annual report 2013 - perkins

Annual Report 2013

1PERKINS.ORG.AU

Contents

Chairman’s Message 2

Director’s Message 4

Perkins Board of Directors, Ex-Officio Members 6

Scientific Advisory Board and Perkins Fellows 10

2013 Research Highlights 12

2013 Events 18

Our Supporters and Partners 25

Financial Summary 30

How You Can Help 33

Assistant Professor Gina Ravenscroft, who works on Foetal Akinesias and Pathbiology, Neurogenetic Diseases, won our annual photography competition for this image of skeletal muscle.

About the Harry Perkins Institute of Medical ResearchOur focus is on Cancer and Cell biology, Cardiovascular, Diabetes and Metabolism, Molecular medicine and Ageing.

2 3HARRY PERKINS INSTITUTE OF MEDICAL RESEARCH / Annual Report 2013 PERKINS.ORG.AU

2013 Chairman’s Message

The retirement of long-standing Institute Director

Professor Peter Klinken and the appointment of

Professor Peter Leedman as the new Director.

This change will take place early in 2014.

The renaming of the Western Australian Institute

of Medical Research (WAIMR) to the Harry Perkins

Institute of Medical Research.

The decision to rename the Institute was made in honour of the Institute’s inaugural Chairman, Harry Perkins. I was delighted to make the announcement at the Wesfarmers Harry Perkins Oration, when Harry’s wife, son and daughter, Margaret, Charles and Jane were all present.

The end of 2013 also marked the long-awaited completion of two new medical research buildings for the Harry Perkins Institute of Medical Research. These are located at the QEII Medical Centre in Nedlands and the Fiona Stanley Hospital at Murdoch.

Researchers and administration staff moved into the Nedlands facility just before Christmas and plans are currently underway for an official opening of the building in March 2014.

Laurence Iffla

Chairman

Harry Perkins Institute of Medical Research Chairman, Mr Laurence Iffla with Institute Supporter Anne Pickett and Professor Ruth Ganss at the 2013 Annual General Meeting.

I look forward to this very much as the Prime Minister of Australia, Tony Abbott has agreed to attend. We are indebted to the Federal Government’s support for this project as well as to our other project partners, the State Government, the University of Western Australia and the Lions Eye Institute.

At the Board, we were delighted to have appointed three new Board members: Dr Bob Every, AO (Chairman of Wesfarmers and Boral), Dr Erica Smyth (Chairman, Toro Energy) and Dr Stephen Davis (Partner, Perth Radiological Clinic). All have made very valuable contributions to our Board proceedings, and Dr Every has graciously (and enthusiastically) taken up the role of Chair of the Fundraising subcommittee.

We thanked former Board member Terry Bowen who retired from the Board during the year, having made a great contribution to our work, particularly in strategic planning and financial management areas.

Public support for the Perkins is going from strength to strength, with a new event being launched for people keen to walk and fundraise for our women’s cancer research. Our first Weekend to End Women’s Cancer, which is a 60 kilometre weekend walk through Perth’s most picturesque areas, will be held in March 2014.

It was also my pleasure to participate in the Ride to Conquer Cancer as part of the large WAIMR/Harry Perkins Team for the second time this year. While the weather wasn’t quite as kind to the 1500 riders as during the inaugural ride, spirits were certainly high! It was a genuinely wonderful and uplifting event to participate in, and there was a huge sense of achievement for all involved when it was announced that the participants had raised $5.2 million for cancer research at the Perkins.

Finally, I would like to express my deep appreciation to outgoing Director, Professor Peter Klinken. Peter has been the impetus behind all the growth and development of the Perkins since its beginning in 1998. Without his passion and dedication, staff and researchers would not be moving into new facilities and the Perkins would have recruited far fewer talented scientists to join the team. While I look forward to working closely with Deputy Director, Professor Peter Leedman, who will take over in March 2014, Peter Klinken’s efforts to expand and improve medical research in Western Australia will always be remembered with a great deal of gratitude by myself, the Board, researchers and the general community.

I am pleased to be introducing the 2013 annual report to you, following an exciting 12 months during which we announced two major changes:

I thank you for your support and look forward to another year of excitement and progress for the

Harry Perkins Institute of Medical Research.


Peter Klinken Director

This year, once again, our fantastic research teams have continued to make vital discoveries into the causes of various human diseases. In recognition of their achievements our researchers have received several awards. Aleksandra Filipovska was recognized by the Australian Academy of Sciences with the Ruth Gani

medal, the prestigious national award for genetics, while the Cancer Council of WA recognized Ruth Ganss as the Cancer Researcher of the Year, and Terry Boyle as the Early Career Cancer Researcher of the Year. In addition, Nigel Laing received a Teaching Excellence award from the University of Western Australia (UWA).

As a result of the terrific data generated by our researchers they have been able to secure numerous grants and Fellowships from the National Health and Medical Research Council (NHMRC), Australian Research Council (ARC), National Heart Foundation, Raine Foundation, Diabetes Research Foundation, Prostate Cancer Foundation, Alzheimer’s Australia Research Foundation and the Cancer Council. Congratulations go to Peter Leedman, Juliana Hamzah, Ruth Ganss, Aleksandra Filipovska, Oliver Rackham, Grant Morahan, Susan Peters, Lin Fritschi, Evan Ingley, George Yeoh, Vance Matthews, Kevin Pfleger, Anna Johnasson, Archa Fox, Tom Ratajczak, Sarah Rea, Leon Flicker, Glen Arendts and Andy Redfern on their successful applications.

We are very excited about a number of new recruits who will be joining the Institute next year. With the support of UWA, Julian Heng, NHMRC Senior Research Fellow, will join us from Monash University to work on brain cancer.

Wow ! Another year has flown by so quickly, and some amazing things have happened in the Institute during 2013.

Pilar Blancafort, an ARC Future Fellow originally from Spain and the USA, will be conducting her breast cancer genetic research in the Institute, again in partnership with UWA. The Cancer Research Trust is providing invaluable support for Alistair Forrest to relocate from the premier Japanese research organization RIKEN, where he has been heading a huge international consortium examining all the genes expressed in the various parts of the body, and how these go awry in diseases such as cancer and leukemia.

Significantly, the Institute’s early phase clinical trials company, Linear Clinical Research Ltd, won a number of Western Australian Industry and Export awards in 2013. These included the top award, the Premier’s Award for Excellence, as well as the Health and Biotechnology category. These awards recognize the outstanding efforts of the entire Linear team since its inception, under the impressive leadership of Cameron Johnson. We are very grateful to Janakan Krishnarajah who is the acting CEO of Linear in the interim.

The year has also been special because we completed the construction of not one, but two, new medical research buildings. This project to generate new buildings at the QEII Medical Centre and the Fiona Stanley Hospital had its genesis way back in 2005, and both were finished in late 2013. Our architects Hames Sharley, headed by James Edwards, designed 2 truly world-class facilities, and our builders Doric Construction and Brookfield Multiplex did a great job producing 2 outstanding buildings, which will make a huge difference to research in this State.

To deliver these state-of-the-art buildings, we are indebted to many people who have contributed enormously over several years. People such as the Implementation Committee and the Project Control Group, chaired by the eternally effervescent Dick Lester. Project Director Trevor Dunn, and his marvellous assistant Elise Darsow, have overseen the design, construction, management and governance superbly.

We are also grateful to all the researchers who provided invaluable assistance, particularly Kathy Davern. Thanks also go to all the numerous experts and consultants who guided us along the way.

With the completion of the buildings it is timely to remember the remarkable financial support of almost $200 million that the Institute received from our partners. We are extremely grateful to the State and Commonwealth Governments, through their respective Health Departments, and UWA for their considerable investment in these buildings. The Institute also received wonderful support from Lotterywest, the McCusker Charitable Foundation and the Perron Charitable Foundation.

With a mixture of excitement and trepidation, we began relocating our researchers and staff into the building at the QEII campus in December. Despite all the challenges associated with such a major relocation, the move went particularly smoothly. Thanks goes to everyone involved in orchestrating this seamless transition, especially Tracey Bock, Kathy Davern, and Gwen Pfleger.

Another highly significant event took place in October 2013, when the Institute changed its name from the Western Australian Institute for Medical research (WAIMR) to the Harry Perkins Institute of Medical Research. The name change was designed to recognize the seminal contribution of the Institute’s inaugural Chairman Harry Perkins to the establishment and growth of the organization. Without his determined commitment and the support of our founding sponsor Wesfarmers, headed by Michael Chaney, the Institute would simply not have got off the ground.

October was a busy month as the second Ride to Conquer Cancer took place over the weekend of October 19/20, with over 1300 riders pedalling 220 kilometres from Perth to Pinjarra, and back. Once again the Ride was an emotional and inspirational journey for all participants. The riders raised an awesome $5.2 million for the Institute’s cancer research, with the amazing MACA team of 240 riders, led by Geoff Baker and Tim Gooch, raising over $1 million!

Another important announcement during the year was that Peter Leedman would take over as Institute Director when the building at the QEII Medical Centre was opened. I am absolutely delighted that the Board endorsed Peter to take over the Director’s role, as Peter and I have been “partners in crime” over the past 2 decades, trying to create a strong medical research environment in WA. I am extremely confident that all the exceptional skills that Peter brings to the position will allow the Institute to really blossom in the new facilities.

I would like to take this opportunity to thank all our supporters and donors for their on-going generosity. We really, really do appreciate all that you do for the Institute! Thank you to our major corporate supporters Wesfarmers, MACA, Sunsuper and Supcorp, as well as our community-based supporters, who fund numerous initiatives including the Scott Kirkbride Centre for Melanoma Research, Sock it to Sarcoma and the Rachel Doherty Foundation.

My deep gratitude goes to the Board, so wonderfully led by Larry Iffla, for all their efforts to oversee the activities of the Institute. Behind the scenes our administration does a terrific job supporting our researchers, ably led by John Fitzgerald (Chief Operating Officer), Tony Spezzacatena (Finance) and Lesley Hooper (Fundraising / Communications). To my long-suffering Executive Assistant Lucy Conte – grazie mille.

Finally, to all our researchers, thanks for another great year. I am so proud of all of you, and the great work that you perform. Keep it up because the community is relying on you to make discoveries, which will improve health in this State and globally.

Director’s Message


Mr Laurence Iffla has been Non-Executive Director since March 2005 and Chairman of the Board from 20 May 2009. He is a partner in the legal firm Iffla Wade and prior to that was a partner for 25 years with the national legal firm Mallesons Stephen Jaques. He practices primarily in the area of commercial property law, State taxes and trusts and joint ventures.

Mr Iffla is a Non-Executive Director of the Perron Group and is Chairman of the not-for-profit body Future Living Trust Inc. He is a former member of the Council of Law Society of Western Australia and previously held the position of Treasurer at the society.

Dr Stephen Davis joined the Board in 2012. He is a Radiologist and Partner of Perth Radiological Clinic. He is a medical graduate of UWA, a Member of the Royal College of Physicians UK and Fellow of the Australian and New Zealand College of Radiologists. Dr Davis has clinical experience in Australia, England and the USA, including 14 years as a Consultant at Sir Charles Gairdner Hospital. Dr Davis was Chairman of Perth Radiological Clinic for 9 years. He has experience as a non-executive director in England and Australia and is a Fellow of the Australian Institute of Company Directors.

Professor Gary Geelhoed, the Chief Medical Officer of Western Australia, joined the Board in June 2013. He is a Paediatric Emergency Physician who received his qualifications at The University of Western Australia. Previously he was Director of the Emergency Department at Princess Margaret Hospital for 21 years. He is a Federal and State Australian Medical Association Councillor; Chairman of the Drug and Alcohol Organisation and is a member of the Healthway Board. He is a past President of the Australian Medical Association WA. Professor Geelhoed’s main research interest lies in acute respiratory illness in children.

Professor Peter Klinken has been on the Board since 1998 and was appointed as Director in 2002. Late this year it was announced that Professor Klinken will stand aside from his position in 2014 so that Director-Designate Professor Peter Leedman can take on the role of Director. Professor Klinken’s research has a focus on blood cell development and how leukemias emerge from normal cells. He has been involved in the discovery of novel cancer and leukemia causing genes and first described the phenomenon of “lineage switching”, the process whereby leukemic cells suddenly change their appearance. Professor Klinken has nearly 100 publications in international journals and has attracted $6m in research funding.

Dr Bob Every AO joined the Board in April 2013. He is a metallurgist by profession having completed his Bachelor’s Degree in 1968 and a Doctorate in 1971. In 2000 he was awarded a Centenary Medal and in 2012 was recognised as an Officer of the Order of Australia. His first role as a CEO of a listed company was as Chief Executive Officer of Steel & Tube Holdings Limited in New Zealand from 1988-91 and he then was appointed Managing Director and CEO of Tubemakers. He subsequently worked for BHP and held a number of senior roles before becoming President of BHP Steel in 1999. He took up the role of Managing Director and CEO of OneSteel in February 2000. Dr Every AO is now Chairman of Wesfarmers Limited and Chairman of Boral Limited, as well as a Patron of Redkite.

Dr Erica Smyth joined the Board in 2013. She has almost 40 years experience in the mineral and petroleum industries. She was Principal Geologist for BHP Minerals Limited for 7 years, and then BHP-Utah Minerals International’s Beenup Project Manager for 4 years, before moving to BHP Petroleum as their Manager Gas Market Development WA. She later joined Woodside Petroleum Limited as General Manager – Corporate Affairs. Dr Smyth has a Bachelor of Science from The University of Western Australia and an Applied Master of Science from McGill University in Montreal, Canada. She is the Chair of Toro Energy Limited, Scitech and the Diabetes Research Foundation of WA. She is also a Director of Emeco Holdings Ltd.

Mr Laurence Iffla (Chair of the Board)

Dr Stephen Davis

Professor Gary Geelhoed

Professor Peter Klinken (Director)

Dr Bob Every AO

Dr Erica Smyth

Board of Directors Board of Directors

8 HARRY PERKINS INSTITUTE OF MEDICAL RESEARCH / Annual Report 2013 9PERKINS.ORG.AU

Professor Peter Leedman was appointed Director Designate of WAIMR in 2013, shortly before it became the Harry Perkins Institute of Medical Research. Professor Leedman had been Deputy Director and an ex-officio member of the Board since 2003. In that year he was also promoted to Professor of Medicine and appointed Director of Research at Royal Perth Hospital. Professor Leedman’s laboratory is focused on understanding the biology that underlies cancer and translating novel discoveries at the bench into new clinically useful diagnostics and treatments. He has published numerous scientific papers, attracted $10 million in competitive grant funding, is a co-founder of MiReven (a spin out company commercialising a new anti-cancer treatment) and is Chairman of Linear Clinical Research Ltd. .

Professor Peter Thompson is Deputy Director and has been an ex- officio member of the Board since 2004.

Professor Thompson has over 30 years experience as a clinician and cardiologist attached to the Sir Charles Gairdner Hospital and in private practice. Currently, he is Director of Research Development and a cardiologist at Sir Charles Gairdner Hospital, and the Mount Hospital, as well as Clinical Professor Medicine and Population Health, University of Western Australia.

Mr Tony Spezzacatena was appointed as Director – Finance in August 2009 and became Company Secretary in December 2009. Mr Spezzacatena is responsible for the overall financial management of the institute including the provision of leadership within the Finance Directorate. In addition, he is responsible for the financial management of Linear Clinical Research Ltd. Mr Spezzacatena has extensive experience at a senior management level in the delivery of finance services in medical and health care related organisations, including the management of large capital projects.

Professor Peter J Leedman (Deputy Director)

Professor Peter L Thompson AM (Deputy Director)

Mr Tony Spezzacatena (Company Secretary)

Mr Keith Kessell joined the Board in August 2010. He was Executive General Manager, Corporate Affairs at Wesfarmers Limited for 12 years, retiring in 2008. Previously he worked as a journalist in Western Australia and Canberra and as a senior adviser to the Hon Fred Chaney and with Dr John Hewson, Leader of the Federal Opposition. Mr Kessell has been a member of the Board of the Western Australian Symphony Orchestra since June 2007.

Mr Peter Leonhardt has been a Non-Executive Director since 1998 and is responsible for the Perkins Finance Committee. He is an independent company director and advisor with extensive business, financial and corporate experience. He is a Chartered Accountant, former Senior Partner with PricewaterhouseCoopers and Managing Partner of Coopers & Lybrand in Western Australia. He is Chairman of Carnarvon Petroleum and a Non-Executive Director of CTI Logistics Limited together with a number of private companies. He is also a member of the Cancer Research Trust. Mr Leonhardt is a member of a number of professional bodies including the Australian Institute of Company Directors of which he is a life member and a former State Councillor.

Mr Peter Leonhardt

Mr Keith Kessell

Professor Robyn Owens joined the Board in 2009 representing the Vice-Chancellor of The University of Western Australia. She is Deputy Vice-Chancellor (Research) at UWA and has a Bachelor of Science (Hons) from UWA and a Masters of Science and a DPhil from Oxford, all in Mathematics. She worked at l’Université de Paris-Sud, Orsay, continuing research in mathematical analysis before returning to UWA to work as a research mathematician. She has lectured in Mathematics and Computer Science at UWA and Electrical Engineering and Computer Science at Berkeley.

Professor Robyn Owens

Board of Directors Members Board – Ex-Officio Menbers

10 HARRY PERKINS INSTITUTE OF MEDICAL RESEARCH / Annual Report 2013

NHMRC Principal Research FellowProfessor Nigel Laing

NHMRC Senior Research FellowsProfessor Lin FritschiProfessor Ruth Ganss Professor Aleksandra Filipovska

ARC Future FellowsProfessor Oliver RackhamAssociate Professor Kevin PflegerAssociate Professor Kristen Nowak

Cancer Council FellowsDr Archa FoxAssociate Professor Evan IngleyAssociate Professor Anna Johansson

Scientific Advisory Board Perkins Fellows 2013

Professor Lawrie Beilin AO (Chair), University of Western Australia, WA

Professor John Shine AO, Garvan Institute, NSW

Professor John Funder AO, Prince Henry’s Institute, VIC

NHMRC Career Development FellowProfessor Simon Brown

NHMRC Career Development AwardAssistant Professor Vance Matthews

NHMRC Early Career AwardDr Gina Ravenscroft

NHMRC Peter Doherty FellowshipDr Dimitar Azmanov

NHMRC Clinical Practitioner FellowshipProfessor Peter Thompson

Motor Neuron Disease Research Institute of Australia (MNDRIA) Bill Gole FellowshipDr Rachael Duff

Professor Douglas Hilton, Walter and Eliza Hall Institute, VIC

Professor Ian Constable AO, Lions Eye Institute, WA

11PERKINS.ORG.AU


MarchWA team working to create test to predict diabetes WA researchers are working to develop a test that could indicate a person’s chances of developing type 1 diabetes, as well as predict the risk of those with the condition developing diabetic complications.

Professor Grant Morahan, Director of the Centre for Diabetes Research at the Harry Perkins Institute of Medical Research, says a test that can be applied at the time of diagnosis will be a great help to the children affected, their families and the clinicians caring for them, as well as saving vital health dollars.

“Likewise, a test that gives us the ability to be able to say that brothers or sisters of a child with type 1 diabetes will likely remain unaffected will also provide relief to anxious families,” he said

Professor Aleksandra Filipovska.

Professor Grant Morahan.

Professor Nigel Laing.Ms Jennifer Girschik.

February Sleep study reassures shift workers June

Important gene discovery In Muscle disease

Janurary Medal for mitochondrial researcherProfessor Aleksandra Filipovska received the prestigious Ruth Stephens Gani medal for research in human genetics.

Each year the Australian Academy of Science presents honorific awards to early career researchers under the age of 40. Professor Filipovska is a leader in her field of the genes involved in mitochondrial research.

Women who are poor sleepers are not necessarily at higher risk of breast cancer, as some studies have suggested, according to epidemiologists at the Perkins.

The research under Professor Lin Fritschi questioned previous international studies that suggested a reduction in sleep hours or quality of sleep was leading to an increase in breast cancer cases.

‘’It’s nice to be able to reassure women who don’t sleep well because they’re waking in the night to children or doing shift work that their sleeping habits have no association with breast cancer,” researcher Jennifer Girschik said.

An international collaboration of scientists coordinated by the Harry Perkins Institute of Medical Research has discovered one of the genes that causes a severe muscle disease which newborn babies rarely survive.

Perkin’s Laboratory for Molecular Genetics, headed by Professor Nigel Laing, is globally recognised for its research into an inherited condition known as nemaline myopathy. The laboratory coordinated the worldwide research effort which led to the discovery of the gene KLHL40.

2013 Research Highlights

15PERKINS.ORG.AU14 HARRY PERKINS INSTITUTE OF MEDICAL RESEARCH / Annual Report 2013

SeptemberCell therapy for diabetics supported

Associate Professor Fang-Xu Jiang, who is head of the Islet Cell Development Program, Centre for Diabetes Research at the Perkins, was awarded a Commercialisation Australia Skills & Knowledge Grant.

Associate Professor Jiang has been working on a cell therapy to restore an insulin-dependent diabetic patient’s own ability to control blood glucose levels. He says the cell therapy aims to replace the need for daily insulin injections, avoid the life-threatening complications, reduce patient ill-health and healthcare costs, and improve quality of life.

An exciting discovery by researchers including the Perkins’ Patrick Candy, from the Leedman laboratory, may lead to more effective chemotherapy treatments of bowel cancer patients.

Researchers found that genes involved in a process called “notch signalling” caused tumours to grow quickly when switched on by the bowel cancers, leading to a lower survival rate for patients.

“Our work is leading to the point where medical professionals may be able to test levels of these notch proteins and use it to decide whether notch-inhibiting drugs might be helpful in making chemotherapy treatment work better,” Dr Candy said.

Dr Patrick Candy.

Associate Professor Evan Ingley.

August Important link to anaemia

JulyCancers resistant to chemotherapy because of “notch signalling”

Research in the Perkins’ Cell Signalling Laboratory has uncovered a link between an enzyme in the body (Lyn) and anaemia, a blood disorder that affects red blood cell production causing serious complications for patients.

The findings could be used to fast-track treatments for patients who suffer specific types of anaemia.

Associate Professor Evan Ingley, and other researchers demonstrated the effects on red blood cells if too much of the Lyn enzyme was produced.

Associate Professor Fang-Xu Jiang.



OctoberResearch awards

NovemberEarly career recognition for muscle disease researcher

December3.6 million Australian workers exposed to carcinogens

Linear Clinical Research Ltd won a number of prizes at the Department of Commerce 2013 Western Australian Industry and Export awards, including the prestigious Premier’s Award for Excellence. The early phase clinical trials facility also won the award for the Health and Biotechnology Export category and received special commendations in the Small Business and Business Services categories.

Professor Ruth Ganss was awarded Cancer Researcher of the Year from the Cancer Council of WA for her pioneering work in the field of vascular normalization, which is now being recognised as an emerging concept in anti-cancer therapy.

Professor Ruth Ganss

Assistant Professor Gina Ravenscroft

Professor Lin Fritschi

Professor Peter Leedman, Chairman Linear Clinical Research Ltd

Assistant Professor Gina Ravenscroft’s study which looked at families with a history of a serious muscle weakening disease, (nemaline myopathy or NEM) and successfully identified 19 mutations in unrelated NEM-affected families, won the Raine Medical Research Foundation 2014 Strachan Memorial Prize.

The prize is awarded annually to a Western Australian early-career researcher in the field of health science for the most outstanding publication that translates medical science into health outcomes.

Australian researchers found that a staggering 40% of workers are exposed to cancer-causing agents in their current jobs, with men at higher risk than women.

The study revealed that the 3.6 million Australian workers most likely to be exposed to carcinogens lived in regional areas and often included men and women working in farming, mining and transport.

Professor Lin Fritschi said that unlike lifestyle cancer risks (alcohol, diet) workers do not have a choice about exposure to carcinogens, with the top four occupational cancer risks being sun exposure, diesel engine exhaust, environmental tobacco smoke and the solvent benzene.



Perkins Director of Fundraising Ms Lesley Hooper with guest Ms Alison Fan and Chairman, Mr Laurence Iffla.

Professor Peter Klinken tries out the accommodation for the Weekend with WA Chief Scientist Professor Lyn Beazley and Mr Laurence Iffla.

Professor Grant Morahan with Ms Kathleen Davern, who heads the Perkins’ Monoclonal Antibody facility and Ms Meredith Campbell.

Left to Right: Ava, Samantha, Sharni and Calene training for the walk.

Launch of “Weekend” walk The Perkins launched its latest fundraising event, known as the Weekend to End Women’s Cancers. The annual 60 kilometre walk, begins in Perth over the 15th and 16th of March in 2014.

“The Weekend is an opportunity to remember those lives we have lost to breast or gynaecologic cancer and to celebrate the lives we are saving,” said one of the organisers, Meredith Campbell.

2013 Major Events


Annual general meeting The 2013 Annual General Meeting was held at the Sir Charles Gairdner Hospital social club which provided views onto the construction site where the new Harry Perkins Institute of Medical Research building was nearing completion.

Supporters and staff heard updates on the Perkins’ two building projects and research overviews by senior researchers Professor Ruth Ganss and Professor Nigel Laing.

Left to Right: Professor Ian Constable AO, Professor Peter Klinken, Mr Stan Perron, Mr Richard (Dick) Lester AM and Mr Brian Hockney.

Perkins’ Chairman, Mr Laurence Iffla

Hames Sharley Director Mr James Edwards gave a progress update on the construction of the two new Perkins buildings.

View of the Nedlands building under constructionProfessor Geoff Laurent and Mr Peter Bruechle

Perkins Chief Operating Officer John Fitzgerald with Ms Michele Clement, Department of Commerce and Trade.

Professor Nigel Laing and Dr Stephen Smith.

2013 Major Events


Name change for WAIMR

2013 Sunsuper Ride to Conquer Cancer

The Western Australian Institute for Medical Research (WAIMR) was renamed the Harry Perkins Institute of Medical Research in honour of a remarkable WA businessman, who was passionate about forming an institute that provided collaboration among medical researchers.

Mr Harry Perkins AO, was Chairman of the Institute’s Board from 1998 to 2002. He passed away due to cancer.

“The Institute would not have begun without Harry’s drive, enthusiasm and passion,” said Director Peter Klinken. ”We are delighted to have received so much support, both internally and externally for the name change. It is a measure of the esteem in which Harry was held.”

The name change was announced at the annual Wesfarmers’ Harry Perkins Oration which was presented by Professor John Eikelboom, MBBS, MSc, FRCPC, an international expert in blood disorders and clotting

The second annual Sunsuper Ride to Conquer Cancer in Perth was an outstanding success, with 1336 riders raising $5.2 million for medical research.

“Funds raised through the ride immediately go to support our ground-breaking cancer research. As a result, we are improving treatments, diagnosis and therapies, which is leading to better patient outcomes for all Australians,” said the Director of the Harry Perkins Institute of Medical Research, Professor Peter Klinken.

Professor Klinken paid a special tribute to MACA Limited, the Ride’s “Powered by” sponsor, which mobilised 230 employees to raise over $1 million in 2013.

Professor John Eikelboom. Left to Right: Professor Peter Leedman, Mr Charles Perkins, Mrs Margaret Perkins, Professor John Eikelboom and Professor Peter Klinken.

Members of Team MACA at the start line at McCallum Park in Perth.Pinjarra here we come! Team WAIMR takes off.

2013 Major Events

HARRY PERKINS INSTITUTEOF MEDICAL RESEARCH


Staff move into new Nedlands building Staff from the Harry Perkins Institute of Medical Research began moving out of their offices and laboratories at Royal Perth Hospital and QEII Medical Centre and into a state-of-the-art new building at the end of 2013.

The 10 storey facility in Nedlands will be officially opened by the Prime Minister in March 2014.

The move marked the end of an era for the institute which had operated campuses at Royal Perth Hospital and QEII for 15 years.

First visit to the Level 7 tea room for a celebratory morning tea. Left to Right: Mr James Edwards, Professor Peter Leedman, Mr John Stephens, Mr Robert Sharpe, Mr Lee Wright, Mr Eric Gomez, Mr Matt Luckhurst, Mr John Fitzgerald, Mr Trevor Dunn, Mr Richard (Dick) Lester AM.

BENEFACTORSWesfarmers

Lotterywest

In a year of incredible achievements both from our researchers and new buildings, we would like to recognise our wonderful donors. So much of what we achieve would simply have not happened without your help. You let us simply get on with our core business; research into diseases that affect our community. Thank you.

PIONEERSMACA Ltd

McCusker Charitable Foundation

Australian Cancer Research Foundation

ADVOCATESAXIS Financial Group

Angela Bennett

Doreen Bolts

BP Foundation

Busby Holdings Pty Ltd

The Carcione Foundation

EMJC Earthmoving & Plant Hire

Euroz Charitable Foundation

John & Margaret Gadsdon

Gavin Gillespie

Joseph Glover

Paul Guilfoyle

Alison Ham

Hardie Finance Corporation Pty Ltd

Win Hewitt

Komatsu Australia Pty Ltd

Lululemon Athletica Australia Pty Ltd

Frank & Sharon Maher

Mandurah Murray Mayday Club

DISCOVERERSRegis Resources Ltd

Sunsuper

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AUism Charitable Foundation

Geoff Baker

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David Edwards

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Hitachi Construction Machinery

Max & Lorraine Kousins

Frank & Sharon Maher

Jim & Julia Moore

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Regis Resources

Stan Perron Charitable Trust

Striker Australia Pty Ltd

Suncorp Bank

WesTrac Pty Ltd

Wind Over Water Foundation

ESTATESLone Ereka Alexandra Hester

Bernadette Jolly

Jean Kahan

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Andrew Hutchison

Larry & Nicola Iffla

Dean Irvine

ISA Group Pty Ltd

Jacaranda Management

Walter & Sue James

Adrian Jameson

Zoran Jelenovic

Job Done Trees

Anna Johansson

Paul Johnson

Peter Johnson

Grant Johnston

John Jones

Richard Jones

Mansour Kabbani

Patricia Kailis

Peter Klinken

Knight Frank Australia Pty Ltd

Ferenc Kocsis

William Koolhof

Nigel Laing

Margaret Lawrie

Helene Le Bel

Chris Le Page

Graham & Viv Lee

Malcolm C Lee

Dick Lester

Mark Lewis

Yi-Liang Liew

Linkforce Engineering Pty Ltd

LWP Property Group

Joan Lyons

Jeff Mansell

Brendan Manuel

Bhagwan Marine

John Maravillas

Rebecca Maslen-Stannage

Kim Massey

Maya Masala Joondalup

Fraser Maywood

Chris McCabe

Kim McDonald

Craig McLeish

Shaun McRobert

Melanoma WA

Grant Menhennett

Dawn Metcalfe

Peter Meurs

Joseph Merenda

Steven Mills

Kath Millward

Jake Minear

Sud Mkte

Hamish Moffat

Steven Molloy

Paul Montauban

Peter Mora

Graeme Morgan

Craig Morris

Peter Morris

Mount Lawley Golf Club

Robert Mule

Gail Mulligan

Danny Murphy

Kyla Murray

Kim Nairn

Daryl Naismith

Neptune Diving Services

Jeremy Newman

Novus Homes

Offshore Plant Hire Pty Ltd

Gary Olsen

Ged & Joanne Oxley

Brian & Hilda Parker

Greg Parker

Daniel Paull

Robert Pearce

Craig Pedley


Jocelyn Perkins

Margaret Perkins

Anne Pickett

Barrick Plutonic

John Poynton

David Preedy

Terry Primeau

Jamie Prendiville

Craig Proctor

Ben Pruden

Ali Qamar

Clive Rawson

Resource Engineering and Design

Adam Rhodes

Chris Richards

Emma Richard

Angela Roberts

Raymond & Kerry Robinson

Tony Robinson

Michelle Romano

Rotary Club of Western Endeavour

S & L Ciavalini Pty Ltd

Richard Sallie

Rachelina Santella

Andrew Sarich

Ralph & Patricia Sarich

Patrick Schimanski

Schneider Electric

Marjorie Scholz

Mark Seares

Brad Shallard

Emma Shand

Shell Company

Peter Shelley

Bob Shier

Carey Simpson

Iain Simpson

John Simpson

Nigel Sinclair

Skilled Offshore Group

Wayne Smit

Darren Smith

Michael Smith

Solutions Building Group

Prashanthan Sooriakumaran

Jonathan Steel

Linda Stewart-Richardson

Sara Stockdale

Frances Strutt

Stephen Sutton

Adam Taylor

Ashley Taylor

Claudia Taylor

Linlee Taylor

TC Drainage (WA) Pty Ltd

Gregg Teets

Sue Thomas

Natasha Thompson

Peter Thompson

Peter J Toll

Tomcat Hardchrome Engineering Ltd

Debbi Tomilson

John Toohey Chambers

Torrens Energy Ltd

Transwag Pty Ltd

Craig Trestrail

Alan & Marisa Tribe

Jules Tripodi

Glen Trouchet

TSA Telco Group

Sue Turpin

The UPC Group & Eisenbau Krämer mbH

Richard Vaughan

Johanna Verboon on behalf of Julker Pty Ltd

Victa Golf Club

Darren Verwijmeren

Yvonne Valentine

Albert Walmsley

Brian Ward

Christopher Webster

Wentworth Plaza Hotel

WesTrac Pty Ltd

Nicola White

Carolyn Williams

Cecil Williams

Glenda Wilson

Janice Wilson

Karen Wilson

James Yewers

Tully Young

Our Supporters

30 HARRY PERKINS INSTITUTE OF MEDICAL RESEARCH / Annual Report 2013 31PERKINS.ORG.AU

2013 2012 %%

Research activities $24,249,848 80.0% $21,782,542 82.3%

Research support $4,616,917 15.2% $3,791,199 14.3%

Depreciation and ammortisation $1,213,912 4.0% $883,379 3.3%

Unexpended grant income - current periods (c) $219,524 0.7% - 0.0%

Total Expenditure $30,300,201 100% $26,457,120 100%

National competitive grants $5,370,924 16.9% $5,790,929 19.8%

International grants $174,990 0.6% $784,374 2.7%

Other grants $2,813,209 8.9% $1,895,260 6.5%

Commercial contracts $6,069,672 19.2% $4,823,921 16.5%

Government contracts $1,733,450 5.8% $1,701,096 5.8%

Donations and fundraising $9,849,455 31.1% $7,216,390 24.7%

Investment income $811,649 2.6% $958,328 3.3%

Research support - UWA $2,409,428 7.6% $2,687,653 9.2%

Research support - Dept of Health WA $1,038,756 3.3% $1,036,497 3.6%

Miscellaneous income $1,412,809 4.5% $1,200,639 4.1%

Unexpended grant income - prior periods (b) - - $1,098,865 3.8%

Total Income $31,671,360 100% $29,193,952 100%

Financials 2013 - The Year in Brief

Income

Expenditure

Capital Grants Work Income

Net Surplus $26,952,099 $76,730,638

Federal $9,347 $51,966,080

State $24,768,589 $20,357,455

Other $803,004 $1,670,271

$25,580,940 $73,993,806

National Competitive Grants

International Grants

Other Grants

Commercial Contracts

Government Contracts

Donations and Fundraising

Investment Income

Research Support - UWA

Research Support - Dept of Health WA

Miscellaneous Income

Research Activities

Research Support

Public Education

Unexpected grant income - current period (c)

Unexpected grant income - prior periods (b)

National Competitive Grants

International Grants

Other Grants

Commercial Contracts

Government Contracts

Donations and Fundraising

Investment Income

Research Support - UWA

Research Support - Dept of Health WA

Miscellaneous Income

Research Activities

Research Support

Public Education

Unexpected grant income - current period (c)

Unexpected grant income - prior periods (b)

Income

Expenditure

Notes(a) The above results incorporate the statutory financial reporting results of the Harry Perkins Institute of Medical Research Inc., and the research operations

conducted by researchers through the Institute’s affiliation agreement with the University of Western Australia via the Centre for Medical Research. The financial results of the Institute include the operating results of its subsidiary entity, Linear Clinical Research Ltd, and any grants administered by the Institute.

(b) Unexpended grant income represents grant income from prior periods which has been utilised during the current year.

(c) Unexpended grant income for current period represents grant income received but not expended at year-end.

Net operating Surplus/(Deficit) $1,371,159 $2,736,832


We are dedicated to translating our discoveries from the bench in the laboratory to the bedside, offering better treatments and

hopefully cures for a range of diseases.

However, using the latest technologies to gain faster results and attracting top researchers is a constant challenge.

The fact is, medical research is expensive and we would not be achieving the results we are without the generous support of the community, so

please donate or consider leaving a bequest to the Perkins.

Donors can support specific projects or give to the Perkins as a general donation. We will use your gift in the area of greatest need. We accept

donations by post, phone or online Donations over $2 are tax deductible.

If you have any queries please contact Lesley Hooper, Director of Fundraising, on +61 8 6151 0708. We greatly appreciate your support. Thank you for

providing hope for future generations.

The Harry Perkins Institute of Medical Research continues to achieve scientific breakthroughs that offer real hope for the patients and their families.

How you can help - Hope Starts Here!

Phone: +61 8 6151 0700 Fax: +61 8 6151 0701

perkins.org.au

Head OfficeQQ Block, QE11 Medical Centre6 Verdun St, Nedlands, WA 6009

PO Box 7214, Shenton Park Western Australia 6008

annual report 2013 - perkins

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