danese 2009 ppt
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ADVERSE CHILDHOOD EXPERIENCES AND ADULT RISK FACTORS FOR AGE-RELATED DISEASEDepression, Inflammation, and Clustering of Metabolic Risk Factors
Danese A, Moffitt TE, Harrington H, Milne BJ, Polancyzk G, Pariante CM, Poulton R, Caspi A., (2009).
By: Karen Kaye
INTRODUCTION People are living longer, thus age-related diseases are increasing
(Lutz et al., 2008; Murray et al., 1997).
Effective strategies are needed to improve quality of longer lives from these age-related diseases (Braunwald et al., 1997; Edbrahim et al., 2006).
Interventions in later adulthood have limited efficacy, so there is increasing knowledge that many of these diseases can be triggered by childhood experiences (McGill et al., 2003).
Age-related conditions examined:
Depression- HPA hyperreactivity- CVD- diabetes- dementia- Vascular changes- Hypercoagulability
Inflammation- Atherosclerosis- Insulin resistance- Neurodegeneration- Diabetes- Dementia
Metabolic Risk Markers- CVD- Diabetes- Dementia - Hormonal imbalance- Vascular lesions
INTRO CONTINUED
It is important to get a better understanding of the origins of these diseases through studying adverse childhood experiences:
1. Low SES
2. Maltreatment
3. Social Isolation
Research Questions:1. Are the effects of different adverse childhood experiences distinct
from each other?2. Do these experiences have different effects on biological systems?3. Are childhood experiences independent of other risk factors for
disease?
METHODSParticipant sample:
Dunedin Multidisciplinary Health and Development Study, New Zealand
1037 (52% male) born between 1972-73, full range SES, mostly white
Assessments started at age 3, stopped at age 32 (final N=892)
Timeline:
1972-73 2004-05
3 5 7 181513119 2621 32
Childhood SES
Social IsolationBMI
Maternal rejectionHarsh discipline
Primary caregiverPhysical abuseSexual abuse
Blood samplesDepression
MRMFamily History Current SES
Health behaviors
RESULTS
RESULTS
RESULTS
DISCUSSIONAre the effects of different adverse childhood experiences distinct from each other? Each adverse childhood experience independently predicts a greater number of
age-related disease
Do these experiences have different effects on biological systems? Adverse childhood experiences were found to affect metabolic risk
factors and inflammation
Are childhood experiences independent of other risk factors for disease? After accounting for the effects of established developmental and
concurrent risk factors, each childhood experience still predicted a greater number of age-related-disease risks
DISCUSSION
Do you have questions about the methods?
DISCUSSION
Do you have any critiques?
DISCUSSION
What are the implications?
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