analysis of pharmaceuticals & personal care products
DESCRIPTION
Analysis of Pharmaceuticals & Personal Care Products. USEPA New England Laboratory Peter Philbrook {EIA} & Hilary Snook {ECA}. PPCPs What Are They?. Prescription medications Over The Counter medication Shampoo, perfume, insect repellent, sunscreen, detergents - PowerPoint PPT PresentationTRANSCRIPT
USEPA New England Laboratory
Peter Philbrook {EIA}
&
Hilary Snook {ECA}
Analysis of Pharmaceuticals & Analysis of Pharmaceuticals & Personal CarePersonal Care ProductsProducts
PPCPs What Are They?PPCPs What Are They?
Prescription medications Over The Counter medicationShampoo, perfume, insect repellent,
sunscreen, detergentsCoffee, tea, soft drinks, nicotine…
HistoryHistory
1975 detection of Clofibric AcidSubsequent Investigations found
Aspirin, Caffeine, NicotineWaste Water Treatment Plants are
not effective in removal
Last DecadeLast Decade
Numerous studies have found anthropogenic compounds
USGS Study March 2002 139 Streams 95 Organic Wastewater Contaminants
SourcesSources
Household discharges to WWTP or Septic Systems
HospitalsTerrestrial Run-Off from Confined
Animal Feeding Operations (CAFOs) Veterinary Antibiotics and pharmaceuticals
Improvements in TechnologyImprovements in Technology
Solid Phase Extraction EnrichmentDetection by LC/MS
Solid Phase Extraction ManifoldSolid Phase Extraction Manifold
HPLC / MS InstrumentationHPLC / MS Instrumentation
ESI + Target CompoundsESI + Target Compounds
Acetaminophen Pain reliever .050
Caffeine Stimulant .050
1,7-Dimethylxanthine Caffeine metabolite .050
Cotinine Nicotine metabolite .050
Sulfamethazine Antibiotic .025
Sulfamethoxazole Antibiotic .025
Trimethoprim Antibiotic .010
Lincomycin Antibiotic .010
Tylosin Antibiotic .010
Compound Application RL (ug/L)
APCI / ESI - Target APCI / ESI - Target CompoundsCompounds
Bisphenol A Plasticizer 0.050
Mestranol Ovulation Inhibitor 0.050
Estrone Reproductive Hormone 0.050
17 b-Estradiol Reproductive Hormone 0.050
Estriol Reproductive Hormone 0.050
cis-Androterone Urinary Steroid 0.050
17a-Ethynyl Estradiol Ovulation Inhibitor 0.050
19-Norethisterone Ovulation Inhibitor 0.050
Compound Application RL (ug/L)
How Much is One Part Per TrillionHow Much is One Part Per Trillion
One drop of water in 660 rail tank cars. That’s a train six miles long!
Dissolve one grain of salt in 1247 bath tubs full of water(44,893 gals), that’s like taking a shower for 12.5 days!
Why Do We Care?Why Do We Care?
Pathogen resistance to antibiotics– Over prescribed & under used– Human and Veterinary (biosolids)
Endocrine system disruption– Macho Mosquito Fish– Vitellogenin– Wombmate studies
Nutshell EndocrinologyNutshell Endocrinology
Project GoalsProject Goals
Regional targeted screening– WWTP’s & effluent dominated waters
Develop the analytical capabilitiesSynoptic look at what is going into
our waters…..first stepNext steps?
How Are We Doing It?How Are We Doing It?
Clean hands, grab or composite sampling
Sampling being conducted by State agencies– Maine: 19 locations
– Vermont: 12 Locations
– New Hampshire: 2 samples, 1 location
– Connecticut: 12 locations?
FOR MORE INFO...
http://www.epa.gov/esd/chemistry/pharma