first lecture gihan e-h gawish, msc, phd ass. professor molecular genetics and clinical biochemistry...
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Introduction to Molecular BiologyFirst Lecture
Gihan E-H Gawish, MSc, PhDAss. Professor
Molecular Genetics and Clinical Biochemistry
KSU
Molecular BiologyWhat is the molecular biology science? And
Why it is important to study?!
Timeline Events of Molecular Biology:
• 1860 Mendel – Mendel’s law of inheritance, gene& chromosome
• 1868 Miescher – nuclein, contained an acidic material
• 1890 Weismann - substance in the cell nuclei controls development.
• 1900 Chromosomes shown to contain hereditary information, later shown to be composed of protein & nucleic acids.
• 1928 Griffith’s Transformation Experiment
• 1944 Avery’s Transformation Experiment
• 1953 Hershey-Chase Bacteriophage Experiment
• 1953 Watson & Crick propose double-helix model of DNA
• 1956 Gierer & Schramm/Fraenkel-Conrat & SingerDemonstrate RNA is viral genetic material.
The law of independent assortment
The law of independent segregation
The law of dominance
1 -Mendel’s Three Law of Inheritance:// . . / / /http www sumanasinc com webcontent animations c
/ / .ontent mendel mendel html
Comment: Genes are located on chromosomes
Called in nuclein since it was from the nucleus
Had large amounts of phosphorous and no sulfur so was very different than protein
2 -Friedrick Miescher, a Swiss chemist
(Discovery of Deoxyribonucleic acid)
Comment: the two constituents of chromosomes; Proteins & DNA
Analytical Tests forC, H,P,O and N
“Nuclein”
DNA the molecule of life
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