Bechet D, Ligon K, Ellezam B, Ingram W, Moore A, Stinson C, Warren KE, Karamchandani J, Packer RJ, Jabado N*, Majewski J*, Nazarian J* (2016). Spatial and Temporal Homogeneity of Driver Mutations in Diffuse Intrinsic Pontine Glioma. Nat Commun 7:11185 doi: 10.1038/ncomms11185 ISI 11.470.

15. Bouffet E, Larouche V, Campbell BB, Merico D, de Borja R, Aronson M, Durno C, Krueger J, Cabric V, Ramaswamy V, Zhukova N, Mason G, Farah R, Afzal S, Yalon M, Rechavi G, Magimairajan V, Walsh MF, Constantini S, Dvir R, Elhasid R, Reddy A, Osborn M, Sullivan M, Hansford J, Dodgshun A, Klauber‐Demore N, Peterson L, Patel S, Lindhorst S, Atkinson J, Cohen Z, Laframboise R, Dirks P, Taylor M, Malkin D, Albrecht S, Dudley RW, Jabado N, Hawkins CE, Shlien A, Tabori U (2016). Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency. J Clin Oncol 34(19):2201‐2211. IS 18.428

16. Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Gururangan S, McLendon RE, Bigner DD, Lipp ES, Perreault S, Cho YJ, Grant G, Kim SK, Lee JY, Rao AA, Giannini C, Li KK, Ng HK, Yao Y, Kumabe T, Tominaga T, Grajkowska WA, Perek‐Polnik M, Low DC, Seow WT, Chang KT, Mora J, Pollack IF, Hamilton RL, Leary S, Moore AS, Ingram WJ, Hallahan AR, Jouvet A, Fèvre‐Montange M, Vasiljevic A, Faure‐Conter C, Shofuda T, Kagawa N, Hashimoto N, Jabado N, Weil AG, Gayden T, Wataya T, Shalaby T, Grotzer M, Zitterbart K, Sterba J, Kren L, Hortobágyi T, Klekner A, László B, Pócza T, Hauser P, Schüller U, Jung S, Jang WY, French PJ, Kros JM, van Veelen MC, Massimi L, Leonard JR, Rubin JB, Vibhakar R, Chambless LB, Cooper MK, Thompson RC, Faria CC, Carvalho A, Nunes S, Pimentel J, Fan X, Muraszko KM, López‐Aguilar E, Lyden D, Garzia L, Shih DJ, Kijima N, Schneider C, Adamski J, Northcott PA, Kool M, Jones DT, Chan JA, Nikolic A, Garre ML, Van Meir EG, Osuka S, Olson JJ, Jahangiri A, Castro BA, Gupta N, Weiss WA, Moxon‐Emre I, Mabbott DJ, Lassaletta A, Hawkins CE, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka JT, Korshunov A, Pfister SM, Packer RJ, Ramaswamy V, Taylor MD (2016) . Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis. Lancet Oncol 17(4):484‐495. IS 24.690

17. Lévesque N, Leclerc D, Gayden T, Lazaris A, De Jay N, Petrillo S, Metrakos P, Jabado N, Rozen R (2016). Murine diet/tissue and human brain tumorigenesis alter Mthfr/MTHFR 5'‐end methylation. Mamm Genome 27(3‐4):122‐34. IS 3.068

18. Lagresle‐Peyrou C, Luce S, Ouchani F, Soheili S, Sadek H, Chouteau M, Durand A, Pic I, Majewski J, Brouzes C, Lambert N, Bohineust A, Hivroz C, Verhoeyen E, Cosset F‐L, Magerus‐Chatinet A, Rieux‐Laucat F, Gandemer V, Monnier D, Hejmans C, van Gijn M, Dalm VA, Mahlaoui N, Stephan J‐L, Picard C, Durandy A, Kracker S, Jabado N, de saint Basile G, Fischer A, Cavazzana M and André‐Schmutz I (2016). X‐linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN gene). J Allergy Clin Immunol S0091‐6749(16)30423‐7 DOI: 10.1016/j.jaci.2016.04.032. ISI 11.48.

19. Johann PD, Erkek S, Zapatka M, Kerl K, Buchhalter I, Hovestadt V, Jones DT, Sturm D, Hermann C, Segura Wang M, Korshunov A, Rhyzova M, Gröbner S, Brabetz S, Chavez L, Bens S, Gröschel S, Kratochwil F, Wittmann A, Sieber L, Geörg C, Wolf S, Beck K, Oyen F, Capper D, van Sluis P, Volckmann R, Koster J, Versteeg R, von Deimling A, Milde T, Witt O, Kulozik AE, Ebinger M, Shalaby T, Grotzer M, Sumerauer D, Zamecnik J, Mora J, Jabado N, Taylor MD, Huang A, Aronica E, Bertoni A, Radlwimmer B, Pietsch T, Schüller U, Schneppenheim R, Northcott PA, Korbel JO, Siebert R, Frühwald MC, Lichter P, Eils R, Gajjar A, Hasselblatt M, Pfister SM, Kool M (2016). Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell 29(3):379‐393. ISI 23.523.


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DANIELLE MALO 1. Beatty SC, Yuki KE, Eva MM, Dauphinee SM, Lariviere L, Vidal SM, Malo D. 2016. Survival analysis and microarray profiling identify

Cd40 as a candidate for the Salmonella susceptibility locus, Ity5. Genes Immun 17: 19‐29. 2. Duerr CU, McCarthy CDA, Mindt BC, Rubio M, Meli AP, *Eva MM, Gauchat JF, Qureshi ST, Mazer BD, Mossman KL, Malo D, Gamero

AM, Vidal SM, King IL, Sarfati M, Fritz JH. 2016. Type I interferon restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. Nat Immunol 17 :65‐75.

3. Beatty SC, Rached‐D’Astous L, D Malo. Complex genetics architecture contributes to Salmonella resistance in AcB60 mice. Mamm Genome. 2017 Feb;28(1‐2):38‐46.

4. Willemetz A, Beatty S, Richer E, Rubio A, Auriac A, Milkereit RJ, Thibaudeau O, Vaulont S, Malo D and Canonne‐Hergaux F. Iron and hepcidin independent downregulation of the iron exporter ferroportin in macrophages during salmonella infection. Front Immunol.

5. JG Emond‐Rheault, J Jeukens, L Freschi, Irena Kukavica‐Ibrulj, Brian Boyle, Marie‐Josée Dupont, Anna Colavecchio, Virginie Barrere, Brigitte Cadieux, Maud Kerhoas, Alanna Crouse, Lei Zhu, Line Larivière, Ana Victoria Pilar, Camille Cavestri, Travis K. Chapin, Denise Tremblay, Caroline Vincent, Eric Fournier,Khadidja Yousfi, Ida Ngueng Feze, Lingqiao Song, Valentine Usongo, Florence Doualla‐Bell, Chrystal Berry, Aleisha R. Reimer, Nguyet Kong, Carol B. Huang, Karen Fong, Emily D. Wilson, Kakali Mukhopadhyay, Walid Mottawea, Dele Ogunremi, Hongsheng Huang, Gitanjali Arya, Ann Perets, Catherine Yoshida, James Andrew Robertson, Joel Weadge, Michelle D. Danyluk, John Rohde, Rafael Garduno, Siyun Wang, Céline Nadon, Paul Thomassin, Yann Joly, Ismail Fliss, Gisele LaPointe, Linda Harris, Roger Stephan, Elton Burnett, Sylvain Moineau,Sandeep Tamber, Sadjia Bekal, France Daigle, S Gruenheid, D Malo, Thomas Wittum, Pascal Delaquis, A Gill, Kenneth E. Sanderson, M Wiedmann, E Franz, L Wijnands, B C. Weimer, L Goodridge and Roger C. Levesque. A Syst‐OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis.Front.Microbio.‐FoodMicrobiology.

JUDITH MANDL 1. Vrisekoop, N., Artuso, P., Monteiro, J.P., and Mandl, J.N. (2017) “Weakly self‐reactive T cell clones can homeostatically expand when

present at low numbers.” Eur J Immunol 47(1):68‐73. 2. Textor, J., Mandl, J.N., and de Boer, R.J. (2016) “The reticular cell network: a robust backbone for immune responses.” PLos Biology

14(10):e2000827, Commentary. 3. Lippens, C., Duraes, F. V., Guery, L., Dubrot, J., Brighouse, D., Lacroix, M., Magali, I., Aubry‐Lachainaye, J., Reith, W., Mandl, J.N., and

Hugues, S. (2016) “IDO‐orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity.” Journal of Autoimmunity 75:39‐49.

ANA NIJNIK 1. *Förster M, *Boora RK, *Petrov JC, Fodil N, *Albanese I, *Kim J, Gros P, Nijnik A. A role for the histone H2A deubiquitinase MYSM1 in

maintenance of CD8+ T cells. Immunology. 2016 doi: 10.1111/imm.12710. [Epub ahead of print]. 2. *Förster M, *Farrington K, *Petrov JC, *Belle JI, Mindt BC, *Witalis M, Duerr CU, Fritz JH, Nijnik A. MYSM1‐dependent checkpoints in

B cell lineage differentiation and B cell‐mediated immune response. J Leukoc Biol. 2017 Mar;101(3):643‐654. doi: 10.1189/jlb.1AB0415‐177RR. Epub 2016 Nov 28.

3. *Petrov JC, Nijnik A. Mysm1 expression in the bone marrow niche is not essential for hematopoietic maintenance. Exp Hematol. 2017 Mar;47:76‐82.e3. doi: 10.1016/j.exphem.2016.10.013. Epub 2016 Nov 8.

4. You L, Li L, Zou J, Yan K, *Belle J, Nijnik A, Wang E, Yang XJ. BRPF1 is essential for development of fetal hematopoietic stem cells. J Clin Invest. 2016 Sep 1;126(9):3247‐62. doi: 10.1172/JCI80711. Impact Factor: 12.6.

5. *Belle JI, *Petrov JC, Langlais D, Robert F, Cencic R, *Shen S, Pelletier J, Gros P, Nijnik A. Repression of p53‐target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance. Cell Death Differ. 2016 May;23:759‐75. doi:10.1038/cdd.2015.140. Impact Factor: 8.2.

MARTIN OLIVIER

1. P.A. Casgrain, C. Martel, W.R. McMaster, J. Mottram, M. Olivier and A. Descoteaux. Cysteine protease B regulates Leishmania mexicana virulence through the modulation of GP63 expression. PLoS Pathogens DOI:10.1371/journal.ppat.1005658 May 18 (2016).

2. V.D. Atayde, K. Hassani, A. da Silva Lira Filho, A. Raposo Borges, A. Adhikari, C. Martel and M. Olivier. Leishmania Exosomes and other Virulence Factors : Impact on Innate Immune Response and Macrophage Functions. Cellular Immunology S0008‐8749(16)30062‐4. 10.1016/j.cellimm.2016.07.013 (2016).

3. F.A. Kassa, K. Van Den Ham, A. Rainone, S. Fournier, É. Boilard and M. Olivier. Absence of Apolipoprotein E Protects Mice from Cerebral Malaria. Scientific Reports 6, 33615; doi: 10.1038/srep33615 (2016).

4. A. Adhikari, C. Martel, A. Marette and M. Olivier. Hepatocyte SHP‐1 is a Critical Modulator of Inflammation During Septic Shock. Scientific Reports DOI:10.1038/s41598‐017‐02512‐7 (2017).

5. A. Cinti, M. P. Milev, V. Le Sage, C.a Crossie, F. Valiente‐Echeverría, I. Toposirovic, M. Olivier and A.J. Mouland. HIV‐1‐mediated redistribution of mTOR‐associated 1 lysosomal membranes is dependent on the small Rag GTPases. Scientific Reports (Accepted) (2017).

6. K. Van den Ham, L. Smith, M. Richer and M. Olivier. Protein tyrosine phosphatase activity is required for liver injury and pathogenic T cell trafficking during Plasmodium berghei Anka infection. Scientific Reports (Accepted) (2017).


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SALMAN QURESHI

1. Shalaby, K.H., Al‐Heialy, S., Tsuchiya, K., Farahnak, S., McGovern, T.K., Risse, P.A., Suh, W.K., Qureshi, S.T., Martin, J.G. The TLR4‐TRIF pathway can protect against the development of experimental allergic asthma. Immunology. 2017 May 14. doi: 10.1111/imm.12755. [Epub ahead of print] PMID: 28502093

2. Downey, J., Pernet, E., Coulombe, F., Allard, B., Meunier, I., Jaworska, J., Qureshi, S., Vinh, D.C., Martin, J.G., Joubert, P., Divangahi, M. RIPK3 interacts with MAVS to regulate type I IFN‐mediated immunity to Influenza A virus infection. PLoS Pathog. 2017 Apr 14;13(4):e1006326. doi: 10.1371/journal.ppat.1006326. eCollection 2017 Apr. PMID: 28410401

3. Gowing, S.D., Chow, S.C., Cools‐Lartigue, J.J., Chen, C.B., Najmeh, S., Jiang, H.Y., Bourdeau, F., Beauchamp, A., Mancini, U., Angers, I., Giannias, B., Spicer, J.D., Rousseau, S., Qureshi, S.T., Ferri, L.E. Gram‐positive pneumonia augments nonsmall cell lung cancer metastasis via host toll‐like receptor 2 activation. Int J Cancer. 2017 Apr 12. doi: 10.1002/ijc.30734. [Epub ahead of print] PMID: 28401532

4. Goldberg, A.A., Nkengfac, B., Sanchez, A.M., Moroz, N., Qureshi, S.T., Koromilas, A.E., Wang, S., Burelle, Y., Hussain, S.N., Kristof, A.S. Regulation of ULK1 Expression and Autophagy by STAT1. J Biol Chem. 2017 Feb 3;292(5):1899‐1909. doi: 10.1074/jbc.M116.771584. Epub 2016 Dec 23. PMID: 28011640

5. Silva‐Barrios S, Smans M, Duerr CU, Qureshi ST, Fritz JH, Descoteaux A, Stäger S. Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia. Cell Rep. 2016 Jun 14;15(11):2427‐37. doi: 10.1016/j.celrep.2016.05.028. Epub 2016 Jun 2. PMID: 27264176

MAYA SALEH

1. Diamanti, M. A., Gupta, J., Bennecke, M., De Oliveira, T., Ramakrishnan, M., Braczynski, A. K., Richter, B., Beli, P., Hu, Y., Saleh, M., Mittelbronn, M., Dikic, I., Greten, F. R. IKKα controls ATG16L1 degradation to prevent ER stress during inflammation. (2017) J Exp Med. doi: 10.1084/jem.20161867. [Epub ahead of print].

2. *Skeldon, A. M., *Morizot, A., *Douglas, T., Santoro, N., Kursawe, R., Kozlitina, J., Caprio, S., Mehal, W. Z., Saleh, M. Caspase‐12, but Not Caspase‐11, Inhibits Obesity and Insulin Resistance. (2016). The Journal of Immunology. 196 (1): 437‐447.

3. *Dagenais, M., *Dupaul‐Chicoine, J., **Champagne, C., *Skeldon, A., *Morizot, A., Saleh, M. A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis‐associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. (2016). Mucosal Immunology. 9 (1): 146‐158.

4. *Dagenais, M. and Saleh, M. Linking cancer‐induced Nlrp3 inflammasome activation to efficient NK cell‐mediated immunosurveillance. (2016). Oncoimmunology. 5(5):e1129484.

SILVIA VIDAL

1. Kanagaratham, C., Camateros, P., Ren, J., Sladek, R., Vidal, S. and Radzioch, D. Identification of chromosomal regions associated with the allergic IgE phenotype. Submitted. Genes, Genomes, Genetics, 2017. MOP‐89821

2. Marton, J., Wiltshire, S., Marshuk, D., and Vidal, S. The TNNI3K kinase inhibits STAT3‐dependent cardiprotective pathways during cardiotropic CVB3 infection. Submitted. Circ. Res., 2017. MOP‐86592

3. Mancini M, Caignard G, Leiva‐Torres G, Charbonneau B, Dumaine A, Caron M, Sladek R, Vidal SM. An ENU‐induced mutation in Rel confers susceptibility to herpes simplex encephalitis, submitted to PLOS Path, 2017.

4. Leiva‐Torres, Nebesio, N., and Vidal, S. Discovery of variants underlying host susceptibility to virus infection using whole‐exome sequencing, 2017. Methods Mol Biol, in press. 2017. MOP‐133487

5. Torre, S., Polyak, M., Torres‐Leiva, G., Langlais, D., Fodil, N., Kennedy, J., Radovanovic, I., Berghout, J., Lathrop, M., Vidal, S., Gros, P. USP15 regulates type I interferon response in vivo and is required for pathogenesis of microbial and autoimmune neuroinflammation. Nature Immunology 18:54‐63, 2017. MOP‐133487

6. Rahim MM, Wight A, Mahmoud AB, Aguilar OA, Lee SH, Vidal SM, Carlyle JR, Makrigiannis AP. Expansion and Protection by a Virus‐Specific NK Cell Subset Lacking Expression of the Inhibitory NKR‐P1B Receptor during Murine Cytomegalovirus Infection. J Immunol, 197:2325‐2337, 2016. MOP‐777781

7. Stewart, K, Gaitan, Y, Shafer, M, Aoujit, L, Hu, D, Sharma, R, Tremblay, M, Ishii, H, Marcotte, M, Stanga, D, Tang, Y, Boualia, S. K, Nguyen, A, Lamarche‐Vane, N, Takano, T, Vidal, S. and Bouchard, M. A point mutation in p190A RhoGAP affects ciliogenesis and leads to glomerulocystic kidney defects. PLOS Genet, 12:e1005785, 2106. CTP‐87520

8. Duerr, CA, McCarthY, CDA, Mindt, BC, Rubio, M., Meli, AP, Pothlichet, J., Eva, MM, Gauchat, JF, Qureshi, ST, Mazers, BD, Mossman, KL, Malo, D, Gamero, AM, Vidal, SM, King, IL, Sarfati, M., and Fritz, JH. Type I interferon restricts type 2 immunopathology through regulation of group 2 innate lymphoid cells. Nature Immunol 17:65‐75, 2016. MOP‐89821.


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DON VINH

1. Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez‐Quintero LA, Zhang S, Cruz‐Munoz ME, Wu N, Vinh DC, Sinha M, Lowell CA, Danska JS, Veillette A. SLAMF7 is critical for phagocytosis of hematopoietic tumor cells via a Mac‐1 integrin mechanism. Nature 2017 Apr 27;544(7651):493‐497.

2. Downey J, Pernet E, Coulombe F, Allard B, Meunier I, Jaworska J, Qureshi S, Vinh DC, Martin J, Joubert J, Divangahi M. RIPK3 interacts with MAVS to regulate type I IFN‐mediated immunity to Influenza A Virus infection. PLoS Pathogens 2017 Apr 14;13(4):e1006326.

3. *Gavino C, *Landekic M, *Zeng J, Wu N, Jung S, Zhong MC, Cohen‐Blanchet A, Langelier M, Neyret O, Lejtenyi D, *Rochefort C, Cotton‐Montpettit J, McCusker C, Mazer B, Veillette A, Vinh DC. Morpholino‐based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency. J Allergy Clin Immunol 2017 May;139(5):1688‐1692.

4. *De L’Etoile‐Morel S, Feteih A, *Hogan CA, Vinh DC, Thanassoulis G. A case of reversible complete heart block. Am J Med (accepted, in press).

5. Schatorjé E, van der Flier M, Seppänen M, Browning M, Morsheimer M, Henriet S, Neves JF, Vinh DC, Alsina L, Grumach A, Soler‐Palacin P, Boyce T, Celmeli F, Goudouris E, Hayman G, Herriot R, Förster‐Waldl E, Seidel M, Simons A, de Vries E. Primary immunodeficiency associated with chromosomal aberration ‐ an ESID survey. Orphanet J Rare Dis. 2016;11(1):110‐24.

6. Parkes LO, Nguyen TT, Longtin J, Beaudoin MC, Bestman‐Smith J, Vinh DC, Boivin G, Loo VG. A Cluster of Three Cases of Hantavirus Pulmonary Syndrome among Canadian Military Personnel. Can J Infect Dis Med Microbiol. 2016:2757969.

7. Wang Q, Dufesne SF, Vinh DC, Aubin MJ. Chronic Mucocutaneous Candidiasis Presenting as Candida Endophthalmitis. Can J Ophth 2016;51(2):e55‐8.

8. Lachance S, Christofides AL, Lee JK, Sehn LH, Ritchie BC, Shustik C, Stewart DA, Toze CL, Haddad E, Vinh DC. A Canadian perspective on the use of immunoglobulin therapy to reduce infectious complications in chronic lymphocytic leukemia. Curr Oncol. 2016;23(1):42‐51.

9. *Gavino C, Hamel N, Zeng J, Legault C, Guiot MC, Chankowsky J, Lejtenyi D, Lemire M, Alarie I, Dufresne S, Boursiquot JN, McIntosh F, Langelier M, Behr MA, Sheppard DC, Foulkes WD, Vinh DC. Impaired RASGRF1/ERK‐mediated GM‐CSF response characterizes CARD9 deficiency in French‐Canadians. J Allergy Clin Immunol. 2016;137(4):1178‐1188.

Publications: MRCCT Associate members 1. Abbas, Y.M., Laudenbach, B.T., Martinez‐Montero, S., Cencic, R., Habjan, M., Pichlmair, A., Damha, M.J., Pelletier, J. & Nagar, B.

Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'‐O methylations. Proc Natl Acad Sci U S A 114, E2106‐E2115 (2017).

2. Abud, E.M., Ramirez, R.N., Martinez, E.S., Healy, L.M., Nguyen, C.H.H., Newman, S.A., Yeromin, A.V., Scarfone, V.M., Marsh, S.E., Fimbres, C., Caraway, C.A., Fote, G.M., Madany, A.M., Agrawal, A., Kayed, R., Gylys, K.H., Cahalan, M.D., Cummings, B.J., Antel, J.P., Mortazavi, A., Carson, M.J., Poon, W.W. & Blurton‐Jones, M. iPSC‐Derived Human Microglia‐like Cells to Study Neurological Diseases. Neuron 94, 278‐293 e9 (2017).

3. Albert, M., Barrantes‐Freer, A., Lohrberg, M., Antel, J.P., Prineas, J.W., Palkovits, M., Wolff, J.R., Bruck, W. & Stadelmann, C. Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis. Brain Pathol (2016).

4. Andries, A.C., Duong, V., Cappelle, J., Ong, S., Kerleguer, A., Ly, S., Tarantola, A., Horwood, P.F., Sakuntabhai, A., Dussart, P. & Buchy, P. Proteinuria during dengue fever in children. Int J Infect Dis 55, 38‐44 (2017).

5. Antel, J. Widening spectrum of inflammatory disorders of the central nervous system. Curr Opin Neurol 29, 337‐9 (2016). 6. Arrieta, M.C., Sadarangani, M., Brown, E.M., Russell, S.L., Nimmo, M., Dean, J., Turvey, S.E., Chan, E.S. & Finlay, B.B. A humanized

microbiota mouse model of ovalbumin‐induced lung inflammation. Gut Microbes 7, 342‐352 (2016). 7. Arseneault, M., Monlong, J., Vasudev, N.S., Laskar, R.S., Safisamghabadi, M., Harnden, P., Egevad, L., Nourbehesht, N.,

Panichnantakul, P., Holcatova, I., Brisuda, A., Janout, V., Kollarova, H., Foretova, L., Navratilova, M., Mates, D., Jinga, V., Zaridze, D., Mukeria, A., Jandaghi, P., Brennan, P., Brazma, A., Tost, J., Scelo, G., Banks, R.E., Lathrop, M., Bourque, G. & Riazalhosseini, Y. Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma. Sci Rep 7, 44876 (2017).

8. Astle, W.J., Elding, H., Jiang, T., Allen, D., Ruklisa, D., Mann, A.L., Mead, D., Bouman, H., Riveros‐Mckay, F., Kostadima, M.A., Lambourne, J.J., Sivapalaratnam, S., Downes, K., Kundu, K., Bomba, L., Berentsen, K., Bradley, J.R., Daugherty, L.C., Delaneau, O., Freson, K., Garner, S.F., Grassi, L., Guerrero, J., Haimel, M., Janssen‐Megens, E.M., Kaan, A., Kamat, M., Kim, B., Mandoli, A., Marchini, J., Martens, J.H., Meacham, S., Megy, K., O'Connell, J., Petersen, R., Sharifi, N., Sheard, S.M., Staley, J.R., Tuna, S., van der Ent, M., Walter, K., Wang, S.Y., Wheeler, E., Wilder, S.P., Iotchkova, V., Moore, C., Sambrook, J., Stunnenberg, H.G., Di Angelantonio, E., Kaptoge, S., Kuijpers, T.W., Carrillo‐de‐Santa‐Pau, E., Juan, D., Rico, D., Valencia, A., Chen, L., Ge, B., Vasquez, L., Kwan, T., Garrido‐Martin, D., Watt, S., Yang, Y., Guigo, R., Beck, S., Paul, D.S., Pastinen, T., Bujold, D., Bourque, G., Frontini, M., Danesh, J., Roberts, D.J., Ouwehand, W.H., Butterworth, A.S. & Soranzo, N. The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. Cell 167, 1415‐1429 e19 (2016).

9. Atkins, H.L., Bowman, M., Allan, D., Anstee, G., Arnold, D.L., Bar‐Or, A., Bence‐Bruckler, I., Birch, P., Bredeson, C., Chen, J., Fergusson, D., Halpenny, M., Hamelin, L., Huebsch, L., Hutton, B., Laneuville, P., Lapierre, Y., Lee, H., Martin, L., McDiarmid, S., O'Connor, P., Ramsay, T., Sabloff, M., Walker, L. & Freedman, M.S. Immunoablation and autologous haemopoietic stem‐cell transplantation for aggressive multiple sclerosis: a multicentre single‐group phase 2 trial. Lancet 388, 576‐85 (2016).

10. Aubert‐Broche, B., Weier, K., Longoni, G., Fonov, V.S., Bar‐Or, A., Marrie, R.A., Yeh, E.A., Narayanan, S., Arnold, D.L., Verhey, L.H., Banwell, B., Collins, D.L. & Canadian Pediatric Demyelinating Disease, N. Monophasic demyelination reduces brain growth in children. Neurology 88, 1744‐1750 (2017).

11. Audet‐Walsh, E., Papadopoli, D.J., Gravel, S.P., Yee, T., Bridon, G., Caron, M., Bourque, G., Giguere, V. & St‐Pierre, J. The PGC‐1alpha/ERRalpha Axis Represses One‐Carbon Metabolism and Promotes Sensitivity to Anti‐folate Therapy in Breast Cancer. Cell Rep 14, 920‐31 (2016).


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12. Audiger, C., Rahman, M.J., Yun, T.J., Tarbell, K.V. & Lesage, S. The Importance of Dendritic Cells in Maintaining Immune Tolerance. J Immunol 198, 2223‐2231 (2017).

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231. Yegorov, S., Galiwango, R.M., Ssemaganda, A., Muwanga, M., Wesonga, I., Miiro, G., Drajole, D.A., Kain, K.C., Kiwanuka, N., Bagaya, B.S. & Kaul, R. Low prevalence of laboratory‐confirmed malaria in clinically diagnosed adult women from the Wakiso district of Uganda. Malar J 15, 555 (2016).


33

Appendix 9: Funding: Individual and Joint Grants

Collaborative Funding (with >1 MRCCT Primary Members) 2014‐2019 Title of grant : “Immunopathogenesis of Inflammatory Diseases: genetic, cellular and molecular pathways regulating acute and chronic inflammation” Source: Canadian Institutes of Health Research Grant#: MOP‐133487 (Operating Grant) Amount Awarded: $150,414/year; Renewable Dates of Approved Project: 04/2014‐04/2019 Co‐investigator: Name of P.I: Silvia Vidal, Co‐PI: Philippe Gros 2015‐2019 Source: Genome Canada/Genome Quebec Title: “A Syst‐OMICS approach to ensuring food safety and reducing the economic burden of salmonellosis” Amount Awarded: $9,800,000 over 4 years Dates of Approved Project: 10/2015‐09/2019 P.I: Lawrence Goodridge and Roger Levesque (co‐PIs) Co‐investigators: Sadjia Bekal; Stephanie Bonneau; France Daigle; Michelle Danyluk; Pascal Delaquis; Ken Dewar; Rafael Garduno; Alex Gill; Samantha Gruenheid; Hongsheng Huang; Yann Joly; Giselle Lapointe; Danielle Malo; Sylvain Moineau; Celine Nadon; Dele Ogunremi; John Rohde; Sandeep Tamber; Paul Thomassin; Cecile Tremblay; Siyun Wang; Joel Weadge; Bart Weimer. 2017‐2022 Source: Genome Canada Genomics Technology Platforms: Operations Support and Technology Development Funds Title of Project: The Center for Phenogenomics Amount Awarded: $12,750,000 over 4 years Dates of Approved Project: 07/2017‐06/2022 PI: Colin McKerlie and Silvia Vidal, co‐leaders Co‐Investigators in technology development: Daniel Durocher, Janet Rossant, Jerry Pelletier


34

Individual Funding (MRCCT Primary Members)

INDIVIDUAL RESEARCH GRANTS HELD – MRCCT (Primary Members) MAY 1, 2016 – APRIL 30, 2017

Primary members Funding Agency and Program Project Title

Awarded Period

Start date

Awarded Period

End Date

Amount Awarded (PI Portion)

CIHR/MOP‐114972 (Operating Grant)

Functions of Nod1 and Nod2 in host resistance 2011 2016 $132,523/year;

renewable

NSERC Discovery Grant

Cellular and molecular mechanisms regulating immunoglobulin A production

2012 2017 $30,000/year

CIHR “Functions of Nod1 and Nod2 in host resistance.” New Investigator Award:

$60,000/year 2012 2017 $300,000

Fonds de recherche du Québec ‐ Santé (FRQS)

“Functions of Nod1 and Nod2 in host resistance.” Junior 1 Salary Award:

$9,381.5/year 2013 2017 $37,526

Jörg FRITZ (Grants awarded as

Principal Researcher)

CIHR (Foundation Grant)

“Tracing Control Mechanisms of Mucosal Immunity in Health and Disease” 07/2016 06/2021 $1,093,374

(Grants awarded as Co-Investigator) CIHR

GET‐FACTS: Genetics, Environment and Therapies: Food Allergy Clinical Tolerance Studies. Share/$81,500yr

2013 2018 $1,960,606;

non‐renewable (Co‐Pi)

CIHR Operating Grant

Role of Vangl proteins in normal development and in neural tube defects 10/2011 09/2016 $146,148/yr

CIHR/MOP‐79343 Operating Grant

Genetic determinants of susceptibility to blood‐stage malaria

03/2012 04/2017 $142,233/yr

McGill University James McGill Professorship 01/2010 12/2016 $15,000/yr

Blueline Bioscience Discovery Grant

Characterization of pharmacological targets in the CCDC88B‐defined

inflammatory pathway 02/2016 02/2018 $102,900

CIHR Foundation

Genetic control of susceptibility to infections and to inflammation

10/2016 09/2023 $2,170,000

Corbin Therapeutics Inc.

Development of pharmacological modulators of USP15 for use in Multiple

Sclerosis 01/2017 12/2018 $559,000

Philippe GROS

(Grants awarded as Principal Researcher)

CIFAR Senior Fellow of the Canadian Institute for Advanced Research program: Huamns and

the Microbiome 2015 2019 $30,000/yr

(Grants awarded as Co-Investigator)

CIHR

Immunopathogenesis of Inflammatory Diseases: genetic, cellular and molecular

pathways regulating acute and chronic inflammation

04/2014 04/2019 $150,414/yr; renewable

FRQS Chercheur‐boursier Senior (Salary Award) 2016 2017 $39,919/yr

NSERC Bacterial effector proteins as tools to Bacterial effectors as tools study cell biology

04/2014 04/2019 $41,000/yr renewable

Samantha GRUENHEID

(Grants awarded as

Principal Researcher) CIHR/MOP‐133580 Rspo2: Tipping the balance between intestinal homeostasis versus dysfunction

04/2014 03/2019 $135,000/yr


35



Awarded Period

Start date

Awarded Period

End Date


Génome Canada/Genome

Quebec

A Syst‐OMICS approach to ensuring food safety and reducing the economic burden of

salmonellosis 10/2015 09/2019

$9,800,000/4 yrs Portion of money

=$49,000/yr (Grants awarded as Co-Investigator)

FQRNT Novel antibiotics from the artic soil microbiome 04/2017 04/2020 $54,000/yr

Genome Canada/Quebec

Biomarkers for pediatric Glioblastoma through Genomics and Epigenomics 2013 2017 $5,074,844

CIHR Role of chromatin remodeling in the genesis of pediatric and young adult astrocytomas 2013 2018 $788,500

Nada JABADO (Grants awarded as

Principal Researcher FRQS Chaire de recherhce, Fonds de la Recherche

du Québec en Santé 2015 2019 $15,000/yr

National Institutes of Health, PO1, PAR‐13‐321

Mechanisms of histone H3 mutants‐mediated oncogenesis in pediatric cancers 2016 2020 20% of USD

1,248,306 (Grants awarded as

Co-Investigator) Stand Up to Cancer, CDN Cancer Stem Cell Dream Team

Targeting Brain Tumor Stem Cell Epigenetic and Molecular Networks 2015 2019 $452,000

NSERC Genetic mechanisms of Host‐Salmonella interactions

2017 2022 $22,000/yr


Functional characterization of new mouse models for susceptibility to Salmonella infection identified in a genome‐wide

ENU mutagenesis screen.

2014 2019 $128,927/yr

Danielle MALO


IOF Reserve Fund (McGill Internal)

Phenomics Platform 2015 2017 $125,000

Institut Carnot Genetic and microbiotal control of Salmonella carriage in chicken and mice

2015 2017 150,000 €

Oxford McGill ZNZ Partnership in the Neurosciences

Analyzing the dual function of a novel nuclear receptor coactivator in the CNS 2015 2017 $15,000/yr (Grants awarded as

Co-Investigator) Génome

Canada/Genome Quebec


salmonellosis 2015 2019 $9,800,000/4 yrs

($100,307/yr)

McGill University Startup Funds

Startup Funds 2015 2017 $125,000/yr

Canada Foundation for Innovation (CFI) Leaders Opportunity Fund

CFI Leaders Opportunity Fund: Program in T cell interaction and migration dynamics in

health and immunodeficiency 2015 2016 $450,000

Canada Research Chairs (CRC) Tier 2 Canada Res. Chair (CRC)

CRC in Immune Cell Dynamics 2015 2020 $100,000/yr


Linking T cell receptor sequence to T cell function

2016 2021 $36,000/yr

Judith MANDL

(Grants awarded as


CIHR Project Grant

The impact of perturbations in T cell migration on the spatio‐temporal dynamics of CD4 T cell homeostasis and effector cell

differentiation

2016 2021 181,000/yr


36



Awarded Period

Start date

Awarded Period

End Date


CFI ‐ LOF The Roles of Histone H2A Deubiquitinases

(H2A‐DUBs) in Hematopoiesis and Immunity

2012 2016 $ 200,000


Roles of Histone H2A Deubiquitinase Mysm1 in Hematopoiesis and Immunity

2012 2017 $ 649,300

Canada Research Chair

Canada Research Chair in Hematopoiesis and Lymphocyte Differentiation, Tier 2 2013 2018 $ 500,000

NSERC Regulation of B cell Class Switching by Histone H2A Deubiquitinating Enzymes

2016 2021 $165,000

Ana NIJNIK (Grants awarded as


CIHR Project Grant

Chromatin‐Binding Factor MYSM1 in B Lymphocyte Development

2017 2022 $ 669,375


Role of Iron in the Regulation of PTPs: Impact on Cell Signaling and Functions

2012 2017 $240,000

CIHR

Hemozoin and Malaria Biomarkers: Role in the modulation of inflammatory responses

and development of Malaria‐related Pathologies. (extension 6 months)

2012 2018 $825,000 Martin OLIVIER




(renewal… Bridging) 2017 2018 $28,000

CIHR Innovative Ebola Research Grants ‐ Ebola

biology

Deciphering the signaling mechanisms underlying Ebola virus‐mediated inflammatory response upon

interaction/entry with human macrophages.

2015 2017 50% of $239,140 (Grants awarded as

Co-Investigator) FQRNT Projet de

Recherhe en Équipe

Rôles d’une famille de régulateurs transcriptionnels chez le pathogène humain Candida glabrata.

2017 2020 $68,348/year

CIHR

Rare Diseases: Models & Mechanisms” Network (RDMM) Mouse model of human primary immunodeficiency caused by the

Card9 y91h mutation

2015 2017 $25,000/yr

RI‐MUHC

Bridge Funding competition (Ranked #1) Genetic and Functional Analysis of Host

Resistance to Cryptococcus

2016 2017 $50,000

Costello Memorial Research Fund

Use of CRISPR to interrogate innate Immunity against Cryptococcus

2016 2017 $25,000/yr

Salman QURESHI


MUHC ‐ Department of Critical Care

Innate immunity against Cryptococcus

2016 2017 $25,000/yr


Leukemia and Lymphoma Society of

Canada

Critical Care Outcomes in Hematology Malignancy and Stem Cell Transplant 2017 2019 5% of $199,742.52


37



Awarded Period

Start date

Awarded Period

End Date


CIHR Inflammasome regulatory mechanisms in health and inflammatory diseases

2016 2021 $940,335

CIHR

Genetic and functional analyses of the inflammatory caspases and inflammasomes in obesity, metabolic inflammation and

insulin resistance

2016 2017 $100,000


Cellular and molecular mechanisms regulating the inflammasomes

2016 2021 $210,000

McGill University William Dawson renewal Scholarship 2016 2021 $15,000/yr

FRSQ Chercheur‐Boursier Senior 2013 2017 $303,086 Merck, Sharpe & Dohme Corp.

/McGill Faculty of Medicine

Translational Research Program

Genetic and environmental control of programmed necrosis in IBD: Novel therapeutic targets and strategies.

2015 2017 $200,000

Maya SALEH

(Grants awarded as Principal Researcher

CIHR The inflammasome and dysfunctional adipose tissue: why should apoB‐lipoproteins be targeted in humans

2012 2017 $720,054

Silvia VIDAL (Grants awarded as


Canada Research Chair Research Allowance

Genetics of host susceptibility to virus infections

2011 2018 $50,000/yr

CIHR


pathways regulating acute and chronic inflammation.

04/2014 04/2019 $150,960/yr

Genome Canada Genomics Tech. Platforms

Operations Support and Technology Development Funds

The Center for Phenogenomics 2017 2022

$1,750,000 (McGill node: $250,000)

Faculty of Medicine and Fund Raise

Funds to support 1st International Symposium on Immunogenetics of

Infectious and Inflammatory Diseases 11/2016 11/2016 $27,000


Genome Canada Genomics Technology Platforms



FRSQ Chercheur‐boursier clinicien junior 1 (RANK: 1st) 2014 2018

Annual support based on entente

with FMSQ

FRQS Human Genetics in Infectious Diseases program

2014 2018 $15,000/yr

Jeffrey Modell Foundation Specific Defect Grant

The impact of CARD9 deficiency on Dendritic cellmediated mucosal defenses against Chronic mucocutaneous candidiasis

2016 2018 $50,000/USD

Don VINH (Grants awarded as

Principal Researcher

Rare Disease Foundation Microgrant

Proof‐of‐concept study: Rescue of a Missense/misfolding Defect in a Patient with Combined Immunodeficiency due to ICOSLG deficiency

2016 2017 $3,500

U.S. Dept. of Def. Discovery Grant

Fecal Biomarkers in Clostridium difficile Infection

2016 2018 $250,000 (Grants awarded as Co-Investigator)

CIHR Project Grant 2016

Defining the Role of CARD9 in Monocyte/Macrophage Immunity to Candida albicans

2016 2017 $100,000


38

Appendix 10: Collaborations Each Primary MRCCT Members has a number of on‐going collaborations with other members of the MRCCT, with other McGill scientists and with other scientists elsewhere in Canada and abroad. Jörg Fritz 1. Dr. Silvia Vidal: Regulation of group 2 innate lymphoid cells during pulmonary viral infections. 2. Dr. Salman Qureshi: Regulation of innate lymphoid cells during pulmonary fungal infections. 3. Dr. Bruce Mazer: Regulation of B cell responses in oral tolerance. 4. Dr. John White: UV exposure regulates innate lymphoid cells: role of the vitamin D receptor. 5. Dr. Carolyn Baglole: UV exposure regulates innate lymphoid cells: role of the arylhydrocarbon receptor. 6. Dr. Ciriaco Piccirillo: Plasticity of T regulatory cells during infection. 7. Dr. Bushan Nagar: Structure‐function relationship of Nod‐like receptor proteins. 8. Dr. Woong‐Kyung Suh (IRCM, Montreal): The role of innate lymphoid cell‐derived ICOS for the regulation of intestinal B cell responses. 9. Drs. Sheela Ramanathan & Ilangumaran Subburaj (University of Sherbrooke): The role of SOCS1 and SOCS3 in Nod1 and Nod2 signaling. 10. Dr. Jean Marshall (Dalhousie University, Halifax): Role of type III interferons for the regulation of oral tolerance. 11. Drs. Sergei Kotenko & Joan Durbin (Rutgers New Jersey Medical School, USA): Regulation of B cell responses by type III interferon. 12. Dr. Samantha Gruenheid: Mucosal immunity and susceptibility to intestinal infection. 13. Judith Mandl (McGill University), Paige Lacy (University of Alberta), Paul Kubes (University of Calgary), Sergio Grinstein (University of Toronto), Fabio Rossi and Kelly McNagny (University of British Columbia): A Multi‐institutional Canadian Network for next generation imaging of immune‐mediated disease. 14. Ana Nijnik, (McGill University): Role of MYSM1 in ILC2 development and function Philippe Gros 1. Jean‐Laurent Casanova, Rockefeller University, Genetic studies of susceptibility to mycobacterial infections in humans. 2. Anavaj Sakunbathai, Institut Pasteur, Genetic determinants of susceptibility to blood‐stage malaria in endemic and hyper‐endemic areas. 3. Kevin Kain, University of Toronto, Studies of pyruvate kinase deficiency and resistance to malaria in PK‐deficient individuals. 4. Sophie Hambleton, Newcastle University, Role of IRF8 in maturation of myeloid cells, and susceptibility to mycobacterial infections. 5. Anny Fortin, Dafra Pharmaceuticals, Potentiation of Artemisinin anti‐malarial activity by cysteamine. 6. Mary M. Stevenson, Montreal General Hospital, Genetic control of susceptibility to blood‐stage malaria in mice. 7. Mark Lathrop, Genome Quebec and McGill University Innovation Center; Characterization of mouse mutants resistant to neuro‐inflammation. 8. Marcel Behr, Montreal General Hospital. Genetic control of susceptibility to pulmonary tuberculosis in different mouse mutants. 9. Silvia Vidal, McGill University. ENU mutagenesis screening for mutations that convey protection against cerebral malaria. 10. Maya Saleh, McGill University. Functional characterization of immune cells and phenotypes in inflammatory conditions. Effect of host inflammation‐protective mutations on intestinal microbiota. 11. Valeria Capra, Intituto G. Gaslini, Genova, Italy. Mutational analysis of Vangl genes in human neural tube defects. 12. Nicole Beauchemin, McGill University. Genetic control of susceptibility to colorectal cancer in mice. 13. Michael Rout, Rockefeller University. Identification of proteins interacting with CCDC88B. 14. Michel Georges, Universite de Liege, Belgium. Role of CCDC88B in Cronh’s Disease. 15. Stephen Sawcer, Oxford University. Validation of genetic effects detected in association studies of multiple sclerosis in humans.


39

Samantha Gruenheid 1. Herve LeMoual, McGill University, Fitness factors of Gram negative pathogens. 2. John Hanrahan, McGill University, Intestinal ion transporters and intestinal infections. 3. Lawrence Goodridge (McGill University, MacDonald campus), Roger Levesque (Université Laval) and Danielle Malo (McGill): Assessing virulence of different Salmonella serovars isolated from fresh produce with the aim of developing better control stratégies 4. John Rohde, Dalhousie University. Mouse models for Shigella infection. 5. Ben Willing, University of Alberta, Nutrition, microbiome, and susceptibility to intestinal infection. 6. Jorg Fritz: Mucosal immunity and susceptibility to intestinal infection. 7. Judith Mandl: Neutrophil function and intestinal immunity. 8. Lyle Whyte, McGill University: Novel antibiotics from the arctic microbiome 9. Michel Desjardins and Heidi McBride, McGill University, mitochondrial antigen presentation and infection Danielle Malo 1. François Canonne‐Hergaux (Université de Toulouse, France) : Metabolism of iron during Salmonella infection 2. Sophie Vaulont (Institut Cochin, France) : Metabolism of iron during Salmonella infection 3. Marco Prinz (University of Freiburg, Germany) : role of Usp18 in the central nervous system 4. Peter Oliver (University of Oxford, UK) : role of Ncoa7 in the central nervous system 5. SM Vidal (McGill University): characterization of ENU‐induced mutants 6. Robert Sladek (McGill Uni.): Use of BioID to unreveal Fam49b protein interaction 7. Martin Olivier (McGill Uni.) : protein composition of exosomes isolated from Salmonella infected cells 8. Lawrence Goodridge (McGill University, MacDonald campus), Roger Levesques (Université Laval) and Samantha Gruenheid (McGill): Assessing virulence of different Salmonella serovars isolated from fresh produce with the aim of developing better control stratégies Judith Mandl 1. Johannes Textor (Radboud University Medical Centre, Netherlands): Linking T cell receptor sequence to T cell function 2. Irah King (McGill University): role of GMCSF in host protection in Cryptococcus infection 3. Rob de Boer (Utrecht University, Netherlands): Competition of T cells for self‐peptide MHC interactions 4. Heather Melichar (University of Montreal): Optimizing the effector T cell response for improved adoptive cell therapy 5. Luis Barreiro (University of Montreal); Rolf Mueller (Virginia Tech, USA; Shandong University, China): Bats, flight and tolerance mechanisms 6. Jean‐François Côté (IRCM): Protein interaction partners of DOCK8 7. Philippe Gros (McGill University): Dendritic cell migration in CCDC88B mutants 8. Helen Su (NIAID, NIH, USA): DOCK8 in T cell host responses 9. Nienke Vrisekoop (Utrecht University, Netherlands): Naïve CD4 T cell heterogeneity in humans 10. Kathrin Kalies, Jürgen Westermann (Lübeck University, Germany): Linking T cell receptor sequence to T cell function 11. Daniel Barber (NIAID, NIH, USA): T cell diversity in Cryptococcus neoformans infection 12. Salman Qureshi (McGill University): Host responses to Cryptococcus neoformans 13. Jörg Fritz (McGill University), Paige Lacy (University of Alberta), Paul Kubes (University of Calgary), Sergio Grinstein (University of Toronto), Fabio Rossi and Kelly McNagny (University of British Columbia): A Multi‐institutional Canadian Network for next generation imaging of immune‐mediated disease 14. Alexandre Orthwein (Lady Davis Institute): Migration defects in DNA damage response mutant mice 15. Maz Divangahi (MUHC, McGill): Innate immune responses to skin infection with Zika virus 16. Paul Wiseman (McGill): Actin dynamics during T cell migration. 17. Danielle Malo (McGill): Role of Fam49b in neutrophil migration.


40

Ana Nijnik

1. Philippe Gros, McGill University: analysis of the genome‐wide DNA binding pattern of MYSM1 through ChIP‐Seq 2. Silvia Vidal, Philippe Gros, Jorg Fritz, McGill University: MYSM1 in immune response to bacterial and viral pathogens. 3. Jorg Fritz, McGill University: role of MYSM1 in ILC2 development and function 4. Xiang‐Jiao Yang, McGill University: the role of BRPF chromatin interacting proteins in hematopoiesis 5. Maziar Divangahi, McGill University: effects of BCG vaccination on hematopoietic stem cell function 6. Bachir El Affar, Universite de Montreal: role of BAP1 in hematopoiesis and immunity 7. Neil Blake, University of Liverpool, UK: MYSM1 in the regulation of antiviral immunity 8. Dr. Simon Clare, Prof. Gordon Dougan, Wellcome Trust Sanger Institute: novel knockout mouse models to study the roles of histone‐binding deubiquitinases in hematopoiesis and immunity 9. Luda Diatchenko: The role of immune system in chronic pain conditions. I provided advice, protocols and technical assistance with isolation and analysis of immune cells from the patients’ blood

Maya Saleh

1. Thomas A. Ferguson, Washington University, St Louis. Characterization of the immunogenic properties of HMGB1. 2. Thomas S. Griffith, University of Minnesota. Examination of the role of Trail in Influenza pathogenesis. 3. Ivan Dikic, Goethe University, Germany. The role of ubiquitination in regulating the inflammasome. 4. Denise Monack, Stanford University. The role of ubiquitination in regulating the inflammasome. 5. Emad Alnemri, Thomas Jefferson University. The role of HtrA2 in the inflammasome pathway. 6. Wajhat Mehal and Sonia Caprio, Yale University. Defining the role of human caspase‐12 SNP in metabolic inflammation. 7. Helen Hobbs, University of Texas Southwestern. Defining the role of human caspase‐12 SNP in metabolic disease. 8. Arnim Pause, McGill University. Characterization of the role of caspase‐12 in obesity and T2D. May Faraj, IRCM. Characterization of the role of caspase‐12 in obesity and T2D. 9. Silvia Vidal, McGill University. ENU mutagenesis screening for mutations that convey protection against colon cancer metastasis. 10. Nicole Beauchemin, McGill University. Defining the role of the inflammasome pathway in colon cancer metastasis to the liver. 11. Peter Metrakos, McGill University. Defining the role of the inflammasome pathway in colon cancer metastasis to the liver. 12. Samantha Gruenheid, McGill University. Functional characterization of the role of IL‐18 in mucosal immunity to C. rodentium enteric infection. 13. Philippe Gros, McGill University. Effect of host inflammation‐protective mutations on intestinal microbiota. 14. Michel Georges, Université de Liège, Belgium. Role of programmed necrosis in Cronh’s Disease. 15. Sylvain Latour, Centre National de la Recherche Scientifique, France. Role of programmed necrosis in Cronh’s Disease. 16. Mark Lathrop and Tomi Pastinen, Genome Quebec and McGill University Innovation Center; Role of programmed necrosis in Cronh’s Disease. 17. Anavaj Sakunbathai, Institut Pasteur, Human Caspase‐12 polymorphisms in susceptibility to blood‐stage malaria in endemic and hyper‐endemic areas. 18. Philip Awadalla, Université de Montréal, Human Caspase‐12 polymorphisms in susceptibility to blood‐stage malaria in endemic and hyper‐endemic areas. 19. Ciriacco Piccirillo, MUHC. Characterizing the role of caspase‐1 in T cells and T cell‐mediated colitis. 20. Donald Sheppard, McGill University. Defining the role of the inflammatory caspases in Aspergillus fumigatus lung colonization. 21. Lee (Ted) Denson, Cincinnati Children Hospital; Role of programmed necrosis in Cronh’s Disease 22. Alain Bitton, MUHC; Role of programmed necrosis in Cronh’s Disease. 23. Sabah Hussain, McGill University. Dissecting the role of autophagy in inflammasome activation. 24. Hal Hoffman, University of California San Diego. Dissecting the role of autophagy in inflammasome activation. 25. Thomas Tompkins, Lallemand Health Solutions, Investigating the role of probiotics in host defense against bacterial and viral infections. 26. Elena Verdu, McMaster University, Assessing the impact of the microbiota on cancer progression.


41

Silvia Vidal 1. Stipan Jonjic, University of Rijeka, Croatia, Identification of cytomegalovirus evasion mechanisms from NK cell responses. 2. Lewis L Lanier, University of California in San Franciso (CA), USA, Molecular mechanisms of NK cell‐ recognition of infected cells. 3. Luis Sigal, Fox Chase Cancer Center (PA), USA, Genetic susceptibility to poxviruses. 4. Theo Gorgels and Arthur Bergen, Netherlands Institute of Neuroscience (The Neatherlands), Role of the ABCC6 transporter the host response to cardiotropic enteroviruses. 5. Douglas A Marchuk, Duke University Medical Center (NC), USA, Role of TNNI3K in susceptibility to viral myocarditis. 7. Colin MacPhee, GlaxoSmithKline, King of Prussia, (PA), USA, Role of the phospholipase Lp‐Pla2 in host response to mouse influenza. 8. Malik Peiris and Ben Cowling, School of Public Health, The University of Hong Kong, Hong Kong, Role of the phospholipase Lp‐PLA2 is severity and transmission of pandemic and seasonal influenza infections. 9. Earl Brown, University of Ottawa, Host response to mouse‐adapted influenza viruses. 10. Yan Burelle, Université de Montréal, Understanding the role of mitochondrial dysfunction in the cardiovascular phenotype of Abcc6‐/‐ mice. 11. Angela Pearson, Institut Armand Frappier, Host susceptibility mechanisms causing herpes encephalitis. 12. Rob Sladek, MUHC‐RI. Mapping eQTLs controlling the host response to influenza virus infection. 13. Philippe Gros, McGill University. ENU mutagenesis screening for protective mutations against cerebral malaria. 14. Danielle Malo, McGill University. ENU mutagenesis screening for mutations that convey susceptibility to Salmonella infection. 15. Salman Qureshi, MUCH‐RI, Characterization of a new ENU Unc93b mutant for host susceptibility to RNA virus infections. 16. Maya Saleh, McGill University. Identification of genes that influence colon cancer metastasis using mouse ENU mutagenesis. 17. Jamie Engert, MUCH‐RI, Genetic control of plasma lipids. 19. Mathieu Blanchette, McGill University, Identification of regulatory mechanisms of IFNg expression in NK cells. 20. Danuta Radzioch, MUHC‐RI, Genetic analysis of airway hyperresponsiveness in mice. 21. Ji Zhang, Dentistry, Mouse model of Gillan Barré syndrome.

Monday and Tuesday November 28-29, 2016

New Residence Hall | Ballroom A & B

3625 Park Avenue, Montreal

McGill University Research Center on Complex Traits

1st International Symposium on Immunogenetics of Infectious and Inflammatory Diseases

transcriptomic

complexvariants

co

litis

immunegwas

ulcerative

Crohn’s disease

big

da

ta

inflammatory

traitsgenetic

statisticalmalaria

autoimmune

genomics

bioinformatics

infection

model

genotyping

virus

analysis

mouse

multiple sclerosis

Bridging the research community…

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Welcome remarks from Dr Silvia VidalCo-director of the McGill Research Center on Complex Traits

Professor, Dept. of Human Genetics, McGill University

Dear Friends and Colleagues,

Welcome to the 1st International Symposium on Immunogenetics of Infectious and

Inflammatory Diseases in Montreal!

The Symposium marks the inauguration of the McGill University Research Center

on Complex Traits (MRCCT). Our international Center networks 35 basic and

clinical investigators from academia and private sector using a multidisciplinary

approach to study human diseases with a complex genetic etiology. The MRCCT

central theme is immune-mediated diseases, from severe infections to chronic

inflammatory disorders such as multiple sclerosis, rheumatoid arthritis and

Inflammatory bowel disease. Our mission is to establish a Center of excellence

in basic and translational research, education, and entrepreneurship to accelerate new scientific discoveries

enabling personalized medicine approaches to cure immune-mediated disorders.

For our first Symposium, we are delighted to feature an exceptional program showcasing the breadth of

research, and its applications to human health, undertaken by MRCCT members. They will present their latest

discoveries about the role of host genetic factors, the immune system and the microbiota on the development

and outcome of immune-mediated diseases, using mouse and human models. Others will discuss how this

new knowledge is informing new clinical approaches and successful treatments. A number of talks will tackle

the new trends in computational medicine to unlock epigenetic regulators and characterize their role in cell

homeostasis and their contribution to disease states. Finally, other presentations will focus on new

technologies including intra-vital imaging to understand immune responses in live animals as well as gene

editing methods to validate new drug targets.

Canada has the highest rate of multiple sclerosis in the world. So to further stimulate discussion, our keynote

speaker, Dr Marco Prinz, Director of the Institute of Neuropathology University Medical Center, University of

Freiburg, and a specialist in the study of brain-specific immune functions, will be presenting new work on the

function of the innate immune system in autoimmune and neurodegenerative CNS disorders.

This Symposium places great importance on the involvement of students and post‐doctoral fellows. Forty-

seven posters will be presented during the event, and we thank in advance our panel of judges who will have

to make tough decisions to identify the winners of the poster competition!

By presenting the various aspects of fundamental, clinical and translational research related to various

infectious and inflammatory diseases, we hope that the Symposium will provide a platform that promotes

interdisciplinary thinking, generates new ideas and fosters scientific advancement. The Symposium has

attracted 215 participants from universities, hospitals and biotech companies that will have an opportunity to

join the conversation, network and discuss with our experts.

We sincerely thank all those involved in the organization of the symposium, in particular all of our speakers.

We acknowledge the team of volunteers, lead by Ms Marianne Provost, for their diligence and enthusiasm in

the preparation of this event. We are also very grateful to our sponsors and partners for their generous support

that has permitted to organize a Symposium free of charge.

We look forward to an exciting meeting that promises great scientific debates and enjoyable social

interactions. Let’s make together an unforgettable event in snowy Montreal!

Silvia Vidal

On behalf of the organizing committee

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6 x McGill Departments• Microbiology and Immunology

• Human Genetics

• Medicine

• Biochemistry

• Physiology

• Computer Science

4 x Canadian Institutions• McGill University

• University of Toronto

• Université de Montréal

• University of British Columbia

3 x International Institutions• Université de Liège

• Institut Pasteur

• University of Cambridge

2 x Private Sector Partners• Janssen

• Lallemand

MRCCT Members

35 experts in immune-mediated disease

Bio

chem

ical

Fun

ctio

n

Human Genetic Variation Creation o

f Mouse

Mo

dels C

ellu

lar Fu

nctions Microbiome E ects

Pre

cl

inic

al M

ouse

Mo

dels

6 Departments

4 Canadian Institutions

3 International Institutions

3 Private Sector Partners

Basic

Clinical

Translational

Research

Martin Olivier

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agenda – Monday Nov 28th, 2016

8:30 am Registration (Coffee is provided)

9:00 am Opening remarks by MRCCT Director, Dr Silvia Vidal

9:10 – 10:10 am Session I - Mechanisms of inflammatory disorders: Mouse ModelsChair: Dr Sidong Huang, Dept of Biochemistry, McGill University

9:10 am Dr. Jörg Fritz, Dept. Microbiology and Immunology, McGill University

Roles of Group 2 Innate Lymphoid Cells in Health and Disease

9:40 am Dr. Maya Saleh, Dept. of Medicine, McGill

Inflammasome control of inflammatory diseases and cancer

10:10 – 10:45 am Coffee break

10:45 am – 12:30 pm Session II - Mechanisms of Infectious and inflammatory disorders: Human ModelsChair: Dr Salman Qureshi, MUHC

10:45 am Dr. Luis Barreiro, Université de Montréal

Genetic and epigenetic regulation of immune responses to infection

11:15 am Dr. Donald Vinh, Dept of Medicine, MUHC

Human Genetic Susceptibility to Infectious Diseases: When the Rubber of Immunology Hits the

Road of Life

11:45 am Dr. Kevin Kain, SAR Laboratories, Rotman Centre for Global Health, UHN

Preventing death and disability from Life-threatening infections

12:15 pm Dr. Amit Bar-Or, Montreal Neurological Institute (MNI)

Antibody-independent roles of B cells in autoimmune regulation and infection control

12:30 – 2:00 pm Lunch break (*provided)

Poster session I

2:00 – 3:00 pm Session III - Genetic determinants of neuroinflammation and malignancyChair: Dr Sylvie Lesage, Centre de recherche Hôpital Maisonneuve-Rosemont

2:00 pm Dr. Stephen Sawcer, Cambridge University, UK

MS genetics: Pitfalls and Prospects

2:30 pm Dr. Nada Jabado, Dept of Medicine, MUHC

Oncohistones: a tale of histone tail

3:00 – 3:45 pm Coffee break

Poster session II

3:45 – 4:00 pm MRCCT: Opening of the new Center

Dr. Philippe Gros, Co-Director, MRCCT

Dr. Rose Goldstein, VP Research & International Relations

Dr. David Eidelman, Vice-Principal & Dean, Faculty of Medicine

4:00 – 5:00 pm Keynote session IDr. Marco Prinz, Dir. Institute of Neuropathology, University of Freiburg, Germany

Myeloid cells in the brain

5:00 – 5:05 pm Closing Remarks by Dr Samantha Gruenheid

5:05 – 7:00 pm WINE & CHEESE mixer

Poster session III

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agenda – Tuesday Nov 29th, 2016

8:30 am Arrival (Coffee is provided)

9:00 – 9:40 am Session I – New TechnologiesChair: Caitlin Schneider, Laboratory of Dr Mandl, McGill University

9:00 am Dr. Judith Mandl, Dept. of Physiology, McGill University

Visualizing the spatio-temporal dynamics of T cells in homeostasis and immunodeficiency

9:15 am Dr. Jerry Pelletier, Dept. of Biochemistry, McGill University

Drug-Target Validation using CRISPR/Cas9

9:30 am Christopher Kenny, Eve Technologies

Immune Biomarker Array To Enable Precision Medicine

9:40 – 10:20 am Session II - Computational MedicineChair: Dr David Langlais, Laboratory of Dr Gros, McGill University

9:40 am Dr. Mathieu Blanchette, School of Computer Sciences, McGill University

Know thy Ancestors to Know Thyself: Improving our understanding of the human genome using

paleogenomics

9:55 am Dr. Guillaume Bourque, McGill University and Genome Quebec Innovation Center

Epigenomic resources to better understand human non-coding DNA

10:10 am Dr. Michael G. Smith, Executive Sales Specialist, Sequencing & Data Analysis, Illumina

Analyzing the Microbiome using BaseSpace Sequence Hub

10:20 am Coffee break

10:50 – 11:15 am Session III – Stem CellsChair: Barbara Mindt, Laboratory of Dr Fritz, McGill University

10:50 am Dr. Ana Nijnik, Dept of Physiology, McGill University

Hematopoietic stem cells: transcriptional regulation and genomic stability

11:05 am Dr. Roger Bossé, Sr. Market Segment Leader, Perkin Elmer

Functional Stem Cell Characterization

11:15 – 11:45 am Session IV – InfectionChair: Todd Douglas, Laboratory of Dr Saleh, McGill University

11:15 am Dr. Erwin Schurr, Dept. of Medicine, Human Genetics, RI-MUHC

Leprosy as human model for inflammatory disease susceptibility

11:30 am Dr. Martin Olivier, Dept. Microbiology and Immunology, McGill

Vector-Transmitted Pathogen Exosomes: Impact on Innate Immune Response and Infection

11:45 am – 12:15 pm Session V – Inflammatory DiseasesChair: Mathieu Mancini, Laboratory of Dr Vidal, McGill University

11:45 am Dr. Ciro Piccirillo, Dept. Microbiology and Immunology, McGill

Development and functional dynamics of immunoregulatory mechanisms in human health and

disease

12:00 pm Dr. Jack Antel, Montreal Neurological Institute, McGill

Dynamic properties of human microglia


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agenda – Tuesday Nov 29th, 2016 (CONt’d)

1:30 – 2:00 pm Keynote session II (Chair: Dr Judith Mandl)

Dr. Jayne Danska, University of Toronto - Hospital for Sick Children

The complex causes of autoimmunity: genes, sex and microbes

2:00 – 4:00 pm Round Table

* Scientific Board Members (SAB) and Clinical Advisory Committee (CAC) meeting

Moderators: Drs Vidal & Gros

2:00 – 4:00 pm 3 min Talks

* Students and PDF session

Moderator: Mathieu Mancini

4:00 pm Award Ceremony for winners of poster competition in PDF, Ph.D. and M.Sc. categories

4:15 pm Closing Remarks by Dr Silvia Vidal

4:30 – 7:00 pm Mixer

* 1 free beverage included

Location: Thomson House, 3650 McTavish St, Montreal

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KEYNOTE SPEAKERS

Marco Prinz is Professor of Neuropathology and Chair of the Institute of

Neuropathology at the University of Freiburg, Germany. Dr. Prinz obtained

his MD at the Charité, Humboldt-University Berlin in 1997. During his MD

thesis he investigated the pathology of cortical interneurons in humans at

the Institute of Neuroanatomy at the Charitè Berlin. He did a postdoc at

the Max-Delbrück-Centre (MDC) of Molecular Medicine dedicated to the

function of glial cells in the central nervous system (CNS), especially

microglia. He performed his residency in Neuropathology at the University

Hospital Zurich, Switzerland and studied there the role of the peripheral

and CNS-restricted immune system for the pathogenesis of

neurodegenerative diseases such as prion diseases. In 2003 he became

a group leader at the University Hospital in Göttingen, Germany and in

2007 lecturer of Neuropathology there.

Dr Marco PrinzDirector of the Institute of Neuropathology

University of Freiburg, Germany

He was recruited to the University of Freiburg, Germany, in 2008 and was promoted to the rank of

Full Professor and Chair of the Institute of Neuropathology.

Dr. Prinz laboratory studies the mechanisms that regulate the development and function of the

mononuclear phagocyte lineage in the central nervous system including microglia, perivascular and

meningeal macrophages. His laboratory has made seminal discoveries in CNS macrophage biology

revealing their embryonic origin and their local maintenance in situ. Dr. Prinz belongs to several

German Research Foundation (DFG)- and EU-funded scientific consortia to decipher the

transcriptional regulation of the macrophage lineage in the CNS.

Currently, his research group aims to understand myeloid cell biology in the CNS during health and

disease and studies the impact of the immune system on the pathogenesis of neurological

disorders such as neurodegenerative diseases, ultimately aimed at recognizing novel therapeutic

strategies and targets to treat these central nervous system diseases.

Dr. Prinz has authored more than 170 primary papers and reviews in high profile journals and has

obtained extensive DFG and EU funding for his studies on macrophage biology in the CNS in mice

and humans.

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KEYNOTE SPEAKERS

Dr. Danska was raised in New York City, and educated in the United

States at Kenyon College, Cornell University, Cold Spring Harbor Labs

and Stanford University. She holds The Anne and Max Tanenbaum Chair

in Molecular Medicine, is a Senior Scientist at the Hospital for Sick

Children and a Professor in the Faculty of Medicine at University of

Toronto with appointments in the Departments of Immunology, and

Medical Biophysics. Her research is focused on defining the mechanisms

underlying immune system diseases and application of this knowledge to

improve their diagnosis, prevention and treatment. Her lab works on the

genetic and environmental causes of autoimmune disease, particularly

Type 1 diabetes (T1D), the molecular mechanisms of acute lymphoid

leukemia (ALL), and innate immune surveillance of leukemia and

leukemia stem cells. She has led multi-disciplinary projects applying

genetic, genomic and immunological analysis to identify T1D-risk genes

and to determine how these variants control autoimmune pathogenesis.

Dr JAYNE DANSKAHospital for Sick Children

University of Toronto, Canada

An evolving focus is the roles of environmental factors in the rising rates of autoimmune and

inflammatory diseases, specifically the role of the intestinal microbiome in modifying inherited risk

of autoimmunity in rodent models and in longitudinal studies in children with high genetic risk for

type 1 and type 2 diabetes. This work is also investigating the impact of sex as a key determinant

of autoimmune diseases, many of which are far more prevalent in females. In addition, Dr. Danska

and her collaborators discovered a signaling pathway in macrophages pivotal to the survival of

human normal hematopoietic stem cells and acute leukemia stem cells that sustain leukemic

growth. They have developed a biologic therapy to manipulate this immune checkpoint to impair

the survival of leukemia and other blood cell cancers that is now in clinical trials.

Dr. Danska has an active training program of post-doctoral fellows, graduate students and

technologists. She is a Chair of the College of Reviewers, Canadian Institutes of Health Research,

and serves as a panel member and Chair in the Canadian Diabetes Association, the Juvenile

Diabetes Research Foundation, the Canadian Cancer Society and the National Institutes of Health

(U.S). She is actively engaged in knowledge translation beyond the medical community to

patients, their advocates and government policy makers.

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POSTER PRESENTATIONS

List of posters presented on Nov 28th, 2016.

# Presenter Status Inst. Lab Title

1 Anupam Adhikari Postdoc MUHC M. OlivierLeishmania-induced SHP-1 Activation in Hepatocytes Inhibits

NO Production

2 Fernando Alvarez PhD student McGill C. PiccirilloIL-3 modulates the functional plasticity of Foxp3+ T cells in

infections

3 Patricio Artusa PhD student McGill J. MandlThe role of T cell repertoire diversity in CD4+ T cell

responses

4 Vanessa Diniz Atayde RA MUHC M. OlivierMultifaceted roles of Leishmania exosomes in the

exacerbation of the infection

5 Audiger Cindy PhD student CR-HMR S. Lesage Bim regulates merocytic dendritic cell proportion

6 Giselle Boukhaled PhD student McGill C. KrawczykPolycomb group factor 6, PCGF6, controls dendritic cell

responses to inflammatory microenvironments

7Christopher J.F.

CameronPhD student McGill M. Blanchette Improved Hi-C Contact Maps by Adaptive Density Estimation

8 Tyler Cannon MSc student McGill S. GruenheidInvestigating the Impact of EPEC Infection on Mitochondrial

Antigen Presentation

9 Julien Chambon Undergrad McGill J. ZhangCharacterization of gut macrophages and CD8 T cells in

mice developing autoimmune peripheral neuropathy

10 Anastasia Cheng MSc student McGill I. ColmegnaMesenchymal Stromal Cell Derived Extracellular Vesicles:

Role on T-cell Suppression

11 Roxanne Collin PhD student CR-HMR S. Lesage

Genetic interaction between two insulin-dependant diabetes

susceptibility loci in determining immunoregulatory CD4-

CD8- T cell proportion

12 Alanna Crouse MSc student McGill D. MaloA Syst-OMICS Approach to Ensuring Food Safety and

Reducing the Economic Burden of Salmonellosis

13 Todd Douglas PhD student McGill M. SalehCross-regulation between the inflammasome and linear

ubiquitination machinery

14 Megan Eva Postdoc McGill D. Malo

Identifying the transcriptional coactivator NCOA7 as an

immune regulator of the host response to Salmonella

infection by genome-wide mutagenesis

15 Nassima Fodil RA McGill P. GrosCcdc88b is required for pathogenesis of inflammatory bowel

disease

16 Benjamin P Forestell Undergrad McGill J. MandlDistinct regulatory subsets differ in their recirculation

dynamics through secondary lymphoid organs

17 Michael Forster Postdoc McGill A. NijnikMysm1 as a potential drug target for p53 activation in B cell

malignancies

18Natalia

GiannakopoulouPhD student McGill

S. Gruendheid,

H. Le Moual

Two-component systems and altered virulence of Citrobacter

rodentium

19 Hannah Guak PhD student McGill C. Krawczyk Induction of glycolysis is required for dendritic cell migration

20 Boram Ham Postdoc McGill J. Mogil

Cytotoxic T cells may induce pain hypersensitivity in female

but not male mice after nerve injury in an interferon-g-

receptor-dependent manner

21 Saloua Jeidane PhD student IRCM C. Deschepper

Association of a Network of Interferon-Stimulated Genes with

a Locus Encoding a Negative Regulator of Non-conventional

IKK Kinases and IFNB1

22 Thiviya Jeyakumar MSc student McGill P. GrosThemis and IRF1-deficient Mice Show Increased

Susceptibility to Colitis-Associated Colorectal Cancer

23 Eugene Kang PhD student McGill S. Gruenheid

Establishing a primary mouse intestinal epithelial cell

monolayer culture system to study Citrobacter rodentium

infection

24 James Kennedy PhD student McGill P. GrosCcdc88b is a Novel Regulator of Maturation and Effector

Functions of T Cells During Pathological Inflammation

25 Vijay Kumar PostdocPanjab

UniversityS. Chhibber

A Comparison of inflammatory innate immune response

during Klebsiella pneumoniae B5055 induced pneumonia

and sepsis in BALB/c mice

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POSTER PRESENTATIONS (CONT’D)


26 Edward Kwarteng PhD student INRS K. HeinonenHematopoietic stem cell activation in chronic LCMV

infections

27 David Langlais Postdoc McGill P. GrosThe IRF8 and IRF1 regulome: driver of pathological

neuroinflammation

28Gabriel André Leiva-

TorresPhD student McGill S. Vidal

An N-Ethyl-N-Nitrosourea Induced mutation in the GNL1

GTPase causes an NK cells deficiency and a susceptibility to

Cytomegalovirus

29 Vicki Leung PhD student McGill P. GrosVangl2 is required for intraretinal pathfinding of mouse retinal

ganglion cell axons.

30 Alonso Lira PhD student McGill M. Olivier

Impact of Leishmanial Exosomes on Skin Hyperinflammatory

Response During Cutaneous Leishmaniasis is GP63

Dependent.

31 Mathieu Mancini PhD student McGill S. VidalAn ENU-induced mutation in Rel confers susceptibility to

herpes simplex encephalitis

32 Diana Matheoud Postdoc U. Montreal M. DesjardinsThe role of PINK1/Parkin in Parkinson's disease: repressing

mitochondrial antigen presentation (MitAP)

33 Barbara Mindt PhD student McGill J. FritzEssential role of c-Rel in IL-33-mediated activation of group 2

innate lymphoid cells

34Victor Mullins-

DansereauMSc student CR-HMR S. Lesage

An unbiased linkage approach reveals that the p53 pathway

is coupled to NK cell maturation

35 Oladayo Oladiran PhD student McGill J. Zhang

Characteristics of monocytes and macrophages in B7.2

transgenic mice developing spontaneous autoimmune

peripheral neuropathy.

36 Jean-Frédéric Olivier PhD student McGill P. GrosAltered Activity of Dendritic Cells in Cerebral Malaria

Resistant Ccdc88b Mutant Mice

37 Sakina Orkhis PhD student CR-CHUS S. RamanathanIL-15 regulates the initiation of immune responses during

systemic infections

38 Alexandre Paradis RA CR-HMR S. LesageBiological profiles of patients with inflammatory bowel

disease based on genetic risk factors

39 Sarah Rosen PhD student McGill J. Mogil T-cell Dependent Reversal of Allodynia in Pregnant Mice

40 Joaquín Sanz PostdocCHU Ste-

JustineL. Barreiro

Genetic ancestry and natural selection drive population

differences in immune responses to pathogens in humans

41 Caitlin Schneider PhD student McGill J. Mandl

The type-2 CD4 T cell effector bias associated with a

DOCK8-mediated migration defect is T cell extrinsic and

GMCSF-dependent

42 Mitra Shourian PhD student McGill S. QureshiCritical role of IL-1RI signaling in protection against

Cryptococcus neoformans infection

43 Sabrina Torre PhD student McGill P. GrosUSP15 regulates type-I interferon response in vivo and is

required for pathogenesis of neuroinflammation

44 Kristin Van Den Ham PhD student McGill M. OlivierProtein Tyrosine Phosphatase Inhibition Attenuates Cerebral

and Hepatic Pathology during Experimental Cerebral Malaria

45 Frances Wang MSc student McGill J. ZhangPotential Role of Macrophages/Microglia in a Mouse Model

of Orofacial Pain

46 Mu Yang Postdoc McGill J. ZhangInjury facilitates the development of autoimmune peripheral

neuropathy in predisposed inflammatory environment

47 Mitra Yousefi Postdoc McGill S. GruenheidStudying the role of microbiota and nutrition in the

susceptibility to C. rodentium infection

48 Dahn Hahm PhD student U. Ottawa SH LeeModulation of Natural Killer cell function through 4-1BB

stimulation

49 Saeedah Almutairi PhD student U. Ottawa SH Lee Reactive oxygen species as signaling molecules in immunity

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1 slide - 3 min talks

Presenter Lab Institution

Fernando Alvarez Ciriaco Piccirillo McGill

Patricio Artusa Judith Mandl McGill

Vanessa Diniz Atayde Martin Olivier RI-MUHC

Cindy Audiger Sylvie Lesage CR-HMR

Christopher Cameron Mathieu Blanchette McGill

Tyler Cannon Samantha Gruenheid McGill

Jennifer Chu Jerry Pelletier McGill

Brendan Cordeiro Connie Krawczyk McGill

Todd Douglas Maya Saleh McGill

Megan Eva Danielle Malo McGill

Vinicius Medeiros Fava Erwin Schurr RI-MUHC

Marija Landekic Donald Vinh RI-MUHC

Minnie Lin Ana Nijnik McGill

Mathieu Mancini Silvia Vidal McGill

Barbara Mindt Jorg Fritz McGill

Victor Mullins-Dansereau Sylvie Lesage CR-HMR

José Navarro Ines Colmegna McGill

Jean-Frédérick Olivier Philippe Gros McGill

Simon Papillon-Cavanagh Nada Jabado RI-MUHC

Joaquin Sanz Luis Barreiro CR-CHU Ste-Justine

Mitra Shourian Salman Qureshi RI-MUHC

Yibo Xue Sidong Huang McGill

List of 3 minute talk presenters showcased on Nov 29th, 2016.

All speakers will be presenting on behalf of their laboratory. They are invited to present

either an overview of their own research project, their lab research focus or a

breakthrough story recently published by the lab.

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Human Genetics

Major Sponsors

General Sponsors

We thank our generous sponsors!

Premium Sponsor

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acknowledgements

Symposium Organizing Committee

• Silvia Vidal, Prof. Dept. Human Genetics

• Samantha Gruenheid, Prof, Dept. Microbiology and Immunology

• Danielle Malo, Prof. Dept. Human Genetics

• Philippe Gros, Prof, Dept. Biochemistry

• Maya Saleh, Prof, Dept. Medicine

• Jörg Fritz, Prof, Dept. Microbiology and Immunology

• Ana Nijnik, Prof, Dept. Physiology

• Judith Mandl, Prof, Dept. Physiology

• Erwin Schurr, Prof, Dept. Human Genetics and Medicine

• David Langlais, PDF, Dept. Biochemistry

• Mathieu Mancini, Ph.D. student, Dept. Human Genetics

• Caitlin Schneider, Ph.D. student, Dept. Microbiology and Immunology

• Barbara Mindt, Ph.D. student, Dept. Microbiology and Immunology

• Todd Douglas, Ph.D. student, Dept. Microbiology and Immunology

• Marianne Provost, Senior Adm. Coordinator, Dept. Biochemistry

MRCCT BBQ Organizing Committee





• Benoit Charbonneau, Research Assistant, Dr Silvia Vidal lab


Volunteers

• Eugene Kang, Ph.D. Student, Dept. Microbiology and Immunology

• Tyler Cannon, M.Sc. student, Dept. Microbiology and Immunology

• Alanna Crouse, M.Sc. student, Dept. Human Genetics

• Dakota Rogers, Ph.D. student, Dept. Physiology

• Benjamin Forestell, Honour's Undergraduate student, Dept. Physiology

• Thiviya Jeyakumar, M.Sc. student, Dept. Biochemistry


• Claudia Champagne, Research Assistant, Dr Maya Saleh lab

• Geneviève Perreault, Animal Technician, Dr Philippe Gros lab

• Line Larivière, Research Assistant, Dr Danielle Malo lab

• Nadia Prud’homme, Animal Technician, Dr Danielle Malo lab

• Normand Groulx, Research Assistant, Dr Philippe Gros lab

Thanks to the 215 participants for making this Symposium a success!!

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Appendix 12

Appendix 2

Research Centre, Core Facility, Network name:

Director and Administrator (names and contact information):

Sources of Income/Revenue:Cash In‐kind

From Faculty of Medicine $64,000.00

CFI6 /IOF (yearly amount ‐ ended/2017) $149,970.00 BWF: Burrows Wellcome Fund ($1,000/USD)Sponsorship for 1 seminar

$1,315.79

MRCCT symposium ‐ Fundraising $27,000.00

TOTAL Income/Revenue: $242,285.79

Expenditures

Cash In‐kindPersonnel Salaries and related costs

1 Senior Adm. Coordinator (salary + benefit) $51,338.481 Animal Health Technician (salary + benefits: CFI6) $62,275.001 Animal Health Technician (salary + benefits: CFI6) $87,695.00Centre miscellaneous expenses + maintenance

Materials & supplies $2,064.70Maintenance & repairs ‐Fisher: new motor, decontaminaXon, new cerXficaXon

$2,437.51

PrinXng + office supplies $371.80Miscellaneous expenses $45.00

55

Dr. Silvia Vidal (514‐398‐2362 / [email protected])M. Provost (514‐398‐3667 / [email protected])

Year‐End Financial Statement for May 1st 2016 to April 30th 2017

Faculty of Medicine funds

Where applicable, provide details of items of expenditure as indicated below, e.g. salary components should be listed by individual, the cost of each workshop, individual working group, or other meeXngs should be given, as well as any research project funds expended

DescripHonContribuHng OrganizaHon

contribuHons

MRCCT: McGill University Research Centre on Complex Traits

Appendix 12REGULAR MRCCT Seminar series: expenses(10 seminars)

‐$3,226.67

Meal expenses $1,922.45TransportaXon $247.60Travel ‐ General $6,870.72RecepXon/ Special events $31.70

Other expenditure: MRCCT symposium ‐ FundraisingMRCCT Symposium (Nov 28‐29, 2016)Airfare, travel, Taxi $7,227.28Hotel $1,664.05Venue | New Residence Hall $2,262.00Posterboards $1,419.94Photograph $309.00IT Services $1,266.50Poster Awards $500.00Name tag $252.66Catering + Breakfast ‐ fruits + Wine and cheese mixer $9,595.45Dinner / out of town speakers ‐ Nov 28, 2016 $380.14Mixer ‐ Tuesday night $507.39Maintenance & repairs Serviceau: repair Mili QMillipore/Sigma: repair power board

$1,615.59

Provide the reason for carryover* if permifed: It is essenDal that reasons be provided by carryover requests

Director of Research Centre, Core Facility or Network or his/her Delegate:

56

Signature

Date: June 2, 2017

$239,073.29

*It is the responsibility of the Centre, Core Facility, Network to ensure that the carryover amount requested in this document has been discussed with the Financial Affairs Office of the Faculty of Medicine

As of May 18, 2017, the balance in fund #216592 was $3,212.50. This amount needs to be carried over since we have open ERs + invoice in the system that are sXll linked to this fund for the seminar period 2016‐2017. ERs 00784185, 00784198, 00784774, 00787445, 0078730…, as well as Dr Michel Nussenzweig seminar budgeted in the 2016‐17 period.Many thanks in advance,MRCCT Centre

Carryover amount: $3,212.50Please note that a carryover balance is not permitted for some accounts

(to clarify accounts affected, please consult Financial Affairs)

TOTAL EXPENDITURES

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Appendix 12

Budget plan for May 1st 2017 to April 30th 2018

Total request from Faculty of Medicine for 2017‐18: Sources of Income/Revenue:

Cash In‐kindFrom Faculty of Medicine $64,000.00Other sources – List all sources (add rows as needed):BioLegend ($1,000/CDND) Sponsorship for 1 seminar

$1,000.00

Stemcell ($1,500/CDN)Sponsorship for 1 seminar

$1,500.00

Carl Zeiss Canada Ltd ($500/CDN)Sponsorship for 1 seminar

$500.00

Genome Canada Plaqorm $170,181.00TOTAL Income/Revenue: $237,181.00

Expenditures

Cash In‐kindPersonnel Salaries and related costsFaculty of Medicine1 Senior Adm. Coordinator $40,591.00Benefits $10,749.00Genome Canada Pla4orm1 Animal Health Technician: 80%: salary + benefits paid from Genome Canada Plaqorm (20% balance to be paid from Personal Grant CIHR)

$49,379.00 80%

1 Research Assitant / 40% salary + benefits paid from Genome Canada Plaqorm (60% balance to be paid from Personal Grant CIHR

$31,902.00 40%

1 Core Manager: 100% salary + benefits paid from Genome Canada Plaqorm

$88,900.00 100%

Centre miscellaneous expenses + maintenanceMaterials & supplies $3,000.00New printers and scanners $500.00

57


DescripHon Faculty of Medicine funds

ContribuHng OrganizaHon

Appendix 12Expected Maintenance & repairsGel Doc (BioRad), Jacketed CO2 Incubator, Repair Fluorescence microscope, pipefe calibraXng, …

$4,000.00

PrinXng + office supplies (uPrint, copy paper, etc...) $400.00MRCCT Seminar Series: 8 guest speakers (Airfare, travel, taxi, accomodaXons, meals, …)+3 speakers from Toronto (co‐hosXng and co‐sponsored with the Goodman Cancer Research Centre)

$11,000.00

TOTAL EXPENDITURES $240,421.00

58

APPENDICES CTG.

Table of Contents


‐Table I: Training Graduate Students Page 1

‐Table II: Post‐Doctoral Fellows Page 1

‐Table III: Contributions to undergraduate & graduate teaching Page 2

‐Table IV: Students Project Titles Pages 3‐5


‐Table V: Work in progress: MRCCT Group meetings Pages 6‐7

Appendix 3: List of Seminars hosted by the MRCCT in 2016‐2017 Page 8

Appendix 4: Invitation of MRCCT Core Center PIs as guest speaker Pages 9‐11

Appendix 5: Honours awards and prizes Page 12

Appendix 6: Outreach Activities Page 13

Appendix 7: Consulting Activities Pages 14‐15

Appendix 8: PUBLICATIONS ‐ Primary members (pp 16‐21) ‐ Associate members (pp 21‐32)

Pages 16‐32

Appendix 9: Funding: Individual and Joint Grants Pages 33‐37

Appendix 10: Collaborations Pages 38‐41

Appendix 11: Program of our first symposium Pages 42‐54

Appendix 12: Year End Financial Report form Pages 55‐58


1


TABLE I: TRAINING GRADUATE STUDENTS / MAY 1, 2016 ‐ APRIL 30, 2017 MRCCT Primary

Members Number of

M.Sc. Students Number of

Ph.D. Students Number of M.Sc. Degrees

Awarded Number of Ph.D. Degrees

Awarded Jörg FRITZ 1 2

Philippe GROS 2 5 1 2

Samantha GRUENHEID 3 2 1

Nada JABADO 2 1

Danielle MALO 1 3 3

Judith MANDL 3

Ana NIJNIK 3 2

Martin OLIVIER 5 3 1 1

Salman Qureshi 1

Maya SALEH 3 1

Silvia VIDAL 1 3 1 1

Don VINH 2 1

TOTAL: 19 27 6 9

TABLE II: POST‐DOCTORAL FELLOWS / MAY 1, 2016 – APRIL 30, 2017

MRCCT Primary members NAME PROJECT TITLE

Jörg FRITZ Claudia U. Duerr 2011‐2018: “Regulation of group 2 innate lymphoid cells and its implications in type 2 immunity”

David Langlais 2011‐Jan. 2017: “Identification of the IRF8, IRF1, and PU.1 Transcriptional programs in Myeloid cells, and in response to Interferon Gamma” Philippe GROS

Neda Moradin 2014‐2016. “Role of the CCDC88B protein in intestinal colitis” Samantha GRUENHEID Mitra Yousefi 2014‐Present: “Genetic control of susceptibility to intestinal infections”

Jonathan Pratt 2017‐present, Department of Human Genetics Elvis Valera 2016‐present, Department of Human Genetics

Melissa McConechy 2015‐present, Department of Human Genetics

Michele Zeinieh 2015‐present, Department of Human Genetics Alexander Weil 2014‐present, Department of Human Genetics

Ashot Harutyunyan 2014‐present, Department of Human Genetics

Nada JABADO

Tenzin Gayden 2012‐present, Department of Human Genetics

Ana NIJNIK Michael Foerster June 2013‐Dec. 2016. Project title: “Roles of Histone H2A Deubiquitinase MYSM1 in B and T Cell Mediated Immunity”

Vanessa Atayde 2012‐Present. Project title: “LRV1 and Macrophage activation” Martin OLIVIER

Anupam Adhikari 2013‐2017. Project title: “Role of hepatocytes in leishmaniasis” Salman Qureshi n/a

Ian Gervais‐Rodrigue

2009‐June 2016 “Characterization of the molecular network required for virus‐induced inflammasomes”

Mostafa Khair Oct 2016‐Present: “Investigation of the role of O‐Glcnacylation in macrophage function, inflammation and cell death signaling”

Maya SALEH

Mario Songane Jan 2017‐Present: “Defining the role of the inflammasome in cancer immunosurveillance and immunotherapy”

Danielle MALO Megan Eva March 2016‐Present: “Characterization of the function and mechanism of action of the gene Ncoa7 (nuclear receptor coactivator 7) during infection with Salmonella Typhimurium and in inflammatory conditions”

Judith MANDL Angelica Gopal January 2017 – present: “Actin dynamics in migrating T cells”

Silvia VIDAL Mu Yang Co‐supervision with Dr Ji Zhang, Dentristry, McGill. “Production of MCMV mutant strains to explore the impact of inflationary memory in model of Guillan Barré syndrome”

Don VINH N/A


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TABLE III: CONTRIBUTIONS TO UNDERGRADUATE & GRADUATE TEACHING ‐ MAY 1, 2016‐APRIL 30, 2017

MRCCT Primary members

TEACHING LOAD (HRS) (not including

research project supervision)

COURSE # UNDERGRADUATE RESEARCH

PROJECT STUDENTS SUPERVISED (# OF STUDENTS)

3 hrs MIMM509B 3 hrs EXMD609 6 hrs MIMM384 3 hrs PHGY313

Jörg FRITZ

3 hrs PHGY531B Philippe GROS n/a n/a

2 hrs MIMM211 50 hrs MIMM212 2 hrs MIMM465 5 hrs MIMM384 3 hrs MIMM386 1

Samantha GRUENHEID

6 hrs PHGY419 1 2 hrs HGEN690 2 hrs EXMD635 Nada JABADO

5 hrs HGEN695 30 hrs EXMD602 12

Danielle MALO 32 hrs PHGY419 1 33 hrs PHGY212 5 hrs MIMM384 32 hrs PHGY419 3 hrs PHGY313

Judith MANDL

2 hrs PHGY513 24 hrs PHGY488 1 10 hrs PHGY351 24 hrs PHGY419

Ana NIJNIK

3 hrs PHGY516 Martin OLIVIER n/a n/a

5 hrs EXMD 516‐508B 10‐20 6 hrs MIMM509 18 5 hrs Block B Leader: Respiration

Salman Qureshi

5 hrs PHYG 531 3 hrs PHGY13 9 hrs MIMM386 15 hrs MMIM502D1/D2

Maya SALEH

6 hrs MIMM618 6 hrs MIMM498/499 (coordinator) 6 hrs MIMM384D Silvia VIDAL

3 hrs PHGY552‐531B 2 hrs per BIM6074 5 1 hr per INDS‐117 (Meningitis) 100 1 hr per INDS‐117 (Bone and joint infections) 100 1 hr per INDS‐117 (Genetic defects of Immunity & Infections) 100 2 hrs per BIM6074 5

Don VINH

12 hrs ID‐MM Primary Immunodeficiencies


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Table IV: Students Project Titles (MRCCT Primary Members) JORG FRITZ LAB: ‐Claudia U. Duerr, PDF, 2011‐2018. Department of Microbiology and Immunology (Project title: Regulation of group 2 innate lymphoid cells and its implications in type 2 immunity).

‐Barbara Mindt, PhD, 2012‐present. Department of Microbiology and Immunology (Project title: Role of c‐Rel in regulating group 2 innate lymphoid cell function). ‐Fernando Alvarez, PhD, 2014‐present (co‐supervision with Dr. Ciriacco Piccirillo), Department of Microbiology & Immunology (Project title: Plasticity of T regulatory cells during infection).

‐ Alex Harrison, M.Sc., 2016‐present (cu‐supervision with Dr. Nathalie Grandvaux), Department of Microbiology & Immunology. (Project Title: Functional analysis of the redox post‐translational modifications of STAT1 Cysteines).

PHILIPPE GROS LAB: ‐David Langlais, PDF, 2011‐Jan 2016. Department of Biochemistry (Project title: Identification of the IRF8, IRF1, and PU.1 Transcriptional programs in Myeloid cells, and in response to Interferon Gamma) ‐Neda Moradin, PDF, 2014‐2016. Department of Biochemistry (Project title: Role of the CCDC88B protein in intestinal colitis) ‐Aurélie Laroque, PhD, 2008‐2017. Department of Biochemistry (Project title: “Creation of a mouse mutant lacking pantetheinase (Vnn3); Characterization of role of Vnn3 in resistance to infections”) ‐ James Kennedy, PhD, 2011‐present. Department of Biochemistry (Project title: Identification of novel genes involved in neuroinflammation by ENU mutagenesis) ‐ Vicki Leung, PhD, 2012‐present. Department of Human Genetics (Project title: Role of Vangl proteins in retinal development) ‐Jean‐Frédéric Olivier, PhD, 2013‐present. Department of Biochemistry (Project title: Functional role of CCDC88B in myeloid cells) ‐ Thiviya Jeyakumar, MSc, 2016‐present. Department of Biochemistry (Project title: Contribution of inflammatory response genes to colorectal cancer) ‐Christian Gualtieri, MSc, 2013‐2016. Dept of Biochemistry (Project title: Role of Human PKLR variants in susceptibility to malaria) ‐Nassima Fodil, Research Associate, 2013‐present. Department of Biochemistry (Project title: Immunological studies of resistance to encephalitis in independent ENU‐generated mouse mutants) ‐Maria Polyak, Research Associate, 2014‐present. Department of Biochemistry (Project title: Role of USP15 in acute neuroinflammation) SAMANTHA GRUENHEID LAB: ‐Mitra, Yousefi, PDF, Sept. 2013‐present. Department of Microbiology and Immunology (Project title: Genetic control of susceptibility to intestinal infections). ‐Nathalia Giannakopoulou, PhD Sept. 2014‐present. Department of Microbiology and Immunology (Project title: Virulence and fitness factors of pathogenic E. coli). ‐Eugene Kang, PhD, Sept. 2013‐present. McGill University, Department of Microbiology and Immunology (Project title: Rspondins link inflammation and intestinal homeostasis). ‐Tyler Cannon, MSc, Sept. 2016‐present. Department of Microbiology and Immunology (Project title: Mitochondrial antigen presentation and infection). ‐Alanna Crouse, MSc, Sept. 2016‐present. Department of Microbiology and Immunology (Project title: Genomic variation and virulence in Salmonella serovars). ‐Travis Ackroyd, MSc, Sept. 2013‐Sept. 2016. Department of Microbiology and Immunology (Project title: CFTR and intestinal infection).


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NADA JABADO LAB: ‐Jonathan Pratt, PDF, 2017‐present, Department of Human Genetics. ‐Elvis Valera, PDF, 2016‐present, Department of Human Genetics ‐Melissa McConechy, PDF, 2015‐present, Department of Human Genetics, awarded the Banting Postdoctoral Fellowship by the Canadian Institutes of Health Research. ‐Michele Zeinieh, 2015‐present, PDF, Department of Human Genetics, funded by the Rosalind & ‐Morris Goodman Cancer Research Center throught the McGill Integrated Cancer Research Training Program (MICRTP). ‐Alexander Weil, PDF, 2015‐present, Dept of Human Genetics, funded by R. Shibata Cedars Cancer Fellowship Award ‐Ashot Harutyunyan, PDF, 2014‐present, Department of Human Genetics, funded by postdoctoral fellowship from Fonds de Recherche de Quebec en Sante. ‐Tenzin Gayden, PDF, 2012‐present, Department of Human Genetics , funded by an Internal Postdoctoral fellowship from the Faculty of Medicine. ‐Shriya Deshmukh, BSc, MD/Ph.D. Program, 2015‐present, Department of Human Genetics. Degree expected PhD. Funded by the Sir Edward W. Beatty Memorial Scholarship. ‐Abdulshakour Mohammadnia, 2016‐present, MSc. Department of Human Genetics; ‐Sima Khazaei, 2014‐present, MSc, Department of Human Genetics; Degree expected PhD. DANIELLE MALO LAB: ‐Sean Beatty, PhD, 2008‐2016. McGill University, Department of Human Genetics (Project title: Identification and characterization of the genetic basis of Salmonella resistance/susceptibility in the recombinant congenic strains AcB60 and AcB61). ‐Megan Eva, PhD, 2009‐2016. McGill University, Department of Human Genetics (Project title: Identification of novel susceptibility genes to Salmonella Typhimurium infection using ENU chemical mutagenesis in mice: positional cloning of Ity14). Studentship from the MUHC. ‐Alanna Crouse, MSc, 2016‐Present. Department of Human Genetics (Project Title: Genomic variation and virulence in Salmonella serovar) ‐Kyoko Yuki, PhD, 2008‐2016, McGill University, Department of Human Genetics (Project title: Identification of novel susceptibility genes to Salmonella Typhimurium infection using ENU chemical mutagenesis in mice: positional cloning of Ity16. Studentship from the Faculty of Medicine). JUDITH MANDL LAB: ‐ Dakota Rogers, PhD, NSERC USRA, May 2016 – present, Department of Physiology (Project title: Characterizing naïve CD4 T cell heterogeneity) ‐Caitlin Schneider, PhD, 2016‐present, Department of Microbiology and Immunology (Project title: DOCK8‐deficiency associated migration defects in T cell homeostasis and effector differentiation) ‐Patricio Artusa, PhD, June 2015‐present, Department of Physiology (Project title: The role of T‐cell repertoire diversity in CD4 T cell responses and T cell competition for homeostatic signals) ‐Yvonne Deng, BSc, April 2017‐present, Department of Microbiology and Immunology (undergraduate student volunteer) ‐ Benjamin Forestell, BSc (hons) Sept 2016 – Aug 2017, Department of Microbiology and Immunology (Project title: Regulatory T cell recirculation dynamics through secondary lymphoid organs) ‐ Angelica Gopal, PDF, Jan 2017 – present. Department of Physiology (Project Title: “Actin dynamics in migrating T cells”) ANA NIJNIK LAB: ‐Michael Foerster, PDF, June 2013‐Dec. 2016. McGill University, Department of Physiology (Project title: Roles of Histone H2A Deubiquitinase MYSM1 in B and T Cell Mediated Immunity) ‐Rupinder Boora, MSc, June 2014‐Sept. 2016, Department of of Physiology (Project title: Molecular Mechanisms of p53 Regulation by MYSM1 in Hematopoiesis). ‐Jessica Petrov, MSc, Jan. 2015‐Sept. 2016, Department of of Physiology (Project title: Role of Apoptotic Regulator PUMA/Bbc3 in Mysm1‐knockout Bone Marrow Failure) ‐ Amanda Fiore – 09/2016‐ on medical leave. McGill University, Department of Physiology (Project: Molecular Mechanisms of MYSM1 Activity in Transcriptional Regulation) ‐Yun Hsiao Lin (Minnie) – PhD, 09/2016‐ present. McGill University, Department of Physiology (Project: Testing the role of MYSM1 Catalytic Activity in Hematopoietic Stem Cell Maintenance)


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MARTIN OLIVIER LAB: ‐Vanessa Atayde, PDF, 2012‐Present, Dept. Microbiology and Immunology (Project title: LRV1 and Macrophage activation). ‐Anupam Adhikari, PDF, 2013‐2017. Dept. Microbiology and Immunology (Project title: Role of hepatocytes in leishmaniasis. ‐Kristin Van den Ham, Ph.D, 2011‐present, Dept. Microbiology and Immunology. ‐Alonso da Silva Lira Filho, Ph.D. 2015‐present (Project title: Science without Border» CNpQ Ph.D. Award). ‐Jamilah Abusarah, Ph.D., 2017‐present, Dept. Microbiology and Immunology. ‐Nirmin Alsahafi, Ph.D. 2014‐present, Dpt. Microbiology and Immunology. ‐Alejandra Villa, M.Sc., 2013‐present, Dept. Microbiology and Immunology. ‐Mèlanie Perik, M.Sc. 2016‐2017, Dept. Microbiology and Immunology. ‐Sai Priya Anand, M.Sc., 2016‐present, Dept. Microbiology and Immunology. ‐Andrea Vicutic, M.Sc., 2017‐present, Dept. Microbiology and Immunology. ‐Aretha Chan, M.Sc., 2017‐present, Dept. Microbiology and Immunology. SALMAN QURESHI LAB: ‐Mitra Shourian MSc, 2010‐present, Division of Experimental Medicine, McGill University (Project title: Genetic regulation of host resistance to Cryptococcus neoformans) MAYA SALEH LAB: ‐Ian Gervais‐Rodrigue, PDF, Nov 2009‐June 2016. Department of Medicine, McGill University (Project title: Characterization of the molecular network required for virus‐induced inflammasomes) ‐Mostafa Khair, PDF, Oct 2016‐present. Department of Medicine, McGill University (Project title: Investigation of the role of O‐Glcnacylation in macrophage function, inflammation and cell death signaling) ‐Mario Songane, PDF, Jan 2017‐present. Department of Medicine, McGill University (Project title: Defining inflammasome regulation in inflammatory and metabolic diseases) ‐Alexander Skeldon, PhD, Sept 2010‐Aug 2016. McGill University, Department of Biochemistry (Project title: Characterization of innate immunity sensors in obesity and type 2 diabetes) ‐Maryse Dagenais, PhD, Sept 2010‐present. McGill University, Department of Biochemistry (Project title: Characterization of innate immunity and cell death effectors in colitis, colorectal cancer and breast cancer) ‐Todd Douglas, PhD, Sept. 2012‐present. Department of Microbiology and Immunology (Project title: Ubiquitination mechanisms in inflammasome regulation) SILVIA VIDAL LAB: ‐Gabriel Leiva‐Torres, PhD, 2012‐present, Department of Human Genetics (Project title: Functional genetics approach in mice to identify susceptibility genes to herpes encephalitis). ‐Mathieu Mancini, PhD, 2015‐present. Department of Human Genetics (Project title: Role of c‐Rel in susceptibility to virus infection and neuroinflammation). ‐Jennifer Marton, PhD, 2012‐2016, Department of Human Genetics (Project title: Identification of genetic determinants of host susceptibility to coxsackieviral myocarditis). ‐Kathiriya Vaibhav, MSc., 2016‐present. Department of Human Genetics (Project title: Expression and function of GNL1 GTPase in human natural killer cells). ‐Mu Yang : Co‐supervision with Dr Ji Zhang, Dentristry, McGill. (Project title: Production of MCMV mutant strains to explore the impact of inflationary memory in model of Guillan Barré syndrome).

DON VINH LAB: ‐Marija Landekic, Ph.D. (Micro & Immuno), Aug 2016‐Aug 2020 (Project title: Characterizing the role of CARD9 in monocyte/macrophage immunity to candidiasis). ‐Rebecca Iliza, M.Sc., Biotechnology Research Project (BTEC 623), May 2016‐Sept 2016 (Project title: Characterizing the impact of p.I513T variant on SLP‐76 protein expression and function). ‐Catherine Le, B.Sc. (Pharmacology); Jan 2016‐Sept 2016 (Project title: Genotypic identification of Primary Immunodeficiency).


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Table V: Work in progress: MRCCT Group meetings 2016‐2017 One series of “work in progress” presentations by MRCCT members located around Montreal, graduate students and post‐docs presentations, which is held every week from Sept.‐Oct. to June. This series gives the opportunity to all trainees to present their work to the rest of the group, and provides them with an opportunity to hone their presentation skills, while getting feedback and input on their research by other members of the group. This is an important knowledge transfer activity where all members are exposed to and benefit from specific activities taking place in other PIs labs. http://mcgill.ca/mrcct/mrcct‐group‐meetings

2 0 1 7

January 9 Fernando Alvarez (Piccirillo Lab)

"Understanding the role of alarmins in the functional adaptation of regulatory T cells"

Mathieu Mancini (Vidal Lab) "Neuroinflammation, cell death and viral control

in a model of herpes simplex encephalitis"

January 16 Alonso Lira Filho (Olivier Lab) “Leishmania‐derived Exosomes: From Virulence Factor to a Potential Vaccine? “

1h‐2h PI Presentation ‐ Mathieu Blanchette

“Computational approaches to study chromatin conformation dynamics”

PI Presentation ‐ Judith Mandl "Visualizing the spatio‐temporal dynamics of T cells in homeostasis and immunodeficiency"

January 30

2h‐4h * Wine and cheese mixer right after the group meeting ‐ Bellini *

February 6 Patricio Artusa (Mandl Lab) "The role of T‐cell repertoire diversity in CD4+ T cell responses"

February 13 Genelle Harrison (Schurr & Barreiro Labs) "The advent of agriculture has shaped innate

immune responses to pathogens"

James Kennedy (Gros Lab) "Loss of Zbtb7b Protects Mice from Pathological Inflammation Induced by Cerebral Malaria"

February 20 Barbara Mindt (Fritz Lab) "Role of c‐Rel in IL‐33 mediated ILC2 activation"

Mitra Shourian (Qureshi Lab) "Essential role of IL‐1RI signaling in protection against Cryptococcus neoformans infection"

February 27 Roman Istomine (Piccirillo Lab)

"The role of translation regulation in CD4+ T cell subset differentiation and function"

Jean‐Frédéric Olivier (Gros Lab) “From Cerebral Malaria Resistance to Cellular Migratory Defects: Deciphering the Role

of CCDC88B in Dendritic Cells“

March 6 Maria Polyak (Gros Lab) “USP15: Deciphering its role in neuropathogenesis”

Marija Landekic (Vihn Lab) "CARD9‐mediated Mechanisms of Macrophage

Immunity to Candida albicans"

March 20 Claudia Duerr (Fritz Lab)

“Isolation and Characterization of mouse and human ILC2”

Steven Shao (Piccirillo Lab) Title to come

April 3 Étienne Flamant (Malo Lab)

"Characterization of Fam49b, a new player in regulating the early response to Salmonella infection"

Todd Douglas (Saleh Lab) “Cross‐regulation between the inflammasome and linear ubiquitin assembly complex machinery”

April 10 Alain Pacis (Barreiro Lab)

“Epigenetic regulation of innate immune responses to infection”

Nassima Fodil (Gros Lab) "CCDC88B, a novel immune regulator

for IBD pathogenesis"

April 24 Dakota Rogers (Mandl Lab)

“Predicting functional characteristics of naïve CD4 T Cells by characterizing cell‐Intrinsic heterogeneity”

Victor Mullins‐Dansereau (Lesage Lab) "An unbiased linkage approach reveals that the p53

pathway is coupled to NK cell maturation"


7

Table VI ‐ Continued Work in progress: MRCCT Group meetings 2016‐2017

May 1 Thiviya Jeyakumar (Gros Lab) "Deciphering the role of THEMIS and IRF1

in the pathogenesis of CA‐CRC"

Alanna Crouse (Malo Lab) "A Syst‐OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis"

May 15 Han Chen Wang (Nijnik Lab) “ChIP‐Seq Data Analysis Indicated the Role of MYSM1 in the Transcriptional Regulation of Ribosomal Protein Genes”

June 5 Vickie Leung (Gros Lab) “Characterization of Curlybob a novel Vangl2 mouse mutant”

June 12 Benjamin Foretell (Mandl Lab)

Joaquín Sanz Remón (Barreiro Lab)

June 19 PI Presentation Martin Olivier

PI Presentation Ana Nijnik

June 26 Mostafa Khair (Saleh Lab)

2 0 1 6

October 24 Gabriel André Leiva (Vidal Lab)

"Identification of an ENU mutation in STAT5A crucial for host response to herpesvirus infection"

Maryse Dagenais (Saleh Lab) "A critical role for cIAP2 in intestinal

homeostasis"

October 31 Roxanne Collin (Lesage Lab)

"Genetic interaction between Idd2 and Idd13 loci in determining immunoregulatory CD4‐CD8‐ T cell

proportion"

Megan Eva (Malo Lab) "Ncoa7 regulates inflammation and immunity

to typhoid‐like disease"

November 21 Caitlin Schneider (Mandl Lab)

“The type‐2 CD4 T cell effector bias associated with the migration defect caused by DOCK8 deficiency is T cell extrinsic

and GMCSF‐dependent”

Cindy Audiger (Lesage Lab) "Characterization of mcDC homeostasis”

December 5 Luke Healy (Antel Lab)

"MerTK as a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells"

David Langlais (Gros Lab) From Functional Genomics of Inflammation to

Therapeutics"


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Appendix 3: List of Seminars hosted by the MRCCT in 2016‐2017 http://mcgill.ca/mrcct/2016‐2017‐mrcct‐seminars

DATE SPEAKER TITLE OF TALK Time & Location

2 0 1 7 Monday

January 23

Marc LECUIT, MD, PhD Director of the Biology of Infection Unit Institut Pasteur and Inserm (U1117)

“Listeria invasion of host tissues: mechanisms and

effects”

4:00PM Martin

Room 504

Friday, February 15

Julien Karim MALET, PhD Bacteria‐Cell Interaction Unit (Dr. Pascale Cossart) Institut Pasteur, Paris‐ Candidate for: PDF position

“Alteration of host cell proteome in response to Listeria monocytogenes

infection”

12:15PM Karp

Room 501

Wednesday, March 15

Thomas KUFER, PhD Professor, Head of Department of Immunology University of Hohenheim / Stuttgart, Germany

“The NLR protein NOD1 ‐ cellular function and

regulation”

11:00AM Karp

RM 501

Monday March 27

Jean‐Pierre de VILLARTAY, PhD Directeur de Recherche INSERM Lab Director “Genome Dynamics in the Immune System” (DGSI), Institut Imagine / Paris

“DNA double strand breaks in the Immune System: a

dangerous game“

4:00PM Martin

Room 504

Wednesday April 5

Alexander V. CHERVONSKY, MD, PhD Professor & Chairman, Committee on Immunology, Department of Pathology / University of Chicago

“Host‐commensal symbiosis” 4:00PM Martin

Room 504

Wednesday April 26

Johannes TEXTOR, PhD Tumor Immunology, Radboud University Medical Center, Nijmegen, The Netherlands

“Landscapes of tumor infiltrating Lymphocytes:

Quantification, Modeling and Clinical Relevance”

1:30PM Karp

Room 501

Monday‐Tuesday May 8‐9

RIKEN – McGill Symposium Excellence in Immunology & Genetics

McCord Museum 690 Rue Sherbrooke West Montréal, QC / H3A 1E9

J. Armand Bombardier Amphitheatre

Wednesday May 17

Fumio TAKEI, PhD Distinguished Scientist, Terry Fox Laboratory, Professor, Pathology & Laboratory Medicine, Associate Member, Medical Genetics, Associate Member, Microbiology, UBC

“Group 2 innate lymphoid cell memory: what and how

do they remember?”


Monday May 29

Michel NUSSENZWEIG, PhD Investigator, Howard Hughes Medical Institute, Senior Physician Zanvil A. Cohn and Ralph M. Steinman Professor, Laboratory of Molecular Immunology / The Rockefeller University

"The HIV Vaccine Problem" 4:00PM Martin

Room 504

2 0 1 6 Friday

November 11

Ichiro TANIUCHI, MD, PhD / Riken, Japan Group Director, Laboratory for Transcriptional Regulation Center for Integrative Medical Sciences

“Transcriptional Regulation of T Cell Development in The

Thymus”

12:00PM Karp

Room 501

Monday‐Tuesday November 28‐29

Hosted by the MRCCT: 1st Montreal Symposium on Immunogenetics of Infectious and Inflammatory diseases

McGill University Research Centre on Complex Traits M

– MRCCT ‐

9h‐5h New Residence Hall

Ballroom

Monday December 12

Nan YAN, PhD Assistant Professor, Rita C. and William P. Clements, Jr., Scholar in Medical Research, Department of Immunology, UT Southwestern Medical Center

“Innate immune response in infection and autoimmune

disease”
