nicotine
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WELCOME TO MY PRESENTATION
Submitted By: Ahteramul Haque, Student ID: BPH-
110100779, Northern University of
Bangladesh.
Nicotine
HEADLINES OF THIS PRESENTATION
What is nicotine? Something about the story of tobacco. Effects of nicotine on human. Why is nicotine so dangerous? How does nicotine get to human body? Diseases incurred by smoking. Pharmacokinetics. Pharmacodynamics. Treatment options. Anti-Smoking Ad Campaigns.
WHAT IS NICOTINE?
pyridin-N-metylpyrrolidin.
liquid alkaloid included in tobacco .
it is washable .
fresh is odourless, otherwise dirtily smells.
STRUCTURE : NICOTINE
N
N
CH3
SOMETHING ABOUT THE STORY OF TOBACCO
During Antiquity and Middle Ages Europe didn‘t know
about tobacco.
First tobacco was taken to Europe by Kolumbus in the
year 1492
Seeds of tobacco got here some about 20 years later
EFFECTS OF NICOTINE ON HUMAN
has ability to liberate dopamin thereby evoke
pleasant feelings.
helps smokers to refresh memory namely thanks to
activation of acetylcholine steps.
releases epinephrine from suprarenal gland .
WHY IS NICOTINE SO DANGEROUS?
fatal dose is 50mg
attenuation of CNS> apneusis > death
manifestations of poisoning: nausea, vomiting, diarrhea,
salivation, cold sweat, fuzziness
HOW DOES NICOTINE GET TO HUMAN BODY?
mostly nicotine is included in tobacco (0.6-8%)
to the bodies it gets by smoking,
nicotinic receptors respond very fast
Incidence on body is up to several minutes, however way
nicotine goes from lungs to the brain nicotine mere 7,5
seconds
DISEASES INCURRED BY SMOKING
Cardio-vascular disorder (25%)
Tuberculous disorder (30%)
Chronic pulmonary disorder (75%)
DETERMINANTS OF TOBACCO USE
Socioeconomic status
Cultural characteristics
Biological elements
Stress
Advertising (for and
against)
Price of tobacco products
Peer pressure
Anti-Smoking Ad Campaigns
PHARMACOKINETICS
Readily absorbed from all over the body, including
Lungs (smoked)
Mucosa (cigar, chewing tobacco, gum, nasal spray)
Skin (patch)
Gastrointestinal tract (uncommon)
PHARMACOKINETICS
Nicotine in smoke peaks in brain very rapidly, despite relatively slow increase in blood concentration
A typical cigarette contains 20 mg of nicotine
~2.5 mg of nicotine is absorbed
Half-life: ~ 2 hours
80-90% metabolized in liver
PHARMACODYNAMICS
Nicotine is a direct agonist for
nicotinic ACh receptors
Nicotine initially causes a rapid
release of adrenaline,
Has powerful effects on peripheral
nervous system, heart, and other
organs
POSITIVE EFFECTS
Increases learning and memory
Enhances connections between sets of neurons
CHRONIC EFFECTS: CANCER
Cancers relating to tobacco include: Mouth Throat Stomach Lung Larynx Esophagus Cervix
CONT…….
Cigarette smoking has been linked to about
90 percent of all lung cancer cases
430,000 annual deaths
ADDICTION
Nicotine meets both the psychological and physiological
measures of addiction
Psychological
Physiological
TREATMENT OPTIONS
Behavior modification Nicotine lozenges Nicotine gum Nicotine patches Nicotine inhaler Nicotine nasal spray
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