molecular biomimetics : genetically-engineered molecular materials for technology & medicine

Molecular Biomimetics: Molecular Biomimetics: Genetically-Engineered Molecular Materials for Technology & MedicineGenetically-Engineered Molecular Materials for Technology & Medicine

Mehmet Sarikaya,1,2 Beth Traxler,3 R. Samudrala,3A. Jen,1,4 B. Parviz,5 François Baneyx,2,6 Daniel T. Schwartz,2 & Candan Tamerler1

GEMSEC: Genetically Engineered Materials Science and Engineering (an NSF-MRSEC at the UW)Participating Departments: 1Materials Sci. & Eng., 3Chemical Eng. 2Microbiology, 4Chemistry, Electrical Eng., and 6Bioengineering, University of Washington, Seattle, WA 98195, USA,

sarikaya@u.washington.edu; http://www.GEMSEC.washington.edu & http://depts.washington.edu/nanobio

Summary: Utilizing recent advances in biology and physical sciences, we unite molecular genetic tools with synthetic nanoscale constructs to create a hybrid field, molecular biomimetics. Here, we adapt bio-schemes including combinatorial mutagenesis, bioinformatics, and computational biology to design novel peptides with specific binding to and assembly on functional nanoscale solids. Based on genome-based design, molecular recognition, and self-assembly principles, we engineer peptides as synthesizers, molecular erectors and assemblers in diverse areas from quantum electronic devices to molecular imaging and cell-free tissue engineering. Research supported by GEMSEC, an NSF-MRSEC & NIH.

New Materials Revolution!

Bioinformatics – In silico Designed Peptides

Nanofabrication

Tissue Engineering

Potential Implementations

Molecular Characterization Material Recognition and Selectivity by Peptides

Lessons from Mother Nature

Interdisciplinary Collaboration

Fundamentals&

Implementations

Dissemination

Projects Supported by NSF-MRSEC, NSF-BioMat, NSF-IRES, ARO, NIH

Principles of materials formation in Biology Combinatorial Mutagenesis

Peptides are workhorses in biology via ligand/receptor interactions – If we design a ligand peptide recognizing a nanoinorganic, then we can genetically engineer materials systems for technology & medicine!!

Neurodegenerative DiseasesTowards Quantum Electronic Devices

Cell Adhesion

Polydisciplinary Research & Implementation

Human revolutions proceeded materials revolutions

Summary