receptors and signal transductionhomepage.ntu.edu.tw/~mchuang/receptor signaling.pdf · molecular...
Post on 11-May-2020
7 Views
Preview:
TRANSCRIPT
Receptors and Signal transduction
Min‐Chuan Huang
mchuang@ntu edu twmchuang@ntu.edu.tw
1Molecular Cell Biology 6th ed. Lodish et al.
3
I ll l i li hIntracellular signaling pathways
• Kinases and phsphatases
GTP f il• GTPase superfamily
• Second messengers• Second messengers
4
Kinases vs. phosphatases
Journal of Cell Science 121, 551-559 (2008)
5
GTPase superfamilyp y
6
7
8
Second messengers
9
10
11
12
13
cAMPPKA‐AKAP‐Effector
14
Eight major classes of cell surface receptors
TNFαTNFαreceptors
15
G-protein-coupled receptor (GPCR) signaling
Internalization
Scaffold proteins signaling
RGS
GRKPKAPKC
RGS
16
Modified from TRENDS in Pharmacological Sciences Vol.22 No.7 July 2001, 368-376
TGFβ and TGFβ receptors
17
Activated TGFβ receptors phosphorylate Smadtranscription factorstranscription factors
R‐Smads: receptor‐regulated Smads(Smad2, Smad3, Smad1, Smad5, Smad8/9)( , , , , / )
Co‐Smads: common‐mediated Smads(Smad4)
I Smads: inhibitory SmadsI‐Smads: inhibitory Smads(Smad6, Smad7)
18
Downregulation of Smad transcription activationfunction(Ski d S )(Ski and Sno)
19Ski, Sno, and I‐Smads are negative regulators in TGFβ signaling
Cytokine Receptors and the JAK/STAT Pathway
20
21
Activation of Cytokine Receptors
22
Activation of STAT proteins
23
Termination of EpoR signaling
24
Receptor Tyrosine Kinases
25
Ligand‐induced dimerization of HER1
26
The HER family of receptors and their ligands
27
28
Activation of Ras
29
Ras/MAP kinase pathway
30
MAP kinase regulates the activity of transcription factors controlling early‐response genesfactors controlling early response genes
31
The canonical Wnt signalling pathwayThe canonical Wnt signalling pathway
32
Nat Rev Mol Cell Biol. 2010 Jun;11(6):404-13.
Hedgehog (Hh) signalling pathwayHedgehog (Hh) signalling pathway
33
TNF‐α/NF‐κB signalling pathway
34
Notch signalling pathway
35
top related