renal physiology - semantic scholar
Post on 27-Feb-2022
6 Views
Preview:
TRANSCRIPT
Renal Physiology
Secretion
• Selective process of transferringmolecules from the extracellular fluid intothe lumen.
• K+ regulation by Aldosterone in the distaltubule.
• Aldosterone is synthesized in the adrenalcortex and released when there areincreased levels of K+.
Secretion II
• Through translation of protein channelsand modifier proteins, K+ is secreted intothe lumen of the distal tubule.
• Remember the Na+-K+-ATPase on thebasolateral membrane??
• Well, Na+ reabsorption is necessary forthis mechanism.
Vasopressin/ADH
• Vasopressin is released by the posteriorpituitary and aids in water retention.
• Controls urine concentration in thecollecting duct by reabsorbing water.
• ADH bind to it’s receptor and through acAMP signal, Aquaporin-2 water pores aremoved to the apical membrane.
• Water is recovered.
Effects of Alcohol
• Alcohol inhibits ADH secretion.• Water recovery is significantly diminished
and urine volume increases.
top related