where is the a in mch? a life-course perspective on adolescent health michael c. lu, md, mph...
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Where is the A in MCH?A Life-Course Perspective on
Adolescent Health
Michael C. Lu, MD, MPHAssociate Professor
Department of Obstetrics & GynecologyDavid Geffen School of Medicine at UCLA
Department of Community Health SciencesUCLA School of Public Health
AMCHP Web ConferenceNovember 17, 2006
Life-Course Pespective
A way of looking at life not as disconnected stages, but as an integrated continuum
Life-Course Pespective
To improve adolescent health, we must promote MCH.
To improve MCH, we must promote adolescent health.
MCH
Adolescent Health
0
5
10
15
20
25
1976-1980 1988-1994 1999-2002
Perc
en
t
Black Hispanic White
Children 6-18 Overweight
Source: National Center for Health Statistics, National Health and Nutrition Examination Survey
Note: Estimate not available for 1976-1980 for Hispanic; overweight defined as BMI at or above the 95th percentile ofr the CDC BMI-for-age growth charts
Fetal Origin of Obesity
Fetal Programming
The process whereby a stimulus or insult, at a sensitive or ‘critical’ period, has lasting or lifelong impact on health or function.
Barker DJP. Mothers, babies and health in later life. Edinburgh: Churchill Livingstone. 1998.
Prenatal Programming ofChildhood Overweight & Obesity
Maternal Diabetes & Intrauterine Hyperglycemia
Intrauterine Hyperinsulinemia (Fetal Pancreatic β Cells)
Prenatal& Postnatal
Hyperleptinemia
Preadipocyte Differentiation
Adipocyte Hyperplasia
HypothalamicLeptin Resistance
Pancreatic β- Cell Leptin Resistance
HyperphagiaHyperinsulinism
Programmed Insulin
Resistance
Postnatal Hyperinsulinemia
Adipogenesis
Prenatal Programming of Childhood Obesity
EpigeneticsVolume Control for Genes
R.A. Waterland, R.A. Jirtle, "Transposable elements: targets for early nutritional effects on epigenetic gene regulation," Mol Cell Biol, 23:5293-300, 2003. Reprinted in the New Scientist 2004
Adolescent Health
MCH
Maintain stability through change
Allostasis
Stress
Photo: http://www.lam.mus.ca.us/cats/encyclo/smilodon/
Allostasis
McEwen BS. Protective and damaging effects of stress mediators. N Eng J Med. 1998;338:171-9.
Allostatic Load
McEwen BS. Protective and damaging effects of stress mediators. N Eng J Med. 1998;338:171-9.
Allostatic Load
Wear and tear on the body from chronic stress
Allostasis
Pla
sma
Glu
cose
Time
Insulin Response
Allostatic Load
Pla
sma
Glu
cose
Time
Insulin Resistance
Allostasis vs. Allostatic Load
McEwen BS, Lasley EN. The end of stress: As we know it. Washington DC: John Henry Press. 2002
Summary
Life-Course Perspective A way of looking at life not as disconnected stages,
but as an integrated continuum
Fetal Programming The process whereby a stimulus or insult, at a
sensitive or ‘critical’ period, has lasting or lifelong impact on health or function.
Allostasis Maintain stability through change
Allostatic load Wear and tear on the body from chronic stress
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