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Research Articles: Cellular/Molecular

The dendrites of CA2 and CA1 pyramidal neurons differentially regulateinformation flow in the cortico-hippocampal circuit

Kalyan V. Srinivas1,3, Eric W. Buss1,5, Qian Sun1, Bina Santoro1, Hiroto Takahashi1, Daniel A. Nicholson5 and

Steven A. Siegelbaum1,2,3,4

1Department of Neuroscience2Department of Pharmacology3Howard Hughes Medical Institute4Kavli Institute for Brain Science Columbia University, 1051 Riverside Drive, New York, NY 10032, USA5Department of Neuroscience Rush University Medical Center, Chicago, IL 60612

DOI: 10.1523/JNEUROSCI.2219-16.2017

Received: 12 July 2016

Revised: 27 December 2016

Accepted: 7 February 2017

Published: 17 February 2017

Author contributions: K.V.S., D.A.N., and S.A.S. designed research; K.V.S., E.W.B., Q.S., B.S., and H.T.performed research; K.V.S., E.W.B., Q.S., and B.S. analyzed data; K.V.S., B.S., D.A.N., and S.A.S. wrote thepaper.

Conflict of Interest: The authors declare no competing financial interests.

This work was supported by the Howard Hughes Medical Institute. We thank Yeonsook Shin and Austen Sitkofor their help with biocytin stainings and the Neurolucida system. We also thank Anastasia Barnett for the helpwith immunohistochemistry.

Corresponding Authors: Kalyan V. Srinivas (vks2111@cumc.columbia.edu) or Steven A. Siegelbaum(sas8@cumc.columbia.edu) Postal Address: Columbia University, 1051 Riverside Drive, New York, NY 10032,USA.

Cite as: J. Neurosci ; 10.1523/JNEUROSCI.2219-16.2017

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5Department of Neuroscience Rush University Medical Center, Chicago, IL 60612

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