graduation project i device for controllable administration of drug dosage prepared by: - mona...

Graduation Project I

Device for controllable administration of drug dosage

Prepared By: - Mona Ibrahim 200002091 - Azza Al Hassani 200002019 - Asma Ahmed 200002020 - Hamda Al Ketbi 199902209 - Moza Al Shamsi 199903856

Adviser’s name : - Dr. Yousef Haik

Presentation Layout

Motivation Objectives Design Process Testing Device Dispensing Device Communication Device Conclusion

Motivation

Dispensing Device

Testing Device

Physician

Patient

Project DescriptionProject Description

Blood Clotting

A natural process in which blood cells and fibrin strands clump together to stop bleeding

Blood Coagulation Mechanism

Prothrombin Time (PT)

• The time it takes plasma to clot. • PT is reported in seconds

International Normalization Ratio (inr)

• The ratio of the patient's clotting time to the mean reference value.

)(normal

test

PT

PTINR

Anticoagulants

Medications that delay

the coagulation of blood Some of these are:

Heparin Argatroban

Hirudin Warfarin

Warfarin

the most widely used oral

anticoagulant.

It is a non-habit forming medication.

to prevent formation of new blood

clots in high-risk patients

Motivation

Frequent Monitoring

Dose adjustment

Reduce patient error

Time saving

Availability of a patient medical history

Reduce visitation to clinic.

Objectives

Design a blood testing mechanism

Design a drug dispensing mechanism

Design and construct a working prototype of the system Dispensing

DeviceTesting Device

Physician

Patient

Design Process

Gantt Chart

The ProTime System-PT-

INR Testing

Market Analysis

Coaguchek System

INRatio®PT Monitoring

System

The Harmony INR

Monitoring System

Function Structure

Drug dose

Blood sample

System

Global device function

Overall function structure

Blood Sample Testing

DeviceDispenser

Communicator

INR value Dose

Drug Dosage Hold

Sample

Specifications

Dispensing DeviceMeasuring Device

Touch button operation

Portable and easy to use

Large, easy to read reporting screen

Durable

Repeatable

Cost effective meter and test strip

Dimension 5"×3"

Touch button operation

Portable and easy to use

Large, easy to read reporting screen

Durable

Repeatable

Cost effective meter and test strip

Dimension 5"×3"

Small sample volume: 20 µL

Perform measurement automatically as soon as the sample is applied

Measuring time is less than one minute

Sensitive: can measure less than 1 mg/mL of Prothrombin

Small sample volume: 20 µL

Perform measurement automatically as soon as the sample is applied

Measuring time is less than one minute

Sensitive: can measure less than 1 mg/mL of Prothrombin

Measuring Device

Made of biocompatible materials

Disposable sample holder

Meet the International Biomedical Instrumentation standards

Made of biocompatible materials

Disposable sample holder

Meet the International Biomedical Instrumentation standards

Store medicine

Dispense one tablet at the time Time for dispensing to be less than 2 minutes

Patient interference to the device is negligible

Store medicine

Dispense one tablet at the time Time for dispensing to be less than 2 minutes

Patient interference to the device is negligible

Cost effective

Durable

Dimension 5”×2.5”

Safe, no sharp corner

Cost effective

Durable

Dimension 5”×2.5”

Safe, no sharp corner

Dispensing Device

Cost effective

Dimension 5”×3”

Communication between the medical doctor and the device within one day

Cost effective

Dimension 5”×3”

Communication between the medical doctor and the device within one day

Communication Device

The whole device dimension should not exceed 26.5"×12"

The whole device dimension should not exceed 26.5"×12"

Developing concepts

Testing Morphological Chart

Hold Sample

Testing methods

1.RLC1.RLC

2. Protein 2. Protein separationseparation

3. Contact 3. Contact angleangle

4. Plasma 4. Plasma profileprofile

5. 5. ViscosityViscosity

6. Light 6. Light intensity intensity

7. Shear 7. Shear stressstress

88.Charged.Charged

ParticleParticle

9.Elisa9.Elisa

10.Cantilever 10.Cantilever beam beam

11.Piezoelect11.Piezoelectricric

1212. Blood . Blood layer layer thicknessthickness

Display INR

Digital display

PrinterLED

monitorLCD

Testing Methods

1 .RLC Testing Method

Experiments

Measuring the capacitance across the copper plates with time

Capacitance vrs Time

2

2.1

2.2

2.3

2.4

0 5 10 15 20 25

Time (sec)

C (

Mic

ro F

arad

)

Series1

experiments

Measuring the capacitance across the copper plates with time for different INR values (adding tissue factor)

Capacitance vs time

0

0.2

0.4

0.6

0.8

1

1.2

1.4

1.6

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5

Time (min)

Cap

acit

ance

(µ

F)

INR=1.7

INR=1

INR=2.4

Contact angle Method

Contact angle measurements

camera

sample stage

light source

Syringe

Captive Bubble Contact Angle apparatus

ResultResult

θ is too small to measure

Measure surface area

Surface Area method

Protein Separation Method

viscosity Method

Charged particle Method

Resistance measurements

Measuring the distance moved

Shear stress

Light intensity Blood layer thickness

Cantilever beam Method Plasma profile Method

More

Drug dispensing device

dispenser Morphological Chart

Tablet Holder

Mover

Belt

Shaft

Gear

Pulleys

Manual

Rollers

Piston

dispenser Morphological Chart

ActuatorDc motor

pneumatic

hydraulic

Step motor

countIR sensor

Laser Sensor

Distance Sensor

Lock

solenoidWorm gearSpring damping

Spring solenoid

arm locking)hook(

dispenser Morphological Chart

Cuttercutter

Scissors)Sharp (

Paper cutterUtility

Knife

Ejector

Dispensing concept 1

Dispensing concept 2

Dispensing concept 3

Dispensing concept 4

Dispensing concept 5

Communication device

communication Morphological Chart

Sending signals

Wire

modem

Sound

Fiber optic

Laser

transmitter

Cost estimation

The budget

CONCLUSION

FUTURE WORK

Resuming investigating the testing methods

Evaluating testing methods to select the proper one

Analyzing the design of testing, dispensing, and communication

Building a prototype for the whole device

Experiments