molecular testing in nsclc....pm->en egfr hist3h3 krt8 pld2 krt18 map2k1 mapku p nij map3k3 dnm...

div class=ts-pagebuttonPage 1button div class=ts-image amp-img class=ts-thumb alt=Page 1: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails1jpg width=142 height=106 layout=responsive amp-img divpMolecular testing in NSCLCp pPPauwels UZAUZGpdivdiv class=ts-pagebuttonPage 2button div class=ts-image amp-img class=ts-thumb alt=Page 2: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails2jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 3button div class=ts-image amp-img class=ts-thumb alt=Page 3: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails3jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 4button div class=ts-image amp-img class=ts-thumb alt=Page 4: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails4jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 5button div class=ts-image amp-img class=ts-thumb alt=Page 5: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails5jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 6button div class=ts-image amp-img class=ts-thumb alt=Page 6: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails6jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 7button div class=ts-image amp-img class=ts-thumb alt=Page 7: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails7jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 8button div class=ts-image amp-img class=ts-thumb alt=Page 8: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails8jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 9button div class=ts-image amp-img class=ts-thumb alt=Page 9: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails9jpg width=142 height=106 layout=responsive amp-img divpEGFRp p• Exist as monomersp p• Binds ligand changes shape and homohetero-dimerizep p• Autophosphorylation of tyrosine residuesp p• Recruitment of adaptorsignaling moleculesp p• Downstream signalingPao Miller JCO 200523:2556-2568pdivdiv class=ts-pagebuttonPage 10button div class=ts-image amp-img class=ts-thumb alt=Page 10: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails10jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 11button div class=ts-image amp-img class=ts-thumb alt=Page 11: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails11jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 12button div class=ts-image amp-img class=ts-thumb alt=Page 12: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails12jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 13button div class=ts-image amp-img class=ts-thumb alt=Page 13: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails13jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 14button div class=ts-image amp-img class=ts-thumb alt=Page 14: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails14jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 15button div class=ts-image amp-img class=ts-thumb alt=Page 15: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails15jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 16button div class=ts-image amp-img class=ts-thumb alt=Page 16: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails16jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 17button div class=ts-image amp-img class=ts-thumb alt=Page 17: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails17jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 18button div class=ts-image amp-img class=ts-thumb alt=Page 18: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails18jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 19button div class=ts-image amp-img class=ts-thumb alt=Page 19: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails19jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 20button div class=ts-image amp-img class=ts-thumb alt=Page 20: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails20jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 21button div class=ts-image amp-img class=ts-thumb alt=Page 21: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails21jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 22button div class=ts-image amp-img class=ts-thumb alt=Page 22: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails22jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 23button div class=ts-image amp-img class=ts-thumb alt=Page 23: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails23jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 24button div class=ts-image amp-img class=ts-thumb alt=Page 24: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails24jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 25button div class=ts-image amp-img class=ts-thumb alt=Page 25: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails25jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 26button div class=ts-image amp-img class=ts-thumb alt=Page 26: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails26jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 27button div class=ts-image amp-img class=ts-thumb alt=Page 27: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails27jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 28button div class=ts-image amp-img class=ts-thumb alt=Page 28: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails28jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 29button div class=ts-image amp-img class=ts-thumb alt=Page 29: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails29jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 30button div class=ts-image amp-img class=ts-thumb alt=Page 30: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails30jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 31button div class=ts-image amp-img class=ts-thumb alt=Page 31: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails31jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 32button div class=ts-image amp-img class=ts-thumb alt=Page 32: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails32jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 33button div class=ts-image amp-img class=ts-thumb alt=Page 33: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails33jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 34button div class=ts-image amp-img class=ts-thumb alt=Page 34: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails34jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 35button div class=ts-image amp-img class=ts-thumb alt=Page 35: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails35jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 36button div class=ts-image amp-img class=ts-thumb alt=Page 36: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails36jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 37button div class=ts-image amp-img class=ts-thumb alt=Page 37: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails37jpg width=142 height=106 layout=responsive amp-img divdivdiv class=ts-pagebuttonPage 38button div class=ts-image amp-img class=ts-thumb alt=Page 38: Molecular testing in NSCLCPM-EN EGFR HIST3H3 KRT8 PLD2 KRT18 MAP2K1 MAPKU p NIJ MAP3K3 DNM PRKCI PRKCG PRKCBI MAP2K7 MAPKI SMAD3 APPL2 RALBPI REPS AP2A1 … src=https:reader036vdocumentssitereader036viewer2022062404612f4ce51ecc515869435ad5html5thumbnails38jpg width=142 height=106 layout=responsive amp-img divdiv

molecular testing in nsclc....pm->en egfr hist3h3 krt8 pld2 krt18 map2k1 mapku p nij map3k3 dnm...

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