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Lars Juhl Jensen jensenlab.org
Disease network mining
structured data
Jensen et al., Nature Reviews Genetics, 2012
unstructured data
free text
Danish
busy doctors
typos
unnatural language
central registries
civil registration system
Jensen et al., Nature Reviews Genetics, 2012
national discharge registry
Jensen et al., Nature Reviews Genetics, 2012
19 years
6.6 million patients
163 million diagnoses
only hospitals
reimbursement
linking diseases!
comorbidity
contingency table
Jensen et al., Nature Reviews Genetics, 2012
confounding factors
“known knowns”
sex
age
type of hospital encounter
Jensen et al., Nature Communications, 2014
“known unknowns”
smoking
diet
“unknown unknowns”
reporting biases
disease trajectories!
temporal correlations
trajectories
directional network
Jensen et al., Nature Communications, 2014
global map of diseases
Jensen et al., Nature Communications, 2014
targeted trajectories
sepsis
stratify patients
diabetes-related sepsis
Beck et al., Scientific Reports, 2016
alcohol-related sepsis
Beck et al., Scientific Reports, 2016
predict mortality
Acknowledgments!Anders Bøck Jensen Mette Kristina Beck
Annelaura Bach Nielsen Anders Perner Tudor Oprea
Pope Moseley Søren Brunak
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