amr collaborative grants at the university of bristol
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Dr Matthew B. Avison, Senior Lecturer in MicrobiologySchool of Cellular & Molecular Medicine
AMR Collaborative Grants at the University of Bristol
AMR transmission in the real world.
• Dairy Farming uses a lot of cephalosporins.• Is there a link with AMR and can it be reversed?• Do dogs and people pick up E. coli from the environment?• Is there a link to UTIs caused by Cephalosporin Resistant
E. coli in humans?• And can this be reversed?
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AMR transmission in the real world.
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Theme 3
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Driving Down Antibiotic Usage on Farms.
Proteomics to Identify AMR.6
Theme 2
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•Comparative proteomics to identify putative mechanisms of resistance. E.g. coming out of pK/pD models.
•Knockouts/over-expression studies to confirm involvement in AMR and relative importance.
•Surveys of clinical isolates to identify if novel AMR mechanism is present; how different mechanisms work together.
•Impact includes development of strain collections.
Identifying AMR Mechanisms.
8Finding New Antibiotic Lead Compounds
Theme 2