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TabletsDR M Hussain: PHC500: DRUG DELIVERY SYSTEMS

What is a tablet?

Tablets are solid dosage forms

Obtained by single or multiple compression of powders or granules.

They are uncoated or coated.

What is a tablet? Uncoated tablets

Metformin 500mg

Coated Aspirin Enteric Coated

What is a tablet? Effervescent/

Soluble/Dispersable Multilayerd

Nurofen Plus

What is a tablet? Multilayered

What is a tablet? Sublingual Buccal

Quality Control What would you expect from a tablet?

1. Accurate Dose

2. Physical stability Visual acceptability Handling / Storage

3. Fast acting: Efficacy

Quality Control: Physical Stability

Appearance Is the manufacturing process suitable Visual Inspection

Size and shape (unofficial tests) Uniformity of Diameter Uniformity of Thickness

Durability (unofficial tests) Hardness test Friability test

Quality Control: Accurate Dose

Official British Pharmacopeia (BP) tests Uniformity of weight Uniformity of content (API)

Quality Control: Efficacy

Official British Pharmacopeia (BP) tests Disintegration test Dissolution test

Hardness

Tablet require a degree of strength to withstand the

mechanical shocks of handling, packaging and

shipping.

Hardness generally measures a tablets crushing

strength.

Hardness Hardness can affect the disintegration.

If the tablet is too hard, it may not disintegrate in the required period of time.

if the tablet is too soft, it will not withstand the handling during subsequent processing such as coating or packaging.

If tablet hardness is too high, disintegration is tested before rejecting.

Factors affecting hardness

• Compressive force used to produce tablet

• Quantity of binder.

• Method of production• Wet methods produce harder tablets than direct

compression methods

Friability

Uniformity of weight

Uniformity of content

Disintegration test

Dissolution test