reisel et al., nature neuroscience. 2002
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Let us assume that repetition tends to induce lastingcellular changes... When an axon of cell A is near enoughto excite a cell B, some growth or metabolic change takesplace such that A's efficiency is increased.
Donald Hebb, 1949
The problem which philosophers have set themselves is thatof ascertaining, between thoughts which appear to spoutone out of the other, the principles of connection wherebytheir peculiar succession or coexistance might be explained.
William James, 1892
dendritic spine
sprouting of new terminal bouton
smaller, thicker neck of dendriticspine: offers less electrical resistance
increased release ofneurotransmitter
more postsynaptic receptors,larger response to neurotransmitter
nucleus from egg
nucleus from sperm
insert deletor for ampareceptor subunit glur1
allow eggto divide
birth: only some offspringcarry the deletion
CA1 field
entorhinal cortex
stimulate axons
record from dentate gyrus
dentate gyrus
CA3 field
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Reisel et al., Nature Neuroscience. 2002
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Reisel et al., Nature Neuroscience. 2002
1 deletion of the glur1 gene disrupts plasticity
3 it is however involved in working memory
2 this type of plasticity is not involved in long term memory
Schmitt et al., Journal of Neuroscience, 2003
Schmitt et al., Journal of Neuroscience, 2003
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Reisel et al., Nature Neuroscience. 2002
10 seconds delay Response
time
GluR1 knockout mice are impaired on a delayed response task (DRL), with a delay of 15 seconds
GluR1 knockout mice show normal acquisition of a non-spatial delayed response task (DRL), with a delay of 10 seconds
Delayed Response Task (DRL): 10 vs. 15 seconds delays
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Hopfield's terrain model of memory
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