Conference Proceedings

26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

EMBC

2004

LINKAGES FOR INNOVATION

IN 81O ML DICi NE

SAN FRANCISCO, USA

1-5 September 2004

San Francisco, California

Volume V

Conference Chair Program Chair Publications Chair

Donna Hudson, Ph.D. Zhi-Pei Liang, Ph.D. Guy Dumont, Ph.D.

A Novel Mobile Telemedicine SystemforAmbulance Transport, Design andEvaluationMandellos, G. J.; Lymberopoulos, D. K.; Koukias,M. N.; Tzes, A.; Lazarou, N.; Vagianos, C. 3080

Using Telehealth Technology to Improve the

Delivery ofHealth Services to People who are

Deaf

Hughes, Glen; Hudgins, Bernard; MacDougall,James 3084

Networking Technology andHealth Care in

Eastern North Carolina

Brinn, JackE. 3088

Establishing a Rural Telehealth Project: the

WyomingNetworkfor Telehealth

Gantenbein, Rex E.; Cadez, Fran; Stamm, BethHudnall 3089

Session 7.1.2: Telemedicine Technologyand Deployment II

Design ofan Interoperability Framework in a

Regional Healthcare SystemBerler, Alexander A.; Pavlopoulos, Sotiris;Koutsouris, Dimitris

ntegration ofMonitoring Devices in thee-Vital

Service

Jakka, Eleni; Prentza, Andriana; Lamprinos, Ilias

E.; Leondaridis, Lefteris; Koutsouris, Dimitris

Bio~Stream: A System Architecturefor Real-

Time Processing ofPhysiological SignalsBar-Or, Amir; Goddeau, David M.; Healey,Jennifer A.; Kontothanassis, Leonidas; Logan,Beth;Nelson, Alex; Van Thong, Jean-Manuel

UsingHandheldDevicesfor Real-Time Wireless

Teleconsultation

Banitsas, Konstantinos A.; Georgiadis, P,;Tachakra, S.; Cavouras, D.

Design ofMultimedia Telemedicine SystemforInter-hospital ConsultationSun K. Yoo, Kwang M. Kim, Suck M. Jung,Kyung Joung Lee, Nam H. Kim

TM-Provider: a New Communicatory ModelforTelemedicine Services SupportKolovou, Lamprini T.; Triantafyllou, George N.;Chassomeris, Constantine A.;Karavatselou, Evy I.; Lymberopoulos, Dimitris K.

A Front-end Platform ofthe Network-based

Intelligent Home Healthcare Embedded SystemTang, Shuo; Chan, Weng Chi; Vai, Mang I.; Mak,

Peng Un

3093

3097

3101

3105

3109

3112

3116

Track 7.2: Virtual and AugmentedReality Technology in Healthcare

Session 7.2.1: Telesurgery and Virtual

Reality Technology in Healthcare I

Modeling Liver Physiology: Combining Fractals,Imaging andAnimationLin, Debbie 3120

Virtual Planning ofMulticatheter BrachytherapyImplants for Accelerated Partial

Breast Irradiation

Schmidt-Ullrich, P. N.; Todor, D. A.; Cuttino, L.W.; Arthur, D. W. 3124

Linking Ontologies with Three-Dimensional

Models ofAnatomy to Predict the Effects ofPenetrating InjuriesRubin, Daniel L.; Bashir, Yasser; Grossman,David; Dev, Parvati; Musen, Mark A. 3128

A NovelNavigation Principle in Computer-Assisted SurgeryBuzug, Thorsten M.; Hering, Peter; Bongartz,Jens; Ivanenko, Michael 3132

Session 7.2.2: Telesurgery and Virtual

Reality Technology in Healthcare II

Content-Based Video Codingfor Remote

Monitoring ofNeurosurgeryXu, Jian; Ilgin, Hakki; Liu, Qiang; Kassam, Amin;Sclabassi, Robert J.; Chaparro, Luis F.; Sun,Mingui 3136

Networked Interaction Therapy: Relieving Stress

in Memory-Impaired People and Their

Family MembersKuwahara, Noriaki; Kuwabara, Kazuhiro; Utsumi,Akira; Yasuda, Kiyoshi; Tetsutani, Nobuji 3140

Identification ofLenke Spine DeformityClassification By Simplified 3D Spine ModelLin, Hong; Sucato, Dan 3144

Track 7.4: Electronic Health Records

and Medical Databases

Session 7.4.1: Electronic Health Records

and Medical Databases I

Personal Recognition using Head-Top Imagefor

Health-Monitoring System in the Home

Nakajima, Kazuki; Sasaki, Kazuo 3147

A Home Health Monitoring System Including

Intelligent Reporting andAlerts

Garsden, Hugh; Basilakis, Jim; Celler, Branko G.;Huynh, Khang; Lovell, Nigel H. 3151

xl

An Extensible FrameworkforSharing Clinical

Guidelines and Services

Xiong, Fei; Cao, Kefei; Wang, Zhifeng; Ford,James; Pearlman, J. D.; Makedon, F. S. 3155

Application and Evaluation ofPersonal HealthInformation Management SystemKim, Eung-Hun; Wang, Maisie; Lau, Christopher;Kim, Yongmin 3159

Towards Total Knowledge ManagementforHealthcare: Clinical and OrganizationalConsiderations

Baskaran, Vikram; Bali, Rajeev K.; Arochena,Hisbel; Naguib, RaoufN. G.;Dwivedi, Ashish N.; Nassar, Nahy S. 3163

Session 7.4.2: Electronic Health Records

and Medical Databases II

An IndexedAtlasfor Content-basedRetrieval

andAnalysis ofMammogramsLau, Howard; Mok, Kelvin; So, Donald; Tse,Courtney; Rangayyan, Rangaraj M. 3167

The Knowledge Management Landscape:

Implicationsfor Clinical KnowledgeManagementandPractice

Dwivedi, Ashish R; Bali, Rajeev K.; Naguib,RaoufN. G.; Nassar, Nahy S.

Declarative Algebra and Continuous QueryLanguagefor Biomedical Stream Processing in

Fetal Monitoring SystemWrobel, Janusz; Widera, Michal; Horoba,

Krzysztof; Jezewski, Janusz; Winiarczyk, Ryszard

A DatabseApplication to Manage Patients'Data

with a Cochlear ImplantatZhou, Guohong

Track 7.5: Machine Learning and

Clinical Decision Support

Session 7.5.1: Machine Learning andClinical Decision Support I

Transitional Appearance-BasedMotion Tracking

for Real-Time Breast

Self-Examination SupervisionHu, Yuqin; Naguib, RaoufN. G.; Todman Alison

G.; Aram, Saad A.; Al-Omishy, Hassanein

Support Vector Machinefor DeterminingDose of

DialysisRay, Monika; Array, Naveen

Computer Aided Interactive Remote Diagnosis

Using Self-Organizing MapsVbros, Tibor; Laczk6, Jozsef; Keresztenyi, Zoltan;

Fazekas, Csaba

3171

3175

3179

3182

3186

3190

Classification ofLungData bySampling andSupport VectorMachine

Dehmeshki, Jamshid; Chen, Jun; Casique, ManlioValdivieso; Karakoy, Mustafa

An Input Classification Schemefor Use in

Evidence-Based Dynamic Recurrent

Neuro-Fuzzy PrognosisWang, Yu; Winters, Jack M.

Predicting Clinical Outcomesfor Newborns

using Two Artificial Intelligence ApproachesFrize, Monique; Ibrahim, Doaa; Seker, Husvein;Walker, Robin C;

Odetayo, Michael 0.; Naguib, RaoufN. G.

A New Melanoma Diagnosis Active SupportSystemFiorini, Rodolfo A.; Dacquino, G.; Laguteta, G.

Session 7.5.2: Machine Learning andClinical Decision Support II

Estimating the Efficiency ofMedicalDiagnosticSystemsLehocki, Fedor; Pis, Pavel; Kukucka, Marek

Creating a TextData-Mining Applicationfor Use

in Public Health InformaticsMichel, Martha

SAGEDesktop: An Environmentfor TestingClinical Practice Guidelines

Berg, David; Ram, Prabhu; Glasgow, Julie; Castro,

Jonathan

HandMotion Segmentation AgainstSkin Co/our

Background in BreastAwareness ApplicationsHu, Yuqin; Naguib, RaoufN. G.; Todman, Alison

G.; Amin, Saad A.; Oikonomou, Andreas;

Al-Omishy, Hassanein; Tucker, Nick

MedicalDecision Support SystemforDiagnosisofSoft Tissue Tumors Basedon

DistributedArchitecture

Garcia-Gomez, Juan M.; Vidal, Cesar, Vicente,

Javier; Marti-Bonmati, Luis; Robles, Montserrat

Hereditary Non-Polyposis Colorectal Cancer

RiskAssessmentBased on AIAnalysis of

Pedigree Data

Kokuer, Munewer; Naguib, RaoufN. G.;

Jancovic, Peter; Younghusband, H. Banfield;

Green, Roger

3194

3198

3202

3206

3210

3214

3217

3221

3225

3229

xli

Track 7.6: PACS, Data Compression,

Storage, Retrieval, Communication

and Security

Session 7.6.1: PACS, Storage, Retrieval

and Watermarking

Tracing Medical Images Using Multi-Band

Watermarks

Li, Mingyan; Narayanan, Sreeram; Poovendran,Radha 3233

Reversible WatermarkingforAuthentication of

DICOMImagesZain, Jasni M.; Clarke, Malcolm; Baldwin, LynneP. 3237

A Multiple Watermarking Scheme Applied to

Medical Image ManagementGiakoumaki, Aggeliki; Pavlopoulos, Sotiris;

Koutsouris, Dimitris 3241

Wavelet Coding of Volumetric MedicalImageswith High Throughput and OperabilityWu, Xiaolin; Qiu, Tong 3245

Efficient Similarity Retrievalfor Temporal Shape

Sequences: A Case Study using Cardiac

MR ImagesHuang, Heng; Makedon, Fillia; Ford, James; Shen,Li; Wang, Yuhang; Steinberg, Tilmann;

Gao, Ling; Pearlman, Justin 3250

HbRASCH - A Programming FrameworkforTransparent Access to Physiological SignalsSchneider, Raphael; Bauer; Axel; Barthel, Petra;

Schmidt, Georg 3254

Track 7.7: Emerging IT for

Efficient/Low-Cost Healthcare Delivery

Session 7.7.1: Emerging IT for Efficient,Low-Cost Healthcare Delivery

Low-Bandwidth TelephonyforAccess to NursingServicesfor Stroke Sun'ivors and

Their CaregiversTran.BinhQ. 3258

A Mobile-Phone Based Telecare Systemfor the

ElderlyTamura, Toshiyo 3260

Home Health and Home Monitoring in Rural

and Frontier Counties: Human Factors

in ImplementationWeeg, Stephen C. 3264

VTAMN-A Smart ClotheforAmbulatoryRemote Monitoring ofPhysiological Parameters

and ActivityNoury, N. M.; Dittmar, A.; Corroy, C; Baghai, R.;Weber, J. L.; Blanc, D.; Klefstat, F.; Blinovska,A.;Vaysse, S.; Comet, B. 3266

Reconfigurable Point-of-Care Systems Designedwith Interoperability Standards

Warren, Steve; Yao, Jianchu; Schmitz, Ryan;

Lebak, Jeff 3270

Status ofMobile Computing in Health Care: An

Evidence StudyGollol Raju, Narasimha S.; Anthony, James P.;

Jamadagni, Radhakrishna $.; Laxminarayan, S.;

Suri, J.; Istepanian, R. 3274

Session 7.7.2: Emerging IT in Healthcare I

A Wearable Devicefor a Fully Automated In-

Hospital Staff and Patient IdentificationCavalleri, M.; Morstabilini, R.; Reni, G. 3278

A Mobile Teletrauma Systemfor Rural Trauma

Care

Chu, Yuechun; Ganz, Aura 3282

Design Considerations and Implementation ofa

Cost-Effective, Portable Remote Monitoring Unit

Using 3G Wireless Data Networks

Gupta, Shashank; Ganz, Aura 3286

DI(g)L-hg BY DESIGN: ANINTEGRATED

TELE-CARE COMMVNICAHON

INFRASTRUCTURE

Black, Lesley-Ann; McTear, Mike F.; Black,Norman D.; Harper, Roy; Lemon, Michelle 3290

The Potential ofa Store and Forward Tele-

Behavioral Platformfor Effective Treatment and

Research ofAutism

Oberleilner, Ronald M.; Laxminarayan, Swamy;Suri, Jasjit 3294

A Low-Cost Frameworkfor Individualized

Interactive Teterehahllitatlon

Jadhav, Chetan; Krovi, Venkat 3297

Wearable Devicesfor Emerging Healthcare

ApplicationsScheffler, Michael; Hirt, Ktienne 3301

Session 7.7.3: Emerging IT In Healthcare

It

ACTIDOM-A MicroSystem based on MEMSforActivity Monitoring ofthe Frail Elderly in their

Daily LifeNorbert. N M ; Rarralon, P

,Couturier, P .

Favre-

Reguillon, F.Guillcnmud. R

,Mesial"., I*; Caritu,

Y.;

xlii

David, D.; Moine, S.; Franco, A.; Guiraud-By, F.;Berenguer, M.; Provost, H. 3305

Realization ofan e-Health System to Perceive

Emergency Situations

Shin, S. C; Ryu, C. Y.; Kang, J. H.; Nam, S. H.;Song, Y. S.; Lim, T. G; Lee, J. W.; Park, D. G.;Kim,S.H.;Kim,Y.T. 3309

A Communication Platformfor DiabetesSurveillance

Tang, Shih-Tsang 3313

A Mobile Phone-BasedSafety Support SystemforWandering Elderly Persons

Ogawa, Hidekuni; Yonezawa, Yoshiharu; Maki,Hiromichi; Sato, Haruhiko; Caldwell, W, Morton 3316

Design ofa Wearable Devicefor ECGContinuous Monitoring Using Wireless

TechnologyLed, Santiago; Fernandez, Jorge; Serrano, Luis 3318

SCIENT- Smart Configurable InfrastructureforNext-Generation TeleMonitoringGupta, Shashank; Ganz, Aura 3322

Track 7.8: Web-Based Medical

Information Systems

Session 7.8.1: Medical Information

Systems I

Java-BasedBrowsing, Visualization and

Processing ofHeterogeneous MedicalDatafromRemote RepositoriesMasseroli, Marco; Bonacina, Stefano; Pinciroli,Francesco 3326

Design ofa Web-BasedHealth Promotion SystemandIts PracticalImplementationfor CycleErgometer Exercise

Wang, Zhihui; Kiryu, Tohru 3330

Towards a Web Senices InfrastructureforPerinatal, Obstetrical, and Neonatal Clinical

Decision SupportCatley, Christina; Frize, Monique; Petriu, Dorina

C; Walker, C.Robin; Yang, Lan 3334

HL 7-Compliant Healthcare Information Systemfor Home MonitoringLebak, Jeffrey W.; Yao, Jianchu; Warren, Steve 3338

"On-demand" Access to a Multi-PurposeCollection ofBest Practice Standards

Del Fiol, Guilherme; Rocha, Roberto A.;

Washburn, Jeffrey; Rhodes, Julie; Hulse, Nathan

C;Bradshaw, Richard L.; Roemer, Lorrie K. 3342

Integrating Clinical Trial Datafor Decision

Making via Web Senices

Jiang, Keyuan 3346

Session 7.8.2: Medical Information

Systems II

The Knowledge Authoring Tool: An XML-based

Knowledge Acquisition Environment

Hulse, Nathan C.; Rocha, Roberto A,; Del Fiol,Guilherme; Bradshaw, Richard L.;Hanna, Timothy P.; Roemer, Lorrie K. 3350

Application ofHLlin a Collaborative Healthcare

Information SystemCheng, Po-Hsun; Yang, Chou-Han; Chen, Heng-Shuen; Chen, Sao-Jie; Lai, Jin-Shin 3354

Teleconsultations Using Content-Based Retrieval

ofParametric ImagesRuminski, Jacek 3358

Track 7.9: Mobile Health

Session 7.9.1: Mobile Telehealth and

Wireless Patient Monitoring

A Systemfor Ubiquitous Health Monitoring in

the Bedroom via a Bluetooth Network and

Wireless LAN

Choi, Jong Min; Choi, Byung Hun; Seo, Jin Woo;Sohn, Ryang Hee; Ryu, Myung Suk;Yi, WonJin; Park, Kwang Suk 3362

Multi-Channel Measurement ofPhoto-

Plethysmography andEvaluationfor the OptimalSite ofa Thigh in a Toilet

Kim, Jungsoo; Park, Juwan; Ryu, MyungSuk;Park, Kwangsuk 3366

Development of "MobileAudiometer"forScreening using Mobile Phones

Nakamura, Norio 3369

Experiences Using WinCEPocketPCs as

Computation andData Acquisition Platformsfor

Ambulatory TelemonitoringNagl, Luke J.; Krishnamurthi, Balakumar;

Schoenig, Scott; Warren, Steve; Andresen, Dan 3373

Use ofM3Sfor Mobile/Local Controls Over a

Remote/Fixed Environment

Chang, Yi-Chu 3377

A Novel Communications Networkfor the

Provision ofMedical Care in Disaster and

Emergency Situations

Dembeyiotis, Spiro; Konnis, Georgios J.;Koutsouris, Dimitris 3380

Development of Wireless Blood Glucose Meter

and Diabetes Self-Management SystemChen,You-Yin 3384

Mobile Telemedicine Systemfor Home Care and

Patient MonitoringFigueredo, Marcus V. M.; Dias, JoSo S, 3387

xliii

Theme 8. Clinical Engineering

Track 8.1: Clinical Applications for

Telemedicine

Session 8.1.1: Clinical Applications for

Telemedicine

Telellealth - Operational Issues to Consider

David, Yadin 3391

The Telemedicine and Teleconsultation System

Application in Clinical Medicine

Chang, Tzyh-Chyang; Lee, Jiann-Der; Wu, Shwu-

Jiuan 3392

Transmission ofDigital Electrocardiogram

(ECG) via Modem Connection in Southern BrazilRussomano, Thais; Sparenberg, Adolfo L. F;Azevedo, Dario F. G. de 3396

An Image-BasedAnalysisfor ClassifyingMultimodal Brain Images in the Image-GuidedMedical Diagnosis Model

Lau, Phooi Yee; Ozawa, Shinji 3400

An Open Strategyfor Implementing PACS and

Its Primary ApplicationTiquan, Liu; Siping, Chen; Jingyi, Feng; Duan,Huilong 3404

Track 8.2: Medical

Operations/Decision Support Systems

Session 8.2.1: Medical

Operations/Decision Support Systems

Engineering Managed Care Automation via the

Treatment Planning Process: A

Bottom-up ApproachHanna, Darrin 3408

Remote Expert System ofSupport the Prostate

Cancer DiagnosisPereira, Marcos A.; Schaefer, Marcela B.;Marques, Jefferson L, B. 3412

DESSA: A New Decision Support SystemforNeurosurgeryDimopoulos, K. G.; Baltogtannis, C; Scorila, E.;Kimonides, V. G.; Sakas, D.; Lymberopoulos, D.

K. 3416

Towards Ethical Decision Support andKnowledge Management in Neonatal Care

Yang, Lan; Frize, Monique; Walker, C. Robin;Catley, Christina 3420

Automatic 3D I 'oscular Tree Cons/ruction ofPerforator Flapsfor Plastic Surgery PlanningGao, Jean; Wen, Quari

"

3424

Damper Designfor Improving S/NRatio ofthe

Seistnocardiogram Monitoring in the OpenMRI-guided Operating Theater

Naemura, Kiyoshi; Iseki, Hiroshi 3428

Using The Full Scale 3D Solid AnthropometricModel in Radiation Oncology Positioningand VerificationSun, Shuh-Ping; Wu, Ching-Jung 3432

Track 8.3: Critical-Care and IntelligentMonitoring Systems

Session 8.3.1: Critical-Care and IntelligentMonitoring Systems

Determining Critical Values of CalculatedParameters Within a Physiologic ModelHutchinson, George

A Wireless ECG Smart Sensorfor Broad

Application in Life Threatening Event DetectionWelch, James P,; Guilak, Farzin; Baker, Steve

Mobile Medical Device Connectivity in the

Hospital EnvironmentPelt us, Dan C.

3436

Development ofan Implantable Intrathecal DrugInfusion PumpHong, Soyoung; Lee, Jung Seok; Park, Jim Woo;Nam, Kyoungwon; Choi, Jaesoon; Lee, JungChan;Park Chan Young; Ko, Young Pil; Jo, Young Ho 3440

The Shape ofElectrical Impedance Spectroscopy(EIS) is Altered in Stroke Patients

Bonmassar, Giorgio; Iwaki, Sunao 3443

3447

3450

End Tidal Carbon Dioxide Measurement Usingan Electro Acoustic Sensor

Foike, Mia K.; Hftk.Bertil; Kkstrfim, Mikael;Backlund, Ylva 3452

Estimation ofBeat-to-Beat Systolic BloodPressure Using Pulse Arrive Time and Pulse

Width Derivedfrom the PhotoplethysmogramLin, Yuan-Hsiang; Ko, Patrick Chow-In; Wang,Hsiang-Yao; Lu, Tsung-C'hien; Chen, Yen-Yu;Jan, I-Chicn; Jan, Gwo-Jcn; Chou, Nai-Kuan 3456

Automated Agitation Management Accountingfor Saturation DynamicsRudge, Andrew D.; Chase, J, Geoffrey, Shaw,

Geoffrey M.; l.ee, Dominic 3459

xliv

Session 8.3.2: Critical Care & IntelligentMonitoring

Adaptive Bolus-Based Set-PointRegulation ofHyperglycemia in Critical Care

Lin, Jessica; Chase, J. G; Shaw, G. M.; Doran, C.

V.; Hann, C. E.; Robertson, M. B.; Browne, P. M.;Lotz, T.; Wake, G. C; Broughton, B. 3463

Construction ofa Conformal Water Bolus Vest

Applicatorfor Hyperthermia Treatment ofSuperficial Skin Cancer

Juang, Titania; Neuman, Daniel; Schlorff, Jaime;Stauffer, Paul R. 3467

Track 8.4: Technology Assessmentand Management

Session 8.4.1: Technology Assessmentand Management

A TechnologyRoadmapfor Rehabilitation

EngineeringPrice, Sheila; Summers, Ron 3471

Automatic Characterization ofEvents on Sp02Signal: Comparison of Two MethodsChambrin, Marie-Christine; Charbonnier, Sylvie;Sharshar, Samir; Becq, Guillaume; Badji, Lyes 3474

Neural Networksfor Predicting TechnologicalUse in Neonatal Care

Scalon, Joao D. 3478

Application ofSpectral Entropy to EEG and

Facial EMG Frequency Bandsfor theAssessment ofLevel ofSedation in ICU

Rautee, Riina; Sampson, Timothy; Sarkela, Mika;Melfo, Sari; Hovilehto, Seppo; van Gils, Mark 3481

Evalutate Alternative Service ContractsforMedical EquipmentDe Vivo, Liliana; Derrico, Pietro; Tomaiuolo,Daniela; Capussotto, Carlo; Reali, Alfredo 3485

Targeting Shock Waves in Human Tissuefor

Extracorporeal Shock Wave TherapyManousakas, loannis; Wan, Long-Ray; Liang,Shen-Min 3489

Track 8.5: Ethics, Standardization,Policy, Cost and Safety

Session 8.5.1: Ethics, Standardization,

Policy, Cost and Safety

Applications ofthe PetriNet to Simulate, Test,and Validate the Performance and Safety of

Complex, Heterogeneous, Multi-Modality Patient

Monitoring Alarm SystemsSloane, Elliot B.; Gelhot, Vijay 3492

Failure Mode EffectAnalysis Applied to the Use

ofInfusion PumpsFechter, Richard J.; Barba, Julio J. 3496

Improving A Health Care System Following AnIncident InvestigationShepherd, Marvin 3500

The Square Peg and theRoundHole: Murphy'sLaw and Medical Device Connections

Baretich, Matthew F. 3503

Risk Assessment - Hospital View in SelectingMedical TechnologiesDavid, Yadin 3504

Session 8.5.2: Medical TechnologyStandardization, Policy, Cost and Risk

A Thirty-Two Year Perspective on a Clinical

Engineer's Contributions to Patient SafetyHyndman, Bruce H. 3505

Cost Management ofMedical EquipmentMaintenance

Rocha, Leticia S.; Bassani, Jose W. M. 3508

Medical Device SecurityGrimes, Stephen L. 3512

Electromagnetic Interference To Infusion PumpsFrom GSMMobilePhones

Calcagnini, Giovanni; Bartolini, Pietro; Floris,Matteo; Triventi, Michele; Cianfanelli, Plinio;Scavino, G.; Proietti, L.; Barbara, Vincenzo 3515

Benchmarking Clinical Engineering ProgramDavid, Yadin 3519

Theme 9. Drug Delivery and Gene

Therapy

Track 9.1: Novel Carriers for Drug and

Gene Delivery

Session 9.1.1: Drug and Gene Delivery I

DirectedEvolution ofAA VMutantsforEnhanced Gene DeliverySchaffer, David V.; Maheshri, Narendra

Systemic Virus Dissemination duringLocal Gene

Delivery in Solid Tumors

Wang, Yong; Li, Chuan-Yuan; Yuan, Fan

Ultrasound Enhancement ofDrug Release

Across Non Ionic Surfactant Vesicle Membranes

Hood, Elizabeth; Gonzalez, Monica; Strom, Joel;VanAuker, Michael

3520

3524

3527

xlv

Sonoporation ofCellsfor Drug and Gene

DeliveryPan, H.; Zhou, Y.; Sieling, F.; Shi, J.; Cui, J.;

Deng, Cheri

Applying Models of Targeted Drug Delivery to

Gene DeliveryLam, Tai Ning; Hunt, C. Anthony

Quantitative Description and Model ofMolecule

Transport through Skin

Bao, Jiali; Wang, Hong; Wang, Huiping; Ge,

Jiguang

Track 9.2: Facilitated Transport of

Drugs and Genes

Session 9.2.1: Drug and Gene Delivery II

Investigations ofNeedle-free Jet InjectionsBaxter, Joy R.; Mitragotri, Samir

3531

3535

3539

The Development ofNovel Flexible Electrode

Arraysfor the Electrochemotherapy ofSolid

Tumour Tissue (Potentialfor EndoscopicTreatment ofInaccessible Cancers)Soden, Declan M.; Larkin, John; Collins,Christopher; Aarons, Simon; Piggott, John;

Morrissey, Anthony; Norman, Aaron; Dunne,:olum; O'Sullivan, Gerald C.

Sequential Finite Element Model of Tissue

llectropermeabilisationdiklavcic, Damijan; Sel, Davorka; Cukjati, David;latiuskaire, Danute; Slivnik, Tomaz; Mir, Lluis

A.

Theme 10. Cardiovascular and

Pulmonary Systems

Track 10.1: Electrocardiology

Session 10.1.1: Bioelectric and

Biomechanical Forward and Inverse

Problems

Using Models of the Passive Cardiac

Conductivity and Full Heart AnisotropicBldomain to Study the Epicardial Potentials in

Ischemia

Stinstra, Jeroen G.; Hopenfeld, Bruce; MacLeod,RobS.

ECGSIM: an Interactive Toolfor the Study ofthe Relation BetH'een the Electric Activity oftheHeart and the QRST Waveforms at the BodySurface

Oostendorp, Thorn I\; van Oosterom. Adriaan

3543

3547

3551

3555

3559

Forward Modeling of Ventricular

Electromechanical Interactions: Normal and

Failing Hearts

Usyk, Taras P.; McCulIoch, Andrew D. 3553

Inverse Electrocardiography in the Framework

ofDynamic Imaging Problems

Brooks, Dana H.; Ghodrati, Alireza; Zhang,Yiheng; Tadmor, Gilead; MacLeod, Robert S. 3555

The Influence of Volume Conduction Effects onthe EEG/MEG Reconstruction ofthe Sources ofthe Early Left Anterior NegativityWolters, Carsten H.; Amvander, Alfred; Maess,Burkhard; MacLeod, Rob S.; Friederici, AngelaD. 3569

Electrical Impedance ImagingIsaacson, David 3573

Session 10.1.2: Cardiac Activation

Mapping and Wall Mlcrostructure

Optical Mapping Systemfor Recording Action

Potential Durations in Adult Mouse Left and

Right Atrium

Nygren, Anders; Lomax, Alan K.; Giles, WayneR. 3576

High Resolution Optical Mapping ofCardiacAction Potentials in Freely Beating Rabbit

Hearts

Inagaki, Masashi; Hidaka, Ichiro; Aiba, Takeshi;Tatewaki, Teiji; Sunagawa, Kenji; Sugimachi,Masaru

"

3578

Siimulations of Optical Mapping DuringElectroporattonJanks, Deborah L,; Roth, Bradley J. 3581

A Study of the Dynamics of Cardiac Ischemia

using Experimental and Modeling ApproachesShome, Shibaji; Stinstra, Jeroen G.; Hopenfeld,Bruce; Punske, Bonnie B.; Maeleod, Rob S. 3585

Constructing a Tissue-Specific Model ofVentricular Mlcrostructure

Sands, Gregory; Trew, Mark; I looks, Darren; Le

Grice, Ian; Pullan, Andrew; Smaill. Bruce 3589

Conduction Velocit}' in Myocardium Modulated

by Strain: Measurement Instrumentation

and Initial Results

Sachse, F. B.; Steadman, B W,; Bridge, J, H. B.;Punske, B. B.; Taceardi. ». 3593

Session 10.1.3: Electro and

Magnetocardfology and Cardiac

Arrhythmia AnalysisECG QRS Complex Detection I "sing SlopeVector Waveform (SVW) AlgorithmXu, Xiaomin; l.iu, Yimj 3597

xlvi

ComparingRegularizedB-splineNeural

Network, Multilayer Perceptron andBoosted-CARTon Two Problems ofHeart ArrhythmiaDiagnosisZhou, Jie 3601

Analysis ofBeat-To-Beat Variability ofVentricular Late Potentials by a Spectro-Temporal Technique in Patients with Chagas'Disease

Laciar, Eric; Jane\ Raimon 3605

Monitoring Fetal Development with

MagnetocardiographyPadhye, Nikhil S.; Brazdeikis, A.; Verklan, M. T. 3609

Physiologic Responses to Acupuncture Point

Stimulation: A Pilot Study to Evaluate Methods

and Instrumentation

Tsunami, Daniel T.; Colbert, Agatha; Lu,

Zhaoxue; Pearson, Sean;McNames, James; Hammerschlag, Richard 3611

Session 10.1.4: Molecular Cardiology

Electrocardiographic Characterization ofEmbryonic ZebrafishForouhar, Arian S,; Hove, Jay R.; Calvert,Christopher; Flores, Jorge; Jadvar, Hossein;Gharib, Morteza 3615

IL-2 Confers Cardioprotection by InhibitingMitochondrial Permeability Transition Pore

Cao, Chun-Mei; Chen, Jun-Zhu; Xia, Qiang;

Zhang, Shi-Zhong; Lin, Guo-Hua; Wong, Tak-

Ming 3618

Role ofthe Mitochondrial PermeabilityTransition Pore in TNF-AIpha-Jnduced Recovery

ofVentricular Contraction andReduction of

Infarct Size in IsolatedRat Hearts Subjected to

Ischemia/ReperfusionGao, Qin; Xia, Qiang; Cao, Chun-Mei; Zhang,

Shi-Zhong; Bruce, Iain C. 3622

The Mitochondrial Calcium Uniporter

Participates in Ischemia/Reperfusion Injur}' and

in Cardioprotection by Ischemic Preconditioning

Zhang, Shi-Zhong; Xia, Qiang; Cao, Chun-Mei;

Gao, Qin; Bruce, Iain C. 3625

Effects ofInterleukin-2 on theMechanical

Restitution andPost-Rest Contraction in Rat

Ventricular Papillary Muscle

Lin, Guo-Hua; Ru, Hai-Long; Wu, Pei-Lin; Cao,

Chun-Mei; Xia, Qiang 3628

Negative Inotropic Effect ofInterleukin-2 in the

Isolated Ventricular Myocytes: Role ofNitric

Oxide/sGC Pathway

Wang, Hui-Ping; Xia, Qiang; Jin, Hong-Feng;

Cao, Chun-Mei; Lin, Guo-Hua 3632

Track 10.2: Ventricular Mechanics

Session 10.2.1: Cardiac Mechanics:

Systolic and Diastolic Functions

Hemodynamic Interventions and the Pressure-

Diameter Loop ofthe Left Ventricle andthe

ProximalAorta in the Conscious DogKerkhof, Peter L.; Li, John K.-J. 3636

Cardiac Parametric Variations in Post-Ischemic

MyocardiumLi, John K-J; Zhu, Ying; Khaw, Kenneth; Kedem,

Joseph 3639

A Kalman FilteringApproach to Estimation ofMaximum Ventricle Elastance

Borella, Benedetta; Lucchi, Elena; Nicosia,Salvatore; Valigi, Paolo 3642

Computing Work in the Ischemic Heart

Niederer, Steven A.; Buist, Martin L.; Pullan,Andrew J.; Smith, Nicolas P. 3646

Frequency-BasedAnalysis ofDiastolic Function:

Detrimental Phase-Shift ofthe Pressure-FlowRelation Characterizes the 'Delayed Relaxation'

Transmural Flow Pattern

Wu, Yue; Kovacs, Sandor J. 3650

Evaluation oflsovolumic Relaxation Phase in

the Process of Ventricular Remodeling FollowingMyocardial InfarctionKheradvar, Arash; Gorman, Robert C; Gorman,

III, Joseph H.; Zeeshan, Ahmad; Gharib, Morteza 3654

Session 10.2.2: Modeling and Imaging of

Ventricular Mechanics

Model Generation Interfacefor Simulation ofLeft Ventricular Motion

Amano, Akira; Kanda, Kenichi; Shibayama,

Tsukasa; Kamei, Yuu; Matsuda, Tetsuya

Intracardiac Echocardiographic Measurement of

Left Ventricular Volume

Ding, Chuxiong; Rao, Liyun; Nagueh, Sherif F.;

Khoury, Dirar S.

Regional Differences in Systolic Active Stress

Profiles in the Normal BeatingHeart. Assesment

Using an Ultrasound BasedMathematical Model

Mc Laughlin, Myles; Langeland, Stian; Streb,

Witold; Marciniak, Maciej; D'hooge, Jan;

Bijnens, Bart; Claus, Piet

Construction ofthe Global Lagrangian Strain

Field in the Myocardium Using DENSE MRIData

Saber, Nikoo R.; Wen, Han

3658

3662

3666

3670

xlvii

Evidence of Time-Varying MyocardialContribution by In Vivo Magnitude and Phase

Measurement in Mice

Wei, Chia-Ling; Valvano, Jonathan W.; Feldman,Marc D.; Kottam, Anil; Altaian, David;Raghavan, Karthik; Fernandez, Daniel J.; Reyes,Maricela; Escobedo, Daniel; Pearce, John A. 3674

Track 10.3: Valvular and Vascular

Mechanics and Blood Flow

Session 10.3.1: Vessel Wall Mechanics

Hemodynamic Simulation of Vascular Prosthesis

Altering Pulse Wave PropagationChung, Juhyun; Li, John K-J. 3678

One Important Area Gradient Force Has Been

Omitted in the Moens and Korteweg's EquationJan, Ming-Yie; Hsiu, Hsi; Bao, Jian-Guo; Lin

Wang, Yuh-Ying 3681

Measurement ofPulse Wave }relocity usingMagnetic Resonance ImagingGao, Gang; Mark, Patrick; Cockshott, Paul; Foster,John; Martin, Thomas; Blyth, Kevin;Steedman, Tracey; Elliott, Alex; Dargie, Henry;Groenning, Bjoern 3684

Noninvasive Ultrasonic Measurement ofArterial

Wall Motion in Mice

Hartley, Craig J.; Reddy, Anilkumar K.; Madala,Sridhar; Entman, Mark L.;Michael, Lloyd H.; Taffet, George E. 3688

i Two-Layer Model ofthe Static Behaviour ofBlood Vessel Walls

Payne, Stephen J. 3692

Blood Flow through Axially Symmetric Sections

ofCompliant Vesselsrnew Effective Closed

Models

Canic, Suncica; Tambaca, Josip; Mikelic, Andro;

Hartley, Craig; Mirkovic, Dragan;Chavez, Joy; Rosenstrauch, Doreen 3696

Optimal Lymphatic Vessel Structure

Venugopal, Arun M.; Stewart, Randolph H.;

Rajagopalan, Shruti; Laine, Glen A.; Quick,

Christopher M. 3700

Session 10.3.2: Peripheral Vascular Flow

Doppler Ultrasound Determination oftheDistribution ofHuman Cardiac Output: Effects

ofAge and Physical Stresses

Greene, E. R.; Roach, R. C. 3704

Variations ofthe Maximum Blood Flow Velocityin the Carotid, Brachial and FemoralArteries in

a Passive Postural Changes by a DopplerUltrasound Method

Azhim, Azran; Hirao, Yuji; Kinouchi, Yohsuke;Yamaguchi, Hisao; Yoshizaki, Kazuo 3708

Cardiac Output Monitoring in Intensive Care

Patients by Radial Artery Pressure

Waveform AnalysisMukkamala, Ramakrishna; Kuiper, Jacob; Ahmad,Salman; Lu, Zhenwei 3712

A Comprehensive Physiological Model ofCirculation Enables AutomaticPiloting ofHemodynamics in Patients with Acute Heart

Failure

Sugimachi, Masaru 3716

Effect of Cellular Elements on Pressure-Velocity

Relationship in Mice

Reddy, Anilkumar K; Taffet, George E.; Prcha],JosefF.; Michael, Lloyd H.;Entman, Mark L.; Hartley, Craig J. 3720

Methodfor the Measurement ofthe Sensitivity ofVascular Beds to Ischemia

Maltz, Jonathan S. 3723

Session 10.3.3: Valvular Mechanics

Mechanics ofthe Mitral Valve: In Vitro Studies

Jimenez Jorge, Ritchie Jenniffer, Zhaoming He,

Yoganathan Ajit P. 3727

Development ofMarkers of Valve StiffnessforPrediction ofHemodynamic Progression ofAortic Stenosis

VanAuker, Michael D.; Rhodes, Katherine; Singh,Alok.; Strom, Joel A. 3730

A Structural Constitutive Modelfor the Native

Pulmonary Valve

Sacks, Michael S.; Lam, Thanh V.; Mayer, Jr.,John E. 3734

Fibrotic vs. Myxomatous Remodeling ofMitralValves

Grande-Allen, K. Jane 3737

Skewness Angle ofInterfibrillar ProteoglycanIncreases with Applied Load on Chordae

Tendineae

Liao, Jun; Vesely, Ivan 3 741

Modelling Chorded Prosthetic Mitral ]ralves

using the Immersed Boundary Method

Watton, Paul N.; Luo, Xiao Yu; Singleton, Roger;Molloy, Paul; Bernacca, Gill M.; Wheatley, David

J. 3745

xlviii

Session 10.3.4: Cardiovascular SystemsParameter Estimation by Descent and GeneticAlgorithm Methods ofan In-Vitro StenosisBypass Model

Woo, Tony; Palafox, Gilbert; Diong, Bill; WickerRyan

'

3749

Endothelium-Independent Vasorelaxant Effect ofLidocaine in RatAortic RingsShan, Qi-Xian; Lin, Ding-Sheng; Jin, Hong-Feng;Gao, Qin; Lu, Yuan; Xia, Qiang 3753

The Endothelium-independent VasorelaxantEffect ofPuerarin on Rat ThoracicAortaDong, Kan; Tao, Qian-Min; Shan, Qi-Xian; Jin,Hong-Feng; Pan, Guo-Biao; Zhu, Jian-Hua;Chen, Jun-Zhu; Xia, Qiang 3757

Session 10.3.5: Cardiopulmonary AssistDevices

Hemodynamic andLeft VentricularPressure-Volume Responses to Counterpulsation in MockCirculation andAcute LargeAnimal ModelsKoenig, Steven G; Pantalos George M.; Litwak,Kenneth N.; Gillars, Kevin J.; Giridharan,Guruprasad A.; Maguire, Mark; Spence, Paul A.

Recent Progress ofMoving-Actuator TypeMechanical Circulator}' Support Systems:AnyHeart and T-PLS

Min, Byoung Goo

An ArchitectureforRapidPrototyping of Control

Schemesfor Artificial Ventricles

Ficola, Antonio; Pagnottelli, Stefano; Valigi,Paolo; Zoppitelli, Maurizio

In Vitro Evaluation ofControl Strategiesfor an

Artificial Vasculature Device

Glower, Jacob S.; Cheng, Rolando; Giridharan,Guruprasad A.; Gillars, Kevin J.; Pantalos, GeorgeM.;Litwak, Kenneth N.; Ewert, Dan L.; Koenig,Steven C.

Dynamic Response ofthe Pulmonary Circulation

in Continuous FlowArtificialHeart Systems

Olegario, Paul S.; Yoshizawa, Makoto; Tanaka,

Akira; Shiraishi, Yasuyuki; Ogawa, Daisuke;Hanaoka, Tetsubumi; Abe, Ken-ichi; Yambe,

Tomoyuki; Nitta, Shin-ichi

A Closed-Loop Model ofthe Ovine

Cardiovascular SystemHa, Roy; Qian, Junhui; Wang, Dongfang;Zwischenberger, Joseph B.;

Bidhani, Akhil; Clark, Jr., John W.

3761

3765

3769

3773

3777

3781

Energetics andHemodynamic Changes ofNormal and trartous Right Heart Bypass(Fontan) Circulations in Lambs under VaryingRespiration ParametersKetner, Mark E.; Lucas, Carol L ; Mill, MichaelR.; Sheridan, B.; Lucas, W, 3715

Session 10.3.6: Coronary Blood FlowDynamics

Flow Patterns and WallShear StressDistributions at Atherosclerotic-Prone Sites in aHuman Left Coronary Artery - An ExplorationUsing CombinedMethods ofCTandComputationalFluid DynamicsSuo, Jin; Yan, Yang; Oshinski, John;Tannenbaum, Allen; Gruden, James; Giddens, Don

3789

Devices to Improve CoronaryArtery BypassGrafting (CABG) SurgeryHoagland, Benjamin D.; Ryan, Thomas P.;Durrani, Amir K.; Burton, Lucas J.; Tumkur,Santosh K. 3792

A Systemfor On-Line Laser Doppler MonitoringofECG-TracedMyocardialPerfusionFors, Carina; Karlsson, Daniel M. G.; Ahn, Henrik

C; Wardell, K. 3796

BloodFlow in Stented Coronary Artery:Numerical FluidDynamics AnalysisBenard, Nicolas; Perrauit, Robert; Coisne,Damien 3800

Identification ofBrachialArtery Characteristic

Using a Cufffor Noninvasive Detection ofCoronary Artery Disease

Pouladian, Majid 3804

A ComputationalModel ofMicroctrcutatoryNetwork Structure and Transient

Coronary Microcirculation

Lee, Jack C. J.; Pullan, Andrew J.; Smith, Nicolas

p. 3808

Track 10.4: Respiratory Systems and

Sleep Apnea

Session 10.4.1: Swallowing and

Respiratory Systems Analysis

Analysis ofNormalSwallowing Sounds UsingNonlinear Dynamic Metric Tools

Aboofazeli, Mohammad; Moussavi, Zahra 3812

Automated Classification ofSwallowing and

Breath Sounds

Aboofazeli, Mohammad; Moussavi, Zahra 3816

xlix

Swallowing Sound Characteristics in HealthyandDysphagicIndividuals

Lazareck, Lisa J.; Moussavi, Zahra 3820

Adaptive Modeling ofSound Transmission in the

Respiratory SystemCiftci, Koray; Yeginer, Mete; Sen, Ipek; Cini,Ugur; Kahya, Yasemin P. 3824

A Comparison ofVarious Respiratory SystemModels Based on Parameter Estimates From

Impulse Oscillometry DataWoo, Tony; Diong, Bill; Mansfield, Lyndon;Goldman, Michael; Nava, Patricia; Nazeran,

Homayoun 3828

Session 10.4.2: Lung Sounds: Modeling,Classification and Analysis

On Applying Continuous Wavelet TransforminWheezeAnalysis

Taplidou, Styliani A.; Hadjileontiadis, Leontios J.;Kitsas, Ilias K.; Panoulas, Konstantinos I.;Penzel, Thomas; Gross, Volker; Panas, Stavros

M.

Analysis of Wheezes in Asthmatic Patients during

Spontaneous RespirationJane, Raimon; Cortes, Sandra; Fiz, Jose A.;Morera, Jose

Heart Sound Cancellation Based on Multiscale

Prodcut and Linear Prediction

Moussavi, Zahra; Flores, Daniel; Thomas, Gabriel

Classification ofLung Sounds during Bronchial

Provocation Using Waveform Fractal

Dimensions

Gnitecki, January E.; Moussavi, Zahra;

Pasterkamp, Hans

Classification ofPulmonary Diseases Based on

Impulse Oscillometric Measurements ofLungFunction Using Neural Networks

Barua, Miroslava; Nazeran, Homayoun; Nava,

Patricia; Granda, Virginia; Diong, Bill

Finding the Lung Sound-Flow Relationship in

Normal andAsthmatic SubjectsHossain, Irina; Moussavi, Zahra

3832

3836

3840

3844

3848

3852

Session 10.4.3: Sleep Apnea I: Diagnosticand Therapeutic Modalities

Ambulatory Recording ofSleep Apnea Using

Peripheral Arterial TonometryPenzel, Thomas; Kesper, Karl; Ploch, Thomas;

Becker, Heinrich F,; Vogelmeier, Claus 3856

The Use ofEsophageal Manometry in the

Diagnosis ofSleep-Related Breathing Disorders

Kushida, Clete A. 3860

Central Aortic Pressure Wave Changes with

SleepStage andDisordered Breathing in

Children Estimated by Application ofan Arterial

Transfer Function to PeripheralBloodPressure

McConnell, Keith B.; Wagner, M.; Urbina, E.;

Daniels, S.; Helmicki, A.; Hunt V.; Amin, R. S. 3864

Non-invasive Estimation ofEsophageal Pressure

Based on Intercostal EMG MonitoringStoohs, Riccardo A.; Blum, Hans-Christian;

Knaack, Lennart; Guilleminault, Christian 3867

NoninvasiveAssessment ofCardiovascular

Autonomic Control in Congenital Central

Hypoventilation SyndromeLin, Zheng; Chen, M. L.; Keens, T. G.; Ward, S.

L. D.; Khoo, M. C. K. 3870

Long-Term Monitoring ofSleep Apnea at Home

in Heart Failure Patients: Preliminary Results

from the HHHStudyPinna, Gian Domenico 3874

Women Have a Greater Ventilatory Responses to

Upper Airway Obstruction in Than Men

Pichard, Luis E.; Patil, Susheel P.; Gladmon,

Elisabeth; Smith, Philip L.;Schwartz, Alan R; Schneider, Hartmut 3878

Session 10.4.4: Sleep Apnea II: Analysisof Cardiorespiratory Variability

The Use ofR-Wave Morphology in the Detection

ofSleep-Disordered Breathing Using the

Electrocardiogram- a Comparison Between

Leads

Vijendra, S.; Behbehani, Khosrow; Lucas, E. A.;

Burk, J. R.; Burli, D. N; Dao, D. H. 3881

Time Domain Analysis ofR-Wave Attenuation

Envelopefor Sleep Apnea Detection

Suhas, SanjeeR.; Behbehani, Khosrow; Vijendra,Sridhar; Burk, John R.; Lucas, Edgar A. 3885

Heart Rate Chaos in Obstructive Sleep Apnea In

Children

Zapanta, Laurence F.; Poon, C.-S.; White, D. P.;Marcus, C. L.; Katz, E. S. 3889

Closed-Loop Minimal Model Analysis oftheCardiovascular Response to Transient Arousal

from Sleep in Healthy Humans

Blasi, Anna; Khoo, Michael C. K.; Jo, Javier;Valladares, Edwin; Juarez, Ricardo; Baydur,Ahmet N. 3893

The Effects ofRepetitive Arousalfrom Sleep on

CardiovascularAutonomic Control

Chaicharn, J.; Carrington, M.; Trinder, J.; Khoo,M. C.K. 3897

Simulation ofSpontaneous Cardiovascular

Variability Using PNEUMA

Ivanova, Olga V.; Khoo, Michael C. K. 3901

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