table 1. properties of primitive lymphoid progenitors

Table 1.

Properties of primitive lymphoid progenitors.

c-Kit Progenitor Tissue Phenotypea Lineage potential

Hi LSK Flt3− HSC BM, blood Lin− c-KitHi Sca1Hi IL-7Rα− CD27− Multipotent LSK Flt3+ MPP BM, blood thy Lin− c-KitHi Sca1Hi IL-7Rα− CD27+ MultipotentLSK Thy1.1− LSP BM Lin− c-KitHi Sca1Hi IL-7Rα− Thy1.1− T, (w)B, (w)myeloid LSK Flt3+ CD62L+ BM, blood Lin− c-KitHi Sca1Hi IL-7Rα− CD44+ T, BLSK Flt3+ ELP BM, blood Lin− c-KitHi Sca1Hi IL-7Rα− CD44+ CD27+ RAG-1+/− B, T, NK, (w)myeloid

Lo/– Pro-L BM Lin− c-KitLo Sca1Lo IL-7Rα+/− Flt3+ CD27+ RAG-1+ B, T, NK CLP BM Lin− c-KitLo Sca1Lo IL-7Rα+ Flt3+ AA4.1+ B, T, NK, DC, pDC Fraction A BM B220+ CD19− CD43+ CD24−/Lo BP-1− B, NK, DCCLP-2 BM, blood, thy Lin− B220+ CD19− IL-7Rα+ c-Kit− Sca1+ pTα+ T, B

Hi ETP Thymus Lin− c-KitHi Sca1Hi IL-7Rα−/Lo CD25− T, B, NK, DC, myeloid DN1a Thymus Lin− CD25− c-KitHi IL-7Rα− CD44Hi Thy1− CD24− T, NK DN1b Thymus Lin− CD25− c-KitHi IL-7Rα− CD44Hi Thy1− CD24Lo T, NK

Lo/– DN1c Thymus Lin− CD25− c-KitLo IL-7Rα− CD44Hi Thy1−/+ CD24+ T, B DN1d Thymus Lin− CD25− c-Kit− IL-7Rα− CD44Hi Thy1+ CD24+ T, B DN1e Thymus Lin− CD25− c-KitLo/− IL-7Rα+ CD44HiThy1−/+ CD24− T

Hi DN2 Thymus Lin− CD25+ c-Kit+ IL-7Rα−/+ CD44+ Thy1−/Lo T, DC