fusion 1 day presentation

The contact lens that The contact lens that thinks its an eye dropthinks its an eye drop

Contact Lens Related Dry Contact Lens Related Dry EyeEye

55% of wearers experience end-of-day discomfortMost common cause of drop-out is

due to discomfort41% due to dryness symptoms

FUSION CONCEPTThe new generation of contact lenses that release a natural tear substitute

Safilens has dedicated years of research and innovation looking for ways to maximise contact lens comfort and optimise ocular hydration. Safilens believes the controlled release of bio-active substances during contact lens wear to be the key to maintaining the delicate relationship between the contact lens and the tear film

Hyaluronic AcidHyaluronic AcidBenefits in EyecareBenefits in Eyecare

Biological polymerHA’s function in nature

is to attract waterextremely effective, even at very low concentrationsAttracts 3000x its own weight in water

Bio-adhesive propertiesNon Newtonian

behaviourProtective effect on

corneal epithelium

Tamarind Seed Tamarind Seed Polysaccharide (TSP)Polysaccharide (TSP)

Similar structure to ocular mucin

Similar structure to ocular mucin

HA + TSPHA + TSPThe interaction between HA and TSP is

cooperative forming a new bi-polymer

Resulting performance > SUM of its 2 partsResulting performance > SUM of its 2 parts

Relative Performance of Relative Performance of tear substitutestear substitutes

Natural Semi-synthetic Synthetic

HA TSP HPMC CMC PVA PVP

Hydration **** **** ** **** **** *

Lubrication

**** **** ** *** *** ***

Muco-adhesive

**** **** * **** * *

Muco-mimetic

**** **** * * * *

Viscoelastic

**** **** * *** * *

Wound healing

*** *** * ** * *

Ref: Current Medical Research and Opinion (2006)

Non Newtonian Fluid at High Viscosity Non Newtonian Fluid at Low Viscosity

Non-Newtonian BehaviourNon-Newtonian Behaviour

How it works…How it works…

Polymer chains become more disorganised with heating increasing its fluiditySheer force from blinking aids flow into

tearsNon-Newtonian behaviour mimics the

natural tearsMore fluid during blink – more viscous between blinks

Fusion Technolog

y

Increased tear film stability for

improved comfort

Prolonged muco-

mimetic activity

Maintains lens

hydration longer

Constant hydration

and lubrication

for excellent VA

Minimal friction

between lens and lid

Ultra-thin lens designHandles wellLens can be pulled quite robustly without breaking

Excellent DK/t: 40 (-3.00 at 35ºC)

More or less same as other hydrogel daily disposables

Lens design Lens design

ParametersParameters

-0.50 to -6.00 (0.25 steps)

-6.50 to -12.00 (0.50 steps)

Filcon IVIncorporating a bipolymer of HA-TSP

At the end of the day, At the end of the day, which would you choose?which would you choose?

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