nmdp and be the match registry overview

NMDP and Be The Match Registry™ Overview

John P. Miller, MDPhD Cord Blood Symposium, San Francisco

June 5, 2013

About Transplant

A marrow or umbilical cord blood transplant is often the best or only hope of a cure for many patients with leukemia, lymphoma and other life-threatening diseases.

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70% of all patients who need a transplant do not have a matching donor in their family. They turn to the NMDP’s Be The Match Registry® to find an unrelated donor.

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National Marrow Donor Program is a nonprofit organization dedicated to creating an opportunity for all patients to receive the marrow or umbilical cord blood transplant they need, when they need it.

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Overview of Our Work

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Support Patients

Conduct & Support Research

Manage the Be The Match

Registry®

Educate Doctors

Facilitate Transplants

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NMDP Network

174 Transplant Centers (36 International)

100 Apheresis Centers (15 International)

44 Recruitment Centers

92 Collection Centers (15 International)

49 Donor Centers (8 International)

25 Cord Blood Banks (5 International)

1 Sample Repository 26 Testing

Laboratories

40 Cooperative Registries

Cord Blood Bank Network Membership Types US Number International

Number

NMDP Member Cord Blood Banks 19 NA

NMDP Affiliated Listing CBBs 1 (has own IND)

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CBBs Qualified under NMDP IND 19 63

Total CBBs accessible through NMDP

20 63

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International Activity

• 45% of transplants we facilitate have either an international donor or recipient

• More than 18.5 million potential adult donors and more than 590,000 cord blood units available worldwide

FY 2011

Be The Match Registry 2012 A

dult

Don

ors C

ord Blood U

nits

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Growth of Cord Blood Units on the Be The Match Registry®

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Diversity of Adult Donors on the Be The Match Registry® 2012

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Diversity of Cord Blood Units on the Be The Match Registry® 2012

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Transplants by Cell Source

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Transplants – Distribution of Cell Source

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Minority includes those patients with race of CAU, DEC, OTH, and UNK in combination with Hispanic ethnicity.

NMDP Transplants for Minority and Caucasian Patients

Transplants for Minority Patients by Cell Source

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Role of Cord Blood in Transplants by Patient Race

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Meeting Need of Minority Patients

• 44% of CBUs on the registry are from a minority donor (compared to 27% of adult donors)

• Over last 5-6 years cord blood has been product source for ~20% of all transplants • In 2012 thirty-nine percent of minority patients who received a transplant used cord blood • In 2012, 33 percent of cord blood transplants were for minority patients

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Transplants by Recipient Age

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Overall Survival, 3-year

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45 (42-48)%

55 (52-58)%

Malignant diseases, age <18 yrs

Non-malignant diseases Malignant diseases, age ≥ 60 yrs

Malignant diseases, age 18-59 yrs

P<0.001 P<0.001

25 (21-30)%

35 (33-37)%

60 (55-64)%

69 (66-72)%

P<0.001

2000-2004

2005-2009

Access to Transplant

• With expanded indications and age ranges, the calculated “need” for unrelated transplant has increased by 25%

• NMDP facilitated transplants have grown by 200% overall and 250% for minorities during that same timeframe

• Challenge – Meeting only 25% of the need in Minority communities and 50% of the need in the Caucasian population

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Access has improved since 2006

We advance transplant science through our research partner, CIBMTR®

(Center for International Blood and Marrow Transplant Research)

• Improved matching: making

it easier and faster to find the best donor or cord blood unit

• Improved timing: earlier

transplant is leading to better outcomes

• Advances in treatment:

making transplant a better option for patients 51-75 years old.

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We will continue to:

• Increase recruitment and availability of adult donors, cord blood and new cell sources.

• Help all patients get the

transplant they need, when they need it.

• Improve outcomes

through advances in research and clinical practice.

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Future Goals

• Join the Be The Match Registry®

• Make a donation to: - grow the registry - help patients cover uninsured costs - advance research • Spread the word about

the opportunity to help save a life

• Help collect high quality cord blood units (CBUs)

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You Can Help

The NATIONAL

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