lecture questions. hypothesis? lactose persistence evolved by strong natural selection in african...
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LECTURE QUESTIONS
Hypothesis?Lactose Persistence evolved by strong natural selection in African populations but independently from European populations
Methods?
They conducted a genotype by phenotype association study in 470 Tanzanians, Kenyans and Sudanese
They also tested if the novel association significantly enhance transcriptionfrom the LCT promoter in vitro.
Frequency of lactase persistence in East African populations
Are the SNPs associated with lactase persistence in Africans?
LP = lactase persistence
LIP = lactase intermediate persistence
LNP = lactase non-persistence
Are the SNPs associated with lactase persistence in Africans?
Do C-14010, G-13915 and G-13907 SNPs affect expression in vitro?
How old are these haplotypes?
Are there evidences of Natural Selection?
Are there evidences of Natural Selection?
Yes! Convergent evolution of LP-associated variants
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