diffuse tensor imaging - powerpoint presentation

Diffusion Tensor Imaging (DTI)

Kevin Li

Paul Mozo

Cesar Quintana

Andrea Rolong

Introduction To DTI Diffusion Tensor Imaging (DTI)

MR Imaging Modality Utilizes Diffusion Rate and Direction

of Diffusion Measurements Evaluate Various Conditions

Mainly Involving the Brain

Mori, Susumu, and Jiangyang Zhang. "Principles of Diffusion Tensor Imaging and Its Applications to Basic Neuroscience Research." Neuron. (527-539): 2006. Print.Presentation by Jay A. Van Gerpen, M.D., Neurologist Mayo Clinic Jacksonville, FL

Comparison to MRI

Main difference lies in the process of data acquisition Visualization techniques for diffusion tensor

data. Two groups: Image-based methods and the 3D rendering of

those images Symbolic (or geometric) display methods by

using various types of glyph such as ellipsoid

Tractography based on diffusion tensor tracking is the most attracting tools for visualizing and analyzing white matter fiber tracts

http://graphics.cs.ucdavis.edu/~lfeng/sig/tensor/papers/MR%20diffusion%20tensor%20imaging%20recent%20advance%20and%20new%20techniques%20for%20diffusion%20tensor%20visualization%20science.pdf

Image-based display of diffusion tensor data

Ellipsoidal visualization of diffusion tensor data

http://graphics.cs.ucdavis.edu/~lfeng/sig/tensor/papers/MR%20diffusion%20tensor%20imaging%20recent%20advance%20and%20new%20techniques%20for%20diffusion%20tensor%20visualization%20science.pdf

Fiber tractography by tracking diffusion tensor

http://graphics.cs.ucdavis.edu/~lfeng/sig/tensor/papers/MR%20diffusion%20tensor%20imaging%20recent%20advance%20and%20new%20techniques%20for%20diffusion%20tensor%20visualization%20science.pdf

Physics

• Tensor diffusion imaging uses the diffusion of water to measure the intensity of signal.

• The physics of weighted imaging f(x,y)=M0(1-e-TR/T1)e-TE/T2e-bD where b=(G∆)2(∆-/3) .

• Tensors are used to limited number of measurements.

• Diffusion tensor can be determined by using vector multiplications

B=

X=BD

http://books.google.com/books?id=QJ-l7p0seTMC&printsec=frontcover&dq=diffusion+tensor+imaging&cd=1#v=onepage&q&f=true

http://books.google.com/books?id=N20nnxByjVAC&printsec=frontcover&dq=diffusion+mri&cd=5#v=onepage&q&f=true

Ref: Jay A. Van Gerpen, M.D., Neurologist Mayo Clinic Jacksonville, www.medical.siemens.com/siemens/sv_SE/gg_mr_FBAs/files/brochures/DTI_HT_FINAL_HI.pdf, Filippi M, Cercignani M, Inglese M, Horsfield M, Comi G (2001) Diffusion tensor magnetic resonance imaging in multiple sclerosis, HARVARD REV PSYCHIATRY 2002, Department of Radiology, University of Michigan Health System, Fundamentals of Human Neuropsychology By Bryan Kolb

• DTI is an important tool in Neuroscience research

• Significant role in evaluation of brain tumor

• DTI complements BOLD fMRI

• Finding new clinical applications for DTI is a hot topic in the MR research community

APPLICATIONS

Image fusion of anatomical image, DTI data and fMRI BOLD results

Review of specific applications of Diffusion Tensor Imaging in brain tumors

Ref: HARVARD REV PSYCHIATRY 2002, Department of Radiology, University of Michigan Health System, Department of Radiology Division of NMR Johns Hopkins University, JOURNAL OF MAGNETIC RESONANCE IMAGING 13:534–546 (2001), Fundamentals of Human Neuropsychology By Bryan Kolb, Ian Q. Whishaw, bic.missouri.edu.

FutureReal Time ImagingDecrease The Number of Programs Validate and Develop New AlgorithmsUse of Contrast AgentsUse of DTI in Other Areas of Medicine

Questions???