what’s new in research at the anschutz medical campus: colorado clinical translational sciences...
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What’s New in Research at the What’s New in Research at the
Anschutz Medical Campus:Anschutz Medical Campus:
Colorado Clinical Translational Colorado Clinical Translational
Sciences InstituteSciences Institute
Ronald J. Sokol, MDRonald J. Sokol, MD
DirectorDirector
Colorado Clinical and Translational Sciences Colorado Clinical and Translational Sciences InstituteInstitute
Professor and Vice ChairProfessor and Vice Chair
Department of Pediatrics, SOMDepartment of Pediatrics, SOM Oct., 2007
CTSA Objectives: Speed Discoveries to CTSA Objectives: Speed Discoveries to Improved Patient CareImproved Patient Care
• Develop a Develop a distinct disciplinedistinct discipline for clinical and translational for clinical and translational science at institutions science at institutions
• Provide opportunities and resources for Provide opportunities and resources for original research on original research on novel methodsnovel methods
• Develop Develop translational technologiestranslational technologies and a knowledge base for and a knowledge base for the full spectrum of the full spectrum of clinical and translational scienceclinical and translational science
• Synergize partnershipsSynergize partnerships with industry, foundations, and with industry, foundations, and community physicianscommunity physicians
• Train the interdisciplinary teamsTrain the interdisciplinary teams who will conduct the clinical who will conduct the clinical and translational research of the futureand translational research of the future
BasicBasicResearchResearch
Clinical Clinical InvestigationInvestigation
Clinical TrialsClinical Trials
PracticePracticeIn the In the
CommunityCommunityT1T1
BenchBench BedsideBedside TrenchTrench
Bidirectional Translational ResearchBidirectional Translational Research
Molecules & Cells, Molecules & Cells, Animal ModelsAnimal Models
PatientsPatients Community & PopulationCommunity & Population
T2T2
NIH CTSA Awards: NIH CTSA Awards: A Home for Clinical and Translational ScienceA Home for Clinical and Translational Science
Trial DesignTrial Design
AdvancedAdvanced Degree-GrantingDegree-Granting
ProgramsPrograms
ParticipantParticipant& Community& CommunityInvolvementInvolvement
RegulatoryRegulatorySupportSupport
Biostatistics
ClinicalResources
BiomedicalInformatics
ClinicalClinicalResearchResearch
EthicsEthics
CTSACTSAHOMEHOMECTSACTSAHOMEHOME
IndustryIndustry
Other Other Institutions
Institutions
Housed in a Department, Center or InstituteHoused in a Department, Center or Institute
CSTA – Reorganizes Current CSTA – Reorganizes Current UCDHSC InfrastructureUCDHSC Infrastructure
• CTSA will subsume GCRC grants CTSA will subsume GCRC grants (M01), K30 grant – will end in 2010-11(M01), K30 grant – will end in 2010-11
• These programs will be integrated into These programs will be integrated into CTSACTSA
• Must develop a K12 programMust develop a K12 program• Optional – new predoctoral T32 Optional – new predoctoral T32
programprogram
• Adds many new programsAdds many new programs
• NIH to award 60 CTSA grants by 2011NIH to award 60 CTSA grants by 2011
Ten CTSA Key FunctionsTen CTSA Key Functions(New Organization - NIH)(New Organization - NIH)
• New translational and clinical methods New translational and clinical methods
developmentdevelopment
• Regulatory knowledge and supportRegulatory knowledge and support
• Design, biostatistics and clinical Design, biostatistics and clinical
research ethicsresearch ethics
• Translational technologies and Translational technologies and
resourcesresources
Ten CTSA Key FunctionsTen CTSA Key Functions
• Pilot and collaborative translational and Pilot and collaborative translational and clinical studiesclinical studies
• Participant and Clinical InteractionsParticipant and Clinical Interactions
• Translational informaticsTranslational informatics
• Community EngagementCommunity Engagement
• Research Education, Training and Career Research Education, Training and Career Development Development
• Evaluation and TrackingEvaluation and Tracking
Why a Colorado CTSA?Why a Colorado CTSA?
• MustMust be part of CTSA national program to be part of CTSA national program to have a voice in CTS research, shape national have a voice in CTS research, shape national programsprograms
• Ability to attract and retain outstanding Ability to attract and retain outstanding faculty, trainees and physicians at all faculty, trainees and physicians at all affiliated institutions and campusesaffiliated institutions and campuses
• Provision of essential infrastructure, support Provision of essential infrastructure, support and improved trainingand improved training
• Be eligible for special NIH funding (RFAs)Be eligible for special NIH funding (RFAs)
Current CTS Research and Training Current CTS Research and Training Strengths at UCDHSC and CUStrengths at UCDHSC and CU
• Many successful collaborative Translational Many successful collaborative Translational research efforts across campuses research efforts across campuses
• Outstanding clinical research facilities (two Outstanding clinical research facilities (two General Clinical Research Centers and two General Clinical Research Centers and two satellites) and core resourcessatellites) and core resources
• Excellent community research programs Excellent community research programs (including Native American Health)(including Native American Health)
• One of first Clinical Science PhD and Masters One of first Clinical Science PhD and Masters programs in U.S.programs in U.S.
• Strong Child Health Research ProgramsStrong Child Health Research Programs
Progress toward CTSA Progress toward CTSA ApplicationApplication
1. CTSA Planning Grant awarded in 20061. CTSA Planning Grant awarded in 2006• Funded – Funded – $150,000 direct costs $150,000 direct costs
$231,000 total costs$231,000 total costs
• Major critiques: Major critiques: – Expand scope to Expand scope to include more collaboration with include more collaboration with
CU BoulderCU Boulder – Physiology, – Physiology, bioengineeringbioengineering, etc., etc.– Evaluation process to assess outcomes resulting Evaluation process to assess outcomes resulting
from infrastructure changesfrom infrastructure changes
2. New2. New Colorado CST Institute (CCTSI) Colorado CST Institute (CCTSI)
approved by Regents in Aug. 2007approved by Regents in Aug. 2007
3. Grant application – Nov. 7, 2007 deadline3. Grant application – Nov. 7, 2007 deadline
Vision of CCTSIVision of CCTSI
Transform the current clinical and Transform the current clinical and
translational research and training efforts of translational research and training efforts of
all Schools at UCDHSC and affiliated all Schools at UCDHSC and affiliated
institutions into an innovative, institutions into an innovative,
interdisciplinary, collaborative campus-wide interdisciplinary, collaborative campus-wide
academic home for clinical and translational academic home for clinical and translational
sciences, scientists and traineessciences, scientists and trainees
Mission of CCTSIMission of CCTSI
Improve the health of the population of Improve the health of the population of
Colorado by catalyzing the translation Colorado by catalyzing the translation
of biomedical discoveries into of biomedical discoveries into
prevention and intervention strategies prevention and intervention strategies
in the community, and by reducing in the community, and by reducing
health care disparitieshealth care disparities
Goals of Colorado CTSIGoals of Colorado CTSI
1.1. Transformation of the InstitutioTransformation of the Institution: n: UCDHSC will create the CCTSI as a UCDHSC will create the CCTSI as a visible, integrated and interdisciplinary visible, integrated and interdisciplinary statewide academic home for the statewide academic home for the disciplines of clinical and translational disciplines of clinical and translational sciences and research that will remove sciences and research that will remove barriers and obstacles and promote barriers and obstacles and promote successful careers successful careers
Goals of Colorado CTSIGoals of Colorado CTSI
2. Transformation of the Clinical and 2. Transformation of the Clinical and Translational Scientist:Translational Scientist:
The CCTSI will enhance, integrate and The CCTSI will enhance, integrate and transform training of translational transform training of translational scientists to develop a new generation scientists to develop a new generation of investigators with advanced of investigators with advanced degrees, interdisciplinary and degrees, interdisciplinary and collaborative skills and a team collaborative skills and a team approach to scientific investigation approach to scientific investigation
Goals of CCTSIGoals of CCTSI
3. 3. Transformation of Discovery Translational Transformation of Discovery Translational Research:Research:
The CCTSI will transform the performance of The CCTSI will transform the performance of discovery translational research (bench-to-discovery translational research (bench-to-beside research) by providing new resources beside research) by providing new resources and infrastructure, integrating current and and infrastructure, integrating current and developing new innovative research tools developing new innovative research tools and methodologies, catalyzing new and methodologies, catalyzing new interdisciplinary research programs and interdisciplinary research programs and removing barriers to efficiencyremoving barriers to efficiency
Goals of CCTSIGoals of CCTSI
4. Transformation of Community Translational 4. Transformation of Community Translational Research and PracticeResearch and Practice. .
The CCTSI will transform community and The CCTSI will transform community and population-based research by enhancing, population-based research by enhancing, extending and integrating community-based extending and integrating community-based participatory research into programs that will participatory research into programs that will engage community participation and develop engage community participation and develop novel methodologies for translation of novel methodologies for translation of scientific discoveries into clinical practicescientific discoveries into clinical practice
Basic and Engineering
Sciences
CommunityAnd Population
Sciences
PatientOriented Research
ClinicalTrials
DisadvantagedPopulations
CollaborativeInvestigative
Teams
InterdisciplinaryResearch Programs
New Generationof Trainees
Academic HomeMulti-Institutional
Collaboration BiomedicalBiomedicalDiscoveriesDiscoveriesBiomedicalBiomedicalDiscoveriesDiscoveries
ResearchTeams andLeaders of The Future
ResearchTeams andLeaders of The Future
Colorado CTSI
Discovery Translation
CommunityTranslation
Education, TrainingCareer Development
Child andMaternal Health
EvaluationAnd Improvement
Graduate DegreePrograms
ImprovedCommunity
Health
ImprovedCommunity
Health
CommunityPhysicianOutreach
Novel Methods& Technology
CCTSI Institutional MembersCCTSI Institutional Members
• UCDHSC Schools of Medicine, Nursing, UCDHSC Schools of Medicine, Nursing,
Dental, Pharmacy, Graduate School, Public Dental, Pharmacy, Graduate School, Public
HealthHealth
• CU Boulder, UCDHSC Denver Campus CU Boulder, UCDHSC Denver Campus
(e.g. Bioengineering), (e.g. Bioengineering),
• Affiliated hospitals - UCH, TCH, DH, NJMRC, Affiliated hospitals - UCH, TCH, DH, NJMRC,
VAH, Kaiser PermanenteVAH, Kaiser Permanente
• Graduate Training ProgramsGraduate Training Programs
Chancellor of Chancellor of UCDHSCUCDHSC
Vice ChancellorVice Chancellor of Researchof Research
DirectorDirectorCCTSICCTSI
Executive Committee:Executive Committee:Director, 5 Co-Directors,Director, 5 Co-Directors,
CFO, Chair of IACCFO, Chair of IAC
ExternalExternalAdvisory Advisory CommitteeCommittee
Internal Internal AdvisoryAdvisory
CommitteeCommittee
CFOCFO
Vice ChancellorVice Chancellor of Health Affairsof Health Affairs
CCTSICCTSIAdvisoryAdvisoryCouncilCouncil
CCTSI Organizational Structure and GovernanceCCTSI Organizational Structure and Governance
Chancellor of Chancellor of UCDHSCUCDHSC
Vice ChancellorVice Chancellor of Researchof Research
Director CCTSIDirector CCTSISokolSokol
Executive CommitteeExecutive Committee
CFOCFO
Vice ChancellorVice Chancellor of Health Affairsof Health Affairs
Training andTraining andEducationEducation
DiscoveryDiscoveryTranslationTranslation
CommunityCommunityTranslationTranslation
Novel MethodsNovel Methods& Technology& Technology
Child & Child & MaternalMaternalResearchResearch
SteinerSteiner EckelEckel KramerKramer GeraciGeraciHayHay
FIVE PROGRAMSFIVE PROGRAMS
Training andTraining andEducationEducation
DiscoveryDiscoveryTranslationTranslation
CommunityCommunityTranslationTranslation
Novel MethodsNovel Methods& Technology& Technology
Child & Child & MaternalMaternalResearchResearch
SteinerSteiner EckelEckel KramerKramer GeraciGeraci HayHay
DirectorDirectorSokolSokol
PredoctoralPost-docJr. FacultyCareer Development
K30, T32, K12
CTRCsCTRCsClinical TrialsClinical TrialsCPCCPCPharmaceutical Pharmaceutical developmentdevelopment
Design, Biostatistics, Design, Biostatistics, Research EthicsResearch Ethics
RegulatoryRegulatory
Community Community Engagement & Engagement & ResearchResearch
InformaticsInformatics
Novel Methods Novel Methods DevelopmentDevelopment
Pilot ProjectsPilot Projects
Translational Technology Translational Technology CoresCores
Integrate Integrate Programs Programs ThroughoutThroughoutTCH and otherTCH and otherFacilitiesFacilities
ACADEMIC HOMEACADEMIC HOME
TimetableTimetable
• Working Groups for each key function for Working Groups for each key function for
past 10 monthspast 10 months
• External Advisory Committee meeting External Advisory Committee meeting
July 23, 2007July 23, 2007
• Working Groups – final drafts submittedWorking Groups – final drafts submitted
• Executive Committee finalizing and Executive Committee finalizing and
editingediting
• Application Deadline: November 7, 2007Application Deadline: November 7, 2007
SummarySummary
• CTSA application is a exceptional opportunity to CTSA application is a exceptional opportunity to
transform andcatalyze clinical and translational transform andcatalyze clinical and translational
research and training across campuses of research and training across campuses of
University of Colorado, Affiliated Hospitals and University of Colorado, Affiliated Hospitals and
OrganizationsOrganizations
• Will take a University-wide and Hospital-wide Will take a University-wide and Hospital-wide
partnerships partnerships
• Will require broad faculty and institutional Will require broad faculty and institutional
commitmentscommitments
ContactContact
• Sokol.ronald@tchden.orgSokol.ronald@tchden.org
• Phone:Phone: 720 777-6669 720 777-6669
• Pager: 303-890-7744Pager: 303-890-7744
• http://ctsa1.uchsc.eduhttp://ctsa1.uchsc.edu
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