introduction to clinical research: research funding and career development

July 15, 2010 10:00 – 11:00

Introduction to Clinical Research:Research Funding and Career

Development

Michael B. Amey

Associate Dean

Office of Research Administration

July 15, 2010 10:00 – 11:00

Research Funding and Career Development

• Sources of Medical School Revenue• Primary Research Sponsors• Kinds of Support• Primary Initial NIH Grant Types• Where to find NIH Information• Success Rates• Institutional Resources• Usual Sequence

July 15, 2010 10:00 – 11:00

Research Funding and Career Development

• Sources of Medical School Revenue

July 15, 2010 10:00 – 11:00

July 15, 2010 10:00 – 11:00

Research Funding and Career Development

• Primary Research Sponsors

Sponsored Project SourcesJohns Hopkins School of Medicine

0

100

200

300

400

500

600

700

Fiscal Years

$ (

Millio

ns

)

Commercial 39.7 43.9 49.8 50 53.6 69.4 62.9 52.6 32 38 43

Other 50.4 56.7 60.6 66.9 70.4 102.9 97.9 107.1 98 92 98

Federal 208.8 244.4 298.5 328.9 398.8 451.4 461 456.1 475 495 513

99 0 1 2 3 4 5 6 7 8 9

July 15, 2010 10:00 – 11:00

July 15, 2010 10:00 – 11:00

July 15, 2010 10:00 – 11:00

Primary Sponsor Types

• Federal (79%)– NIH provides the majority of the federal

support – NSF is less than 1%– PHS and other Federal are each about 2%

FY 2009 NIH AwardsMedical School Rank

RANK SCHOOL $(Millions)

1 Johns Hopkins 435

2 UCSF 409

3 Penn 369

4 Washington Univ 358

5 Yale 323

6 Duke 322

7 Univ Of Michigan 319

8 Pittsburgh 316

9 Univ of Washington 279

10 UCSD 287

10:00 – 11:00July 15, 2010

July 15, 2010 10:00 – 11:00

Primary Sponsor Types

• Other (15%)– Disease Specific (small grants and fellowships)– Foundations (usually targeted)– State and Local Government (service and

demonstration)– Subcontracts from peer institutions

July 15, 2010 10:00 – 11:00

Primary Sponsor Types

• Commercial (6%)– Evaluation of Products– Development of JHU inventions– Some collaborative research

July 15, 2010 10:00 – 11:00

Research Funding and Career Development

• Kinds of Support

July 15, 2010 10:00 – 11:00

July 15, 2010 10:00 – 11:00

Kinds of Support

• Gifts– No benefit to donor– Can restrict purpose– No specified project

July 15, 2010 10:00 – 11:00

Kinds of Support

• Grants (assistance for a specified project)– Fellowships– Training Grants– Career Development Awards– Research Projects– Program Project and Center Grants

July 15, 2010 10:00 – 11:00

Kinds of Support

• Cooperative Agreements (federal assistance with program control)– NIH Multi-Center Clinical Trials

• Contracts (acquisition of materials or services)– Defines a deliverable material or service

– Federal are usually cost-reimbursement

– Commercial clinical trials usually fee based

July 15, 2010 10:00 – 11:00

Research Funding andCareer Development

• Primary Initial NIH Grant Types

July 15, 2010 10:00 – 11:00

Primary Initial NIH Grant Types

• F 32 Post-doctoral Fellowship (537 awards in '09)• Career Development Awards

– K (01-02) Mentored/Independent Research Scientist Award (144/26 awards in '09)

– K 08 Mentored Clinician Scientist Development Award (221 awards in '09)

– K 23/24 Mentored/Mid-Career Patient Oriented Research Career Development Award (227/41 awards in '09)

– K 99 NIH Pathway to Independence Award (204 awards in '09)

July 15, 2010 10:00 – 11:00

Primary Initial NIH Grant Types

• Research Project – R 01 Research Project Grant – usually

Investigator Initiated (3,601 new awards in '09)– R 03/21 Small/Exploratory & Development

Awards (543/1,423 competing awards in '09)

July 15, 2010 10:00 – 11:00

Research Funding andCareer Development

• Success Rates

July 15, 2010 10:00 – 11:00

July 15, 2010 10:00 – 11:00

NIH Award RatesInitial Grant Mechanisms

FY 2008

R01-Equivalent grants Applications, awards, and success rates

July 15, 2010 10:00 – 11:00

R01-Equivalent grants, New (Type 1) Success rates, by career stage of investigator

July 15, 2010 10:00 – 11:00

Research Career Development Awards Number of entry-level awards

July 15, 2010 10:00 – 11:00

July 15, 2010 10:00 – 11:00

Research Funding andCareer Development

• Institutional Resources

July 15, 2010 10:00 – 11:00

Institutional Resources

• Clinician Scientist Award

• Clinical Research Centers

• Fund for Medical Research

July 15, 2010 10:00 – 11:00

Institutional Resources

• Clinician Scientist Program– To protect research time of promising young

clinical faculty– Application – draft, submitted or already

awarded proposal to a peer review sponsor, Ltrs from Dept. Director & 2 others and interview (due Nov and April 1st)

– Reviewed by a senior faculty committee representing basic and clinical disciplines

July 15, 2010 10:00 – 11:00

Institutional Resources

• Clinician Scientist Program– Instructor or Assistant Professor who is an

active physician clinician with excellent potential for external awards (is/has completed research training)

– Provides up to $80/yr for a max of 2 yrs to support unfunded research effort up to 75% (max when holding an award >$50K is a CSA of $40K)

July 15, 2010 10:00 – 11:00

Institutional Resources

• Clinical Research Centers - CTSA– Provides patient care costs for investigator

initiated clinical research approved by each centers peer review committee

– Funded by NIH grants from NCRR

July 15, 2010 10:00 – 11:00

Institutional Resources

• Clinical Research Centers (part of the Clinical Translational Science Award - CTSA)

– Johns Hopkins has 4• JHBMC

• JHH

– Adult Inpatient (Osler 5)

– Adult Outpatient (Carnegie 3)

– Combined Pediatric PCRU (Blalock 3)

– Pediatric Neuro Imaging (KKI)

July 15, 2010 10:00 – 11:00

Institutional Resources

• Fund for Medical Discovery– Pilot or matching support for new

interdisciplinary/interdepartmental research initiatives that will lead to new extramural support

– Requires departmental matching of 25%– Proposals are due Sep, Jan and May 15th

July 15, 2010 10:00 – 11:00

Research Funding andCareer Development

• Usual Sequence

July 15, 2010 10:00 – 11:00

Usual Sequence

• Basic Scientist

– F32 or NRSA Training grant

– K (01/02) Mentored/Independent Research Scientist Career Development Award

– Research Project Award (R 01/ R 03/R 21)

July 15, 2010 10:00 – 11:00

Usual Sequence

• Clinician Scientist

– Mentored Clinician Scientist (K-08) or Patient Oriented Research Development Award (K 23)

– Clinician Scientist Award

– Research Project Grant (R 01, R 03, R 21)

July 15, 2010 10:00 – 11:00

Research Funding and Career Development

• Sources of Medical School Revenue• Primary Research Sponsors• Kinds of Support• Primary Initial NIH Grant Types• Where to find NIH Information• Success Rates• Institutional Resources• Usual Sequence

July 15, 2010 10:00 – 11:00