featuring neuromics blood brain barrier model and components

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Image: Neurons+Astrocytes Co-cultures

Our Cornerstone: “Hard to Find” Human Primary Cells and 3-D Tissue Models

Cells, 3-D Models, Media and Custom Services

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3rd Party Service For Customer FeedbackNeuromics review summary5   74★4   27★3   1★102 reviewsSample Reviews

• The order arrived quickly. The service was great!Product Name: Human Brain Microvascular Endothelial Cells, 500,000+ Cells, - (Cat# HEC02)Human Brain Microvascular Pericytes (HBMPVCs), 500,000+ Cells, - (Cat# HMP104) ENDO-Growth Media, - (Cat#MED001) Pericyte-Growth Media, - (Cat# PGB001) Organization: UCS

• I use their O4-PE antibody for flow and it works really well, I'm very pleased with the product and haven't found anything nearly as good from other manufacturers. Product Name: Oligodendrocyte Marker 04 Phycoerythrin (Clone 04), Mouse – (Cat# FC15013). http://bit.ly/1bGhVSS Organization: Johns Hopkins University.

Free Cell and Media Replacements if cultures are not “healthy and happy” (or 100% refunds).

• Enables us to troubleshoot and get it right.• It prevents us from being “one and done”

Fetal Bovine Serum

• High Quality FBS – Used to culture our primary human cells, and in our optimized media

• Testimonial: “We have used the FBS from Neuromics in feeding media for primary mouse astrocytes as well as for some cell lines. Your product is good and we plan to continue using it.” - Svetlana Vidensky, MS, Senior Research Specialist in Dr. Jeffrey Rothstein lab, Department of Neurology, Johns Hopkins University

Blood Brain Barrier Model + Components• Human Blood Brain Barrier Model• Human Brain Microvascular Endothelial Cells• Human Brain Microvascular Pericytes (HBMVPCs)• Human Brain Astrocytes• Immortalized Human Brain Microglia Cells• hN2™ Neurons• Human Oligodendrocyte Precursors (OPCs)-Custom Services• Extra-cellular Matrix Designed for Neurons and Astroglia

Astrocyte, Brain Microvascular Endothelial/PericytesCross-talk key to generating “in-vivo” like data

Focus For 2017More Primary Human Cells

For example OligodendrocytesCells derived from diseased tissue

Add Content to 3-D Models

endothelial cells (high magnification) astrocytes (high magnification)

Compounds, Oligos and Small Molecules This model mimics the transport properties of the BBB due to the formation of tight junctions, higher expression of specific carriers, or great cell viability. This 3-D in vitro model is developed by culturing brain endothelial cells with pericytes and astrocytes layered in an insert. This model improves endothelial cell polarization and enhance the formation of tight junctions, provide better endothelial cell-to-cell contact that is important for barrier development, and prevent the dilution of secreted neurotrophic factors, and these conditions collectively led to the development of an in vitro model that can truly mimic the BBB.

BBB Assay Example• ABC Transporter and P-glycoprotein

• BBB Model used to measure penetration of hydrophobic molecules and compounds.

• P-gp antagonists and agonists used to modulate penetration.

BBB Permeability Assay

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Astro-glia Neurons Coculture Tox Assay• Cross-talk matters!

Isolating Oligodendrocyte Precursor Cells (OPCs)• Custom Services Example

• Client required 10,000,000• Human Microglia for TBI Related• Assays-Capture for • Auto-antibodies

• Isolated Cells from Adult Donor Tissue• Delivery of cells takes 4-6+ weeks (depends on cell numbers)

Sampling of Customers

Human Schwann Cells-SCI Derived

Phone: 952-374-616Fax: 612-677-3976Email: brett@neuromics.com for orders rose@neuromics.com for tech questions

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Pete Shuster-CEO and OwnerDirect Phone: 612-801-1007Email: pshuster@neuromics.com

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