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Page 1: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomy & Anatomy & PhysiologyPhysiology

Page 2: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

What is Anatomy & What is Anatomy & Physiology?Physiology?•AnatomyAnatomy

–Is the study of structure

Page 3: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

What is Anatomy & What is Anatomy & Physiology?Physiology?•AnatomyAnatomy

–Subdivisions of anatomy

• Gross anatomy• Microanatomy

• CellularCellular• HistologyHistology

• Systemic anatomy• Regional anatomy

Page 4: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

What is Anatomy & What is Anatomy & Physiology?Physiology?

•PhysiologyPhysiology–Is the study of function–Structure determines function

Page 5: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical PositionAnatomical Position

Page 6: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

InferiorInferior: below

DistalDistal:: toward the fingers

or toes

Anatomical TerminologyAnatomical Terminology•Directional TermsDirectional TermsSuperiorSuperior: above

ProximalProximal: towards the attachment of a limb

Page 7: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical TerminologyAnatomical Terminology•Directional TermsDirectional TermsAnteriorAnterior: toward/from the frontPosterorPosteror: toward/from

the back

PeripheralPeripheral: toward the

surface

Page 8: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical TerminologyAnatomical Terminology•Directional TermsDirectional TermsSuperficialSuperficial: toward the surfaceDeepDeep: Away from the surface

Page 9: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical PlanesAnatomical Planes

•Sagittal PlaneSagittal Plane

divides the body into a right and a left half

• mid sagittal

• parasagittal

Page 10: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical PlanesAnatomical Planes

•Frontal or Frontal or CoronalCoronal

divides the body into a front and a back

Page 11: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical PlanesAnatomical Planes

•TransversTransverse or e or horizontalhorizontaldivides the body into upper and lower portions

Page 12: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical TerminologyAnatomical Terminology•PlanesPlanes

Median or Median or mid-mid-

sagittalsagittal

ParamedianParamedian

Page 13: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

CHECK YOUR CHECK YOUR UNDERSTANDINGUNDERSTANDINGClassify each plane illustrated below:Classify each plane illustrated below:

mid-mid-sagittalsagittal

frontalfrontal horizontahorizontall

Page 14: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Hierarchy of OrganizationHierarchy of Organization

• Cells

• Tissues

• Organs

• Organ Systems

Page 15: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Organ System Overview1. Integumentary System 2. Skeletal System 3. Muscular System 4. Nervous System 5. Endocrine System 6. Cardiovascular System 7. Lymphatic System 8. Respiratory System 9. Digestive System 10. Urinary System 11. Reproductive System

Page 16: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Life ProcessesLife Processes•metabolism•responsiveness•movement•growth•Differentiation•Reproduction

Page 17: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Function:Function: Protection

Organs/Organs/Components: Components: Epidermis and DermisFinger/toe nailsHairSweat glands

Organ Systems Integumentary Integumentary

SystemSystem

Page 18: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Function:Function: provide support for the body, to protect delicate internal organs and to provide attachment sites for the organs.Organs/Organs/Components: Components: Bones, cartilage, joints

Organ Systems Skeletal Skeletal SystemSystem

Page 19: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Function:Function: provide support and movement

Organs/Organs/Components: Components: skeletal muscle, cardiac muscle, smooth muscle, tendons

Organ Systems Muscular Muscular SystemSystem

Page 20: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Function:Function: transport nutrients, gases (such as oxygen and CO2), hormones and wastes through the body.

Organ Systems Circulatory Circulatory SystemSystem

Organs: Organs: Heart, blood vessels and blood

Page 21: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Function:Function: directs behaviour and movement and, along with the endocrine system, controls physiological processes Organs: Organs: Brain, spinal cord and peripheral nerves.

Organ Systems Nervous Nervous SystemSystem

Page 22: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Function:Function: provide gas exchange between the blood and the environmentfor the organs.Organs: Organs: Nose, trachea and lungs. bronchi

RespiratorRespiratory Systemy System

Page 23: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Function:Function: breakdown and absorb nutrients that are necessary for growth and maintenance

Organs: Organs: Mouth, esophagus, stomach, small and large intestines

Digestive Digestive SystemSystem

Page 24: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Function:Function: filter out cellular wastes, toxins and excess water from the circulatory system

Organs: Organs: Kidneys, ureters, bladder and urethra

Excretory Excretory SystemSystem

Page 25: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Function:Function: relay chemical messages through the body and in conjunction with the nervous system, these chemical messages help control physiological processes Organs: Organs: hypothalamus, pituitary, thyroid, ovaries/testies, and adrenal glands

Endocrine Endocrine SystemSystem

Page 26: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Function:Function: manufacture cells that allow reproduction

Organs: Organs: ovaries, oviducts, uterus, vagina and mammary glandstestes, seminal vesicles and penis

ReproductivReproductive Systeme System

Page 27: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical TerminologyAnatomical TerminologyDirectional TermsDirectional TermsCranialCranial: towards the

headCaudalCaudal: towards the feet/buttocksMedialMedial: towards the middleLateralLateral: towards or from the side

Page 28: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical TerminologyAnatomical TerminologyDirectional TermsDirectional Terms

PlantarPlantar: toward or on the soles of the feet

PalmarPalmar: toward or on the palm of the hand

Page 29: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical TerminologyAnatomical TerminologyRegional TermsRegional Terms

a. Abdominal b. Antecubital c. Axillary d. Brachial

e. Buccal f. Carpal g. Cervical

Page 30: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical TerminologyAnatomical TerminologyRegional TermsRegional Terms

j. Inguinal

l. Oral k. Nasal

i. Femoral

n. Patellarm. Orbital

h. Digital

Page 31: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical TerminologyAnatomical TerminologyRegional TermsRegional Terms

o. Pubic

q. Thoracic r. Umbilical

p. Tarsal

Page 32: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical TerminologyAnatomical TerminologyRegional TermsRegional Terms

u. Gluteus

s. Cephalic t. Dorsum

v. Lumbar

Page 33: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical TerminologyAnatomical TerminologyRegional TermsRegional Terms

w. Popiteal

y. Calcaneusx. Sural

Page 34: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

ABDOMINOPELVICABDOMINOPELVIC

QUADRANTSQUADRANTS

Right Upper Right Upper QuadrantQuadrant(RUQ)(RUQ)

Right Lower Right Lower QuadrantQuadrant(RLQ)(RLQ)

Left Upper Left Upper QuadrantQuadrant(LUQ)(LUQ)

Left Lower Left Lower QuadrantQuadrant(LLQ)(LLQ)

Page 35: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Anatomical Anatomical TerminologyTerminology

Abdominopelvic RegionsAbdominopelvic Regions

Page 36: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure
Page 37: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

CranialCranialCavityCavity

ThoracicThoracic

PericardiPericardialal

AbdominAbdominalal

PelviPelvicc

SpinalSpinal

BodyBodyCavitiesCavities

DorsaDorsall

VentralVentral

Abdomino-Abdomino-pelvicpelvic

Page 38: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

HOMEOSTASISHOMEOSTASIS• Is maintaining the internal Is maintaining the internal

environment within environment within physiological limitsphysiological limits–Internal environment refers to the extracellular fluids (EFC)

–Includes lymph, plasma and interstitial fluid

•The maintenance of The maintenance of homeostasis results in healthhomeostasis results in health

Page 39: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

HOMEOSTASISHOMEOSTASIS•And StressAnd Stress

–Homeostatic mechanisms attempt to counteract the effects of the stress and bring the condition back to normal

Page 40: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

HOMEOSTASISHOMEOSTASIS• Homeostasis is regulated by Homeostasis is regulated by

the nervous system and the nervous system and endocrine systemsendocrine systems

Page 41: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

HOMEOSTASISHOMEOSTASIS• And Feedback Systems (Loops)And Feedback Systems (Loops)

–a cycle of events in which information about the status of a condition is continually monitored and fed back (reported) to a central control region.

–Any stress that changes a controlled condition is called a stimulus.

Page 42: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

HOMEOSTASISHOMEOSTASIS•And Feedback Systems And Feedback Systems

(Loops)(Loops)–three basic components

•The control center •The receptor •The effector

Page 43: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure
Page 44: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

HOMEOSTASISHOMEOSTASIS• And Feedback Systems (Loops)And Feedback Systems (Loops)

– Negative Feedback SystemsNegative Feedback Systems a.  Reverses the original stimulsb.  Tend to maintain conditions

that require frequent fine tuning

– Positive Feedback SystemsPositive Feedback Systemsa.  enhances the original stimulusb. tend to regulate conditions that do not occur often and do not require continual fine-tuning

Page 45: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

•And DiseaseAnd Disease– Disease Disease a.  any change from a state of health, characterized by

symptoms & signs

b. Local vs. systemic disease

HOMEOSTASISHOMEOSTASIS

Page 46: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

• Homeostasis Homeostasis And DiseaseAnd Disease– Symptoms vs. Symptoms vs. SymptomsSymptoms a. Symptomsa. Symptoms

are subjective changes in body functions that are not

apparent to an observerb. Signsb. Signs

are objective changes that a

clinician can observe and measure

Page 47: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

What is Anatomy & What is Anatomy & Physiology?Physiology?• AnatomyAnatomy

– Is the study of structure–Subdivisions of anatomy

•surface anatomy• gross anatomy•systemic anatomy•regional anatomy•radiographic anatomy•developmental anatomy•embryology•cytology•pathological anatomy

Page 48: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

THE THE CHEMISTRY CHEMISTRY

OF LIFEOF LIFE

CH 2CH 2

Page 49: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

I. Atoms and molecules A. Atoms are the smallest A. Atoms are the smallest

stable units of matter.stable units of matter. 1.1.NucleusNucleus

• Protons • Neutrons

2. Electron cloud2. Electron cloud• Electrons

3. Atoms are electrically 3. Atoms are electrically neutralneutral # protons = #

electrons

Page 50: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

I. Atoms and molecules B. Elements

Element= A substance that is Element= A substance that is made of only one kind of atommade of only one kind of atom1.1.Contain atoms with the same Contain atoms with the same

number of protonsnumber of protons• Called “atomic number” • Differ in number of electrons

and neutrons 2. 92 naturally occurring 2. 92 naturally occurring

3. Principle elements of human 3. Principle elements of human bodybody

O, C, H, N, Ca, PO, C, H, N, Ca, P

Page 51: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

II. Chemical bonding A. Ionic bonds A. Ionic bonds

1.1.Form when one atom Form when one atom gives up an e- and gives up an e- and another atom gains another atom gains that e-that e- • cations cations • anionsanions

2. Properties of Ionic Compounds2. Properties of Ionic Compounds• readily dissolve in water • dissociate in water into their cations and anions.

Page 52: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

II. Chemical bonding B. Covalent bonds B. Covalent bonds

1.1.Form when two atoms Form when two atoms shareshare electrons, forming a moleculeelectrons, forming a molecule

3. Properties of Covalent Cmpds3. Properties of Covalent Cmpds strong bonds

•Form a molecule•Diatomic mc: H2, 02, N2

2. Kinds of covalent bonds2. Kinds of covalent bonds•Nonpolar Covalent bondsNonpolar Covalent bonds•Polar Covalent bondsPolar Covalent bonds

Page 53: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

II. Chemical bonding C. Hydrogen bonds C. Hydrogen bonds

1.1.Form Form betweenbetween two adjacent polar mc two adjacent polar mc containing H and O, N, or Fcontaining H and O, N, or F• Ex: between water mc

2. Properties of Covalent Cmpds2. Properties of Covalent Cmpds• Very weak• Important in determining the shape of

large biological mc such as protein and DNA

• Important in determining characteristics of water

Page 54: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

II. Chemical bonding D. States of Matter D. States of Matter

1.1.Are determined by the amount of Are determined by the amount of bonding that occurs between mcbonding that occurs between mc• Solid Liquid Gas

2. Properties of Covalent Cmpds2. Properties of Covalent Cmpds• Water is the only substance that can

occur in all three states within temperature ranges consistent with life

Page 55: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Solid

            

     

     

Liquid

Gas

Page 56: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

III. Chemical reactions A. Fundamental Concepts A. Fundamental Concepts

1.1. Metabolism Metabolism 2.2. ReactantsReactants2. Products2. Products3. Chemical reaction3. Chemical reaction4.4. EnergyEnergy

• Potential EnergyPotential Energy• Kinetic EnergyKinetic Energy• Law of Conservation of Matter and EnergyLaw of Conservation of Matter and Energy

Page 57: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

III. Chemical reactions B. Types of reactions B. Types of reactions

1.1. Decomposition Decomposition • AB AB A + B A + B• Catabolic processesCatabolic processes• ExergonicExergonic• HydrolysisHydrolysis

Page 58: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

III. Chemical reactions B. Types of reactions B. Types of reactions

2. Synthesis2. Synthesis• A + B A + B AB AB• Anabolic processesAnabolic processes• EndergonicEndergonic• Dehydration SynthesisDehydration Synthesis

Page 59: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

III. Chemical reactions B. Types of reactions B. Types of reactions

3.3. Exchange Exchange • AB + CD AB + CD AD + CB AD + CB• Decomposition and Decomposition and

synthesis may be paired.synthesis may be paired.

Page 60: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

III. Chemical reactions C. Reversible reactionsC. Reversible reactions

1. Reactants become products 1. Reactants become products while products become while products become reactantsreactants

• A + B A + B AB AB• Continues until equilibrium is reachedContinues until equilibrium is reached

2. Very important to biological 2. Very important to biological systemssystems

ATP ATP ADP + PADP + P

Page 61: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

III. Chemical reactions D. Enzymes and Chemical reactionsD. Enzymes and Chemical reactions

1. Enzymes are important 1. Enzymes are important reaction catalysts in metabolic reaction catalysts in metabolic systemssystems

• Speed up the reactionSpeed up the reaction• Allow the reaction to occur at lower Allow the reaction to occur at lower

than normal temperaturesthan normal temperatures• Lower the activation energyLower the activation energy

2. Are not altered or used up by 2. Are not altered or used up by the reaction the reaction

Page 62: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure
Page 63: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds A.A. Generally ConceptsGenerally Concepts

1.1.Don’t contain both C & HDon’t contain both C & H 2. Important organic cmpds in 2. Important organic cmpds in

the the human bodyhuman body• COCO22

• OO22

• HH22OO• inorganic acids, bases, and salts inorganic acids, bases, and salts

Page 64: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds B. Water B. Water

1.1. Excellent solvent because it is Excellent solvent because it is polarpolar. . Solute + solvent = solutionSolute + solvent = solution

Page 65: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds B. Water B. Water

2.2. Forms a reaction medium, Forms a reaction medium, particularly in hydrolysis particularly in hydrolysis reactions which break down reactions which break down larger molecules. larger molecules.

Page 66: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds B. Water B. Water

3. High heat capacity and thus 3. High heat capacity and thus water stays in a liquid form over water stays in a liquid form over a broad range of temps. a broad range of temps.

4. 4. Water is an important reactant Water is an important reactant in some types of chemical in some types of chemical reactions.reactions.

Page 67: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds B. Water B. Water

4.4.Water carries heat with it when Water carries heat with it when it evaporates - thus water helps it evaporates - thus water helps stabilize body temperature. stabilize body temperature.

5.5.Effective lubricant in joints and Effective lubricant in joints and within body cavities and thus within body cavities and thus serves a protective function. serves a protective function.

Page 68: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds C. Aqueous solutions and C. Aqueous solutions and

electrolytes electrolytes 1.1. ElectrolytesElectrolytes

• Water soluble inorganic cmpdsWater soluble inorganic cmpds• Are capable of conducting an electric Are capable of conducting an electric

current current 2. Electrolytes and the electrical 2. Electrolytes and the electrical

activity they can generate are the activity they can generate are the basis for basis for • nerve impulses nerve impulses • muscle actionmuscle action

Page 69: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds C. Aqueous solutions and C. Aqueous solutions and

electrolytes electrolytes 3. Homeostasis of electrolytes in 3. Homeostasis of electrolytes in

body fluids body fluids • kidneys (rid body of excess ions)kidneys (rid body of excess ions)• digestive (absorb ions from diet)digestive (absorb ions from diet)• skeletal (store and release ions)skeletal (store and release ions)

4. 4. HydrophilicHydrophilic and and HydrophobicHydrophobic Mc Mc

Page 70: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds D. Colloids and suspensionsD. Colloids and suspensions

1.1. ColloidsColloids – are solutions in which large and are solutions in which large and

complex organic mc are dispersed complex organic mc are dispersed – mc stay in solution indefinitelymc stay in solution indefinitely– Example: proteinsExample: proteins

2.2. SuspensionsSuspensions– Contain large particles that will Contain large particles that will

settle out if left undisturbed settle out if left undisturbed – Example: bloodExample: blood

Page 71: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds E. Acids/Bases / Salts and pH E. Acids/Bases / Salts and pH

Page 72: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds E. Acids/Bases / Salts and E. Acids/Bases / Salts and

pHpH1.1.AcidsAcids–Are substances Are substances

which form Hwhich form H+ +

ions when in ions when in solution solution ((the stronger the the stronger the acid the more Hacid the more H++ ions it containsions it contains))

Page 73: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds E. Acids/Bases / Salts and pHE. Acids/Bases / Salts and pH

1.1.AcidsAcids

- can break - can break bonds, bonds,

denature denature proteins, proteins, and disrupt cell and disrupt cell and tissue and tissue functions functions

Page 74: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds E. Acids/Bases / Salts and pHE. Acids/Bases / Salts and pH

1.1.AcidsAcids• pH pH 7 7 • Examples: Examples:

– Carbonic acidCarbonic acid– HClHCl

The lower The lower the pH the the pH the stronger stronger the acidthe acid

Page 75: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds E. Acids/Bases / Salts and pHE. Acids/Bases / Salts and pH

2. Bases2. Bases• Are substances which Are substances which

form OHform OH-- ions when in ions when in solution solution ((the stronger the the stronger the base the more OHbase the more OH-- ions it containsions it contains))

• pH pH 7 7((the stronger the the stronger the base the higher the base the higher the pHpH))

Normal pH of blood is 7.35Normal pH of blood is 7.35

Page 76: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds E. Acids/Bases / Salts and pHE. Acids/Bases / Salts and pH

2. Bases2. Bases– Strong bases are very Strong bases are very

damaging to cell damaging to cell processesprocesses

– Example: NHExample: NH44OHOH

Page 77: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds E. Acids/Bases / Salts and E. Acids/Bases / Salts and

pHpH3. Salts3. Salts

• Contain a cation Contain a cation other than H and an other than H and an anion other than OH anion other than OH

• dissociate in water dissociate in water • Are strong Are strong

electrolyteselectrolytes• pH pH = 7= 7

Page 78: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds E. Acids/Bases / Salts and E. Acids/Bases / Salts and

pHpH3. Salts3. Salts

• Importance in the Importance in the body:body:– provide ions for provide ions for

transport of transport of substances into substances into and out of cellsand out of cells

– function in muscle function in muscle contractioncontraction

– function in nerve function in nerve impulse conductionimpulse conduction

Page 79: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds E. Acids/Bases / Salts and pHE. Acids/Bases / Salts and pH

4.4.Changes in the acid-base Changes in the acid-base balance are resisted bybalance are resisted by – extracellular and extracellular and

intracellular chemical intracellular chemical buffers buffers

– respiratory regulationrespiratory regulation– renal regulationrenal regulation

Page 80: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

IV. Inorganic compounds E. Acids/Bases / Salts and pHE. Acids/Bases / Salts and pH

5. Buffers5. Buffers• compounds help stabilize the compounds help stabilize the

pH of a solution by turning a pH of a solution by turning a strong acid or base into a strong acid or base into a weaker oneweaker one

• usually consist of a weak acid usually consist of a weak acid and its related salt and its related salt

• Example: Example: – bicarbonate ion buffers the bloodbicarbonate ion buffers the blood

Page 81: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds A. GeneralA. General

1.1.Long-chain moleculesLong-chain molecules• Always contain C and H Always contain C and H • Usually contain OUsually contain O

2.2. Linked by covalent bondsLinked by covalent bonds3.3. Many are soluble in waterMany are soluble in water4.4. Classes of Organic CmpdsClasses of Organic Cmpds

• CarbohydratesCarbohydrates• LipidsLipids• ProteinsProteins• Nucleic acidsNucleic acids

Page 82: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds A.A.Carbohydrates Carbohydrates

1.1. Contain C H O Contain C H O in a near 1:2:1 ratioin a near 1:2:1 ratio

2.2. Most important function:Most important function:Primary Primary energy energy source source for the for the cellcell

Page 83: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds A.A. Carbohydrates Carbohydrates

3.3.KindsKinds• MonosaccharidMonosaccharid

eses– Simple sugars Simple sugars – 3-7 carbons in 3-7 carbons in

length length – Example: Glucose Example: Glucose

(C(C66HH1212OO66))• DisaccharidesDisaccharides–Double sugars Double sugars –Example: Example: Lactose, Lactose, sucrosesucrose

• PolysaccharidesPolysaccharides

–Most complex Most complex sugars sugars

–Example: Example: Starch Starch GlycogenGlycogen

Page 84: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds B.B. Lipids Lipids

1.1.Contain C H O in Contain C H O in very large very large numbersnumbers

2.2. IncludeInclude Fats, oils and Fats, oils and

waxeswaxes3.3.Common Common

examplesexamples– triglyceridestriglycerides– steroidssteroids– phospholipidsphospholipids

Page 85: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds B.B. Lipids Lipids

5. Insoluble in 5. Insoluble in waterwater

4. Importance4. Importance• long term energy long term energy

storagestorage• structural structural

component of cell component of cell membranes membranes ((phospholipidsphospholipids))

Page 86: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

B. LipidsB. Lipids

5. Kinds5. Kinds– Fatty AcidsFatty Acids::

• saturatedsaturated C have only C have only

single single bonds bonds • unsaturatedunsaturated

C have 1 or C have 1 or more double more double bonds.bonds. polyunsaturatedpolyunsaturated

double double bondsbonds

occur at multiple sites occur at multiple sites

Page 87: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds B.B. Lipids Lipids

5. Kinds5. Kinds– Eicosanoids:Eicosanoids:

• Have short C chainsHave short C chains• ProstaglandinsProstaglandins – local – local

hormoneshormones• LeukotrienesLeukotrienes – coordinate – coordinate

response to injury or diseaseresponse to injury or disease

Page 88: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

B. LipidsB. Lipids 5. Kinds5. Kinds

– GlyceridesGlycerides• composed of composed of

fatty acids fatty acids and glyceroland glycerol

• FunctionFunction Energy Energy

sourcesource InsulationInsulation ProtectionProtection

Page 89: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

B. LipidsB. Lipids 5. Kinds5. Kinds

– SteroidsSteroidslg lipid mclg lipid mcexamples:examples: cholesterol, cholesterol, testoteronetestoterone, estrogen, estrogen

- FunctionFunctionStabilize cell membraneStabilize cell membraneSex hormonesSex hormonesRegulate metabolism and Regulate metabolism and mineral mineral balancebalanceFormation of bileFormation of bile

Page 90: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

B. Lipids 5. Kinds5. Kinds

– PhospholipdPhospholipdstructural structural lipids that lipids that help form help form and maintain and maintain cell cell membranes membranes

polar head - polar head - hydrophilichydrophilicnonpolar tail- nonpolar tail- hydrophobichydrophobic

Page 91: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds C.C. Proteins Proteins

Examples:Examples: Keratin, hemoglobinKeratin, hemoglobin

1. Basics1. Basics– the most abundant organic the most abundant organic

components in the bodycomponents in the body– contain carbon, hydrogen, contain carbon, hydrogen,

oxygen and nitrogen. oxygen and nitrogen.

– If made of more than 30 If made of more than 30 amino acids it is called a amino acids it is called a polypeptidepolypeptide

Page 92: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

C. ProteinsC. Proteins

Made from amino acids (20 Made from amino acids (20 exist) held together by exist) held together by peptide bondspeptide bonds

Page 93: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds C. Proteins C. Proteins

2. Functions2. FunctionsSupport, movement, transport, buffers, regulate reactions, coordination, control, defense

3. Structure3. StructurePrimary, Secondary, Tertiary, Quatranary

Page 94: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Primary Primary Structure:Structure:

Order of the Order of the amino acid amino acid sequencesequence

Secondary Secondary Structure:Structure:

the tendency of the polypeptide to coil or pleat due to H-bonding between R-groups

Peptide Peptide bondsbonds

Page 95: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

Tertiary Structure:Tertiary Structure:

Describes the overall Describes the overall shape of a protein;shape of a protein;

Quaternary Quaternary Structure:Structure:

Proteins formed from Proteins formed from one or more one or more polypeptidespolypeptides

Shape determines Shape determines function function

Page 96: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds C. Proteins C. Proteins

4. Shape Determines 4. Shape Determines functionfunction

Small changes in pH, temperature, ionic composition can denature a protein (affects protein structure) & cause it not to function properly

5. 5. EnzymesEnzymes• Biological catalysts • Speed up a reaction without being used up in the reaction

Page 97: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds C. Proteins C. Proteins

5. 5. EnzymesEnzymes• Biological catalysts • Speed up a reaction without being used up in the reaction

Lock and Lock and Key Model Key Model of Enzyme of Enzyme

ActionAction

Page 98: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds C. Proteins C. Proteins

5. 5. EnzymesEnzymes• lower the needed activation energy

Induced Induced Fit Fit

Model of Model of Enzyme Enzyme ActionAction

Page 99: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds C. Proteins C. Proteins

5. 5. EnzymesEnzymes• Some poisons bond permanently to an enzyme

Model of Model of How How Some Some

Poisons Poisons WorkWork

Page 100: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds C. Proteins C. Proteins

6.6. GlycoproteinsGlycoproteins• Protein + carbohydrate • Important in cell recognition

Page 101: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds C. Proteins C. Proteins 6.6. GlycoproteinsGlycoproteins

• Function Function As enzymesAs antibodiesAs hormonesAs cell membrane componentsTo secrete mucins which absorb water to form mucus

Page 102: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds D. Nucleic Acids D. Nucleic Acids

1.1.lg organic mc that have lg organic mc that have C, H, O, N and P

2.2. Function Function store and process information

3.3. Structure Structure made ofmade of nucleotides nucleotides

Phosphate, sugar, base Phosphate, sugar, base (adenine, guanine, cytosine, (adenine, guanine, cytosine, thymine, uracil)thymine, uracil)

linked bylinked by dehydration dehydration synthesissynthesis

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V. Organic compounds D. Nucleic Acids D. Nucleic Acids

3.3. Structure Structure • made ofmade of nucleotides nucleotides

Page 104: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds D. Nucleic Acids D. Nucleic Acids

4.4. KindsKinds• DNADNA

Important in inheritance

Codes for and directs the synthesis of proteins

Regulates cell metabolism

Found in nucleus Double stranded Sugar is Deoxyribose Bases are A G C T Able to self replicate

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DNA STRUCTURE

Page 106: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

V. Organic compounds D. Nucleic Acids D. Nucleic Acids

4.4. KindsKinds• RNA RNA

comes in several forms (mRNA, tRNA, rRNA) that cooperate to manufacture proteins

Single stranded Found in nucleus and

cytoplasm Bases are U A G C Sugar is ribose

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E. High Energy E. High Energy CompoundsCompounds

• ATP made of 3 phosphate groups attached to an adenosine (composed of adenine and ribose)

1.1. Energy currency cells is Energy currency cells is ATPATP

V. Organic compounds

Page 109: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

E. High Energy Compounds E. High Energy Compounds

2. Energy is stored when P 2. Energy is stored when P is added to ADPis added to ADP (energonic)(energonic)

Page 110: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

E. High Energy Compounds E. High Energy Compounds

2. 2. Energy is released Energy is released when P is when P is added to ADPadded to ADP (exergonic)(exergonic)

Page 111: Anatomy & Physiology. What is Anatomy & Physiology? AnatomyAnatomy –Is the study of structure

E. High Energy E. High Energy CompoundsCompounds3. Another form, called cyclic-

AMP is used as an intracellular signal.