status of ecr ion sources for carbon ion radiotherapy in japan … · 2014. 3. 6. · status of ecr...

Stat

us o

f EC

R Io

n So

urce

s fo

r Car

bon

Ion

Rad

ioth

erap

y in

Jap

an

HIM

AC

NIR

S

Con

tent

s:1.

App

roac

hes

for t

he p

rom

otio

n in

Jap

an2.

Dev

elop

men

t of i

on s

ourc

es3.

Pre

sent

sta

tus

of io

n so

urce

s

A.

Kita

gaw

aLe

ader

, Pro

mot

ion

of C

arbo

n Th

erap

y Te

am(S

enio

r Res

earc

her,

Dep

t. of

Acc

eler

ator

and

Med

ical

Phy

sics

)R

esea

rch

Cen

ter f

or C

harg

ed P

artic

le T

hera

pyN

atio

nal I

nstit

ute

of R

adio

logi

cal S

cien

ces

1. A

ppro

ache

s fo

r the

pro

mot

ion

in J

apan

HIM

AC

NIR

S

[Com

preh

ensi

ve 1

0-Ye

ar S

trat

egy

for C

ance

r Con

trol

, 198

4-19

93]

1984

HIM

AC

pro

ject

at N

IRS

as

the

1st m

edic

al d

edic

ated

hea

vy-io

n ac

cele

rato

r in

the

wor

ld h

as b

een

fund

ed b

y M

inis

try o

f Edu

catio

n, C

ultu

re, S

ports

, Sci

ence

and

Tec

hnol

ogy

(ME

XT)

.[2

ndC

ompr

ehen

sive

10-

Year

Str

ateg

y fo

r Can

cer C

ontr

ol, 1

994-

2003

]19

94S

tart

of c

linic

al tr

ials

with

car

bon

ions

at N

IRS

und

er p

resc

ribed

clin

ical

pro

toco

ls.

2001

The

2nd

faci

lity

(Hyo

go Io

n B

eam

Med

ical

Cen

ter)

has

bee

n op

ened

. 20

03C

arbo

n io

n th

erap

y ha

s ap

prov

ed a

s “a

dvan

ced

med

ical

tech

nolo

gy”b

y M

inis

try o

f Hea

lth, L

abou

r, an

d W

elfa

re (M

HLW

).[3

rd C

ompr

ehen

sive

10-

Year

Str

ateg

y fo

r Can

cer C

ontr

ol, 2

004-

2013

]20

04“W

orks

hop

for p

opul

ariz

atio

n of

the

char

ged-

parti

cle

radi

othe

rapy

”was

hel

d by

ME

XT

and

the

sum

mar

y re

port

has

been

dis

tribu

ted.

2005

“The

gui

delin

e fo

r cha

rged

par

ticle

radi

othe

rapy

in J

apan

”has

bee

n au

thor

ized

by

the

Japa

nese

S

ocie

ty o

f med

ical

Phy

sics

(JS

MP

).20

04-5

Des

ign

of a

hos

pita

l-bas

ed fa

cilit

y an

d de

velo

pmen

t on

prot

otyp

es o

f var

ious

com

pone

nts

at N

IRS

w

as fu

nded

by

ME

XT.

2005

-7“R

esea

rch

on ra

diat

ion

prot

ectio

n fo

r pro

ton

and

heav

y io

n ra

diot

hera

py”w

as fu

nded

by

MH

LW.

2006

-10

Con

stru

ctio

n of

the

3rd

faci

lity

at G

unm

a U

nive

rsity

as

a de

mon

stra

tion

mod

el w

as fu

nded

by

ME

XT.

2007

-“P

rogr

am fo

r the

Hum

an R

esou

rces

Dev

elop

men

t Rel

atin

g to

Cha

rged

Par

ticle

Rad

ioth

erap

y”ha

s be

en fu

nded

by

ME

XT.

2007

-A

ppro

ved

the

cons

truct

ion

of “t

he n

ext-g

ener

atio

n irr

adia

tion

syst

ems”

at N

IRS

.20

10Fi

rst t

reat

men

t at G

unm

a U

nive

rsity

. 20

11S

tart

of c

linic

al tr

ials

with

the

resp

irato

ry g

ated

3D

sca

nnin

g at

NIR

S.

Stra

tegy

by

Japa

nese

gov

ernm

ent

1. A

ppro

ache

s fo

r the

pro

mot

ion

in J

apan

HIM

AC

NIR

S

[Com

preh

ensi

ve 1

0-Ye

ar S

trat

egy

for C

ance

r Con

trol

, 198

4-19

93]

1984

HIM

AC

pro

ject

at N

IRS

as

the

1st m

edic

al d

edic

ated

hea

vy-io

n ac

cele

rato

r in

the

wor

ld h

as b

een

fund

ed b

y M

inis

try o

f Edu

catio

n, C

ultu

re, S

ports

, Sci

ence

and

Tec

hnol

ogy

(ME

XT)

.[2

ndC

ompr

ehen

sive

10-

Year

Str

ateg

y fo

r Can

cer C

ontr

ol, 1

994-

2003

]19

94S

tart

of c

linic

al tr

ials

with

car

bon

ions

at N

IRS

und

er p

resc

ribed

clin

ical

pro

toco

ls.

2001

The

2nd

faci

lity

(Hyo

go Io

n B

eam

Med

ical

Cen

ter)

has

bee

n op

ened

. 20

03C

arbo

n io

n th

erap

y ha

s ap

prov

ed a

s “a

dvan

ced

med

icin

e”by

Min

istry

of H

ealth

, Lab

our,

and

Wel

fare

(M

HLW

).[3

rd C

ompr

ehen

sive

10-

Year

Str

ateg

y fo

r Can

cer C

ontr

ol, 2

004-

2013

]20

04“W

orks

hop

for p

opul

ariz

atio

n of

the

char

ged-

parti

cle

radi

othe

rapy

”was

hel

d by

ME

XT

and

the

sum

mar

y re

port

has

been

dis

tribu

ted.

2005

“The

gui

delin

e fo

r cha

rged

par

ticle

radi

othe

rapy

in J

apan

”has

bee

n au

thor

ized

by

the

Japa

nese

S

ocie

ty o

f med

ical

Phy

sics

(JS

MP

).20

04-5

Des

ign

of a

hos

pita

l-spe

cifie

d fa

cilit

y an

d de

velo

pmen

t on

prot

otyp

es o

f var

ious

com

pone

nts

at N

IRS

w

as fu

nded

by

ME

XT.

2005

-7“R

esea

rch

on ra

diat

ion

prot

ectio

n fo

r pro

ton

and

heav

y io

n ra

diot

hera

py”w

as fu

nded

by

MH

LW.

2006

-10

Con

stru

ctio

n of

the

3rd

faci

lity

at G

unm

a U

nive

rsity

as

a de

mon

stra

tion

mod

el w

as fu

nded

by

ME

XT.

2007

-“P

rogr

am fo

r the

Hum

an R

esou

rces

Dev

elop

men

t Rel

atin

g to

Cha

rged

Par

ticle

Rad

ioth

erap

y”ha

s be

en fu

nded

by

ME

XT.

2007

-A

ppro

ved

the

cons

truct

ion

of “t

he n

ext-g

ener

atio

n irr

adia

tion

syst

ems”

at N

IRS

.20

10Fi

rst t

reat

men

t at G

unm

a U

nive

rsity

. 20

11S

tart

of c

linic

al tr

ials

with

the

resp

irato

ry g

ated

3D

sca

nnin

g at

NIR

S.

1st D

ecad

e: C

onst

ruct

ion

of H

IMA

C

‘84

‘85

‘86

‘87

‘88

‘89

‘90

‘91

‘92

‘93

‘94

Feas

ibili

ty s

tudy

Des

ign

of m

achi

ne

Man

ufac

turin

g&

inst

alla

tion

of m

achi

ne

Des

ign

of B

uild

ings

Inst

alla

tion

of U

tiliti

esC

onst

ruct

ion

of B

uild

ings

Res

earc

h

com

miss

ioni

ng

Surv

eyM

achi

ne

Inje

ctor

Sync

hrot

ron

Irrad

iatio

n sy

stem

,…

Bui

ldin

gsB

uild

ings

Elec

tric

ity, c

oolin

g sy

stem

, …

Res

earc

h &

dev

elop

men

ts fo

r dev

ices

tech

nolo

gy (i

ncl.

biol

ogy)

Clin

ical

tria

lsPh

ysic

s&

Bio

logy

“S

umm

ary

at th

e 10

th a

nniv

ersa

ry o

f the

hea

vy io

n ra

diot

hera

py”,

edite

d by

ME

XT,

Mon

bu-K

agak

uJi

hou

No.

1541

, Aug

ust 2

004,

pp.

10-

49.

Siz

e: 6

0 x

120

mC

onst

ruct

ion

cost

: 32.

6GJP

Y(B

uild

ing

14.6

GJP

Y)

(mac

hine

18.

0GJP

Y)

1. A

ppro

ache

s fo

r the

pro

mot

ion

in J

apan

HIM

AC

NIR

S

2nd

Dec

ade:

Clin

ical

tria

ls[C

ompr

ehen

sive

10-

Year

Str

ateg

y fo

r Can

cer C

ontr

ol, 1

984-

1993

]19

84H

IMA

C p

roje

ct a

t NIR

S a

s th

e 1s

t med

ical

ded

icat

ed h

eavy

-ion

acce

lera

tor i

n th

e w

orld

has

bee

n fu

nded

by

Min

istry

of E

duca

tion,

Cul

ture

, Spo

rts, S

cien

ce a

nd T

echn

olog

y (M

EX

T).

[2nd

Com

preh

ensi

ve 1

0-Ye

ar S

trat

egy

for C

ance

r Con

trol

, 199

4-20

03]

1994

Sta

rt of

clin

ical

tria

ls w

ith c

arbo

n io

ns a

t NIR

S u

nder

pre

scrib

ed c

linic

al p

roto

cols

.20

01Th

e 2n

d fa

cilit

y (H

yogo

Ion

Bea

m M

edic

al C

ente

r) h

as b

een

open

ed.

2003

Car

bon

ion

ther

apy

has

appr

oved

as

“adv

ance

d m

edic

ine”

(form

er “a

dvan

ced

med

ical

tech

nolo

gy”)

by

Min

istry

of H

ealth

, Lab

our,

and

Wel

fare

(MH

LW).

[3rd

Com

preh

ensi

ve 1

0-Ye

ar S

trat

egy

for C

ance

r Con

trol

, 200

4-20

13]

2004

“Wor

ksho

p fo

r pop

ular

izat

ion

of th

e ch

arge

d-pa

rticl

e ra

diot

hera

py”w

as h

eld

by M

EX

T an

d th

e su

mm

ary

repo

rt ha

s be

en d

istri

bute

d.20

05“T

he g

uide

line

for c

harg

ed p

artic

le ra

diot

hera

py in

Jap

an”h

as b

een

auth

oriz

ed b

y th

e Ja

pane

se

Soc

iety

of m

edic

al P

hysi

cs (J

SM

P).

2004

-5D

esig

n of

a h

ospi

tal-s

peci

fied

faci

lity

and

deve

lopm

ent o

n pr

otot

ypes

of v

ario

us c

ompo

nent

s at

NIR

S

was

fund

ed b

y M

EX

T.20

05-7

“Res

earc

h on

radi

atio

n pr

otec

tion

for p

roto

n an

d he

avy

ion

radi

othe

rapy

”was

fund

ed b

y M

HLW

.20

06-1

0C

onst

ruct

ion

of th

e 3r

d fa

cilit

y at

Gun

ma

Uni

vers

ity a

s a

dem

onst

ratio

n m

odel

was

fund

ed b

y M

EX

T.20

07-

“Pro

gram

for t

he H

uman

Res

ourc

es D

evel

opm

ent R

elat

ing

to C

harg

ed P

artic

le R

adio

ther

apy”

has

been

fund

ed b

y M

EX

T.20

07-

App

rove

d th

e co

nstru

ctio

n of

“the

nex

t-gen

erat

ion

irrad

iatio

n sy

stem

s”at

NIR

S.

2010

Firs

t tre

atm

ent a

t Gun

ma

Uni

vers

ity.

2011

Sta

rt of

clin

ical

tria

ls w

ith th

e re

spira

tory

gat

ed 3

D s

cann

ing

at N

IRS

.

1. A

ppro

ache

s fo

r the

pro

mot

ion

in J

apan

277

110

113

138

166

189

183

233

152

5628

632

4

411

476

495

509

458

473

276

241

201

188

168

159

126

2183

0

100

200

300

400

500

600

700

800

1994

1995

1996

1997

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

adva

nced

med

icin

e

clin

ical

tria

l

2nd

deca

de’s

Tot

al:

1463

(Jun

199

4 –

Feb

2002

)

Perm

issi

on fo

r“a

dvan

ced

med

icin

e”(P

harm

aceu

tical

Aff

airs

Law

)

Cov

ered

by

Nat

iona

l Hea

lth

Insu

ranc

e sy

stem

Perm

issi

on fo

r “m

edic

al

devi

ces”

(Pha

rmac

eutic

al

Aff

airs

Law

)

Dev

elop

men

t of n

ew

med

ical

dev

ices

HIM

AC

NIR

S

3rd

Dec

ade:

Dow

n-si

zing

[Com

preh

ensi

ve 1

0-Ye

ar S

trat

egy

for C

ance

r Con

trol

, 198

4-19

93]

1984

HIM

AC

pro

ject

at N

IRS

as

the

1st m

edic

al d

edic

ated

hea

vy-io

n ac

cele

rato

r in

the

wor

ld h

as b

een

fund

ed b

y M

inis

try o

f Edu

catio

n, C

ultu

re, S

ports

, Sci

ence

and

Tec

hnol

ogy

(ME

XT)

.[2

ndC

ompr

ehen

sive

10-

Year

Str

ateg

y fo

r Can

cer C

ontr

ol, 1

994-

2003

]19

94S

tart

of c

linic

al tr

ials

with

car

bon

ions

at N

IRS

und

er p

resc

ribed

clin

ical

pro

toco

ls.

2001

The

2nd

faci

lity

(Hyo

go Io

n B

eam

Med

ical

Cen

ter)

has

bee

n op

ened

. 20

03C

arbo

n io

n th

erap

y ha

s ap

prov

ed a

s “a

dvan

ced

med

icin

e”by

Min

istry

of H

ealth

, Lab

our,

and

Wel

fare

(M

HLW

).[3

rd C

ompr

ehen

sive

10-

Year

Str

ateg

y fo

r Can

cer C

ontr

ol, 2

004-

2013

]20

04“W

orks

hop

for p

opul

ariz

atio

n of

the

char

ged-

parti

cle

radi

othe

rapy

”was

hel

d by

ME

XT

and

the

sum

mar

y re

port

has

been

dis

tribu

ted.

2005

“The

gui

delin

e fo

r cha

rged

par

ticle

radi

othe

rapy

in J

apan

”has

bee

n au

thor

ized

by

the

Japa

nese

S

ocie

ty o

f med

ical

Phy

sics

(JS

MP

).20

04-5

Des

ign

of a

hos

pita

l-spe

cifie

d fa

cilit

y an

d de

velo

pmen

t on

prot

otyp

es o

f var

ious

com

pone

nts

at N

IRS

w

as fu

nded

by

ME

XT.

2005

-7“R

esea

rch

on ra

diat

ion

prot

ectio

n fo

r pro

ton

and

heav

y io

n ra

diot

hera

py”w

as fu

nded

by

MH

LW.

2006

-10

Con

stru

ctio

n of

the

3rd

faci

lity

at G

unm

a U

nive

rsity

as

a de

mon

stra

tion

mod

el w

as fu

nded

by

ME

XT.

2007

-“P

rogr

am fo

r the

Hum

an R

esou

rces

Dev

elop

men

t Rel

atin

g to

Cha

rged

Par

ticle

Rad

ioth

erap

y”ha

s be

en fu

nded

by

ME

XT.

2007

-A

ppro

ved

the

cons

truct

ion

of “t

he n

ext-g

ener

atio

n irr

adia

tion

syst

ems”

at N

IRS

.20

10Fi

rst t

reat

men

t at G

unm

a U

nive

rsity

. 20

11S

tart

of c

linic

al tr

ials

with

the

resp

irato

ry g

ated

3D

sca

nnin

g at

NIR

S.

1. A

ppro

ache

s fo

r the

pro

mot

ion

in J

apan

HIM

AC

NIR

S

Prot

otyp

es fo

r hos

pita

l-spe

cifie

d fa

cilit

y Io

n so

urce

Acc

. cav

ity

Lina

c

Irrad

iatio

n sy

stem

Mag

net p

ower

su

pply

Sync

hrot

ron

Mag

net

Size

and

Cos

t1/

3K

. Nod

a et

al.,

J. R

adia

t. R

es. 4

8:Su

ppl.A

A43

(200

7).

Des

ign

conc

ept:

Opt

imiz

atio

n fo

r car

bon

beam

onl

y!!

of H

IMA

C

1. A

ppro

ache

s fo

r the

pro

mot

ion

in J

apan

HIM

AC

NIR

S

Gun

ma

Uni

vers

ity P

roje

ct

Dem

onst

ratio

n of

the

new

do

wns

ized

car

bon-

RT

faci

lity

in J

apan

.-D

edic

ated

car

bon

beam

on

ly-W

obbl

er &

laye

r-st

acki

ng

irrad

iatio

n sy

stem

s

‘01

‘02

‘03

‘04

‘05

‘06

‘07

‘08

‘09

‘10

Surv

eyFe

asib

ility

stu

dy

Man

ufac

turin

g D

esig

n of

m

achi

ne a

nd B

uild

ings

Mac

hine

Man

ufac

turin

g &

inst

alla

tion

of m

achi

ne

Inst

alla

tion

of U

tiliti

esIn

ject

orSy

nchr

otro

nIrr

adia

tion

syst

em,…

Bui

ldin

gs

Con

stru

ctio

n of

Bui

ldin

gsB

uild

ings

Elec

tric

ity, c

oolin

g sy

stem

, …

Dev

elop

men

ts o

f dev

ices

Clin

ical

tria

lsC

linic

al tr

ials

com

miss

ioni

ng

Feas

ibili

ty s

tudy

& fu

ndam

enta

l des

ign

(at N

IRS)

Mac

hine

& B

uild

ings

Proj

ect f

unde

d by

Ja

pane

se g

over

nmen

t

Gun

ma

Uni

vers

ity

Hea

vy io

n M

edic

alC

ente

r

1. A

ppro

ache

s fo

r the

pro

mot

ion

in J

apan

S. Y

amad

a et

al.,

NIR

S-M

-218

, p.1

70 (2

009)

.

HIM

AC

NIR

S

Saga

HIM

AT

Proj

ect

1. A

ppro

ache

s fo

r the

pro

mot

ion

in J

apan

Pub

lic a

nd p

rivat

e pa

rtner

ship

-Fou

ndat

ion

esta

blis

hed

by th

e lo

cal

gove

rnm

ent a

nd p

rivat

e co

mpa

nies

. -M

edic

al s

uppo

rts fr

om s

ever

al c

ore

hosp

itals

in th

is re

gion

.-n

o ow

n ho

spita

l is

held

.

2. D

evel

opm

ent o

f ion

sou

rces

HIM

AC

NIR

S

‘The

Pio

neer

’NIR

S-EC

Rat

HIM

AC

Laun

ched

to th

e lin

acin

199

310

GH

z m

icro

wav

e(E

CR

at 3

.6 k

G)

Sim

ple

min

imum

B s

truct

ure

•M

irror

fiel

d: 9

.3 k

G/ 7

.6 k

G•

Axi

al fi

eld:

8.0

kG

Ext

ract

ion

volta

ge: 2

5kV

max

.C

2+ In

tens

ity: 3

00 e

mA

(C4+

: 430

em

A)

Iron

yoke

Insu

lato

r

40cm

0

Sch

emat

ic V

iew

Of

NIR

S-E

CR

05

(kG

)10

Wat

erC

oolin

g

Plas

ma

Cha

mbe

r

Ext

ract

ion

Elec

trode

Mirr

orC

oil

sext

upol

em

agne

t

A. K

itaga

wa

et a

l., R

ev. S

ci. I

nstru

m. 7

9, 0

2C30

3 (2

008)

.

2. D

evel

opm

ent o

f ion

sou

rces

HIM

AC

NIR

S

Mai

nten

ance

-free

ion

sour

ce

Mic

row

ave

0 >

580

W

Mag

net

0 >

450

A

gas

flow

0 >

0.09

cc/

mVa

cuum

Beam

Inte

nsity

012

0(m

in)

10-6

10-7

(Tor

r)

Varia

tion

in th

e be

am in

tens

ity a

fter s

tarti

ng th

e EC

RIS

Mic

row

ave

0 >

580

W

Mag

net

0 >

450

A

gas

flow

0 >

0.09

cc/

mVa

cuum

Beam

Inte

nsity

012

0(m

in)

10-6

10-7

(Tor

r)

Varia

tion

in th

e be

am in

tens

ity a

fter s

tarti

ng th

e EC

RIS

< 20

min

2. D

evel

opm

ent o

f ion

sou

rces

Mar

. 200

4M

ay 2

007

Mar

. 200

6

Mar

. 200

5

NIR

S-E

CR

Cle

an u

p

HIM

AC

NIR

S

‘1st

Com

mer

cial

Med

ical

Dev

ice’

at H

IBM

C2.

Dev

elop

men

t of i

on s

ourc

es

ECR

1EC

R2

RFQ

linac

+25

kV+2

5 kV

+80

kV+4

5 kV

H2+

C4+

35 k

eV/u

Con

stru

cted

in 1

999

Alm

ost c

opy

of N

IRS-

ECR

Life

time:

ove

r one

yea

rEx

trac

tion

volta

ge: 2

5kV

max

.H

igh

volta

ge p

latfo

rm w

ith 8

0kV

max

.C

4+In

tens

ity: 4

00 e�A

H2+

Inte

nsity

: 1.3

em

A

HIM

AC

NIR

S

Req

uire

men

t for

the

hosp

ital s

peci

fied

faci

lity

�10

023

.6 (1

.6 K

ilp.)

2.5

�0.

3560

01020

061/3

RFQ

7N

orm

aliz

ed A

ccep

tanc

e, �

mm�m

rad

600

Inpu

t Ene

rgy,

keV

/u4,

000

Out

put E

nerg

y, k

eV/u

�0.

35In

side

dia

met

er o

f tan

k, m

3.5

Tank

leng

th, m

23.6

(1.6

Kilp

.)M

ax. s

urfa

ce fi

eld,

MV/

m�

500

Peak

RF

pow

er, k

W

200

Freq

uenc

y, M

Hz

1/3

q/A

IH-A

PFIte

ms

2. D

evel

opm

ent o

f ion

sou

rces

HIM

AC

NIR

S

Des

ign

conc

ept o

f Kei

ser

ies

2. D

evel

opm

ent o

f ion

sou

rces

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NIR

S-EC

RK

ei, K

ei2

1.R

epla

ce c

oils

by

perm

anen

t mag

nets

.2.

But

it’s

mirr

or ra

tio is

adj

uste

d to

goo

d ex

perie

nces

at

NIR

S-E

CR

.3.

Mic

row

ave

coup

ling,

cha

mbe

r coo

ling,

and

vac

uum

st

ruct

ures

follo

w m

any

prac

tices

at N

IRS

-EC

R.

4.H

igh

volta

ge in

sula

tion

stru

ctur

e le

arns

exp

erie

nces

at

NIR

S-H

EC

.

Goa

lK

eep

the

sim

ilar

perfo

rman

ce•

C4+

inte

nsity

•Li

fetim

e•

Eas

y m

aint

enan

ce

& o

pera

tion

HIM

AC

NIR

S

‘The

pro

toty

pe’K

ei2

at th

e te

st b

ench

Dev

elop

ed in

200

2A

ll pe

rman

ent m

agne

ts re

aliz

ed th

e si

mila

r ra

tio o

f mag

netic

fiel

ds a

t NIR

S-EC

R10,

0.25

GH

z 65

0W T

WT

ampl

ifier

H

igh

extr

actio

n vo

ltage

: 30k

V (4

0kV

max

.)Li

fetim

e: o

ne y

ear

C4+

Inte

nsity

: 600

e�A

(1 e

mA

max

.)

2. D

evel

opm

ent o

f ion

sou

rces

M. M

uram

atsu

et a

l., R

ev. S

ci. I

nstru

m. 7

6, 1

1330

4 (2

005)

.

HIM

AC

NIR

S

NIR

STe

chno

logy

Tra

nsfe

r-D

raw

ings

-Cal

cula

tion

resu

lts-O

pera

tion

data

etc…

Gun

ma

Uni

v.

Pro

toty

pem

odel

Orig

inal

Dev

elop

men

t

Ven

der

Man

ufac

turin

g co

mpa

nies

for p

arts

Com

mer

cial

mod

el

Mod

ifica

tion,

Man

ufac

turin

g

Ord

er o

f the

who

le o

f fac

ility

Ord

er o

f the

inje

ctor

par

t

Com

mer

cial

mod

el is

alm

ost a

cop

y of

pro

toty

pe, b

ut it

is n

ot e

xact

sam

e.-s

impl

ified

stru

ctur

e fo

r mas

s pr

oduc

tion

-fix

ed o

pera

tion

para

met

ers

-uni

ficat

ion

for t

he m

aint

enan

ceet

c…

Japa

nese

gov

ernm

ent (

ME

XT)

Fund

to p

roje

ct

Tech

nolo

gy tr

ansf

er

2. D

evel

opm

ent o

f ion

sou

rces

HIM

AC

NIR

S

Kei

GM

at G

unm

a U

niv.

Laun

ched

to th

e lin

acin

200

9A

lmos

t cop

y of

Kei

210,

0.25

GH

z 65

0W T

WT

ampl

ifier

H

igh

extr

actio

n vo

ltage

: 30k

VLi

fetim

e: o

ne y

ear

C4+

requ

irem

ent:

200

e�A

2. D

evel

opm

ent o

f ion

sou

rces

M. M

uram

atsu

et a

l., R

ev. S

ci. I

nstru

m. 7

6, 1

1330

4 (2

005)

.

Pla

sma

cham

ber

Insu

lato

r Ext

ract

ion

elec

trode

(Fix

ed p

ositi

on)

Ein

zel l

ens

Wat

erco

olin

g

3. P

rese

nt s

tatu

s of

ion

sour

ces

HIM

AC

NIR

S

HIB

MC

Hyo

go(2

001)

HIM

AC

Chi

ba(1

994)

GH

MC

Gun

ma

(201

0)

SAG

A-H

IMA

TSa

ga(2

013)

iRO

CK

Kan

agaw

a(2

015)

Hea

vy io

nH

eavy

ion

(und

er c

onst

ruct

ion)

Prot

on (i

nclu

ding

shu

tdow

n)Pr

oton

(und

er c

onst

ruct

ion)

Pres

ent f

acili

ties

3. P

rese

nt s

tatu

s of

ion

sour

ces

2014

(pla

n)iR

OC

KK

?20

12(p

lan)

SAG

A-H

IMA

TK

Kei

SA20

10H

IMA

CK

Kei

220

09G

HM

CK

Kei

GM

1999

HIB

MC

NEC

R2

1999

HIB

MC

NEC

R1

1997

HIM

AC

HN

IRS-

HEC

1993

HIM

AC

NN

IRS-

ECR

Laun

chFa

cilit

yTy

peN

ame

N: N

IRS-

ECR

type

K: K

ei s

erie

sH

: NIR

S-H

EC

HIM

AC

NIR

S

Ope

ratio

n of

NIR

S-EC

R ty

pe

5. D

evel

opm

ent o

f hos

pita

l-spe

cifie

d fa

cilit

y

NIR

S-EC

RSt

atus

in 2

011

Ope

ratio

n tim

e: a

ppro

xim

atel

y 60

00 h

ours

/ ye

ar*

Serio

us fa

ilure

: non

eIte

ms

of ro

utin

ely

mai

nten

ance

:•In

side

of t

he p

lasm

a ch

ambe

r=

no p

olis

h, o

nly

colle

ct d

usts

(1 y

ear)

•Insu

lato

r = cl

ean

up (1

y),

repl

ace

(sev

eral

yea

rs)

•Wat

er s

uppl

y =

repl

ace

(sev

eral

yea

rs)

•TW

T tu

be = re

plac

e (o

ver 1

5,00

0 h)

•Sm

all e

lect

roni

cs p

arts

= re

plac

e (s

ever

al y

ears

)•C

ontr

ol s

yste

m=

repl

ace

(irre

gula

r)

* R

ecen

t yea

rly

oper

atio

n tim

e20

05: 5

900

2006

: 594

820

07: 5

887

2008

: 609

120

09: 5

691

2010

: 592

420

11: 6

305

HIM

AC

NIR

S

Det

erio

ratio

n by

car

bon

depo

sitio

n

5. D

evel

opm

ent o

f hos

pita

l-spe

cifie

d fa

cilit

y

Cle

an u

p

HIM

AC

NIR

S

Ope

ratio

n of

Kei

2 ty

pe

5. D

evel

opm

ent o

f hos

pita

l-spe

cifie

d fa

cilit

y

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e: 4

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rious

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re: 1

at th

e m

icro

wav

e am

plifi

erM

aint

enan

ce it

ems:

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lean

ing

of c

ham

ber (

a ha

lf y)

= po

lish

Ion

sour

ce fo

r iR

OC

KK

ei2

type

has

sel

ecte

d.

Kei

SA The

basi

c pe

rfor

man

ce h

ad b

een

test

ed a

t the

fact

ory

and

has

been

in

stal

led

in th

e fa

cilit

y.

It w

ill b

e la

unch

ed in

Dec

embe

r.

Sum

mar

y1.

App

roac

hes

for t

he p

rom

otio

n in

Jap

anC

arbo

n io

n ra

diot

hera

py (C

-RT)

has

bee

n pr

omot

ed in

Jap

an;

�Th

e yi

eld

of H

IMA

C p

roje

ct h

as a

wak

ened

inte

rest

s of

loca

l re

gion

s. T

here

are

five

faci

litie

s un

der o

pera

tion

or c

onst

ruct

ion

�Th

e ap

proa

ches

for t

he p

rom

otio

n ar

e al

mos

t bas

ed o

n 10

-yea

r S

trate

gy b

y th

e go

vern

men

t. 2.

Dev

elop

men

ts o

f ion

sou

rces

Ther

e ar

e tw

o ty

pes

of E

CR

ion

sour

ces

for C

-RT;

�

NIR

S-E

CR

suc

cess

fully

real

ized

the

daily

clin

ical

use

.�

Kei

ser

ies

had

been

opt

imiz

ed fo

r a C

-RT

dedi

cate

d fa

cilit

y.

3.Pr

esen

t sta

tus

of io

n so

urce

sE

ach

ion

sour

ces

satis

fied

the

requ

irem

ents

.

The

15t

h In

tern

atio

nal C

onfe

renc

e on

Ion

Sour

ces

9 -1

3 Se

ptem

ber

2013

Mak

uhar

iMes

se, C

hiba

, Jap

an

Org

anize

d by

Nat

iona

l Ins

titut

e of

Rad

iolo

gica

l Sci

ence

sFo

r fur

ther

info

rmat

ion

will

be

deliv

ered

on

http

://w

ww

.nirs

.go.

jp/c

onf/i

cis1

3/

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