preface - hindustan herbals · it is our pleasure to announce seamless, synergistic and successful...
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It is our pleasure to announce seamless, synergistic and successful integration of Hindustan Herbals Limited (HHL) with Sanat Products Limited. HHL has GMP Certi�ed, state-of-the-art manufacturing facility in Rohtak, Haryana , India. A leader in Herbal extracts and Phytochemicals, with specialities in Licorice and all its variants.
This catalogue extends good glimpse on products, processes, state-of-the-art laboratory and sophisticated instruments.
Sanat’s strategy is to maintain leadership position in Natural Products market, this amalgamation is a step corresponding to strategy and enable to serve a wide variety of botanicals to global customers in Pharmaceuticals, Nutraceuticals, Foods, Cosmetics and Personal Care Industries.
Sanat always looks forward to expand in the vertical it operates and majorly three factors propelled us for this acquisition:• Expansion of capacities• Diversi�cation into a newline of ingredients: Phytochemicals• Goal to become one stop solution to global customers
HHL has plans to subsequently prepare for WHO-GMP and other accreditations, which is in line with our focus on ful�lling global market requirements. Sanat and HHL has commitment to adhere sustainable environmental practices.
With this, I congratulate enthusiastic and pro�cient team of Sanat and HLL , let us carve strong foothold in the industry for a remarkable growth .
All the best.
PREFACE
Amit SharmaBusiness Head
Incorporated in the year 2010 at Rohtak, Hindustan Herbals is recognized as leading manufacturer of Licorice Extract and its derivatives like MAG, DGL, DPG, Enoxolone and Glabridin. We have a dedicated plant to process 5 MT of Licorice per day.
Hindustan Herbals have strong hold on procurement of high quality raw material from Central Asia and Middle East. We have a strong sourcing network from multiple approved suppliers. To safeguard against any deviation, we always maintain an inventory of Licorice roots that can last 20-24 months.
Hindustan Herbals offers a wide range of Licorice extract and its derivatives which are based on three main components: Glycyrrhizinic Acid, Glycyrrhetinic acid and Glabridin.
ABOUT HINDUSTAN HERBALS
ABOUT LICORICELicorice is the root of Glycyrrhiza glabra from which a sweet �avour can be extracted. The licorice plant is a herbaceous perennial legume native to Southern Europe and parts of Asia. The sweetness in licorice comes from glycyrrhizin, a compound with pharmaceutical effects, that is 30–50 times sweeter than sucrose.
Since the middle age, Licorice was not only important medicinally, but also was used as a �avoring agent in sweets and tobacco, as a foaming agent in �re extinguishers & beers and used in isolated millboard.
Licorice is official in all pharmacopoeias, which only differ as to which variety is recognized, the botanical name, and whether the accepted root be peeled or unpeeled.
INDUSTRIES USING LICORICE AND ITS DERIVATIVES
TobaccoFlavour Enhancing
Moistening Agent
Eliminates undesirable taste
Intensifies & extendssweetness
Intensifies & extendsflavours
Food &Flavouring
Masks unpleasant flavour
Useful in dermatological, gastro-intestinal &
optical disorder
Pharmaceuticals
Anti- inflammatory
Co-emulsifier ingredient
Treat skin disorders
Cosmetics &Personal Care
LICORICE EXTRACT
Grades Offered
Glycyrrhizinic acid Upto 90% by HPLC
Botanical Name: Glycyrrhiza glabra
Family: Fabaceae
Part Used: Roots
Active Substance: Glycyrrhizin/Glycyrrhizinic acid
CAS No.: 68916-91-6
Licorice extract is obtained from the water extraction of Licorice roots. The chief component of Licorice, Glycyrrhizin, gives licorice its characteristic �avor. The taste of glycyrrhizin “overrides” its sweetness, thus giving it a distinct �avor and different sweetness than sugar. The sweetness of glycyrrhizin lingers in the mouth for some time as well.
WaterExtraction
Concentration &Crystallization
Crude LicoriceExtract
Filteration
Food Beverages Nutraceuticals Pharmaceuticals Personal Care Cosmetics Oral Health Products Skin Protection Animal and Pet Products
Applications
ActionPharmacological:Anti-in�ammatory, Anti- irritant
Cosmetic/Personal Care:Increase skin elasticity, penetration enhancer, moisturizing and hydration, anti- in�ammatory, antioxidant, calms visible irritation
Organoleptic:Eliminate aftertaste, enhance and extend sweetness, enhance �avors, enhance mouthfeel
DE-GLYCYRRHIZINATED LICORICE (DGL)
Botanical Name: Glycyrrhiza glabra
Family: Fabaceae
Part Used: Roots
Active Substance: Glycyrrhizinic acid
CAS No.: 1405-86-3
De-glycyrrhizinated Licorice is obtained from the hydro-alcoholic or water extraction of Licorice roots from which the glycyrrhizin has been removed. It is a herbal supplement typically used in the treatment of gastric and duodenal ulcers.
Parameters Speci�cations
Description Light brown to dark brown powder
Solubility Soluble in water
Identi�cation Positive for Glycyrrhiznic acid by TLC
LOD NMT 7% w/w
Ash NMT 20% w/w
Heavy Metals NMT 10 ppm
Assay (by HPLC) Minimum 0.5% and Maximum 5.00%
Residual solvent (by GC-HS) Complies limit as per USP Guidelines
Hydro- AlcoholicExtraction /
Water Extraction
Concentration &Crystallization
De-glycyrrhizinatedLicorice
Filteration
Filtration &Concentration
Food & Confectionery Beverages Nutraceuticals Pharmaceuticals Personal Care Cosmetics Oral Health Products Skin Protection
Applications
ActionPharmacological:Anti-in�ammatory, Antacid, used to relieve heartburn, indigestion and GERD
Cosmetics/Personal Care:Increase skin elasticity, penetration enhancer, moisturizing and hydration, anti- in�ammatory, antioxidant, calms visible irritation
Organoleptic:Enhance and extend sweetness, enhance �avors, enhance mouthfeel
Monoammonium Glycyrrhizinate is the ammonium salt of Glycyrrhizic acid. It is used to increase skin elasticity, enhance penetration, improve moisturizing and hydration. It is used as an anti-in�ammatory, antioxidant and anti-irritant. It is also used in food and beverages to enhance the sweetness and natural �avour.
MONOAMMONIUM GLYCYRRHIZINATE(MAG)
Botanical Name: Glycyrrhiza glabra
Family: Fabaceae
Part Used: Roots
Active Substance: Glycyrrhizic Acid
CAS No.: 53956-04-0
Parameters Speci�cations
Description White or Yellowish White Crystalline powder
SolubilitySlightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone, dissolves in dilute solution of acids and of alkali hydroxides
Identi�cation Positive for Glycyrrhizic acid by TLC
Speci�c Optical Rotation + 49.0° to + 54.0°
Related Substance (by HPLC)18 α- glycyrrhizic acidImpurity AAny other ImpurityTotal unknown impurities
NMT 10.0%NMT 5.0%NMT 2.0%(each)NMT 7.0%
Sulphated Ash NMT 0.2%Water NMT 6%Heavy Metals NMT 20 ppm
Assay (By Titration) Between 98.0% to 102% (on dried basis)
Residual Sovent (By GC-HS) To comply as per ICH guidelines
Hydro- AlcoholicExtraction
Concentration &Crystallization
MonoammoniumGlycyrrhizinate
Filteration
Crude LicoriceExtract
Ammonia Treatment & Puri�cation Food Beverages Nutraceuticals Pharmaceuticals Personal Care Cosmetics Oral Health Products Skin Protection Animal and Pet Products
Applications
ActionPharmacological: Anti-in�ammatory, Anti- allergic, Anti-bacterial, Anti-viral
Cosmetic/Personal Care:Increase skin elasticity, penetrationenhancer, moisturizing and hydration,anti- in�ammatory, antioxidant,calms visible irritation
Organoleptic: Eliminate aftertaste, enhance and extend sweetness, enhance �avors, enhance mouthfeel
Enoxolone is obtained from the hydrolysis of Glycyrrhizic acid. Enoxolone has anti-in�ammatory properties. It is involved in the oxidation of cortisol (hydrocortisone) into cortisone, in the synthesis and release of histamine and in the increase in the intracellular calcium concentration induced by an antigen.
ENOXOLONE(EP)
Botanical Name: Glycyrrhiza glabra
Family: Fabaceae
Part Used: Roots
Active Substance: Glycyrrhizic Acid
CAS No.: 471-53-4
Parameters Speci�cations
Description White crystalline powder
Solubility Practically insoluble in water, soluble in ethanol,sparingly soluble in Methylene Chloride
Speci�c Optical Rotation + 145.0° to + 154.0°
Related Substance (by HPLC)Any impurityTotal impurities
NMT 0.7% (each)NMT 2.0%
Sulphated Ash NMT 0.2%
LOD NMT 0.5%
Heavy Metals NMT 20 ppm
Assay (By Titration) Between 98.0% to101% (on dried basis)
Residual Sovent (By GC-HS) To comply as per ICH guidelines
Hydro- AlcoholicExtraction
Concentration &Crystallization
Enoxolone
Filteration
Crude LicoriceExtract
Hydrolysis
Personal Care Products Cosmetics Skin Protection
Applications
ActionPharmacological:Anti-in�ammatory, Anti-irritant,Anti-allergic, Anti-viral Cosmetic/Personal Care:Increase skin elasticity, penetration enhancer, moisturizing and hydration, anti-in�ammatory, antioxidant, calms visible irritation
Dipotassium Glycyrrhizinate is the potassium salt of Glycyrrhizic acid. It is used to increase skin elasticity, enhance penetration, improve moisturizing and hydration. It is used as an anti-in�ammatory, antioxidant and anti-irrtiant. It is also used in food and beverages to enhance the sweetness and natural �avour.
DIPOTASSIUM GLYCYRRHIZINATE
Botanical Name: Glycyrrhiza glabra
Family: Fabaceae
Part Used: Roots
Active Substance: Glycyrrhizic Acid
CAS No.: 68797-35-3
Parameters Speci�cations
Description White or Off White Crystalline powder
Solubility Soluble in water, slightly soluble in ethanol
Identi�cation Positive for Glycyrrhizic acid by TLC
Speci�c Optical Rotation + 40.0° to + 53.0°
Water NMT 5%
Heavy Metals NMT 20ppm
Assay (By UV) NLT 95%
Residual Sovent (By GC-HS) To comply as per ICH guidelines
Hydro- AlcoholicExtraction
Concentration &Crystallization
DipotassiumGlycyrrhizinate
Filteration
Crude LicoriceExtract
Treatment With KOH & Puri�cation Food Beverages Nutraceuticals Pharmaceuticals Personal Care Cosmetics Oral Health Products Skin Protection Animal and Pet Products
Applications
ActionPharmacological:Anti-in�ammatory, Anti-allergic,Anti-bacterial, Anti-viral, Anti-irritant
Cosmetic/Personal Care:Increase skin elasticity, penetrationenhancer, moisturizing and hydration,anti- in�ammatory, antioxidant,calms visible irritation
Organoleptic: Eliminate aftertaste, enhance and extend weetness, enhance �avors, enhance mouthfeel
Hydro- AlcholicExtraction
Concentration &Crystallization
DipotassiumGlycyrrhizinate
Filteration
Crude LicoriceExtract
Treatment With KOH Puri�cation
Food Beverages Nutraceuticals Pharmaceuticals Personal Care Cosmetics Oral Health Products Skin Protection Animal and Pet Products
Applications
ActionPharmacological:Anti-in�ammatory, Anti-allergic,Anti-bacterial, Anti-viral, Anti-irritant
Cosmetic/Personal Care:Increase skin elasticity, penetrationenhancer, moisturizing and hydration,anti- in�ammatory, antioxidant,calms visible irritation
Organoleptic: Eliminate aftertaste, enhance and extend weetness, enhance �avors, enhance mouthfeel
Stearyl Glycyrrhetinate is an ester of Glycyrrhetinic acid that increase skin elasticity, enhance penetration and improve moisturizing and hydration. It is used as an anti-in�ammatory, antioxidant and anti-irritant.
STEARYL GLYCYRRHETINATE
Botanical Name: Glycyrrhiza glabra
Family: Fabaceae
Part Used: Roots
Active Substance: Glycyrrhetinic acid
CAS No.: 13832-70-7
Parameters Speci�cations
Description White or Yellowish White Crystalline powder
Solubility Soluble in Mineral Oil, Polyethylene glycol, Stearyl Alcohol,very slightly soluble in water
Identi�cation Positive for Glycyrrhetinic acid by UV
LOD NMT 1%
Heavy Metals NMT 20 ppm
Assay by UV (ODB) NLT 95.0%
Residual Sovent (By GC-HS) To comply as per ICH guidelines
Melting point 70 - 77°C °C
Hydro- AlcoholicExtraction
Concentration &Crystallization
StearylGlycyrrhetinate
Filteration
Crude LicoriceExtract
Hydrolysis
18-ß GlycyrrhetinicAcid
Esteri�cation
Personal Care Products Cosmetics Skin Protection
Applications
ActionPharmacological:Anti-irritant, Anti-stinging Cosmetic/Personal Care:Increase skin elasticity, penetration enhancer, moisturizing and hydration, anti- in�ammatory, antioxidant, calms visible irritation
Hydro- AlcholicExtraction
PhaseExchange
Glabridin
Filteration Personal Care Products Cosmetics Skin Protection
Applications
ActionCosmetic/Personal Care:Cosmetic/Personal Care Whitening
GLABRIDIN
Grades Offered
Glabridin 10%, 40% & 60%
Glabridin 98%
by HPLC
Botanical Name: Glycyrrhiza glabra
Family: Fabaceae
Part Used: Roots
Active Substance: Glabridin
CAS No.: 59870-68-7
Glabridin is a natural whitening agent, used extensively in cosmetics. This product has �ne pigmentation and skin whitening, anti-in�ammatory functions, free radical scavenging activity, lipoxygenase activity inhibition and tyrosinase inhibition activity.
by HPLC
Hydro- AlcholicExtraction
PhaseExchange
Glabridin
Filteration
Personal Care Products Cosmetics Skin Protection
Applications
ActionCosmetic/Personal Care:Skin WhiteningAnti-in�ammatoryAnti-oxidantSpot removingUV absorption
Subsidiary of Sanat Products Ltd.
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