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Table of ContentsNeurology.org/nn � Online ISSN: 2332-7812Volume 2, Number 4, August 2015
EDITOR’S CORNER
e137 The first anniversary issueJ. Dalmau
EDITORIAL
e140 Unique invariant CD81 T cell population persistsin MSJ.J. Sabatino, Jr and S.S. Zamvil
Companion article, e107
ARTICLES
e107 ab T-cell receptors frommultiple sclerosis brain lesionsshow MAIT cell–related featuresK. Held, L. Bhonsle-Deeng, K. Siewert, W. Sato,E. Beltrán, S. Schmidt, G. Rühl, J.K.M. Ng, P. Engerer,M. Moser, W.E.F. Klinkert, H. Babbe, T. Misgeld,H. Wekerle, D.-A. Laplaud, R. Hohlfeld, andK. Dornmair
Editorial, e140
e119 Complement activity is associatedwithdisease severityin multifocal motor neuropathyL. Vlam, E.A. Cats, O. Harschnitz, M.D. Jansen,S. Piepers, J.H. Veldink, H. Franssen, A.C.J. Stork,E. Heezius, S.H.M. Rooijakkers, B.L. Herpers,J.A. van Strijp, L.H. van den Berg, andW.L. van der Pol
e109 Expanding spectrum of neurologic manifestationsin patients with NLRP3 low-penetrancemutationsE. Schuh, P. Lohse, B. Ertl-Wagner, M. Witt,M. Krumbholz, M. Frankenberger, L.-A. Gerdes,R. Hohlfeld, and T. Kümpfel
e111 Hippocampal volume and depressive symptoms arelinked to serum IL-18 in schizophreniaP. Bossù, F. Piras, I. Palladino, M. Iorio, F. Salani,A. Ciaramella, C. Chiapponi, C. Caltagirone, andG. Spalletta
e120 Oral contraceptives combined with interferon b inmultiple sclerosisC. Pozzilli, L. De Giglio, V.T. Barletta, F. Marinelli,F.D. Angelis, V. Gallo, V.A. Pagano, S. Marini,M.C. Piattella, V. Tomassini, and P. Pantano
e123 Hematologic modifications in natalizumab-treatedmultiple sclerosis patients: An 18-monthlongitudinal studyC. Bridel, Y. Beauverd, K. Samii, andP.H. Lalive
e113 Acute lower motor neuron syndrome andspinal cord gray matter hyperintensities inHIV infectionI.I. Bogoch, M.R. Wilson, D.A. Chad, and N. Venna
e121 Aquaporin-4 antibody isoform binding specificities donot explain clinical variations in NMOJ. Kitley, M. Woodhall, M.I. Leite, J. Palace,A. Vincent, and P. Waters
e117 Randomized phase 1b trial of MOR103, a humanantibody to GM-CSF, in multiple sclerosisC.S. Constantinescu, A. Asher, W. Fryze,W. Kozubski, F. Wagner, J. Aram, R. Tanasescu,R.P. Korolkiewicz, M. Dirnberger-Hertweck,S. Steidl, S.E. Libretto, T. Sprenger, andE.W. Radue
e124 Myopathy with anti-HMGCR antibodies: Perimysiumand myofiber pathologyA. Alshehri, R. Choksi, R. Bucelli, and A. Pestronk
e122 ILAE type 3 hippocampal sclerosis in patients withanti-GAD–related epilepsyR.L. Glover, L.V. DeNiro, P.A. Lasala,K.M. Weidenheim, J.J. Graber, and A. Boro
ª 2015 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.
e132 Predictive value of early brain atrophy on response inpatients treated with interferon b
F.C. Pérez-Miralles, J. Sastre-Garriga,A. Vidal-Jordana, J. Río, C. Auger, D. Pareto,M. Tintoré, A. Rovira, and X. Montalban
e127 Caspr2 autoantibodies target multiple epitopesA.L. Olsen, Y. Lai, J. Dalmau, S.S. Scherer, andE. Lancaster
e129 Impact of MS genetic loci on familialaggregation, clinical phenotype, and diseasepredictionF. Esposito, C. Guaschino, M. Sorosina, F. Clarelli,L. Ferre’, E. Mascia, S. Santoro, M. Pagnesi,M. Radaelli, B. Colombo, L. Moiola, M. Rodegher,E. Stupka, V. Martinelli, G. Comi, andF.M. Boneschi
VIEWS & REVIEWS
e110 Aquaporin-4 autoimmunityA. Zekeridou and V.A. Lennon
e135 Acute optic neuritis: Unmet clinical needs and modelfor new therapiesS.L. Galetta, P. Villoslada, N. Levin, K. Shindler,H. Ishikawa, E. Parr, D. Cadavid, andL.J. Balcer
e134 Update on biomarkers in neuromyelitisopticaE. Melamed, M. Levy, P.J. Waters, D.K. Sato,J.L. Bennett, G.R. John, D.C. Hooper,A. Saiz, A. Bar-Or, H.J. Kim, L. Pandit,M.I. Leite, N. Asgari, N. Kissani, R. Hintzen,R. Marignier, S. Jarius, J. Marcelletti, T.J. Smith,M.R. Yeaman, and M.H. Han, on behalf of theGJCF-ICC&BR
CLINICAL/SCIENTIFIC NOTES
e108 Varicella-zoster virus encephalitis localized to thebilateral medial temporal lobesR. Yajima, K. Utsumi, T. Ishihara, M. Kanazawa,K. Okamoto, I. Kawachi, and M. Nishizawa
e114 Allergic encephalitis with gelastic status epilepticusinduced by wasp stingR. Jimenez-Sanders, R. Behrouz, andN. Tsakadze
e118 Posterior cortical and white matter changes on MRI inanti-AMPA receptor antibody encephalitisM. Elamin, R. Lonergan, R.P. Killeen, S. O’Riordan,N. Tubridy, and C. McGuigan
e128 Diagnostic value of MRI in inflammatory myositisT.T. Lai and T. Mozaffar
e130 Earlier treatment of NMDAR antibody encephalitis inchildren results in a better outcomeS. Byrne, C.Walsh, Y. Hacohen, E. Muscal, J. Jankovic,A. Stocco, R.C. Dale, A. Vincent, M. Lim, and M. King
e125 Widespread arterial infection by varicella-zoster virusexplains refractory giant cell arteritisD.Gilden, T.White, S.L. Galetta, F. Fogt, andM.A. Nagel
e126 Transient anti-NMDAR encephalitis in a newborn infantdue to transplacental transmissionM. Hilderink, M.J. Titulaer, M.W.J. Schreurs, K. Keizer,and J.E.H. Bunt
e136 Sleep disorder, chorea, and dementia associated withIgLON5 antibodiesM.M. Simabukuro, L. Sabater, T. Adoni, R.G. Cury,M.S. Haddad, C.H. Moreira, L. Oliveira,M. Boaventura, R.C. Alves, L.A. Soster, R. Nitrini,C. Gaig, J. Santamaria, J. Dalmau, and F. Graus
Table of Contentscontinued
ª 2015 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.
e131 Anti-MOG antibodies are frequently associated withsteroid-sensitive recurrent optic neuritisK. Chalmoukou, H. Alexopoulos, S. Akrivou,P. Stathopoulos, M. Reindl, and M.C. Dalakas
CORRECTION
e133 Encephalomyeloneuropathy with CRMP-5antibodies in a patient with a primary mediastinalserinoma
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Cover image: HMGCR-antibody associated myopathy with involvement of perimysialconnective tissue and muscle fibers demonstrated by abnormal alkaline phosphatase stain.See “Myopathy with anti-HMGCR antibodies: Perimysium and myofiber pathology.”
Table of Contentscontinued
ª 2015 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.
Neurology.org/nn � Online ISSN: 2332-7812Volume 2, Number 4, August 2015
VISION: Neurology: Neuroimmunology & Neuroinflammation will bethe premier peer-reviewed journal for experts in the fields ofNeuroimmunology and Neuroinflammation.
MISSION: Neurology: Neuroimmunology & Neuroinflammation willprovide neurologists with peer-reviewed articles, editorials, andreviews to enhance patient care, education, and clinical &translational research.
EditorNeurology: Neuroimmunology & NeuroinflammationJosep O. Dalmau, MD, PhDICREA-University of BarcelonaBarcelona, SpainUniversity of PennsylvaniaPhiladelphia, PATel: 612-928-6400Toll-free: 800-957-3182 (US)Fax: 612-454-2748nnnjournal@neurology.org
Editor-in-ChiefNeurology®Robert A. Gross, MD, PhD, FAANProfessor of Neurology and of Pharmacology and PhysiologyStrong Epilepsy CenterUniversity of Rochester Medical CenterRochester, NYTel: 612-928-6400Toll-free: 800-957-3182 (US)Fax: 612-454-2748journal@neurology.org
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Academy OfficersTerrence L. Cascino, MD, FAAN, PresidentRalph L. Sacco, MD, MS, FAAN, President ElectJames C. Stevens, MD, FAAN, Vice PresidentAaron E. Miller, MD, FAAN, SecretaryLisa M. Shulman, MD, FAAN, TreasurerTimothy A. Pedley, MD, FAAN, Past President
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& NeuroinflammationLee Ann Kleffman, Managing Editor, Neurology® GeneticsCynthia S. Abair, MA, Senior Graphics EditorRobert J. Witherow, Senior Editorial AssociateKaren Skaja, Editorial AssociateAndrea R. Wagner, Editorial AssistantKaitlyn Aman Ramm, Editorial AssistantKristen Swendsrud, Editorial Assistant
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ª 2015 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.
Neurology.org/nn � Online ISSN: 2332-7812Volume 2, Number 4, August 2015
EDITORNeurology: Neuroimmunology & NeuroinflammationJosep O. Dalmau, MD, PhDICREA-University of BarcelonaBarcelona, SpainUniversity of PennsylvaniaPhiladelphia, PA
EDITOR-IN-CHIEFNeurologyRobert A. Gross, MD, PhD, FAANProfessor of Neurology and of Pharmacology and PhysiologyStrong Epilepsy CenterUniversity of Rochester Medical CenterRochester, NY
DEPUTY EDITORSNeurologyDavid S. Knopman, MD, FAANProfessor of NeurologyDepartment of NeurologyCollege of MedicineMayo ClinicRochester, MN
Neurology: Neuroimmunology & NeuroinflammationScott S. Zamvil, MD, PhD, FAANDepartment of NeurologyUniversity of California, San FranciscoSan Francisco, CA
ASSOCIATE EDITORSNeurology: Neuroimmunology & NeuroinflammationMichael Heneka, MDUniversity of BonnBonn, GermanySpecialties: Neurodegeneration, stroke
Robyn S. Klein, MD, PhDWashington University School of MedicineSt. Louis, MOSpecialty: Infectious disease
Friedmann Paul, MDCharite University HospitalBerlin, GermanySpecialties: Multiple sclerosis, neuromyelitis optica, neuroimaging(magnetic resonance imaging, optical coherence tomography)
Lan Zhou, MD, PhDMount Sinai School of MedicineNew York, NYSpecialty: Neuromuscular
EDITORIAL BOARDRohit Aggarwal, MD, MS, University of Pittsburgh, Pittsburgh, PASergio E. Baranzini, PhD, University of San Francisco, San Francisco, CASusanne Benseler, MD, Calgary, Alberta, CanadaJeffrey L. Bennett, MD, PhD, FAAN, University of Colorado, Aurora, COSéverine Boillée, PhD, Hôpital de la Salpêtriere, Paris, FranceMatthijs C. Brouwer, MD, PhD, Adademic Medical Center, Amsterdam,The Netherlands
David B.Clifford,MD, FAAN,WashingtonUniversity School ofMedicine,St. Louis, MO
Russell C. Dale, MBChB, MRCP, PhD, University of Sydney, Sydney,Australia
Oscar H. Del Brutto, MD, FAAN, Clinica, Kennedy, Guayaquil,Ecuador
Thomas G. Forsthuber, MD, University of Texas, San Antonio, TXJoseph El Khoury, MD, Massachusetts General Hospital, Boston, MAMarkus P. Kummer, PhD, University of Bonn, Bonn, GermanyJun Li, MD, PhD, Vanderbilt University, Nashville, TNLin Mei, MD, PhD, Georgia Regents University, Augusta, GeorgiaChristopher Power, MD, University of Alberta, Alberta, CanadaRichard M. Ransohoff, MD, Biogen Idec, Boston, MAChristine Stadelmann, MD, University of Göttingen, Göttingen,Germany
Israel Steiner, MD, Rabin Medical Center, Petach Tikva, IsraelLawrence Steinman, MD, FAAN, Stanford University, Stanford, CAJesper Tegnér, PhD, MSc, Karolinska University Hospital, Stockholm,Sweden
Maarten J. Titulaer, MD, PhD, Erasmus Medical Center, Rotterdam,The Netherlands
Hugh J. Willison, MBBS, PhD, University of Glasgow, Glasgow, UK
LEVEL OF EVIDENCE REVIEW TEAMMelissa J. Armstrong, MD, Baltimore, MDRichard L. Barbano, MD, PhD, FAAN, Rochester, NYRichard M. Dubinsky, MD, MPH, FAAN, Kansas City, KSJeffrey J. Fletcher, MD, MSc, Ann Arbor, MIGary M. Franklin, MD, MPH, FAAN, Seattle, WADavid S. Gloss II, MD, MPH&TM, Danville, PAJohn J. Halperin, MD, FAAN, Summit, NJJason Lazarou, MSc, MD, Toronto, Ontario, CanadaSteven R. Messé, MD, FAAN, Philadelphia, PAPushpa Narayanaswami, MBBS, DM, FAAN, Boston, MAAlex Rae-Grant, MD, Cleveland, OH
ª 2015 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.
Neurology.org/nn � Online ISSN: 2332-7812Volume 2, Number 4, August 2015
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